Desenvolvimento de novas associações farmacêuticas a base de 5- fluorouracil com vistas à aplicação no tratamento de câncer de pele.

Detalhes bibliográficos
Autor(a) principal: FERREIRA, Elis Cristina de Sousa
Data de Publicação: 2023
Tipo de documento: Dissertação
Idioma: por
Título da fonte: Biblioteca Digital de Teses e Dissertações da UFMA
Texto Completo: https://tedebc.ufma.br/jspui/handle/tede/tede/4990
Resumo: Cancer is a center of several diseases, according to the National Cancer Institute, where cancer cells multiply, gaining space from cells considered good, invading organs and tissues causing cancer itself. Faced with the various types of cancer most incident in the world, such as colorectal, breast, pancreas, head and neck, prostate, uterine cervix, colon and rectum and melanoma skin, traditional treatments are the most used, including surgery, chemotherapy and radiotherapy. In these treatments, 5-Fluorouracil, 5-FU, is one of the most used drugs for different types of cancer. Its continuous use causes several side effects in addition to being rapidly eliminated and having a short plasma half-life. In order to improve its side effects and intensify its action in the treatment of cancer, resorcin was used to prepare associations, which can be used for various purposes, such as contributing to the ability to improve the stability of vitamin D, UV stabilizers, having pharmacological properties which include treatments for the skin. These associations were characterized by FTIR where it was possible to predict the possible interactions between both drugs, while the XRD helped to investigate the crystallinity of the associations. As carriers of the synthesized associations, a biopolymeric matrix of chitosan and gelatin was used, which were processed as homogeneous films with good mechanical properties. Such films were characterized by SEM, in addition to stability, water absorption, transparency and UV light blocking tests, where they were shown to be transparent in visible light and blockers in UV light.
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spelling ALCÂNTARA, Ana Clécia Santos dehttp://lattes.cnpq.br/3149929057352643ALCÂNTARA, Ana Clécia Santos dehttp://lattes.cnpq.br/3149929057352643LIMA, Roberto Batista Dehttp://lattes.cnpq.br/4982744838486744SANTANA, Sirlane Aparecida Abreuhttp://lattes.cnpq.br/1052349578152491http://lattes.cnpq.br/0290325400136663FERREIRA, Elis Cristina de Sousa2023-09-26T18:30:04Z2023-09-13FERREIRA, Elis Cristina de Sousa. Desenvolvimento de novas associações farmacêuticas a base de 5- fluorouracil com vistas à aplicação no tratamento de câncer de pele.. 2023. 54 f. Dissertação( Programa de Pós-graduação em Química/CCET) - Universidade Federal do Maranhão, São Luís, 2023.https://tedebc.ufma.br/jspui/handle/tede/tede/4990Cancer is a center of several diseases, according to the National Cancer Institute, where cancer cells multiply, gaining space from cells considered good, invading organs and tissues causing cancer itself. Faced with the various types of cancer most incident in the world, such as colorectal, breast, pancreas, head and neck, prostate, uterine cervix, colon and rectum and melanoma skin, traditional treatments are the most used, including surgery, chemotherapy and radiotherapy. In these treatments, 5-Fluorouracil, 5-FU, is one of the most used drugs for different types of cancer. Its continuous use causes several side effects in addition to being rapidly eliminated and having a short plasma half-life. In order to improve its side effects and intensify its action in the treatment of cancer, resorcin was used to prepare associations, which can be used for various purposes, such as contributing to the ability to improve the stability of vitamin D, UV stabilizers, having pharmacological properties which include treatments for the skin. These associations were characterized by FTIR where it was possible to predict the possible interactions between both drugs, while the XRD helped to investigate the crystallinity of the associations. As carriers of the synthesized associations, a biopolymeric matrix of chitosan and gelatin was used, which were processed as homogeneous films with good mechanical properties. Such films were characterized by SEM, in addition to stability, water absorption, transparency and UV light blocking tests, where they were shown to be transparent in visible light and blockers in UV light.O câncer é um centro de várias doenças, de acordo com o Instituto Nacional do Câncer, onde as células cancerígenas se multiplicam ganhando espaço das células consideradas boas, invadindo órgãos e tecidos causando o câncer propriamente dito. Diante dos diversos tipos de câncer mais incidentes no mundo como, colorretal, mama, pâncreas, cabeça e pescoço, próstata, colo uterino, cólon e reto e pele melanoma, os tratamentos tradicionais são os mais utilizados, dentre eles a cirurgia, quimioterapia e radioterapia. Nestes tratamentos, o 5-Fluorouracil, 5-FU, é um dos fármacos mais empregados para diversos tipos de câncer. Seu uso contínuo provoca diversos efeitos colaterais além de ser rapidamente eliminado e possuir uma meia-vida plasmática curta. Com o intuito de melhorar seus efeitos colaterais e intensificar sua ação no tratamento do câncer utilizou-se a resorcina para o preparo de associações, que pode ser utilizada para diversos fins, como contribuir para a capacidade de melhoria da estabilidade da vitamina D, estabilizadores UV, possuindo propriedades farmacológicas das quais incluem tratamentos para a pele. Estas associações foram caracterizadas por FTIR onde foi possível prever as possíveis interações entre ambos os fármacos, enquanto o DRX ajudou a investigar a cristalinidade das associações. Como carreadores das associações sintetizadas, empregou-se matriz biopolimérica de quitosana e gelatina, os quais foram processados como filmes homogêneos e com boas propriedades mecânicas. Tais filmes foram caracterizados por MEV, além de testes de estabilidade, absorção de água, transparência e teste de bloqueio de luz UV, onde mostraram ser transparentes na luz visível e bloqueadores na luz UV.Submitted by Maria Aparecida (cidazen@gmail.com) on 2023-09-26T18:30:04Z No. of bitstreams: 1 ELIS CRISTINA DE SOUSA FERREIRA.pdf: 1598611 bytes, checksum: 9ca0edd1b44183c65bacd1d4634a52c5 (MD5)Made available in DSpace on 2023-09-26T18:30:04Z (GMT). No. of bitstreams: 1 ELIS CRISTINA DE SOUSA FERREIRA.pdf: 1598611 bytes, checksum: 9ca0edd1b44183c65bacd1d4634a52c5 (MD5) Previous issue date: 2023-09-13CNPqapplication/pdfporUniversidade Federal do MaranhãoPROGRAMA DE PÓS-GRADUAÇÃO EM QUÍMICA/CCETUFMABrasilDEPARTAMENTO DE QUÍMICA/CCETCâncer de pele;5-FU;resorcina;associação;filmes biopoliméricosSkin cancer;5-FU;resorcin;association;biopolymeric filmsCancerologiaDesenvolvimento de novas associações farmacêuticas a base de 5- fluorouracil com vistas à aplicação no tratamento de câncer de pele.Development of new pharmaceutical associations based on 5-FLUOROURACIL with a view to application in the treatment of skin cancerinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisinfo:eu-repo/semantics/openAccessreponame:Biblioteca Digital de Teses e Dissertações da UFMAinstname:Universidade Federal do Maranhão (UFMA)instacron:UFMAORIGINALELIS CRISTINA DE SOUSA FERREIRA.pdfELIS CRISTINA DE SOUSA FERREIRA.pdfapplication/pdf1598611http://tedebc.ufma.br:8080/bitstream/tede/4990/2/ELIS+CRISTINA+DE+SOUSA+FERREIRA.pdf9ca0edd1b44183c65bacd1d4634a52c5MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-82255http://tedebc.ufma.br:8080/bitstream/tede/4990/1/license.txt97eeade1fce43278e63fe063657f8083MD51tede/49902023-09-26 15:30:04.155oai:tede2: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Biblioteca Digital de Teses e Dissertaçõeshttps://tedebc.ufma.br/jspui/PUBhttp://tedebc.ufma.br:8080/oai/requestrepositorio@ufma.br||repositorio@ufma.bropendoar:21312023-09-26T18:30:04Biblioteca Digital de Teses e Dissertações da UFMA - Universidade Federal do Maranhão (UFMA)false
dc.title.por.fl_str_mv Desenvolvimento de novas associações farmacêuticas a base de 5- fluorouracil com vistas à aplicação no tratamento de câncer de pele.
dc.title.alternative.eng.fl_str_mv Development of new pharmaceutical associations based on 5-FLUOROURACIL with a view to application in the treatment of skin cancer
title Desenvolvimento de novas associações farmacêuticas a base de 5- fluorouracil com vistas à aplicação no tratamento de câncer de pele.
spellingShingle Desenvolvimento de novas associações farmacêuticas a base de 5- fluorouracil com vistas à aplicação no tratamento de câncer de pele.
FERREIRA, Elis Cristina de Sousa
Câncer de pele;
5-FU;
resorcina;
associação;
filmes biopoliméricos
Skin cancer;
5-FU;
resorcin;
association;
biopolymeric films
Cancerologia
title_short Desenvolvimento de novas associações farmacêuticas a base de 5- fluorouracil com vistas à aplicação no tratamento de câncer de pele.
title_full Desenvolvimento de novas associações farmacêuticas a base de 5- fluorouracil com vistas à aplicação no tratamento de câncer de pele.
title_fullStr Desenvolvimento de novas associações farmacêuticas a base de 5- fluorouracil com vistas à aplicação no tratamento de câncer de pele.
title_full_unstemmed Desenvolvimento de novas associações farmacêuticas a base de 5- fluorouracil com vistas à aplicação no tratamento de câncer de pele.
title_sort Desenvolvimento de novas associações farmacêuticas a base de 5- fluorouracil com vistas à aplicação no tratamento de câncer de pele.
author FERREIRA, Elis Cristina de Sousa
author_facet FERREIRA, Elis Cristina de Sousa
author_role author
dc.contributor.advisor1.fl_str_mv ALCÂNTARA, Ana Clécia Santos de
dc.contributor.advisor1Lattes.fl_str_mv http://lattes.cnpq.br/3149929057352643
dc.contributor.referee1.fl_str_mv ALCÂNTARA, Ana Clécia Santos de
dc.contributor.referee1Lattes.fl_str_mv http://lattes.cnpq.br/3149929057352643
dc.contributor.referee2.fl_str_mv LIMA, Roberto Batista De
dc.contributor.referee2Lattes.fl_str_mv http://lattes.cnpq.br/4982744838486744
dc.contributor.referee3.fl_str_mv SANTANA, Sirlane Aparecida Abreu
dc.contributor.referee3Lattes.fl_str_mv http://lattes.cnpq.br/1052349578152491
dc.contributor.authorLattes.fl_str_mv http://lattes.cnpq.br/0290325400136663
dc.contributor.author.fl_str_mv FERREIRA, Elis Cristina de Sousa
contributor_str_mv ALCÂNTARA, Ana Clécia Santos de
ALCÂNTARA, Ana Clécia Santos de
LIMA, Roberto Batista De
SANTANA, Sirlane Aparecida Abreu
dc.subject.por.fl_str_mv Câncer de pele;
5-FU;
resorcina;
associação;
filmes biopoliméricos
topic Câncer de pele;
5-FU;
resorcina;
associação;
filmes biopoliméricos
Skin cancer;
5-FU;
resorcin;
association;
biopolymeric films
Cancerologia
dc.subject.eng.fl_str_mv Skin cancer;
5-FU;
resorcin;
association;
biopolymeric films
dc.subject.cnpq.fl_str_mv Cancerologia
description Cancer is a center of several diseases, according to the National Cancer Institute, where cancer cells multiply, gaining space from cells considered good, invading organs and tissues causing cancer itself. Faced with the various types of cancer most incident in the world, such as colorectal, breast, pancreas, head and neck, prostate, uterine cervix, colon and rectum and melanoma skin, traditional treatments are the most used, including surgery, chemotherapy and radiotherapy. In these treatments, 5-Fluorouracil, 5-FU, is one of the most used drugs for different types of cancer. Its continuous use causes several side effects in addition to being rapidly eliminated and having a short plasma half-life. In order to improve its side effects and intensify its action in the treatment of cancer, resorcin was used to prepare associations, which can be used for various purposes, such as contributing to the ability to improve the stability of vitamin D, UV stabilizers, having pharmacological properties which include treatments for the skin. These associations were characterized by FTIR where it was possible to predict the possible interactions between both drugs, while the XRD helped to investigate the crystallinity of the associations. As carriers of the synthesized associations, a biopolymeric matrix of chitosan and gelatin was used, which were processed as homogeneous films with good mechanical properties. Such films were characterized by SEM, in addition to stability, water absorption, transparency and UV light blocking tests, where they were shown to be transparent in visible light and blockers in UV light.
publishDate 2023
dc.date.accessioned.fl_str_mv 2023-09-26T18:30:04Z
dc.date.issued.fl_str_mv 2023-09-13
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/masterThesis
format masterThesis
status_str publishedVersion
dc.identifier.citation.fl_str_mv FERREIRA, Elis Cristina de Sousa. Desenvolvimento de novas associações farmacêuticas a base de 5- fluorouracil com vistas à aplicação no tratamento de câncer de pele.. 2023. 54 f. Dissertação( Programa de Pós-graduação em Química/CCET) - Universidade Federal do Maranhão, São Luís, 2023.
dc.identifier.uri.fl_str_mv https://tedebc.ufma.br/jspui/handle/tede/tede/4990
identifier_str_mv FERREIRA, Elis Cristina de Sousa. Desenvolvimento de novas associações farmacêuticas a base de 5- fluorouracil com vistas à aplicação no tratamento de câncer de pele.. 2023. 54 f. Dissertação( Programa de Pós-graduação em Química/CCET) - Universidade Federal do Maranhão, São Luís, 2023.
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dc.publisher.initials.fl_str_mv UFMA
dc.publisher.country.fl_str_mv Brasil
dc.publisher.department.fl_str_mv DEPARTAMENTO DE QUÍMICA/CCET
publisher.none.fl_str_mv Universidade Federal do Maranhão
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