Efeitos do treinamento físico aeróbio e resistido em modelo experimental de síndrome metabólica com privação dos hormônios ovarianos: componentes do estresse oxidativo no tecido hepático.
Autor(a) principal: | |
---|---|
Data de Publicação: | 2020 |
Tipo de documento: | Dissertação |
Idioma: | por |
Título da fonte: | Biblioteca Digital de Teses e Dissertações da UFMA |
Texto Completo: | https://tedebc.ufma.br/jspui/handle/tede/tede/3148 |
Resumo: | With the advent of menopause, as well as post-menopause, the protective effects of ovarian hormones are diminished. This fact, which projects permissibility regarding the involvement of cardiometabolic degenerative diseases. Thus, the objective of the present study was to evaluate the effects of aerobic and resistance physical training on the deprivation of ovarian hormones associated with hypertension and chronic fructose consumption on metabolic, cardiovascular and oxidative stress parameters in liver tissue. Female Wistar (n = 8) and SHR (n = 40) rats were divided into: control (C), hypertensive (H), oophorectomized hypertensive (HO), hypertensive treated with oophorectomized fructose (HOF) submitted to aerobic physical training (HFOTa) or resistance physical training (HFOTr). Aerobic physical training (treadmill; 1h / day; 5x / week) and resistance physical training (ladder adapted for rats; 1h / day; 5x / week) were performed for 8 weeks. Parameters of cardiovascular function, metabolic and physical capacity and its relationship with changes in liver oxidative stress were evaluated. The results show a higher HR in the hypertensive group submitted to oophorectomy + fructose overload (HOF: 393 ± 28 bpm), when compared to the groups: C (350 ± 31 bpm), H (355 ± 18 bpm), HO (345 ± 34 bpm), HOFTa (335 ± 25 bpm) and HOFTr (333 ± 37 bpm). The groups that were deprived of ovarian hormones: HO (261 ± 8 g), HOF (261 ± 8 g), HOFTa (264 ± 11 g) had higher body weight at the end of the protocol, except the HOFTr group (241 ± 8 g). The performance of the exercise test at the end of the eight weeks obtained a longer running time for the trained animals (HOFTa: 25 ± 2.3 min) compared to sedentary animals (C: 18 ± 5.6 min, H: 24 ± 4, 8 min, HO: 23 ± 4.8 min, HOF: 22 ± 4.8 min). The final maximum load test, HOFTr (554 ± 42 g) was greater than C (204 ± 31 g), H (360 ± 56 g), HO (335 ± 104 g), HOF (410 ± 56 g), showing the effectiveness of training in these animals. For TBARS, HOF (1.6 ± 0.28 umol / mg protein) was higher compared to H (1.0 ± 0.34 umol / mg protein), HO (1.0 ± 0.25 umol / mg protein) ). For Carbonilas, H (7 ± 3.05 nmol / mgprotein), HO (5.9 ± 1.13 nmol / mg protein), HOF (5.2 ± 1.27 nmol / mg protein), HOFta (5 , 2 ± 1.13 nmol / mg protein), HOFTr (5.3 ± 1.47 nmol / mg protein) were greater than C (1.0 ± 0.42 nmol / mg protein). The concentration of CAT (H: 6.6 ± 1.35 nmol / mg protein; HO: 6.9 ± 2.85 nmol / mg protein; HOF: 7.8 ± 1.92 nmol / mg protein; HOFta: 6 , 2 ± 0.93 nmol / mg protein; HOFTr: 6.4 ± 2.20 nmol / mg protein)) were greater than C (2.7 ± 0.90 nmol / mg protein). SOD activity, in the HOFTa group, 28.0 ± 5.02 nmol / mg protein) was higher than in C (22 ± 7.56 nmol / mg protein), H (18.9 ± 3.72 nmol / mg protein) ), HO (19.4 ± 4.54 nmol / mg protein), HOF (20.1 ± 5.30 nmol / mg protein), and with the exception of HOFTr (16.7 ± 5.19 nmol / mg protein) . GPx activity was higher in all groups (H: 112.2 ± 12.21 nmol / mg protein; HO: 101.4 ± 22.67 nmol / mg protein; HOF: 108.1 ± 20.70 nmol / mg protein; HOFta: 119.6 ± 15.57 nmol / mg protein; HOFTr: 98.4 ± 26.09 nmol / mg protein)) compared to C (41.0 ± 16.36 nmol / mg protein). Therefore, aerobic or resistance training of moderate intensity in this model of association of risk factors attenuated some of the metabolic and cardiovascular dysfunctions probably because it improves the oxidative stress profile in the liver tissue. |
id |
UFMA_13d4cbd4d75f3a16488892020c91eaf9 |
---|---|
oai_identifier_str |
oai:tede2:tede/3148 |
network_acronym_str |
UFMA |
network_name_str |
Biblioteca Digital de Teses e Dissertações da UFMA |
repository_id_str |
2131 |
spelling |
MONZANI, Janaina de Oliveira Brito344.795.378-05http://lattes.cnpq.br/5106100358268027MONZANI, Janaina de Oliveira Brito344.795.378-05http://lattes.cnpq.br/5106100358268027NAVARRO, Antonio Coppihttp://lattes.cnpq.br/7269812755382405NAVARRO, Franciscohttp://lattes.cnpq.br/0628582355687773DIAS, Danielle da Silvahttp://lattes.cnpq.br/6644420445148028052.977.633-20http://lattes.cnpq.br/2350938873358491SEREJO, Jerdianny Silva2021-01-26T14:36:40Z2020-11-26SEREJO, Jerdianny Silva. Efeitos do treinamento físico aeróbio e resistido em modelo experimental de síndrome metabólica com privação dos hormônios ovarianos: componentes do estresse oxidativo no tecido hepático.. 2020. 56 f. Dissertação (Programa de Pós-Graduação em Educação Física) - Universidade Federal do Maranhão, São Luís, 2020.https://tedebc.ufma.br/jspui/handle/tede/tede/3148With the advent of menopause, as well as post-menopause, the protective effects of ovarian hormones are diminished. This fact, which projects permissibility regarding the involvement of cardiometabolic degenerative diseases. Thus, the objective of the present study was to evaluate the effects of aerobic and resistance physical training on the deprivation of ovarian hormones associated with hypertension and chronic fructose consumption on metabolic, cardiovascular and oxidative stress parameters in liver tissue. Female Wistar (n = 8) and SHR (n = 40) rats were divided into: control (C), hypertensive (H), oophorectomized hypertensive (HO), hypertensive treated with oophorectomized fructose (HOF) submitted to aerobic physical training (HFOTa) or resistance physical training (HFOTr). Aerobic physical training (treadmill; 1h / day; 5x / week) and resistance physical training (ladder adapted for rats; 1h / day; 5x / week) were performed for 8 weeks. Parameters of cardiovascular function, metabolic and physical capacity and its relationship with changes in liver oxidative stress were evaluated. The results show a higher HR in the hypertensive group submitted to oophorectomy + fructose overload (HOF: 393 ± 28 bpm), when compared to the groups: C (350 ± 31 bpm), H (355 ± 18 bpm), HO (345 ± 34 bpm), HOFTa (335 ± 25 bpm) and HOFTr (333 ± 37 bpm). The groups that were deprived of ovarian hormones: HO (261 ± 8 g), HOF (261 ± 8 g), HOFTa (264 ± 11 g) had higher body weight at the end of the protocol, except the HOFTr group (241 ± 8 g). The performance of the exercise test at the end of the eight weeks obtained a longer running time for the trained animals (HOFTa: 25 ± 2.3 min) compared to sedentary animals (C: 18 ± 5.6 min, H: 24 ± 4, 8 min, HO: 23 ± 4.8 min, HOF: 22 ± 4.8 min). The final maximum load test, HOFTr (554 ± 42 g) was greater than C (204 ± 31 g), H (360 ± 56 g), HO (335 ± 104 g), HOF (410 ± 56 g), showing the effectiveness of training in these animals. For TBARS, HOF (1.6 ± 0.28 umol / mg protein) was higher compared to H (1.0 ± 0.34 umol / mg protein), HO (1.0 ± 0.25 umol / mg protein) ). For Carbonilas, H (7 ± 3.05 nmol / mgprotein), HO (5.9 ± 1.13 nmol / mg protein), HOF (5.2 ± 1.27 nmol / mg protein), HOFta (5 , 2 ± 1.13 nmol / mg protein), HOFTr (5.3 ± 1.47 nmol / mg protein) were greater than C (1.0 ± 0.42 nmol / mg protein). The concentration of CAT (H: 6.6 ± 1.35 nmol / mg protein; HO: 6.9 ± 2.85 nmol / mg protein; HOF: 7.8 ± 1.92 nmol / mg protein; HOFta: 6 , 2 ± 0.93 nmol / mg protein; HOFTr: 6.4 ± 2.20 nmol / mg protein)) were greater than C (2.7 ± 0.90 nmol / mg protein). SOD activity, in the HOFTa group, 28.0 ± 5.02 nmol / mg protein) was higher than in C (22 ± 7.56 nmol / mg protein), H (18.9 ± 3.72 nmol / mg protein) ), HO (19.4 ± 4.54 nmol / mg protein), HOF (20.1 ± 5.30 nmol / mg protein), and with the exception of HOFTr (16.7 ± 5.19 nmol / mg protein) . GPx activity was higher in all groups (H: 112.2 ± 12.21 nmol / mg protein; HO: 101.4 ± 22.67 nmol / mg protein; HOF: 108.1 ± 20.70 nmol / mg protein; HOFta: 119.6 ± 15.57 nmol / mg protein; HOFTr: 98.4 ± 26.09 nmol / mg protein)) compared to C (41.0 ± 16.36 nmol / mg protein). Therefore, aerobic or resistance training of moderate intensity in this model of association of risk factors attenuated some of the metabolic and cardiovascular dysfunctions probably because it improves the oxidative stress profile in the liver tissue.Com o advento do climatério, assim como a pós-menopausa, os efeitos protetores dos hormônios ovarianos são diminuídos. Fato este, que projeta permissibilidade quanto ao acometimento de doenças degenerativas de ordem cardiometabólica. Desta forma, o objetivo do presente estudo foi avaliar os efeitos do treinamento físico aeróbio e resistido na privação dos hormônios ovarianos associado à hipertensão e ao consumo crônico de frutose em parâmetros metabólicos, cardiovasculares e de estresse oxidativo no tecido hepático. Ratas fêmeas Wistar (n=8) e SHR (n=40) foram divididas em: controle (C), hipertensas (H), hipertensas ooforectomizadas (HO), hipertensas tratadas com frutose ooforectomizadas (HOF) submetidas ao treinamento físico aeróbio (HOFTa) ou treinamento físico resistido (HOFTr). O treinamento físico aeróbio (esteira; 1h/dia; 5x/sem) e o treinamento físico resistido (escada adaptada para ratos; 1h/dia; 5x/sem) foram realizados durante 8 semanas. Parâmetros de função cardiovascular, metabólicos e de capacidade física e sua relação com alterações de estresse oxidativo hepático foram avaliados. Os grupos que foram privados dos hormônios ovarianos: HO (261±8 g), HOF (261±8 g), HOFTa (264±11 g) apresentaram maior peso corporal ao final do protocolo, exceto o grupo HOFTr (241±8g). A realização do teste de esforço ao final das oito semanas obteve maior tempo de corrida das ratas treinadas (HOFTa: 25±2,3 min) em relação as ratas sedentárias (C:18±5,6 min, H:24±4,8 min, HO: 23±4,8 min, HOF: 22±4,8 min). O teste de carga máxima foi maior no grupo HOFTr (554±42 g) quando comparados aos demais grupos estudados (C:204±31 g; H:360±56 g, HO:335±104 g, HOF: 410±56 g), evidenciando a eficácia do treinamento nesses animais. A frequência cardíaca foi maior no grupo hipertenso submetido à ooforectomia + sobrecarga de frutose (HOF:393±28 bpm), se comparado aos grupos: controle C (350±31 bpm), H (355±18 bpm), HO (345±34 bpm), HOFTa (335±25 bpm) e HOFTr (333±37 bpm). Para TBARS, HOF (1,6±0,28 umol/mg proteína) foi maior em comparação ao H (1,0±0,34 umol/mg proteína) e HO (1,0±0,25 umol/mg proteína). Já para Carbonilas, H (7±3,05 nmol/mg proteína), HO (5,9±1,13 nmol/mg proteína), HOF (5,2±1,27 nmol/mg proteína), HOFta (5,2±1,13 nmol/mg proteína), HOFTr (5,3±1,47 nmol/mg proteína) foram maiores que C (1,0±0,42 nmol/mg proteína). A concentração de catalase (H: 6,6±1,35 nmol/mg proteína; HO: 6,9±2,85 nmol/mg proteína; HOF: 7,8±1,92 nmol/mg proteína; HOFta: 6,2±0,93 nmol/mg proteína; HOFTr: 6,4±2,20 nmol/mg proteína) foi maior que C (2,7±0,90 nmol/mg proteína). Já para a atividade da SOD, no grupo HOFTa 28,0±5,02 nmol/mg proteína) foi maior que em C (22±7,56 nmol/mg proteína), H (18,9±3,72 nmol/mg proteína), HO (19,4±4,54 nmol/mg proteína), HOF (20,1±5,30 nmol/mg proteína), e com exceção à HOFTr (16,7±5,19 nmol/mg proteína). Já a atividade da GPx foi maior em todos os grupos (H: 112,2±12,21 nmol/mg proteína; HO: 101,4±22,67 nmol/mg proteína; HOF: 108,1±20,70 nmol/mg proteína; HOFta: 119,6±15,57 nmol/mg proteína; HOFTr: 98,4±26,09 nmol/mg proteína) em comparação a C (41,0±16,36 nmol/mg proteína). Portanto, o treinamento físico aeróbio e/ou resistido de intensidade moderada neste modelo de associação de fatores de risco atenuou algumas das disfunções metabólicas e cardiovasculares provavelmente por melhorar o perfil de estresse oxidativo no tecido hepático.Submitted by Daniella Santos (daniella.santos@ufma.br) on 2021-01-26T14:36:40Z No. of bitstreams: 1 JerdiannySerejo.pdf: 708351 bytes, checksum: 3baa7269cf0462c9560ae2a2cf7d63c7 (MD5)Made available in DSpace on 2021-01-26T14:36:40Z (GMT). No. of bitstreams: 1 JerdiannySerejo.pdf: 708351 bytes, checksum: 3baa7269cf0462c9560ae2a2cf7d63c7 (MD5) Previous issue date: 2020-11-26application/pdfporUniversidade Federal do MaranhãoPROGRAMA DE PÓS-GRADUACAO EM EDUCAÇÃO FÍSICAUFMABrasilDEPARTAMENTO DE EDUCAÇÃO FÍSICA/CCBSMenopausaSíndrome metabólicaHipertensãoEstresse oxidativoFígadoMenopauseMetabolic syndromeHypertensionOxidative stressLiverEducação FísicaFisiologia de Órgaos e SistemasEfeitos do treinamento físico aeróbio e resistido em modelo experimental de síndrome metabólica com privação dos hormônios ovarianos: componentes do estresse oxidativo no tecido hepático.Effects of aerobic and resistance physical training in an experimental model of metabolic syndrome with deprivation of ovarian hormones: components of oxidative stress in liver tissue.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisinfo:eu-repo/semantics/openAccessreponame:Biblioteca Digital de Teses e Dissertações da UFMAinstname:Universidade Federal do Maranhão (UFMA)instacron:UFMAORIGINALJerdiannySerejo.pdfJerdiannySerejo.pdfapplication/pdf708351http://tedebc.ufma.br:8080/bitstream/tede/3148/2/JerdiannySerejo.pdf3baa7269cf0462c9560ae2a2cf7d63c7MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-82255http://tedebc.ufma.br:8080/bitstream/tede/3148/1/license.txt97eeade1fce43278e63fe063657f8083MD51tede/31482021-01-26 11:36:40.529oai:tede2: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Biblioteca Digital de Teses e Dissertaçõeshttps://tedebc.ufma.br/jspui/PUBhttp://tedebc.ufma.br:8080/oai/requestrepositorio@ufma.br||repositorio@ufma.bropendoar:21312021-01-26T14:36:40Biblioteca Digital de Teses e Dissertações da UFMA - Universidade Federal do Maranhão (UFMA)false |
dc.title.por.fl_str_mv |
Efeitos do treinamento físico aeróbio e resistido em modelo experimental de síndrome metabólica com privação dos hormônios ovarianos: componentes do estresse oxidativo no tecido hepático. |
dc.title.alternative.eng.fl_str_mv |
Effects of aerobic and resistance physical training in an experimental model of metabolic syndrome with deprivation of ovarian hormones: components of oxidative stress in liver tissue. |
title |
Efeitos do treinamento físico aeróbio e resistido em modelo experimental de síndrome metabólica com privação dos hormônios ovarianos: componentes do estresse oxidativo no tecido hepático. |
spellingShingle |
Efeitos do treinamento físico aeróbio e resistido em modelo experimental de síndrome metabólica com privação dos hormônios ovarianos: componentes do estresse oxidativo no tecido hepático. SEREJO, Jerdianny Silva Menopausa Síndrome metabólica Hipertensão Estresse oxidativo Fígado Menopause Metabolic syndrome Hypertension Oxidative stress Liver Educação Física Fisiologia de Órgaos e Sistemas |
title_short |
Efeitos do treinamento físico aeróbio e resistido em modelo experimental de síndrome metabólica com privação dos hormônios ovarianos: componentes do estresse oxidativo no tecido hepático. |
title_full |
Efeitos do treinamento físico aeróbio e resistido em modelo experimental de síndrome metabólica com privação dos hormônios ovarianos: componentes do estresse oxidativo no tecido hepático. |
title_fullStr |
Efeitos do treinamento físico aeróbio e resistido em modelo experimental de síndrome metabólica com privação dos hormônios ovarianos: componentes do estresse oxidativo no tecido hepático. |
title_full_unstemmed |
Efeitos do treinamento físico aeróbio e resistido em modelo experimental de síndrome metabólica com privação dos hormônios ovarianos: componentes do estresse oxidativo no tecido hepático. |
title_sort |
Efeitos do treinamento físico aeróbio e resistido em modelo experimental de síndrome metabólica com privação dos hormônios ovarianos: componentes do estresse oxidativo no tecido hepático. |
author |
SEREJO, Jerdianny Silva |
author_facet |
SEREJO, Jerdianny Silva |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
MONZANI, Janaina de Oliveira Brito |
dc.contributor.advisor1ID.fl_str_mv |
344.795.378-05 |
dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/5106100358268027 |
dc.contributor.referee1.fl_str_mv |
MONZANI, Janaina de Oliveira Brito |
dc.contributor.referee1ID.fl_str_mv |
344.795.378-05 |
dc.contributor.referee1Lattes.fl_str_mv |
http://lattes.cnpq.br/5106100358268027 |
dc.contributor.referee2.fl_str_mv |
NAVARRO, Antonio Coppi |
dc.contributor.referee2Lattes.fl_str_mv |
http://lattes.cnpq.br/7269812755382405 |
dc.contributor.referee3.fl_str_mv |
NAVARRO, Francisco |
dc.contributor.referee3Lattes.fl_str_mv |
http://lattes.cnpq.br/0628582355687773 |
dc.contributor.referee4.fl_str_mv |
DIAS, Danielle da Silva |
dc.contributor.referee4Lattes.fl_str_mv |
http://lattes.cnpq.br/6644420445148028 |
dc.contributor.authorID.fl_str_mv |
052.977.633-20 |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/2350938873358491 |
dc.contributor.author.fl_str_mv |
SEREJO, Jerdianny Silva |
contributor_str_mv |
MONZANI, Janaina de Oliveira Brito MONZANI, Janaina de Oliveira Brito NAVARRO, Antonio Coppi NAVARRO, Francisco DIAS, Danielle da Silva |
dc.subject.por.fl_str_mv |
Menopausa Síndrome metabólica Hipertensão Estresse oxidativo Fígado |
topic |
Menopausa Síndrome metabólica Hipertensão Estresse oxidativo Fígado Menopause Metabolic syndrome Hypertension Oxidative stress Liver Educação Física Fisiologia de Órgaos e Sistemas |
dc.subject.eng.fl_str_mv |
Menopause Metabolic syndrome Hypertension Oxidative stress Liver |
dc.subject.cnpq.fl_str_mv |
Educação Física Fisiologia de Órgaos e Sistemas |
description |
With the advent of menopause, as well as post-menopause, the protective effects of ovarian hormones are diminished. This fact, which projects permissibility regarding the involvement of cardiometabolic degenerative diseases. Thus, the objective of the present study was to evaluate the effects of aerobic and resistance physical training on the deprivation of ovarian hormones associated with hypertension and chronic fructose consumption on metabolic, cardiovascular and oxidative stress parameters in liver tissue. Female Wistar (n = 8) and SHR (n = 40) rats were divided into: control (C), hypertensive (H), oophorectomized hypertensive (HO), hypertensive treated with oophorectomized fructose (HOF) submitted to aerobic physical training (HFOTa) or resistance physical training (HFOTr). Aerobic physical training (treadmill; 1h / day; 5x / week) and resistance physical training (ladder adapted for rats; 1h / day; 5x / week) were performed for 8 weeks. Parameters of cardiovascular function, metabolic and physical capacity and its relationship with changes in liver oxidative stress were evaluated. The results show a higher HR in the hypertensive group submitted to oophorectomy + fructose overload (HOF: 393 ± 28 bpm), when compared to the groups: C (350 ± 31 bpm), H (355 ± 18 bpm), HO (345 ± 34 bpm), HOFTa (335 ± 25 bpm) and HOFTr (333 ± 37 bpm). The groups that were deprived of ovarian hormones: HO (261 ± 8 g), HOF (261 ± 8 g), HOFTa (264 ± 11 g) had higher body weight at the end of the protocol, except the HOFTr group (241 ± 8 g). The performance of the exercise test at the end of the eight weeks obtained a longer running time for the trained animals (HOFTa: 25 ± 2.3 min) compared to sedentary animals (C: 18 ± 5.6 min, H: 24 ± 4, 8 min, HO: 23 ± 4.8 min, HOF: 22 ± 4.8 min). The final maximum load test, HOFTr (554 ± 42 g) was greater than C (204 ± 31 g), H (360 ± 56 g), HO (335 ± 104 g), HOF (410 ± 56 g), showing the effectiveness of training in these animals. For TBARS, HOF (1.6 ± 0.28 umol / mg protein) was higher compared to H (1.0 ± 0.34 umol / mg protein), HO (1.0 ± 0.25 umol / mg protein) ). For Carbonilas, H (7 ± 3.05 nmol / mgprotein), HO (5.9 ± 1.13 nmol / mg protein), HOF (5.2 ± 1.27 nmol / mg protein), HOFta (5 , 2 ± 1.13 nmol / mg protein), HOFTr (5.3 ± 1.47 nmol / mg protein) were greater than C (1.0 ± 0.42 nmol / mg protein). The concentration of CAT (H: 6.6 ± 1.35 nmol / mg protein; HO: 6.9 ± 2.85 nmol / mg protein; HOF: 7.8 ± 1.92 nmol / mg protein; HOFta: 6 , 2 ± 0.93 nmol / mg protein; HOFTr: 6.4 ± 2.20 nmol / mg protein)) were greater than C (2.7 ± 0.90 nmol / mg protein). SOD activity, in the HOFTa group, 28.0 ± 5.02 nmol / mg protein) was higher than in C (22 ± 7.56 nmol / mg protein), H (18.9 ± 3.72 nmol / mg protein) ), HO (19.4 ± 4.54 nmol / mg protein), HOF (20.1 ± 5.30 nmol / mg protein), and with the exception of HOFTr (16.7 ± 5.19 nmol / mg protein) . GPx activity was higher in all groups (H: 112.2 ± 12.21 nmol / mg protein; HO: 101.4 ± 22.67 nmol / mg protein; HOF: 108.1 ± 20.70 nmol / mg protein; HOFta: 119.6 ± 15.57 nmol / mg protein; HOFTr: 98.4 ± 26.09 nmol / mg protein)) compared to C (41.0 ± 16.36 nmol / mg protein). Therefore, aerobic or resistance training of moderate intensity in this model of association of risk factors attenuated some of the metabolic and cardiovascular dysfunctions probably because it improves the oxidative stress profile in the liver tissue. |
publishDate |
2020 |
dc.date.issued.fl_str_mv |
2020-11-26 |
dc.date.accessioned.fl_str_mv |
2021-01-26T14:36:40Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
format |
masterThesis |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
SEREJO, Jerdianny Silva. Efeitos do treinamento físico aeróbio e resistido em modelo experimental de síndrome metabólica com privação dos hormônios ovarianos: componentes do estresse oxidativo no tecido hepático.. 2020. 56 f. Dissertação (Programa de Pós-Graduação em Educação Física) - Universidade Federal do Maranhão, São Luís, 2020. |
dc.identifier.uri.fl_str_mv |
https://tedebc.ufma.br/jspui/handle/tede/tede/3148 |
identifier_str_mv |
SEREJO, Jerdianny Silva. Efeitos do treinamento físico aeróbio e resistido em modelo experimental de síndrome metabólica com privação dos hormônios ovarianos: componentes do estresse oxidativo no tecido hepático.. 2020. 56 f. Dissertação (Programa de Pós-Graduação em Educação Física) - Universidade Federal do Maranhão, São Luís, 2020. |
url |
https://tedebc.ufma.br/jspui/handle/tede/tede/3148 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade Federal do Maranhão |
dc.publisher.program.fl_str_mv |
PROGRAMA DE PÓS-GRADUACAO EM EDUCAÇÃO FÍSICA |
dc.publisher.initials.fl_str_mv |
UFMA |
dc.publisher.country.fl_str_mv |
Brasil |
dc.publisher.department.fl_str_mv |
DEPARTAMENTO DE EDUCAÇÃO FÍSICA/CCBS |
publisher.none.fl_str_mv |
Universidade Federal do Maranhão |
dc.source.none.fl_str_mv |
reponame:Biblioteca Digital de Teses e Dissertações da UFMA instname:Universidade Federal do Maranhão (UFMA) instacron:UFMA |
instname_str |
Universidade Federal do Maranhão (UFMA) |
instacron_str |
UFMA |
institution |
UFMA |
reponame_str |
Biblioteca Digital de Teses e Dissertações da UFMA |
collection |
Biblioteca Digital de Teses e Dissertações da UFMA |
bitstream.url.fl_str_mv |
http://tedebc.ufma.br:8080/bitstream/tede/3148/2/JerdiannySerejo.pdf http://tedebc.ufma.br:8080/bitstream/tede/3148/1/license.txt |
bitstream.checksum.fl_str_mv |
3baa7269cf0462c9560ae2a2cf7d63c7 97eeade1fce43278e63fe063657f8083 |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 |
repository.name.fl_str_mv |
Biblioteca Digital de Teses e Dissertações da UFMA - Universidade Federal do Maranhão (UFMA) |
repository.mail.fl_str_mv |
repositorio@ufma.br||repositorio@ufma.br |
_version_ |
1809926196018806784 |