Efeito cardiovascular das saponinas extraídas das folhas de Syzygium cumini (L.) Skeels
Autor(a) principal: | |
---|---|
Data de Publicação: | 2019 |
Tipo de documento: | Tese |
Idioma: | por |
Título da fonte: | Biblioteca Digital de Teses e Dissertações da UFMA |
Texto Completo: | https://tedebc.ufma.br/jspui/handle/tede/tede/5125 |
Resumo: | Cardiovascular diseases (CVD) are the leading causes of death in the world and the search for new medicines that can ensure the treatment of diseases such as hypertension, for example, are becoming more frequent. Among the compounds investigated are products of plant origin that present classes of metabolites with pharmacological potential on the cardiovascular system. Saponins, class of plant origin, are amphiphilic molecules that have been seen as a prominent source of compounds with beneficial activity to the cardiovascular system. The present study evaluated the pharmacological potential of saponins extracted from leaves of Syzygium cumini (L.) Skeels in the cardiovascular system of spontaneously hypertensive rats (SHR). SHR male were treated for a period of 15 days with a rich fraction of S. cumini (FRS) 10 mg / kg / day / week saponins. and FRS 50 mg / kg / day / v.o. The results demonstrated that FRS was able to reduce blood pressure of SHRs, promote a reduction of arrhythmic events such as atrioventricular block and act on peripheral vascular resistance in resistance arteries, causing the decrease of noradrenaline-induced contraction in treated SHR animals with the highest dose. The vasorelaxation mechanisms were also evaluated in mesenteric artery rings. FRS was able to promote the vasorelaxing effect and block the contraction induced by extracellular calcium. With the results presented, it is concluded that FRS appears to act by blocking the influx of calcium and promoting cardioprotection, being therefore a prominent agent with potential antihypertensive effect and in cardiovascular disorders. |
id |
UFMA_93378595034c359643fc8f2979c46e6a |
---|---|
oai_identifier_str |
oai:tede2:tede/5125 |
network_acronym_str |
UFMA |
network_name_str |
Biblioteca Digital de Teses e Dissertações da UFMA |
repository_id_str |
2131 |
spelling |
BORGES, Marilene Oliveira da Rochahttp://lattes.cnpq.br/3283574594616838RIBEIRO, Rachel MeloBORGES, Marilene Oliveira da Rochahttp://lattes.cnpq.br/3283574594616838SILVA JÚNIOR, José Ribamar daBORGES, Antônio Carlos RomãoOLIVEIRA, Rui Miguel Gil da CostaCARTÁGENES, Maria do Socorro de Sousahttp://lattes.cnpq.br/3035412310091857CAMPOS, Matheus Brandão2024-02-01T19:24:36Z2019-08-08CAMPOS, Matheus Brandão. Efeito cardiovascular das saponinas extraídas das folhas de Syzygium cumini (L.) Skeels. 2019. 92 f. Tese( Programa de Pós-Graduação em Biotecnologia - RENORBIO/CCBS) - Universidade Federal do Maranhão, São Luís, 2019.https://tedebc.ufma.br/jspui/handle/tede/tede/5125Cardiovascular diseases (CVD) are the leading causes of death in the world and the search for new medicines that can ensure the treatment of diseases such as hypertension, for example, are becoming more frequent. Among the compounds investigated are products of plant origin that present classes of metabolites with pharmacological potential on the cardiovascular system. Saponins, class of plant origin, are amphiphilic molecules that have been seen as a prominent source of compounds with beneficial activity to the cardiovascular system. The present study evaluated the pharmacological potential of saponins extracted from leaves of Syzygium cumini (L.) Skeels in the cardiovascular system of spontaneously hypertensive rats (SHR). SHR male were treated for a period of 15 days with a rich fraction of S. cumini (FRS) 10 mg / kg / day / week saponins. and FRS 50 mg / kg / day / v.o. The results demonstrated that FRS was able to reduce blood pressure of SHRs, promote a reduction of arrhythmic events such as atrioventricular block and act on peripheral vascular resistance in resistance arteries, causing the decrease of noradrenaline-induced contraction in treated SHR animals with the highest dose. The vasorelaxation mechanisms were also evaluated in mesenteric artery rings. FRS was able to promote the vasorelaxing effect and block the contraction induced by extracellular calcium. With the results presented, it is concluded that FRS appears to act by blocking the influx of calcium and promoting cardioprotection, being therefore a prominent agent with potential antihypertensive effect and in cardiovascular disorders.As doenças cardiovasculares (DCV) são as principais causas de morte no mundo e, a busca por novos medicamentos que possam assegurar o tratamento de doenças como a hipertensão arterial, por exemplo, são cada vez mais frequentes. Dentre os compostos investigados destacam-se os produtos de origem vegetal que apresentam metabólitos secundários com potencial farmacológico sobre o sistema cardiovascular. As saponinas, classe de metabólitos de origem vegetal, são moléculas anfifílicas que tem sido vistas como uma proeminente fonte de compostos com atividade benéfica ao sistema cardiovascular. O presente estudo avaliou o potencial farmacológico da fração rica em saponinas (FRS) extraída das folhas de Syzygium cumini (L.) Skeels, no sistema cardiovascular de ratos espontaneamente hipertensos (SHR). A FRS foi obtida por processo físico (patente (INPI BR 102014003275-4), e sua composição foi comprovada por análise fitoquímica. A FRS apresentou atividade antioxidante pelo método do DPPH. Para a avaliação farmacológica, SHR machos com 90 dias de idade foram tratados diariamente, pelo período de 15 dias, com a fração rica em saponinas isoladas de S. cumini (FRS), nas doses de 10 e 50 mg/kg/v.o. Os resultados demonstraram que a FRS reduziu a pressão arterial (PA) dos SHR, promoveu uma redução de eventos arrítmicos, tais como bloqueio atrioventricular e diminuiu resistência vascular periférica, causando a diminuição da contração induzida por noradrenalina nos animais SHR tratados com a dose mais alta. Os mecanismos do vasorrelaxamento foram investigados em anéis de artéria mesentérica. A FRS foi capaz de promover o efeito vasorrelaxante e bloquear a contração induzida pelo cálcio extracelular. Com os resultados apresentados conclui-se que a FRS diminui a PA por mecanismo que envolve o bloqueio do influxo de cálcio e, promove cardioproteção em SHR, sendo, portanto, um proeminente agente com potencial efeito anti-hipertensivo e em desordens cardiovasculares.Submitted by Maria Aparecida (cidazen@gmail.com) on 2024-02-01T19:24:36Z No. of bitstreams: 1 Matheus_Brandao_Campos.pdf: 23529103 bytes, checksum: f0f3fe05ac6ab79cc3c016169aefde02 (MD5)Made available in DSpace on 2024-02-01T19:24:36Z (GMT). No. of bitstreams: 1 Matheus_Brandao_Campos.pdf: 23529103 bytes, checksum: f0f3fe05ac6ab79cc3c016169aefde02 (MD5) Previous issue date: 2019-08-08CAPESFAPEMAapplication/pdfporUniversidade Federal do MaranhãoPROGRAMA DE PÓS-GRADUAÇÃO EM BIOTECNOLOGIA - RENORBIO/CCBSUFMABrasilDEPARTAMENTO DE CIÊNCIAS FISIOLÓGICAS/CCBSSaponinas;Cardiovascular;Syzygium cumini;Vasorrelaxante;Anti-hipertensivoSaponins;Cardiovascular;Syzygium cumini;Vasorelaxant;AntihypertensiveFarmacologia ClínicaEfeito cardiovascular das saponinas extraídas das folhas de Syzygium cumini (L.) SkeelsCardiovascular effect of saponins extracted from Syzygium cumini (L.) Skeels leavesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/doctoralThesisinfo:eu-repo/semantics/openAccessreponame:Biblioteca Digital de Teses e Dissertações da UFMAinstname:Universidade Federal do Maranhão (UFMA)instacron:UFMAORIGINALMatheus_Brandao_Campos.pdfMatheus_Brandao_Campos.pdfapplication/pdf23529103http://tedebc.ufma.br:8080/bitstream/tede/5125/2/Matheus_Brandao_Campos.pdff0f3fe05ac6ab79cc3c016169aefde02MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-82255http://tedebc.ufma.br:8080/bitstream/tede/5125/1/license.txt97eeade1fce43278e63fe063657f8083MD51tede/51252024-02-01 16:24:36.804oai:tede2: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Biblioteca Digital de Teses e Dissertaçõeshttps://tedebc.ufma.br/jspui/PUBhttp://tedebc.ufma.br:8080/oai/requestrepositorio@ufma.br||repositorio@ufma.bropendoar:21312024-02-01T19:24:36Biblioteca Digital de Teses e Dissertações da UFMA - Universidade Federal do Maranhão (UFMA)false |
dc.title.por.fl_str_mv |
Efeito cardiovascular das saponinas extraídas das folhas de Syzygium cumini (L.) Skeels |
dc.title.alternative.eng.fl_str_mv |
Cardiovascular effect of saponins extracted from Syzygium cumini (L.) Skeels leaves |
title |
Efeito cardiovascular das saponinas extraídas das folhas de Syzygium cumini (L.) Skeels |
spellingShingle |
Efeito cardiovascular das saponinas extraídas das folhas de Syzygium cumini (L.) Skeels CAMPOS, Matheus Brandão Saponinas; Cardiovascular; Syzygium cumini; Vasorrelaxante; Anti-hipertensivo Saponins; Cardiovascular; Syzygium cumini; Vasorelaxant; Antihypertensive Farmacologia Clínica |
title_short |
Efeito cardiovascular das saponinas extraídas das folhas de Syzygium cumini (L.) Skeels |
title_full |
Efeito cardiovascular das saponinas extraídas das folhas de Syzygium cumini (L.) Skeels |
title_fullStr |
Efeito cardiovascular das saponinas extraídas das folhas de Syzygium cumini (L.) Skeels |
title_full_unstemmed |
Efeito cardiovascular das saponinas extraídas das folhas de Syzygium cumini (L.) Skeels |
title_sort |
Efeito cardiovascular das saponinas extraídas das folhas de Syzygium cumini (L.) Skeels |
author |
CAMPOS, Matheus Brandão |
author_facet |
CAMPOS, Matheus Brandão |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
BORGES, Marilene Oliveira da Rocha |
dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/3283574594616838 |
dc.contributor.advisor-co1.fl_str_mv |
RIBEIRO, Rachel Melo |
dc.contributor.referee1.fl_str_mv |
BORGES, Marilene Oliveira da Rocha |
dc.contributor.referee1Lattes.fl_str_mv |
http://lattes.cnpq.br/3283574594616838 |
dc.contributor.referee2.fl_str_mv |
SILVA JÚNIOR, José Ribamar da |
dc.contributor.referee3.fl_str_mv |
BORGES, Antônio Carlos Romão |
dc.contributor.referee4.fl_str_mv |
OLIVEIRA, Rui Miguel Gil da Costa |
dc.contributor.referee5.fl_str_mv |
CARTÁGENES, Maria do Socorro de Sousa |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/3035412310091857 |
dc.contributor.author.fl_str_mv |
CAMPOS, Matheus Brandão |
contributor_str_mv |
BORGES, Marilene Oliveira da Rocha RIBEIRO, Rachel Melo BORGES, Marilene Oliveira da Rocha SILVA JÚNIOR, José Ribamar da BORGES, Antônio Carlos Romão OLIVEIRA, Rui Miguel Gil da Costa CARTÁGENES, Maria do Socorro de Sousa |
dc.subject.por.fl_str_mv |
Saponinas; Cardiovascular; Syzygium cumini; Vasorrelaxante; Anti-hipertensivo |
topic |
Saponinas; Cardiovascular; Syzygium cumini; Vasorrelaxante; Anti-hipertensivo Saponins; Cardiovascular; Syzygium cumini; Vasorelaxant; Antihypertensive Farmacologia Clínica |
dc.subject.eng.fl_str_mv |
Saponins; Cardiovascular; Syzygium cumini; Vasorelaxant; Antihypertensive |
dc.subject.cnpq.fl_str_mv |
Farmacologia Clínica |
description |
Cardiovascular diseases (CVD) are the leading causes of death in the world and the search for new medicines that can ensure the treatment of diseases such as hypertension, for example, are becoming more frequent. Among the compounds investigated are products of plant origin that present classes of metabolites with pharmacological potential on the cardiovascular system. Saponins, class of plant origin, are amphiphilic molecules that have been seen as a prominent source of compounds with beneficial activity to the cardiovascular system. The present study evaluated the pharmacological potential of saponins extracted from leaves of Syzygium cumini (L.) Skeels in the cardiovascular system of spontaneously hypertensive rats (SHR). SHR male were treated for a period of 15 days with a rich fraction of S. cumini (FRS) 10 mg / kg / day / week saponins. and FRS 50 mg / kg / day / v.o. The results demonstrated that FRS was able to reduce blood pressure of SHRs, promote a reduction of arrhythmic events such as atrioventricular block and act on peripheral vascular resistance in resistance arteries, causing the decrease of noradrenaline-induced contraction in treated SHR animals with the highest dose. The vasorelaxation mechanisms were also evaluated in mesenteric artery rings. FRS was able to promote the vasorelaxing effect and block the contraction induced by extracellular calcium. With the results presented, it is concluded that FRS appears to act by blocking the influx of calcium and promoting cardioprotection, being therefore a prominent agent with potential antihypertensive effect and in cardiovascular disorders. |
publishDate |
2019 |
dc.date.issued.fl_str_mv |
2019-08-08 |
dc.date.accessioned.fl_str_mv |
2024-02-01T19:24:36Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/doctoralThesis |
format |
doctoralThesis |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
CAMPOS, Matheus Brandão. Efeito cardiovascular das saponinas extraídas das folhas de Syzygium cumini (L.) Skeels. 2019. 92 f. Tese( Programa de Pós-Graduação em Biotecnologia - RENORBIO/CCBS) - Universidade Federal do Maranhão, São Luís, 2019. |
dc.identifier.uri.fl_str_mv |
https://tedebc.ufma.br/jspui/handle/tede/tede/5125 |
identifier_str_mv |
CAMPOS, Matheus Brandão. Efeito cardiovascular das saponinas extraídas das folhas de Syzygium cumini (L.) Skeels. 2019. 92 f. Tese( Programa de Pós-Graduação em Biotecnologia - RENORBIO/CCBS) - Universidade Federal do Maranhão, São Luís, 2019. |
url |
https://tedebc.ufma.br/jspui/handle/tede/tede/5125 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade Federal do Maranhão |
dc.publisher.program.fl_str_mv |
PROGRAMA DE PÓS-GRADUAÇÃO EM BIOTECNOLOGIA - RENORBIO/CCBS |
dc.publisher.initials.fl_str_mv |
UFMA |
dc.publisher.country.fl_str_mv |
Brasil |
dc.publisher.department.fl_str_mv |
DEPARTAMENTO DE CIÊNCIAS FISIOLÓGICAS/CCBS |
publisher.none.fl_str_mv |
Universidade Federal do Maranhão |
dc.source.none.fl_str_mv |
reponame:Biblioteca Digital de Teses e Dissertações da UFMA instname:Universidade Federal do Maranhão (UFMA) instacron:UFMA |
instname_str |
Universidade Federal do Maranhão (UFMA) |
instacron_str |
UFMA |
institution |
UFMA |
reponame_str |
Biblioteca Digital de Teses e Dissertações da UFMA |
collection |
Biblioteca Digital de Teses e Dissertações da UFMA |
bitstream.url.fl_str_mv |
http://tedebc.ufma.br:8080/bitstream/tede/5125/2/Matheus_Brandao_Campos.pdf http://tedebc.ufma.br:8080/bitstream/tede/5125/1/license.txt |
bitstream.checksum.fl_str_mv |
f0f3fe05ac6ab79cc3c016169aefde02 97eeade1fce43278e63fe063657f8083 |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 |
repository.name.fl_str_mv |
Biblioteca Digital de Teses e Dissertações da UFMA - Universidade Federal do Maranhão (UFMA) |
repository.mail.fl_str_mv |
repositorio@ufma.br||repositorio@ufma.br |
_version_ |
1809926218627153920 |