Associação mediada por TGF-β E IL-10 entre periodontopatógenos em gestantes e nascimento pré-termo

Detalhes bibliográficos
Autor(a) principal: FIGUEIREDO, Camilla Silva de Araujo
Data de Publicação: 2017
Tipo de documento: Tese
Idioma: por
Título da fonte: Biblioteca Digital de Teses e Dissertações da UFMA
Texto Completo: https://tedebc.ufma.br/jspui/handle/tede/tede/4008
Resumo: The woman's body undergoes various physiological, immunological and hormonal changes during pregnancy. In the oral cavity appears to be an increase in the proportion of anaerobic bacteria. Some studies have investigated the association between oral health problems during pregnancy and preterm birth. However, the results are still controversial and the biological mechanisms involved are poorly understood. Two articles are presented. The first one, already published, was a review of the literature on oral changes during pregnancy. The objective was to discuss the major oral changes related to pregnancy, their possible systemic mechanisms and dental treatment during pregnancy, found that the inflammation of the periodontal tissues increases in extent and severity during the course of normal pregnancy, even without change in the amount of biofilm present. In addition, dental treatment during pregnancy is safe, suitable and relevant, constituting an important preventive procedure for both (mother/child). The second article, a case-control study nested in a prospective cohort of pregnant women in the city of São Luís, Brazil (BRISA), aims to evaluate the association between periodontal pathogens in pregnant women and preterm birth. In this study, using structural equation modeling, it was found that the presence of periodontal pathogens was not associated with preterm birth. We conclude that dental treatment during pregnancy promotes the health benefits of the patient, providing an oral condition of comfort, function and aesthetics. Moreover, the presence of periodontal pathogens alone does not represent an independent risk factor for preterm birth, but only when considering all infections during pregnancy.
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spelling THOMAZ, Erika Bárbara Abreu Fonsecahttp://lattes.cnpq.br/3644251156905353ALVES, Cláudia Maria Coelhohttp://lattes.cnpq.br/0697567552425298GOMES FILHO, Isaac Suzarthttp://lattes.cnpq.br/6619912248482019MOREIRA, Ana Regina Oliveirahttp://lattes.cnpq.br/2539041134330503CALDAS , Arlene de Jesus Mendeshttp://lattes.cnpq.br/7214761052240294BENATTI , Bruno Bragahttp://lattes.cnpq.br/7662017198142149THOMAZ, Erika Bárbara Abreu Fonsecahttp://lattes.cnpq.br/3644251156905353http://lattes.cnpq.br/3819994905519785FIGUEIREDO, Camilla Silva de Araujo2022-08-23T12:49:09Z2017-03-09FIGUEIREDO, Camilla Silva de Araujo. Associação mediada por TGF-β E IL-10 entre periodontopatógenos em gestantes e nascimento pré-termo. 2017. 51 f. Tese (Programa de Pós-Graduação em Odontologia/CCBS) - Universidade Federal do Maranhão,São lUÍS, 2017.https://tedebc.ufma.br/jspui/handle/tede/tede/4008The woman's body undergoes various physiological, immunological and hormonal changes during pregnancy. In the oral cavity appears to be an increase in the proportion of anaerobic bacteria. Some studies have investigated the association between oral health problems during pregnancy and preterm birth. However, the results are still controversial and the biological mechanisms involved are poorly understood. Two articles are presented. The first one, already published, was a review of the literature on oral changes during pregnancy. The objective was to discuss the major oral changes related to pregnancy, their possible systemic mechanisms and dental treatment during pregnancy, found that the inflammation of the periodontal tissues increases in extent and severity during the course of normal pregnancy, even without change in the amount of biofilm present. In addition, dental treatment during pregnancy is safe, suitable and relevant, constituting an important preventive procedure for both (mother/child). The second article, a case-control study nested in a prospective cohort of pregnant women in the city of São Luís, Brazil (BRISA), aims to evaluate the association between periodontal pathogens in pregnant women and preterm birth. In this study, using structural equation modeling, it was found that the presence of periodontal pathogens was not associated with preterm birth. We conclude that dental treatment during pregnancy promotes the health benefits of the patient, providing an oral condition of comfort, function and aesthetics. Moreover, the presence of periodontal pathogens alone does not represent an independent risk factor for preterm birth, but only when considering all infections during pregnancy.O organismo da mulher sofre diversas alterações fisiológicas, imunológicas e hormonais no período gestacional. Na cavidade oral parece haver um aumento na proporção de bactérias anaeróbias. Alguns estudos têm pesquisado a associação entre problemas bucais na gestação e o nascimento pré-termo (NPT). Entretanto, os resultados são ainda controversos e os mecanismos biológicos envolvidos são pouco conhecidos. São apresentados dois artigos neste estudo. O primeiro, já publicado, foi uma revisão de literatura sobre alterações bucais na gestação com o objetivo de discutir alterações bucais relacionadas à gestação, seus mecanismos sistêmicos e o tratamento odontológico na gestação, identificou que a inflamação dos tecidos periodontais aumenta em extensão e gravidade durante o curso de uma gravidez normal, mesmo sem alteração na quantidade de biofilme presente. Além disso, o tratamento odontológico durante a gravidez é seguro, indicado e pertinente, constituindo-se em importante conduta preventiva para o binômio mãe/filho. O segundo artigo, um estudo de caso-controle aninhado a uma coorte prospectiva de gestantes na cidade de São Luís-MA, Brasil (BRISA), tem o objetivo de avaliar a associação entre periodontopatógenos em gestantes e NPT. Neste estudo, utilizando análise de equações estruturais, não foi identificada associação entre a presença de periodontopatógenos e NPT. Conclui-se que o tratamento odontológico durante a gestação promove benefícios para a saúde da paciente, oferecendo uma condição oral de conforto, função e estética. Além disso, a presença de periodontopatógenos isoladamente não representa um fator de risco independente para o NPT, mas apenas ao considerar conjuntamente todas as infecções ocorridas durante a gestação.Submitted by Daniella Santos (daniella.santos@ufma.br) on 2022-08-23T12:49:09Z No. of bitstreams: 1 CamillaFigueiredo.pdf: 3764754 bytes, checksum: 47cdf4716de43e0d2fe6bf68504b0c5a (MD5)Made available in DSpace on 2022-08-23T12:49:09Z (GMT). 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dc.title.por.fl_str_mv Associação mediada por TGF-β E IL-10 entre periodontopatógenos em gestantes e nascimento pré-termo
dc.title.alternative.eng.fl_str_mv TGF-β AND IL-10-mediated association between periodontopathogens in pregnant women and preterm birth
title Associação mediada por TGF-β E IL-10 entre periodontopatógenos em gestantes e nascimento pré-termo
spellingShingle Associação mediada por TGF-β E IL-10 entre periodontopatógenos em gestantes e nascimento pré-termo
FIGUEIREDO, Camilla Silva de Araujo
infecção;
doenças periodontais;
bactérias anaeróbias;
nascimento prematuro;
gravidez;
IL-10;
TGF-β;
infection;
periodontal diseases;
anaerobic bacteria;
preterm birth;
pregnancy;
IL-10;
TGF-β.
Periodontia
title_short Associação mediada por TGF-β E IL-10 entre periodontopatógenos em gestantes e nascimento pré-termo
title_full Associação mediada por TGF-β E IL-10 entre periodontopatógenos em gestantes e nascimento pré-termo
title_fullStr Associação mediada por TGF-β E IL-10 entre periodontopatógenos em gestantes e nascimento pré-termo
title_full_unstemmed Associação mediada por TGF-β E IL-10 entre periodontopatógenos em gestantes e nascimento pré-termo
title_sort Associação mediada por TGF-β E IL-10 entre periodontopatógenos em gestantes e nascimento pré-termo
author FIGUEIREDO, Camilla Silva de Araujo
author_facet FIGUEIREDO, Camilla Silva de Araujo
author_role author
dc.contributor.advisor1.fl_str_mv THOMAZ, Erika Bárbara Abreu Fonseca
dc.contributor.advisor1Lattes.fl_str_mv http://lattes.cnpq.br/3644251156905353
dc.contributor.advisor-co1.fl_str_mv ALVES, Cláudia Maria Coelho
dc.contributor.advisor-co1Lattes.fl_str_mv http://lattes.cnpq.br/0697567552425298
dc.contributor.referee1.fl_str_mv GOMES FILHO, Isaac Suzart
dc.contributor.referee1Lattes.fl_str_mv http://lattes.cnpq.br/6619912248482019
dc.contributor.referee2.fl_str_mv MOREIRA, Ana Regina Oliveira
dc.contributor.referee2Lattes.fl_str_mv http://lattes.cnpq.br/2539041134330503
dc.contributor.referee3.fl_str_mv CALDAS , Arlene de Jesus Mendes
dc.contributor.referee3Lattes.fl_str_mv http://lattes.cnpq.br/7214761052240294
dc.contributor.referee4.fl_str_mv BENATTI , Bruno Braga
dc.contributor.referee4Lattes.fl_str_mv http://lattes.cnpq.br/7662017198142149
dc.contributor.referee5.fl_str_mv THOMAZ, Erika Bárbara Abreu Fonseca
dc.contributor.referee5Lattes.fl_str_mv http://lattes.cnpq.br/3644251156905353
dc.contributor.authorLattes.fl_str_mv http://lattes.cnpq.br/3819994905519785
dc.contributor.author.fl_str_mv FIGUEIREDO, Camilla Silva de Araujo
contributor_str_mv THOMAZ, Erika Bárbara Abreu Fonseca
ALVES, Cláudia Maria Coelho
GOMES FILHO, Isaac Suzart
MOREIRA, Ana Regina Oliveira
CALDAS , Arlene de Jesus Mendes
BENATTI , Bruno Braga
THOMAZ, Erika Bárbara Abreu Fonseca
dc.subject.por.fl_str_mv infecção;
doenças periodontais;
bactérias anaeróbias;
nascimento prematuro;
gravidez;
IL-10;
TGF-β;
topic infecção;
doenças periodontais;
bactérias anaeróbias;
nascimento prematuro;
gravidez;
IL-10;
TGF-β;
infection;
periodontal diseases;
anaerobic bacteria;
preterm birth;
pregnancy;
IL-10;
TGF-β.
Periodontia
dc.subject.eng.fl_str_mv infection;
periodontal diseases;
anaerobic bacteria;
preterm birth;
pregnancy;
IL-10;
TGF-β.
dc.subject.cnpq.fl_str_mv Periodontia
description The woman's body undergoes various physiological, immunological and hormonal changes during pregnancy. In the oral cavity appears to be an increase in the proportion of anaerobic bacteria. Some studies have investigated the association between oral health problems during pregnancy and preterm birth. However, the results are still controversial and the biological mechanisms involved are poorly understood. Two articles are presented. The first one, already published, was a review of the literature on oral changes during pregnancy. The objective was to discuss the major oral changes related to pregnancy, their possible systemic mechanisms and dental treatment during pregnancy, found that the inflammation of the periodontal tissues increases in extent and severity during the course of normal pregnancy, even without change in the amount of biofilm present. In addition, dental treatment during pregnancy is safe, suitable and relevant, constituting an important preventive procedure for both (mother/child). The second article, a case-control study nested in a prospective cohort of pregnant women in the city of São Luís, Brazil (BRISA), aims to evaluate the association between periodontal pathogens in pregnant women and preterm birth. In this study, using structural equation modeling, it was found that the presence of periodontal pathogens was not associated with preterm birth. We conclude that dental treatment during pregnancy promotes the health benefits of the patient, providing an oral condition of comfort, function and aesthetics. Moreover, the presence of periodontal pathogens alone does not represent an independent risk factor for preterm birth, but only when considering all infections during pregnancy.
publishDate 2017
dc.date.issued.fl_str_mv 2017-03-09
dc.date.accessioned.fl_str_mv 2022-08-23T12:49:09Z
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dc.identifier.citation.fl_str_mv FIGUEIREDO, Camilla Silva de Araujo. Associação mediada por TGF-β E IL-10 entre periodontopatógenos em gestantes e nascimento pré-termo. 2017. 51 f. Tese (Programa de Pós-Graduação em Odontologia/CCBS) - Universidade Federal do Maranhão,São lUÍS, 2017.
dc.identifier.uri.fl_str_mv https://tedebc.ufma.br/jspui/handle/tede/tede/4008
identifier_str_mv FIGUEIREDO, Camilla Silva de Araujo. Associação mediada por TGF-β E IL-10 entre periodontopatógenos em gestantes e nascimento pré-termo. 2017. 51 f. Tese (Programa de Pós-Graduação em Odontologia/CCBS) - Universidade Federal do Maranhão,São lUÍS, 2017.
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dc.publisher.department.fl_str_mv DEPARTAMENTO DE ODONTOLOGIA II/CCBS
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