Hepatite B (VHB) e Delta (VHD) em cinco municípios do Estado Maranhão: prevalência e fatores associados
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Tipo de documento: | Tese |
Idioma: | por |
Título da fonte: | Biblioteca Digital de Teses e Dissertações da UFMA |
Texto Completo: | https://tedebc.ufma.br/jspui/handle/tede/tede/2247 |
Resumo: | Introduction. Hepatitis B Virus (HBV) infection can lead to chronic disease. Hepatitis Delta virus (HDV) coinfection may favor an increased risk for liver cirrhosis and hepatocellular carcinoma (HCC) in HBV carriers. HBV infected individuals may present detectable HBV DNA with absence of hepatitis B surface antigen (HBsAg). HBV and HDV infections prevalence rates are heterogeneous in Brazil. The aim of this study was to estimate the prevalence of HBV and HDV infections located in the state of Maranhão in Brazil (Axixá, Morros, Icatu, Humberto de Campos and Urbano Santos). Methods. A total of 3.856 to 4,000 individuals participated of this study. Sample size was obtained by considering a prevalence of 0.5% of HBsAg (according to previous national survey), absolute error of 0.3% and 95% confidence interval. Individuals should be age 1 or older to participate in this study. Questionnaires were applied to identify sociodemographic characteristics and transmission risk factors. Samples of blood were collected and serologies were performed for HBsAg, antiHBc, anti-HBs and anti-HDV markers by enzyme-linked immunosorbent assay (ELISA). Results. A total of 3.984 individuals were screened for HBsAg serological markers. The prevalence of HBsAg was 2.30%. Anti-HBc marker was found in 38.47% of samples, 13.95% and 20.10% presented isolated anti-HBc and anti-HBs respectively. Considering the 3,984 samples, anti-HDV was found in 0.35% individuals (among the 92 HBV carriers, eight presented the anti-HDV marker, corresponding to 8.6%). Among the 561 participants with anti-HBc alone, 223 (39.75%) Conclusion. The prevalence of HBV in the region was considered to be intermediate (more than 2% of carriers). Among those carriers, 8% tested positive for anti-HDV. Thus, prevention measures should be implemented to prevent Infection by these viruses and progression to liver cirrhosis and HCC. |
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FERREIRA, Adalgisa de Souza Paiva850.818.767-04http://lattes.cnpq.br/6707376027989566PEREZ, Renata de Mellohttp://lattes.cnpq.br/0870986021644250BRANCO, Maria dos Remédios Freitas Carvalhohttp://lattes.cnpq.br/5449951869928014FONSECA, Lena Maria Barroshttp://lattes.cnpq.br/6007134685901712AZEVEDO, Conceição de Maria Pedrozo e Silva dehttp://lattes.cnpq.br/1702212486285798024.338.143-32http://lattes.cnpq.br/1239440266493234NUNES, Jomar Diogo Costa2018-05-21T18:41:21Z2018-05-17NUNES, Jomar Diogo Costa. Hepatite B (VHB) e Delta (VHD) em cinco municípios do Estado Maranhão: prevalência e fatores associados. 2018. 101 f. Tese (Doutorado em Ciências da Saúde) - Universidade Federal do Maranhão, São Luís, 2018.https://tedebc.ufma.br/jspui/handle/tede/tede/2247Introduction. Hepatitis B Virus (HBV) infection can lead to chronic disease. Hepatitis Delta virus (HDV) coinfection may favor an increased risk for liver cirrhosis and hepatocellular carcinoma (HCC) in HBV carriers. HBV infected individuals may present detectable HBV DNA with absence of hepatitis B surface antigen (HBsAg). HBV and HDV infections prevalence rates are heterogeneous in Brazil. The aim of this study was to estimate the prevalence of HBV and HDV infections located in the state of Maranhão in Brazil (Axixá, Morros, Icatu, Humberto de Campos and Urbano Santos). Methods. A total of 3.856 to 4,000 individuals participated of this study. Sample size was obtained by considering a prevalence of 0.5% of HBsAg (according to previous national survey), absolute error of 0.3% and 95% confidence interval. Individuals should be age 1 or older to participate in this study. Questionnaires were applied to identify sociodemographic characteristics and transmission risk factors. Samples of blood were collected and serologies were performed for HBsAg, antiHBc, anti-HBs and anti-HDV markers by enzyme-linked immunosorbent assay (ELISA). Results. A total of 3.984 individuals were screened for HBsAg serological markers. The prevalence of HBsAg was 2.30%. Anti-HBc marker was found in 38.47% of samples, 13.95% and 20.10% presented isolated anti-HBc and anti-HBs respectively. Considering the 3,984 samples, anti-HDV was found in 0.35% individuals (among the 92 HBV carriers, eight presented the anti-HDV marker, corresponding to 8.6%). Among the 561 participants with anti-HBc alone, 223 (39.75%) Conclusion. The prevalence of HBV in the region was considered to be intermediate (more than 2% of carriers). Among those carriers, 8% tested positive for anti-HDV. Thus, prevention measures should be implemented to prevent Infection by these viruses and progression to liver cirrhosis and HCC.Introdução: A infecção pelo vírus da hepatite B (VHB) pode se tornar crônica. A coinfecção com o vírus Delta (VHD) pode piorar a primeira, favorecendo maior risco para cirrose hepática e carcinoma hepatocelular (CHC). No Brasil, as taxas de prevalência destas infecções são heterogêneas. O objetivo desse estudo foi estimar as prevalências das hepatites B e Delta em cinco municípios localizado no estado do Maranhão no Brasil (Axixá, Morros, Icatu, Humberto de Campos e Urbano Santos). Metodologia: A amostra foi calculada, levando em consideração uma prevalência de 0,5% do HBsAg (considerando o resultado da prevalência do HBsAg, encontrada no inquérito nacional na região Nordeste) com erro absoluto de 0,3%, nível de confiança de 95% com uma amostra total de 3.856 a 4.000 indivíduos maiores de 1 ano de idade. Foram aplicados questionários para identificar características sóciodemográficas e fatores de risco de transmissão. Amostras de sangue foram coletadas e foram realizadas sorologias para HBsAg, anti-HBc, anti-HBs e anti-HDV por ensaio imunoenzimático (ELISA). Resultado: Um total de 3984 participantes foram incluídos. A prevalência de HBsAg foi de 2,30%, 38,47% tinham anti-HBc positivo,13,95% tinham anti-HBc isolado e 20,10% apresentaram anti-HBs isoladamente positivo. A prevalência de VHD na amostra total foi de 0,35% (entre os 92 portadores do VHB, oito tinham o marcador anti-HDV positivo, correspondendo a 8.6%). Conclusão: A prevalência do HBsAg na região foi considerada intermediária (mais de 2% da população é portadora) e entre estes, 8% tinham positividade para o VHD, sugerindo que é uma região em que medidas rigorosas de prevenção devem ser implementadas para prevenir a infecção por estes vírus impedindo a progressão para cirrose hepática e CHC.Submitted by Rosivalda Pereira (mrs.pereira@ufma.br) on 2018-05-21T18:41:21Z No. of bitstreams: 1 JomarNunes.pdf: 5055279 bytes, checksum: 7e0cb837b9b756096b335c44a83af2bc (MD5)Made available in DSpace on 2018-05-21T18:41:21Z (GMT). No. of bitstreams: 1 JomarNunes.pdf: 5055279 bytes, checksum: 7e0cb837b9b756096b335c44a83af2bc (MD5) Previous issue date: 2018-05-17FAPEMAapplication/pdfporUniversidade Federal do MaranhãoPROGRAMA DE PÓS-GRADUAÇÃO EM CIÊNCIAS DA SAÚDE/CCBSUFMABrasilDEPARTAMENTO DE EDUCAÇÃO I/CCSOHepatite BHepatite DeltaPrevalênciaFatores associadosHepatitis BHepatitis deltaPrevalenceAssociated factorsGenética Molecular e de MicroorganismosHepatite B (VHB) e Delta (VHD) em cinco municípios do Estado Maranhão: prevalência e fatores associadosHepatitis B (HBV) and Delta (VHD) in five municipalities of Maranhão State: prevalence and associated factorsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/doctoralThesisinfo:eu-repo/semantics/openAccessreponame:Biblioteca Digital de Teses e Dissertações da UFMAinstname:Universidade Federal do Maranhão (UFMA)instacron:UFMAORIGINALJomarNunes.pdfJomarNunes.pdfapplication/pdf5055279http://tedebc.ufma.br:8080/bitstream/tede/2247/2/JomarNunes.pdf7e0cb837b9b756096b335c44a83af2bcMD52LICENSElicense.txtlicense.txttext/plain; charset=utf-82255http://tedebc.ufma.br:8080/bitstream/tede/2247/1/license.txt97eeade1fce43278e63fe063657f8083MD51tede/22472018-05-21 15:41:21.197oai:tede2: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Biblioteca Digital de Teses e Dissertaçõeshttps://tedebc.ufma.br/jspui/PUBhttp://tedebc.ufma.br:8080/oai/requestrepositorio@ufma.br||repositorio@ufma.bropendoar:21312018-05-21T18:41:21Biblioteca Digital de Teses e Dissertações da UFMA - Universidade Federal do Maranhão (UFMA)false |
dc.title.por.fl_str_mv |
Hepatite B (VHB) e Delta (VHD) em cinco municípios do Estado Maranhão: prevalência e fatores associados |
dc.title.alternative.eng.fl_str_mv |
Hepatitis B (HBV) and Delta (VHD) in five municipalities of Maranhão State: prevalence and associated factors |
title |
Hepatite B (VHB) e Delta (VHD) em cinco municípios do Estado Maranhão: prevalência e fatores associados |
spellingShingle |
Hepatite B (VHB) e Delta (VHD) em cinco municípios do Estado Maranhão: prevalência e fatores associados NUNES, Jomar Diogo Costa Hepatite B Hepatite Delta Prevalência Fatores associados Hepatitis B Hepatitis delta Prevalence Associated factors Genética Molecular e de Microorganismos |
title_short |
Hepatite B (VHB) e Delta (VHD) em cinco municípios do Estado Maranhão: prevalência e fatores associados |
title_full |
Hepatite B (VHB) e Delta (VHD) em cinco municípios do Estado Maranhão: prevalência e fatores associados |
title_fullStr |
Hepatite B (VHB) e Delta (VHD) em cinco municípios do Estado Maranhão: prevalência e fatores associados |
title_full_unstemmed |
Hepatite B (VHB) e Delta (VHD) em cinco municípios do Estado Maranhão: prevalência e fatores associados |
title_sort |
Hepatite B (VHB) e Delta (VHD) em cinco municípios do Estado Maranhão: prevalência e fatores associados |
author |
NUNES, Jomar Diogo Costa |
author_facet |
NUNES, Jomar Diogo Costa |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
FERREIRA, Adalgisa de Souza Paiva |
dc.contributor.advisor1ID.fl_str_mv |
850.818.767-04 |
dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/6707376027989566 |
dc.contributor.referee1.fl_str_mv |
PEREZ, Renata de Mello |
dc.contributor.referee1Lattes.fl_str_mv |
http://lattes.cnpq.br/0870986021644250 |
dc.contributor.referee2.fl_str_mv |
BRANCO, Maria dos Remédios Freitas Carvalho |
dc.contributor.referee2Lattes.fl_str_mv |
http://lattes.cnpq.br/5449951869928014 |
dc.contributor.referee3.fl_str_mv |
FONSECA, Lena Maria Barros |
dc.contributor.referee3Lattes.fl_str_mv |
http://lattes.cnpq.br/6007134685901712 |
dc.contributor.referee4.fl_str_mv |
AZEVEDO, Conceição de Maria Pedrozo e Silva de |
dc.contributor.referee4Lattes.fl_str_mv |
http://lattes.cnpq.br/1702212486285798 |
dc.contributor.authorID.fl_str_mv |
024.338.143-32 |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/1239440266493234 |
dc.contributor.author.fl_str_mv |
NUNES, Jomar Diogo Costa |
contributor_str_mv |
FERREIRA, Adalgisa de Souza Paiva PEREZ, Renata de Mello BRANCO, Maria dos Remédios Freitas Carvalho FONSECA, Lena Maria Barros AZEVEDO, Conceição de Maria Pedrozo e Silva de |
dc.subject.por.fl_str_mv |
Hepatite B Hepatite Delta Prevalência Fatores associados |
topic |
Hepatite B Hepatite Delta Prevalência Fatores associados Hepatitis B Hepatitis delta Prevalence Associated factors Genética Molecular e de Microorganismos |
dc.subject.eng.fl_str_mv |
Hepatitis B Hepatitis delta Prevalence Associated factors |
dc.subject.cnpq.fl_str_mv |
Genética Molecular e de Microorganismos |
description |
Introduction. Hepatitis B Virus (HBV) infection can lead to chronic disease. Hepatitis Delta virus (HDV) coinfection may favor an increased risk for liver cirrhosis and hepatocellular carcinoma (HCC) in HBV carriers. HBV infected individuals may present detectable HBV DNA with absence of hepatitis B surface antigen (HBsAg). HBV and HDV infections prevalence rates are heterogeneous in Brazil. The aim of this study was to estimate the prevalence of HBV and HDV infections located in the state of Maranhão in Brazil (Axixá, Morros, Icatu, Humberto de Campos and Urbano Santos). Methods. A total of 3.856 to 4,000 individuals participated of this study. Sample size was obtained by considering a prevalence of 0.5% of HBsAg (according to previous national survey), absolute error of 0.3% and 95% confidence interval. Individuals should be age 1 or older to participate in this study. Questionnaires were applied to identify sociodemographic characteristics and transmission risk factors. Samples of blood were collected and serologies were performed for HBsAg, antiHBc, anti-HBs and anti-HDV markers by enzyme-linked immunosorbent assay (ELISA). Results. A total of 3.984 individuals were screened for HBsAg serological markers. The prevalence of HBsAg was 2.30%. Anti-HBc marker was found in 38.47% of samples, 13.95% and 20.10% presented isolated anti-HBc and anti-HBs respectively. Considering the 3,984 samples, anti-HDV was found in 0.35% individuals (among the 92 HBV carriers, eight presented the anti-HDV marker, corresponding to 8.6%). Among the 561 participants with anti-HBc alone, 223 (39.75%) Conclusion. The prevalence of HBV in the region was considered to be intermediate (more than 2% of carriers). Among those carriers, 8% tested positive for anti-HDV. Thus, prevention measures should be implemented to prevent Infection by these viruses and progression to liver cirrhosis and HCC. |
publishDate |
2018 |
dc.date.accessioned.fl_str_mv |
2018-05-21T18:41:21Z |
dc.date.issued.fl_str_mv |
2018-05-17 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/doctoralThesis |
format |
doctoralThesis |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
NUNES, Jomar Diogo Costa. Hepatite B (VHB) e Delta (VHD) em cinco municípios do Estado Maranhão: prevalência e fatores associados. 2018. 101 f. Tese (Doutorado em Ciências da Saúde) - Universidade Federal do Maranhão, São Luís, 2018. |
dc.identifier.uri.fl_str_mv |
https://tedebc.ufma.br/jspui/handle/tede/tede/2247 |
identifier_str_mv |
NUNES, Jomar Diogo Costa. Hepatite B (VHB) e Delta (VHD) em cinco municípios do Estado Maranhão: prevalência e fatores associados. 2018. 101 f. Tese (Doutorado em Ciências da Saúde) - Universidade Federal do Maranhão, São Luís, 2018. |
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https://tedebc.ufma.br/jspui/handle/tede/tede/2247 |
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por |
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por |
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info:eu-repo/semantics/openAccess |
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openAccess |
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Universidade Federal do Maranhão |
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PROGRAMA DE PÓS-GRADUAÇÃO EM CIÊNCIAS DA SAÚDE/CCBS |
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UFMA |
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Brasil |
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DEPARTAMENTO DE EDUCAÇÃO I/CCSO |
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Universidade Federal do Maranhão |
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