Métodos eletroanalíticos para detecção de ivermectina em meio aquoso
Autor(a) principal: | |
---|---|
Data de Publicação: | 2024 |
Tipo de documento: | Dissertação |
Idioma: | por |
Título da fonte: | Biblioteca Digital de Teses e Dissertações da UFMA |
Texto Completo: | https://tedebc.ufma.br/jspui/handle/tede/tede/5472 |
Resumo: | During the COVID-19 pandemic, in the period from March 2020 to May 2023, caused by the novel coronavirus SARS-CoV-2, various medications were prescribed for the treatment and early prevention of symptoms associated with this disease. Ivermectin (IVM), being a broad-spectrum antiparasitic drug, was one of these medications, although its use has not demonstrated proven efficacy in combating this disease. Composed of two avermectins, which are toxic to humans at high doses, the unregulated use of ivermectin has become a growing concern, necessitating means for its determination and drawing the attention of the academic community. Among the methods being explored, electrochemical methods have gained considerable prominence due to their high sensitivity, rapid response, and simplicity in analyses. In this study, electrochemical sensors based on laser-induced graphene were developed, as well as a glassy carbon electrode modified with Super-P carbon black (CBSP/GCE) (1 mg L−1 in dimethylformamide) for the determination of ivermectin. Using differential pulse voltammetry (DPV) technique, and following optimization of the parameters, the laser-induced graphene electrode exhibited a linear working range of 10−100 (μmol L−1), a limit of detection (LOD) of 1.6 (μmol L−1), a limit of quantification (LOQ) of 4.8 (μmol L−1), and a sensitivity of 7.08 × 10−3 (μA μmol−1 L mm−2). The developed method was successfully applied to water samples (94% recovery), urine samples (113% and 97% recovery), and pharmaceutical samples (approximately 6.0 mg/tablet as indicated on the labels), with analyses performed in triplicate. For the CBSP/GCE electrode, the DPV technique was also utilized, and after optimization, a linear working range of 10−100 (μmol L−1) was achieved, with LOD and LOQ of 1.3 and 4.2 (μmol L−1), respectively, and a sensitivity of 7.45 × 10−3 (μA μmol−1 L mm−2). The method was successfully applied to water samples (100% and 105% recovery), a urine sample (108% recovery), and pharmaceutical samples (approximately 6.0 mg/tablet as indicated on the labels), with analyses performed in triplicate. These results demonstrate the feasibility of the method for routine analyses involving different samples. |
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SILVA, Iranaldo Santos dahttp://lattes.cnpq.br/1281555528581499SILVA, Iranaldo Santos dahttp://lattes.cnpq.br/1281555528581499ARAUJO, William Reis dehttp://lattes.cnpq.br/2175106835600174ROCHA, Claudia Quintino dahttp://lattes.cnpq.br/5609489233382242https://lattes.cnpq.br/6659104372013988FERREIRA, Dianderson Cristiano Monteiro2024-08-28T11:14:42Z2024-07-23FERREIRA, Dianderson Cristiano Monteiro. Métodos eletroanalíticos para detecção de ivermectina em meio aquoso. 2024. 76 f. Dissertação (Programa de Pós-Graduação em Química/CCET) - Universidade Federal do Maranhão, São Luís, 2024.https://tedebc.ufma.br/jspui/handle/tede/tede/5472During the COVID-19 pandemic, in the period from March 2020 to May 2023, caused by the novel coronavirus SARS-CoV-2, various medications were prescribed for the treatment and early prevention of symptoms associated with this disease. Ivermectin (IVM), being a broad-spectrum antiparasitic drug, was one of these medications, although its use has not demonstrated proven efficacy in combating this disease. Composed of two avermectins, which are toxic to humans at high doses, the unregulated use of ivermectin has become a growing concern, necessitating means for its determination and drawing the attention of the academic community. Among the methods being explored, electrochemical methods have gained considerable prominence due to their high sensitivity, rapid response, and simplicity in analyses. In this study, electrochemical sensors based on laser-induced graphene were developed, as well as a glassy carbon electrode modified with Super-P carbon black (CBSP/GCE) (1 mg L−1 in dimethylformamide) for the determination of ivermectin. Using differential pulse voltammetry (DPV) technique, and following optimization of the parameters, the laser-induced graphene electrode exhibited a linear working range of 10−100 (μmol L−1), a limit of detection (LOD) of 1.6 (μmol L−1), a limit of quantification (LOQ) of 4.8 (μmol L−1), and a sensitivity of 7.08 × 10−3 (μA μmol−1 L mm−2). The developed method was successfully applied to water samples (94% recovery), urine samples (113% and 97% recovery), and pharmaceutical samples (approximately 6.0 mg/tablet as indicated on the labels), with analyses performed in triplicate. For the CBSP/GCE electrode, the DPV technique was also utilized, and after optimization, a linear working range of 10−100 (μmol L−1) was achieved, with LOD and LOQ of 1.3 and 4.2 (μmol L−1), respectively, and a sensitivity of 7.45 × 10−3 (μA μmol−1 L mm−2). The method was successfully applied to water samples (100% and 105% recovery), a urine sample (108% recovery), and pharmaceutical samples (approximately 6.0 mg/tablet as indicated on the labels), with analyses performed in triplicate. These results demonstrate the feasibility of the method for routine analyses involving different samples.Durante a pandemia da COVID-19 no período de março de 2020 a maio de 2023, causada pelo novo coronavírus SARS-CoV-2, diversos medicamentos foram prescritos para o tratamento e prevenção precoce dos sintomas causados por essa doença. A ivermectina (IVM), por ser um fármaco antiparasitário de amplo espectro, foi um destes medicamentos, embora o seu uso não tenha apresentado eficácia comprovada no combate desta doença. Sendo constituída por duas avermectinas, componentes tóxicos para humanos em altas doses, o seu uso desregulado tem sido uma preocupação crescente e com isso a necessidade de meios para a sua determinação tem atraído a atenção da comunidade acadêmica. Dentre eles, os métodos eletroquímicos têm ganhado grande destaque para novos estudos devido suas características como elevada sensibilidade, rapidez e simplicidade de análises. Neste trabalho, desenvolveu-se sensores eletroquímicos a base de grafeno induzido por laser, bem como a utilização de eletrodo de carbono vítreo modificado com carbon black Super-P (CBSP/ECV) (1 mg L−1 em dimetilformamida) para determinação de ivermectina. Através da técnica de voltametria de pulso diferencial (DPV), e após otimização dos parâmetros, obteve-se para o eletrodo de grafeno induzido por laser uma faixa linear de trabalho de 10 − 100 (mol L−1 ), um limite de detecção (LD) de 1,6 (mol L−1 ), limite de quantificação (LQ) de 4,8 (mol L−1 ) e uma sensibilidade de 7,08 × 10−3 (A mol−1 L mm−2 ). O método desenvolvido foi aplicado com sucesso em amostras de água (94% de recuperação), em amostras de urina (113 e 97% de recuperação) e amostras farmacêuticas (aproximadamente 6,0 mg/comprimido presentes no rótulos), as análises foram realizadas em triplicata. Para o eletrodo CBSP/ECV, também foi utilizado técnica de DPV e após sua otimização, obteve- se uma faixa linear de trabalho de 10 − 100 (mol L−1 ), com um LD e LQ de 1,3 e 4,2 μmol L−1, respectivamente e uma sensibilidade de 7,45 × 10−3 (A mol−1 L mm−2 ). O método desenvolvido foi aplicado com sucesso em amostras de água (100 e 105 % de recuperação), em amostra de urina (108 % de recuperação) e amostras farmacêuticas (aproximadamente 6,0 mg/comprimido presentes no rótulos), as análises foram realizadas em triplicata. Tais resultados demonstram a viabilidade do método para análises de rotina envolvendo diferentes amostras.Submitted by Jonathan Sousa de Almeida (jonathan.sousa@ufma.br) on 2024-08-28T11:14:42Z No. of bitstreams: 1 DIANDERSONCRISTIANOMONTEIROFERREIRA.pdf: 3167472 bytes, checksum: d640afc443f28225605e51e29e1f21ba (MD5)Made available in DSpace on 2024-08-28T11:14:42Z (GMT). No. of bitstreams: 1 DIANDERSONCRISTIANOMONTEIROFERREIRA.pdf: 3167472 bytes, checksum: d640afc443f28225605e51e29e1f21ba (MD5) Previous issue date: 2024-07-23CAPESapplication/pdfporUniversidade Federal do MaranhãoPROGRAMA DE PÓS-GRADUAÇÃO EM QUÍMICA/CCETUFMABrasilDEPARTAMENTO DE QUÍMICA/CCETCarbon black;Grafeno induzido por laser;sensores eletroquímicos.Carbon black;Laser−induced graphene;electrochemical sensors.QuímicaMétodos eletroanalíticos para detecção de ivermectina em meio aquosoElectroanalytical methods for detection of ivermectin in media aqueousDocumento sob sigilo. Prazo provável para disponibilização total: 6 meses. 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dc.title.por.fl_str_mv |
Métodos eletroanalíticos para detecção de ivermectina em meio aquoso |
dc.title.alternative.eng.fl_str_mv |
Electroanalytical methods for detection of ivermectin in media aqueous |
title |
Métodos eletroanalíticos para detecção de ivermectina em meio aquoso |
spellingShingle |
Métodos eletroanalíticos para detecção de ivermectina em meio aquoso FERREIRA, Dianderson Cristiano Monteiro Carbon black; Grafeno induzido por laser; sensores eletroquímicos. Carbon black; Laser−induced graphene; electrochemical sensors. Química |
title_short |
Métodos eletroanalíticos para detecção de ivermectina em meio aquoso |
title_full |
Métodos eletroanalíticos para detecção de ivermectina em meio aquoso |
title_fullStr |
Métodos eletroanalíticos para detecção de ivermectina em meio aquoso |
title_full_unstemmed |
Métodos eletroanalíticos para detecção de ivermectina em meio aquoso |
title_sort |
Métodos eletroanalíticos para detecção de ivermectina em meio aquoso |
author |
FERREIRA, Dianderson Cristiano Monteiro |
author_facet |
FERREIRA, Dianderson Cristiano Monteiro |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
SILVA, Iranaldo Santos da |
dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/1281555528581499 |
dc.contributor.referee1.fl_str_mv |
SILVA, Iranaldo Santos da |
dc.contributor.referee1Lattes.fl_str_mv |
http://lattes.cnpq.br/1281555528581499 |
dc.contributor.referee2.fl_str_mv |
ARAUJO, William Reis de |
dc.contributor.referee2Lattes.fl_str_mv |
http://lattes.cnpq.br/2175106835600174 |
dc.contributor.referee3.fl_str_mv |
ROCHA, Claudia Quintino da |
dc.contributor.referee3Lattes.fl_str_mv |
http://lattes.cnpq.br/5609489233382242 |
dc.contributor.authorLattes.fl_str_mv |
https://lattes.cnpq.br/6659104372013988 |
dc.contributor.author.fl_str_mv |
FERREIRA, Dianderson Cristiano Monteiro |
contributor_str_mv |
SILVA, Iranaldo Santos da SILVA, Iranaldo Santos da ARAUJO, William Reis de ROCHA, Claudia Quintino da |
dc.subject.por.fl_str_mv |
Carbon black; Grafeno induzido por laser; sensores eletroquímicos. |
topic |
Carbon black; Grafeno induzido por laser; sensores eletroquímicos. Carbon black; Laser−induced graphene; electrochemical sensors. Química |
dc.subject.eng.fl_str_mv |
Carbon black; Laser−induced graphene; electrochemical sensors. |
dc.subject.cnpq.fl_str_mv |
Química |
description |
During the COVID-19 pandemic, in the period from March 2020 to May 2023, caused by the novel coronavirus SARS-CoV-2, various medications were prescribed for the treatment and early prevention of symptoms associated with this disease. Ivermectin (IVM), being a broad-spectrum antiparasitic drug, was one of these medications, although its use has not demonstrated proven efficacy in combating this disease. Composed of two avermectins, which are toxic to humans at high doses, the unregulated use of ivermectin has become a growing concern, necessitating means for its determination and drawing the attention of the academic community. Among the methods being explored, electrochemical methods have gained considerable prominence due to their high sensitivity, rapid response, and simplicity in analyses. In this study, electrochemical sensors based on laser-induced graphene were developed, as well as a glassy carbon electrode modified with Super-P carbon black (CBSP/GCE) (1 mg L−1 in dimethylformamide) for the determination of ivermectin. Using differential pulse voltammetry (DPV) technique, and following optimization of the parameters, the laser-induced graphene electrode exhibited a linear working range of 10−100 (μmol L−1), a limit of detection (LOD) of 1.6 (μmol L−1), a limit of quantification (LOQ) of 4.8 (μmol L−1), and a sensitivity of 7.08 × 10−3 (μA μmol−1 L mm−2). The developed method was successfully applied to water samples (94% recovery), urine samples (113% and 97% recovery), and pharmaceutical samples (approximately 6.0 mg/tablet as indicated on the labels), with analyses performed in triplicate. For the CBSP/GCE electrode, the DPV technique was also utilized, and after optimization, a linear working range of 10−100 (μmol L−1) was achieved, with LOD and LOQ of 1.3 and 4.2 (μmol L−1), respectively, and a sensitivity of 7.45 × 10−3 (μA μmol−1 L mm−2). The method was successfully applied to water samples (100% and 105% recovery), a urine sample (108% recovery), and pharmaceutical samples (approximately 6.0 mg/tablet as indicated on the labels), with analyses performed in triplicate. These results demonstrate the feasibility of the method for routine analyses involving different samples. |
publishDate |
2024 |
dc.date.accessioned.fl_str_mv |
2024-08-28T11:14:42Z |
dc.date.issued.fl_str_mv |
2024-07-23 |
dc.type.driver.fl_str_mv |
Documento sob sigilo. Prazo provável para disponibilização total: 6 meses. Motivo do sigilo: publicação de artigo info:eu-repo/semantics/masterThesis |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
masterThesis |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
FERREIRA, Dianderson Cristiano Monteiro. Métodos eletroanalíticos para detecção de ivermectina em meio aquoso. 2024. 76 f. Dissertação (Programa de Pós-Graduação em Química/CCET) - Universidade Federal do Maranhão, São Luís, 2024. |
dc.identifier.uri.fl_str_mv |
https://tedebc.ufma.br/jspui/handle/tede/tede/5472 |
identifier_str_mv |
FERREIRA, Dianderson Cristiano Monteiro. Métodos eletroanalíticos para detecção de ivermectina em meio aquoso. 2024. 76 f. Dissertação (Programa de Pós-Graduação em Química/CCET) - Universidade Federal do Maranhão, São Luís, 2024. |
url |
https://tedebc.ufma.br/jspui/handle/tede/tede/5472 |
dc.language.iso.fl_str_mv |
por |
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por |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
dc.publisher.none.fl_str_mv |
Universidade Federal do Maranhão |
dc.publisher.program.fl_str_mv |
PROGRAMA DE PÓS-GRADUAÇÃO EM QUÍMICA/CCET |
dc.publisher.initials.fl_str_mv |
UFMA |
dc.publisher.country.fl_str_mv |
Brasil |
dc.publisher.department.fl_str_mv |
DEPARTAMENTO DE QUÍMICA/CCET |
publisher.none.fl_str_mv |
Universidade Federal do Maranhão |
dc.source.none.fl_str_mv |
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