HPV6 e HPV11: vírus de baixo risco envolvidos na transformação maligna?

Detalhes bibliográficos
Autor(a) principal: SILVA, Leandro Lima da
Data de Publicação: 2023
Tipo de documento: Dissertação
Idioma: por
Título da fonte: Biblioteca Digital de Teses e Dissertações da UFMA
Texto Completo: https://tedebc.ufma.br/jspui/handle/tede/tede/4789
Resumo: Introduction: Cancer is the disorderly growth of cells, which are directed to the surrounding tissues and organs. Among the factors that contribute to the increase of this pathology are the infectious agents that include viruses, bacteria and parasites, with the human papillomavirus (HPV) being strongly associated with cervical, anogenital and oropharyngeal cancers. HPVs are classified as high and low oncogenic risk. Among the high-risk HPVs, subtypes 16 and 18 are the most frequent in neoplasms associated with this virus and are the most aggressive. There are also low-oncogenic HPV subtypes, such as HPV 6, 11, which are mainly associated with benign lesions such as condyloma. Studies also suggest the involvement of low-risk HPVs in malignant non-cervical lesions. Methodology: The present study is a systematic review of the last 10 years to determine the prevalence of HPV6 and HPV11 infections in anogenital and head and neck cancers, evaluating their carcinogenic potential and comparing their viral genomes with the HPV16 genome to identify significant similarities and differences. The three standard databases in biomedicine: PubMed, Embase and Cochrane, accessed in March and April 2022, were used as the basis for carrying out the study. The keywords "cancer AND HPV6" or "cancer AND HPV11" were applied and 541 articles were retrieved from PubMed, 695 articles from Embase and 29 articles from Cochrane. Complete genomes of HPVs were retrieved from the RefSeq and GeneBank databases, both available at NCBI. Results: It was observed that low-risk HPV infections, associated with genital warts (condylomata) and low- grade dysplasias, are associated with a 1 to 3% risk of cancer progression if not resolved. It was also observed that monoinfections by HPV6 and HPV11 were mainly associated with cancers of the larynx and penis, with cancers of the uterine cervix, vagina, vulva, and head and neck (except pharynx) presenting the lowest frequencies of monoinfections by HPV6 and HPV11. The protein most similar in number of identical amino acids or similar chemical properties between HPV16 and HPV6 identified was E7, while the E5 protein had the least similarity. Similar results were obtained between HPV16 and HPV11. Conclusion: Head and neck studies mainly reported data from the larynx, which probably reflects the known role of HPV6 and HPV11 in respiratory papillomas in this anatomical area. The early E7 gene was more similar between high and low oncogenic risk HPVs. In addition, there were limitations such as the small number of cases in some studies added to the lack of data, resulting in the need to draw a cross-section from the moment of inoculation of the low-risk subtypes HPV 6 and 11 with their carcinogenic potential.
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spelling OLIVEIRA, Rui Miguel Gil da Costahttp://lattes.cnpq.br/6785759461393904BRITO, Haissa Oliveirahttp://lattes.cnpq.br/2303050934162020COSTA, Rui Miguel Gil dahttp://lattes.cnpq.br/6785759461393904SANTOS, Joana Maria de OliveiraNASCIMENTO, Maria do Desterro Soares Brandãohttp://lattes.cnpq.br/3958174822396319ANDRADE, Marcelo Souza dehttp://lattes.cnpq.br/6267637354657076CABRAL, Flávia Castello Branco Vidalhttp://lattes.cnpq.br/0085459127860829http://lattes.cnpq.br/8925802340017795SILVA, Leandro Lima da2023-06-28T15:23:54Z2023-05-08SILVA, Leandro Lima da. HPV6 e HPV11: vírus de baixo risco envolvidos na transformação maligna?. 2023. 64 f. Dissertação (Programa de Pós-Graduação em Saúde do Adulto) - Universidade Federal do Maranhão, São Luís, 2023.https://tedebc.ufma.br/jspui/handle/tede/tede/4789Introduction: Cancer is the disorderly growth of cells, which are directed to the surrounding tissues and organs. Among the factors that contribute to the increase of this pathology are the infectious agents that include viruses, bacteria and parasites, with the human papillomavirus (HPV) being strongly associated with cervical, anogenital and oropharyngeal cancers. HPVs are classified as high and low oncogenic risk. Among the high-risk HPVs, subtypes 16 and 18 are the most frequent in neoplasms associated with this virus and are the most aggressive. There are also low-oncogenic HPV subtypes, such as HPV 6, 11, which are mainly associated with benign lesions such as condyloma. Studies also suggest the involvement of low-risk HPVs in malignant non-cervical lesions. Methodology: The present study is a systematic review of the last 10 years to determine the prevalence of HPV6 and HPV11 infections in anogenital and head and neck cancers, evaluating their carcinogenic potential and comparing their viral genomes with the HPV16 genome to identify significant similarities and differences. The three standard databases in biomedicine: PubMed, Embase and Cochrane, accessed in March and April 2022, were used as the basis for carrying out the study. The keywords "cancer AND HPV6" or "cancer AND HPV11" were applied and 541 articles were retrieved from PubMed, 695 articles from Embase and 29 articles from Cochrane. Complete genomes of HPVs were retrieved from the RefSeq and GeneBank databases, both available at NCBI. Results: It was observed that low-risk HPV infections, associated with genital warts (condylomata) and low- grade dysplasias, are associated with a 1 to 3% risk of cancer progression if not resolved. It was also observed that monoinfections by HPV6 and HPV11 were mainly associated with cancers of the larynx and penis, with cancers of the uterine cervix, vagina, vulva, and head and neck (except pharynx) presenting the lowest frequencies of monoinfections by HPV6 and HPV11. The protein most similar in number of identical amino acids or similar chemical properties between HPV16 and HPV6 identified was E7, while the E5 protein had the least similarity. Similar results were obtained between HPV16 and HPV11. Conclusion: Head and neck studies mainly reported data from the larynx, which probably reflects the known role of HPV6 and HPV11 in respiratory papillomas in this anatomical area. The early E7 gene was more similar between high and low oncogenic risk HPVs. In addition, there were limitations such as the small number of cases in some studies added to the lack of data, resulting in the need to draw a cross-section from the moment of inoculation of the low-risk subtypes HPV 6 and 11 with their carcinogenic potential.Introdução: O câncer é o crescimento desordenado de células, que se dirigem aos tecidos e órgãos à sua volta. Dentre os fatores que contribuem para o aumento dessa patologia estão os agentes infecciosos que incluem vírus, bactérias e parasitas, sendo o papilomavírus humano (HPV) fortemente associado a cânceres cervicais, anogenitais e orofaríngeos. Os HPVs são classificados como de alto e baixo risco oncogênico. Dentre os HPVs de alto risco os subtipos 16 e 18 são os mais frequentes nas neoplasias associadas a esse virus e mais agressivos. Têm-se ainda os subtipos de HPV de baixo oncogênico, como HPV 6, 11, que estão associados principalmente às lesões benignas como os condilomas. Estudos também sugerem o envolvimento dos HPVs de baixo risco em lesões não cervicais malignas. Metodologia: O presente estudo trata-se de uma revisão sistemática dos últimos 10 anos para determinar a prevalências de infecções por HPV6 e HPV11 em cânceres anogenitais e de cabeça e pescoço, avaliando seu potencial carcinogênico e comparar seus genomas virais com o genoma do HPV16 para identificar as semelhanças e diferenças significativas. Foi utilizada como base para realização do estudo, os três bancos de dados padrão em biomedicina: PubMed, Embase e Cochrane, acessados em março e abril de 2022. As palavras-chave "cancer AND HPV6" ou "cancer AND HPV11" foram aplicadas e 541 artigos foram recuperados do PubMed, 695 artigos do Embase e 29 artigos da Cochrane. Os genomas completos dos HPVs foram recuperados do banco de dados RefSeq e GeneBank, ambos disponíveis no NCBI. Resultados: Observou-se que infecções por HPVs de baixo risco, associados às verrugas genitais (condilomas) e displasias de baixo grau, estão associadas a um risco de 1 a 3% de progressão do câncer se não forem resolvidas. Observou- se também que as monoinfecções por HPV6 e HPV11 foram associadas principalmente aos cânceres de laringe e pênis, sendo que os cânceres de colo uterino, vagina, vulva e cabeça e pescoço (exceto faringe) apresentaram as menores frequências de monoinfecções por HPV6 e HPV11. A proteína mais similar em número de aminoácidos idênticos ou de propriedades químicas semelhantes entre HPV16 e HPV6 identificada foi a E7, enquanto a proteína E5 com menor similaridade. Resultados semelhantes foram obtidos entre HPV16 e HPV11. Conclusão: Os estudos de cabeça e pescoço relataram principalmente dados da laringe, o que provavelmente reflete o papel conhecido do HPV6 e do HPV11 nos papilomas respiratórios nessa área anatômica. O gene precoce E7 apresentou-se mais similar entre HPVs de alto e baixo risco oncogênico. Ademais, existiram limitações como o pequeno número de casos de alguns estudos somado a ausência de dados, surgindo a necessidade de traçar um corte transversal desde o momento da inoculação dos subtipos de baixo risco HPV 6 e 11 com o seu potencial cancerígeno.Submitted by Jonathan Sousa de Almeida (jonathan.sousa@ufma.br) on 2023-06-28T15:23:54Z No. of bitstreams: 1 LEANDROLIMADASILVA.pdf: 723406 bytes, checksum: 4ec4fcffd2b3934b566cdb5f1d892f7f (MD5)Made available in DSpace on 2023-06-28T15:23:54Z (GMT). No. of bitstreams: 1 LEANDROLIMADASILVA.pdf: 723406 bytes, checksum: 4ec4fcffd2b3934b566cdb5f1d892f7f (MD5) Previous issue date: 2023-05-08CAPESapplication/pdfporUniversidade Federal do MaranhãoPROGRAMA DE PÓS-GRADUAÇÃO EM SAÚDE DO ADULTOUFMABrasilDEPARTAMENTO DE MEDICINA I/CCBSPapiloma vírus humano (HPV);câncer/ HPV 6;HPV 11.Human papilloma virus (HPV);cancer/HPV 6;HPV 11.CancerologiaCiências da SaúdeHPV6 e HPV11: vírus de baixo risco envolvidos na transformação maligna?HPV6 and HPV11: low risk viruses involved in malignant transformation?info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisinfo:eu-repo/semantics/openAccessreponame:Biblioteca Digital de Teses e Dissertações da UFMAinstname:Universidade Federal do Maranhão (UFMA)instacron:UFMAORIGINALLEANDROLIMADASILVA.pdfLEANDROLIMADASILVA.pdfapplication/pdf723406http://tedebc.ufma.br:8080/bitstream/tede/4789/2/LEANDROLIMADASILVA.pdf4ec4fcffd2b3934b566cdb5f1d892f7fMD52LICENSElicense.txtlicense.txttext/plain; charset=utf-82255http://tedebc.ufma.br:8080/bitstream/tede/4789/1/license.txt97eeade1fce43278e63fe063657f8083MD51tede/47892023-06-28 12:23:54.346oai:tede2:tede/4789Biblioteca Digital de Teses e Dissertaçõeshttps://tedebc.ufma.br/jspui/PUBhttp://tedebc.ufma.br:8080/oai/requestrepositorio@ufma.br||repositorio@ufma.bropendoar:21312023-06-28T15:23:54Biblioteca Digital de Teses e Dissertações da UFMA - Universidade Federal do Maranhão (UFMA)false
dc.title.por.fl_str_mv HPV6 e HPV11: vírus de baixo risco envolvidos na transformação maligna?
dc.title.alternative.eng.fl_str_mv HPV6 and HPV11: low risk viruses involved in malignant transformation?
title HPV6 e HPV11: vírus de baixo risco envolvidos na transformação maligna?
spellingShingle HPV6 e HPV11: vírus de baixo risco envolvidos na transformação maligna?
SILVA, Leandro Lima da
Papiloma vírus humano (HPV);
câncer/ HPV 6;
HPV 11.
Human papilloma virus (HPV);
cancer/HPV 6;
HPV 11.
Cancerologia
Ciências da Saúde
title_short HPV6 e HPV11: vírus de baixo risco envolvidos na transformação maligna?
title_full HPV6 e HPV11: vírus de baixo risco envolvidos na transformação maligna?
title_fullStr HPV6 e HPV11: vírus de baixo risco envolvidos na transformação maligna?
title_full_unstemmed HPV6 e HPV11: vírus de baixo risco envolvidos na transformação maligna?
title_sort HPV6 e HPV11: vírus de baixo risco envolvidos na transformação maligna?
author SILVA, Leandro Lima da
author_facet SILVA, Leandro Lima da
author_role author
dc.contributor.advisor1.fl_str_mv OLIVEIRA, Rui Miguel Gil da Costa
dc.contributor.advisor1Lattes.fl_str_mv http://lattes.cnpq.br/6785759461393904
dc.contributor.advisor-co1.fl_str_mv BRITO, Haissa Oliveira
dc.contributor.advisor-co1Lattes.fl_str_mv http://lattes.cnpq.br/2303050934162020
dc.contributor.referee1.fl_str_mv COSTA, Rui Miguel Gil da
dc.contributor.referee1Lattes.fl_str_mv http://lattes.cnpq.br/6785759461393904
dc.contributor.referee2.fl_str_mv SANTOS, Joana Maria de Oliveira
dc.contributor.referee3.fl_str_mv NASCIMENTO, Maria do Desterro Soares Brandão
dc.contributor.referee3Lattes.fl_str_mv http://lattes.cnpq.br/3958174822396319
dc.contributor.referee4.fl_str_mv ANDRADE, Marcelo Souza de
dc.contributor.referee4Lattes.fl_str_mv http://lattes.cnpq.br/6267637354657076
dc.contributor.referee5.fl_str_mv CABRAL, Flávia Castello Branco Vidal
dc.contributor.referee5Lattes.fl_str_mv http://lattes.cnpq.br/0085459127860829
dc.contributor.authorLattes.fl_str_mv http://lattes.cnpq.br/8925802340017795
dc.contributor.author.fl_str_mv SILVA, Leandro Lima da
contributor_str_mv OLIVEIRA, Rui Miguel Gil da Costa
BRITO, Haissa Oliveira
COSTA, Rui Miguel Gil da
SANTOS, Joana Maria de Oliveira
NASCIMENTO, Maria do Desterro Soares Brandão
ANDRADE, Marcelo Souza de
CABRAL, Flávia Castello Branco Vidal
dc.subject.por.fl_str_mv Papiloma vírus humano (HPV);
câncer/ HPV 6;
HPV 11.
topic Papiloma vírus humano (HPV);
câncer/ HPV 6;
HPV 11.
Human papilloma virus (HPV);
cancer/HPV 6;
HPV 11.
Cancerologia
Ciências da Saúde
dc.subject.eng.fl_str_mv Human papilloma virus (HPV);
cancer/HPV 6;
HPV 11.
dc.subject.cnpq.fl_str_mv Cancerologia
Ciências da Saúde
description Introduction: Cancer is the disorderly growth of cells, which are directed to the surrounding tissues and organs. Among the factors that contribute to the increase of this pathology are the infectious agents that include viruses, bacteria and parasites, with the human papillomavirus (HPV) being strongly associated with cervical, anogenital and oropharyngeal cancers. HPVs are classified as high and low oncogenic risk. Among the high-risk HPVs, subtypes 16 and 18 are the most frequent in neoplasms associated with this virus and are the most aggressive. There are also low-oncogenic HPV subtypes, such as HPV 6, 11, which are mainly associated with benign lesions such as condyloma. Studies also suggest the involvement of low-risk HPVs in malignant non-cervical lesions. Methodology: The present study is a systematic review of the last 10 years to determine the prevalence of HPV6 and HPV11 infections in anogenital and head and neck cancers, evaluating their carcinogenic potential and comparing their viral genomes with the HPV16 genome to identify significant similarities and differences. The three standard databases in biomedicine: PubMed, Embase and Cochrane, accessed in March and April 2022, were used as the basis for carrying out the study. The keywords "cancer AND HPV6" or "cancer AND HPV11" were applied and 541 articles were retrieved from PubMed, 695 articles from Embase and 29 articles from Cochrane. Complete genomes of HPVs were retrieved from the RefSeq and GeneBank databases, both available at NCBI. Results: It was observed that low-risk HPV infections, associated with genital warts (condylomata) and low- grade dysplasias, are associated with a 1 to 3% risk of cancer progression if not resolved. It was also observed that monoinfections by HPV6 and HPV11 were mainly associated with cancers of the larynx and penis, with cancers of the uterine cervix, vagina, vulva, and head and neck (except pharynx) presenting the lowest frequencies of monoinfections by HPV6 and HPV11. The protein most similar in number of identical amino acids or similar chemical properties between HPV16 and HPV6 identified was E7, while the E5 protein had the least similarity. Similar results were obtained between HPV16 and HPV11. Conclusion: Head and neck studies mainly reported data from the larynx, which probably reflects the known role of HPV6 and HPV11 in respiratory papillomas in this anatomical area. The early E7 gene was more similar between high and low oncogenic risk HPVs. In addition, there were limitations such as the small number of cases in some studies added to the lack of data, resulting in the need to draw a cross-section from the moment of inoculation of the low-risk subtypes HPV 6 and 11 with their carcinogenic potential.
publishDate 2023
dc.date.accessioned.fl_str_mv 2023-06-28T15:23:54Z
dc.date.issued.fl_str_mv 2023-05-08
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identifier_str_mv SILVA, Leandro Lima da. HPV6 e HPV11: vírus de baixo risco envolvidos na transformação maligna?. 2023. 64 f. Dissertação (Programa de Pós-Graduação em Saúde do Adulto) - Universidade Federal do Maranhão, São Luís, 2023.
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