Clinical utility of a life quality score in dogs with canine transmissible venereal tumor treated by vincristine chemotherapy

Detalhes bibliográficos
Autor(a) principal: Valladão,M.L.
Data de Publicação: 2010
Outros Autores: Scarpelli,K.C., Metze,K.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Arquivo brasileiro de medicina veterinária e zootecnia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352010000500010
Resumo: The clinical utility of a life quality score during vincristine chemotherapy of dogs with canine transmissible venereal tumor (CTVT) was investigated using 93 tumor-bearing dogs in this prospective study. At diagnosis, clinical data and the performance status were evaluated according to a modified Karnofsky score (CKS) adapted for dogs. The animals were treated with vincristine sulphate (0.025mg/kg) at weekly intervals until the tumor had macroscopically disappeared. The time until the first adverse event and death were recorded. In a pilot study, CKS revealed a high inter-observer concordance (kappa=0.735; weighted kappa=0.835). CKS permitted a detailed monitoring of adverse effects during therapy. Cox regressions showed that low performance score and reduced body weight were independent predictive factors for death during chemotherapy. The modified Karnofsky performance score is a simple and reproducible clinical instrument, able to estimate patient outcome after treatment of CTVT.
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spelling Clinical utility of a life quality score in dogs with canine transmissible venereal tumor treated by vincristine chemotherapycanine transmissible venereal tumorvincristinesurvivalperformance scorequality of lifeThe clinical utility of a life quality score during vincristine chemotherapy of dogs with canine transmissible venereal tumor (CTVT) was investigated using 93 tumor-bearing dogs in this prospective study. At diagnosis, clinical data and the performance status were evaluated according to a modified Karnofsky score (CKS) adapted for dogs. The animals were treated with vincristine sulphate (0.025mg/kg) at weekly intervals until the tumor had macroscopically disappeared. The time until the first adverse event and death were recorded. In a pilot study, CKS revealed a high inter-observer concordance (kappa=0.735; weighted kappa=0.835). CKS permitted a detailed monitoring of adverse effects during therapy. Cox regressions showed that low performance score and reduced body weight were independent predictive factors for death during chemotherapy. The modified Karnofsky performance score is a simple and reproducible clinical instrument, able to estimate patient outcome after treatment of CTVT.Universidade Federal de Minas Gerais, Escola de Veterinária2010-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352010000500010Arquivo Brasileiro de Medicina Veterinária e Zootecnia v.62 n.5 2010reponame:Arquivo brasileiro de medicina veterinária e zootecnia (Online)instname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMG10.1590/S0102-09352010000500010info:eu-repo/semantics/openAccessValladão,M.L.Scarpelli,K.C.Metze,K.eng2010-12-21T00:00:00Zoai:scielo:S0102-09352010000500010Revistahttps://www.scielo.br/j/abmvz/PUBhttps://old.scielo.br/oai/scielo-oai.phpjournal@vet.ufmg.br||abmvz.artigo@abmvz.org.br1678-41620102-0935opendoar:2010-12-21T00:00Arquivo brasileiro de medicina veterinária e zootecnia (Online) - Universidade Federal de Minas Gerais (UFMG)false
dc.title.none.fl_str_mv Clinical utility of a life quality score in dogs with canine transmissible venereal tumor treated by vincristine chemotherapy
title Clinical utility of a life quality score in dogs with canine transmissible venereal tumor treated by vincristine chemotherapy
spellingShingle Clinical utility of a life quality score in dogs with canine transmissible venereal tumor treated by vincristine chemotherapy
Valladão,M.L.
canine transmissible venereal tumor
vincristine
survival
performance score
quality of life
title_short Clinical utility of a life quality score in dogs with canine transmissible venereal tumor treated by vincristine chemotherapy
title_full Clinical utility of a life quality score in dogs with canine transmissible venereal tumor treated by vincristine chemotherapy
title_fullStr Clinical utility of a life quality score in dogs with canine transmissible venereal tumor treated by vincristine chemotherapy
title_full_unstemmed Clinical utility of a life quality score in dogs with canine transmissible venereal tumor treated by vincristine chemotherapy
title_sort Clinical utility of a life quality score in dogs with canine transmissible venereal tumor treated by vincristine chemotherapy
author Valladão,M.L.
author_facet Valladão,M.L.
Scarpelli,K.C.
Metze,K.
author_role author
author2 Scarpelli,K.C.
Metze,K.
author2_role author
author
dc.contributor.author.fl_str_mv Valladão,M.L.
Scarpelli,K.C.
Metze,K.
dc.subject.por.fl_str_mv canine transmissible venereal tumor
vincristine
survival
performance score
quality of life
topic canine transmissible venereal tumor
vincristine
survival
performance score
quality of life
description The clinical utility of a life quality score during vincristine chemotherapy of dogs with canine transmissible venereal tumor (CTVT) was investigated using 93 tumor-bearing dogs in this prospective study. At diagnosis, clinical data and the performance status were evaluated according to a modified Karnofsky score (CKS) adapted for dogs. The animals were treated with vincristine sulphate (0.025mg/kg) at weekly intervals until the tumor had macroscopically disappeared. The time until the first adverse event and death were recorded. In a pilot study, CKS revealed a high inter-observer concordance (kappa=0.735; weighted kappa=0.835). CKS permitted a detailed monitoring of adverse effects during therapy. Cox regressions showed that low performance score and reduced body weight were independent predictive factors for death during chemotherapy. The modified Karnofsky performance score is a simple and reproducible clinical instrument, able to estimate patient outcome after treatment of CTVT.
publishDate 2010
dc.date.none.fl_str_mv 2010-10-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352010000500010
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352010000500010
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0102-09352010000500010
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Universidade Federal de Minas Gerais, Escola de Veterinária
publisher.none.fl_str_mv Universidade Federal de Minas Gerais, Escola de Veterinária
dc.source.none.fl_str_mv Arquivo Brasileiro de Medicina Veterinária e Zootecnia v.62 n.5 2010
reponame:Arquivo brasileiro de medicina veterinária e zootecnia (Online)
instname:Universidade Federal de Minas Gerais (UFMG)
instacron:UFMG
instname_str Universidade Federal de Minas Gerais (UFMG)
instacron_str UFMG
institution UFMG
reponame_str Arquivo brasileiro de medicina veterinária e zootecnia (Online)
collection Arquivo brasileiro de medicina veterinária e zootecnia (Online)
repository.name.fl_str_mv Arquivo brasileiro de medicina veterinária e zootecnia (Online) - Universidade Federal de Minas Gerais (UFMG)
repository.mail.fl_str_mv journal@vet.ufmg.br||abmvz.artigo@abmvz.org.br
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