Reactivity of p53 protein in canine transmissible venereal tumor

Detalhes bibliográficos
Autor(a) principal: Moro,J.V.
Data de Publicação: 2010
Outros Autores: Tinucci-Costa,M., Silveira,A.C.T., Gerardi,D.G., Alessi,A.C.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Arquivo brasileiro de medicina veterinária e zootecnia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352010000200011
Resumo: The expression of p53 protein was evaluated in canine transmissible venereal tumor (CTVT), as following: natural occurrence (n=8); resistant to chemotherapy (n=4); and allogeneic transplanted in progression (n=8), stable (n=8), and regression (n=8)stages. The collected specimens were submitted to GM1 immunohistochemical reaction. Results showed a mean percentage of immunomarked cells around 18.6% in CTVT of natural occurrence, 23.8% in CTVT resistant to chemotherapy, 22.9% in allogeneic transplanted CTVT in both progression and stable stages, and 35.8% in transplanted CTVT in regression stage. The results suggest that there is a functional abnormality in p53 gene and its products in the studied tumors; although, it is not possible to correlate the percentage of cells marked by p53 and a prognosis.
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spelling Reactivity of p53 protein in canine transmissible venereal tumorimmunohistochemistryp53oncologytransmissible venereal tumorThe expression of p53 protein was evaluated in canine transmissible venereal tumor (CTVT), as following: natural occurrence (n=8); resistant to chemotherapy (n=4); and allogeneic transplanted in progression (n=8), stable (n=8), and regression (n=8)stages. The collected specimens were submitted to GM1 immunohistochemical reaction. Results showed a mean percentage of immunomarked cells around 18.6% in CTVT of natural occurrence, 23.8% in CTVT resistant to chemotherapy, 22.9% in allogeneic transplanted CTVT in both progression and stable stages, and 35.8% in transplanted CTVT in regression stage. The results suggest that there is a functional abnormality in p53 gene and its products in the studied tumors; although, it is not possible to correlate the percentage of cells marked by p53 and a prognosis.Universidade Federal de Minas Gerais, Escola de Veterinária2010-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352010000200011Arquivo Brasileiro de Medicina Veterinária e Zootecnia v.62 n.2 2010reponame:Arquivo brasileiro de medicina veterinária e zootecnia (Online)instname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMG10.1590/S0102-09352010000200011info:eu-repo/semantics/openAccessMoro,J.V.Tinucci-Costa,M.Silveira,A.C.T.Gerardi,D.G.Alessi,A.C.eng2010-05-03T00:00:00Zoai:scielo:S0102-09352010000200011Revistahttps://www.scielo.br/j/abmvz/PUBhttps://old.scielo.br/oai/scielo-oai.phpjournal@vet.ufmg.br||abmvz.artigo@abmvz.org.br1678-41620102-0935opendoar:2010-05-03T00:00Arquivo brasileiro de medicina veterinária e zootecnia (Online) - Universidade Federal de Minas Gerais (UFMG)false
dc.title.none.fl_str_mv Reactivity of p53 protein in canine transmissible venereal tumor
title Reactivity of p53 protein in canine transmissible venereal tumor
spellingShingle Reactivity of p53 protein in canine transmissible venereal tumor
Moro,J.V.
immunohistochemistry
p53
oncology
transmissible venereal tumor
title_short Reactivity of p53 protein in canine transmissible venereal tumor
title_full Reactivity of p53 protein in canine transmissible venereal tumor
title_fullStr Reactivity of p53 protein in canine transmissible venereal tumor
title_full_unstemmed Reactivity of p53 protein in canine transmissible venereal tumor
title_sort Reactivity of p53 protein in canine transmissible venereal tumor
author Moro,J.V.
author_facet Moro,J.V.
Tinucci-Costa,M.
Silveira,A.C.T.
Gerardi,D.G.
Alessi,A.C.
author_role author
author2 Tinucci-Costa,M.
Silveira,A.C.T.
Gerardi,D.G.
Alessi,A.C.
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Moro,J.V.
Tinucci-Costa,M.
Silveira,A.C.T.
Gerardi,D.G.
Alessi,A.C.
dc.subject.por.fl_str_mv immunohistochemistry
p53
oncology
transmissible venereal tumor
topic immunohistochemistry
p53
oncology
transmissible venereal tumor
description The expression of p53 protein was evaluated in canine transmissible venereal tumor (CTVT), as following: natural occurrence (n=8); resistant to chemotherapy (n=4); and allogeneic transplanted in progression (n=8), stable (n=8), and regression (n=8)stages. The collected specimens were submitted to GM1 immunohistochemical reaction. Results showed a mean percentage of immunomarked cells around 18.6% in CTVT of natural occurrence, 23.8% in CTVT resistant to chemotherapy, 22.9% in allogeneic transplanted CTVT in both progression and stable stages, and 35.8% in transplanted CTVT in regression stage. The results suggest that there is a functional abnormality in p53 gene and its products in the studied tumors; although, it is not possible to correlate the percentage of cells marked by p53 and a prognosis.
publishDate 2010
dc.date.none.fl_str_mv 2010-04-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352010000200011
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352010000200011
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0102-09352010000200011
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Universidade Federal de Minas Gerais, Escola de Veterinária
publisher.none.fl_str_mv Universidade Federal de Minas Gerais, Escola de Veterinária
dc.source.none.fl_str_mv Arquivo Brasileiro de Medicina Veterinária e Zootecnia v.62 n.2 2010
reponame:Arquivo brasileiro de medicina veterinária e zootecnia (Online)
instname:Universidade Federal de Minas Gerais (UFMG)
instacron:UFMG
instname_str Universidade Federal de Minas Gerais (UFMG)
instacron_str UFMG
institution UFMG
reponame_str Arquivo brasileiro de medicina veterinária e zootecnia (Online)
collection Arquivo brasileiro de medicina veterinária e zootecnia (Online)
repository.name.fl_str_mv Arquivo brasileiro de medicina veterinária e zootecnia (Online) - Universidade Federal de Minas Gerais (UFMG)
repository.mail.fl_str_mv journal@vet.ufmg.br||abmvz.artigo@abmvz.org.br
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