Biocompatibility in vivo of elastic cartilage treated in alkaline solutions

Detalhes bibliográficos
Autor(a) principal: Araújo,D.P.
Data de Publicação: 2022
Outros Autores: Araujo,G.H.M., Oliveira,L.P., Leite,L.B.M., Franzo,V.S., Santos,G.P., Souza,T.R., Vulcani,V.A.S.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Arquivo brasileiro de medicina veterinária e zootecnia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352022000100011
Resumo: ABSTRACT This study verified the in vivo biocompatibility of bovine elastic cartilage decellularized with alkaline solution in relation to the non-decellularized cartilage implanted in rats. Fifty Wistar rats were divided into two groups, with the experimental group (EG) receiving subcutaneous implants of cartilage treated in alkaline solution and the control group (CG) receiving subcutaneous implants of untreated cartilage. In both groups, the implants were removed on days 3, 7, 14, 21 and 42 with the preparation of histological slides stained with Hematoxylin and Eosin for the quantification of inflammatory cells, fibroblasts, angiogenesis, and cartilage degradation. The results showed that EG presented a less intense inflammatory infiltrate and better organization of collagen fibers compared to CG. It was concluded that the alkaline treatment provided better biocompatibility for elastic cartilage when implanted subcutaneously in rats.
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spelling Biocompatibility in vivo of elastic cartilage treated in alkaline solutionsalkaline solutionbiomaterialcartilageand collagenABSTRACT This study verified the in vivo biocompatibility of bovine elastic cartilage decellularized with alkaline solution in relation to the non-decellularized cartilage implanted in rats. Fifty Wistar rats were divided into two groups, with the experimental group (EG) receiving subcutaneous implants of cartilage treated in alkaline solution and the control group (CG) receiving subcutaneous implants of untreated cartilage. In both groups, the implants were removed on days 3, 7, 14, 21 and 42 with the preparation of histological slides stained with Hematoxylin and Eosin for the quantification of inflammatory cells, fibroblasts, angiogenesis, and cartilage degradation. The results showed that EG presented a less intense inflammatory infiltrate and better organization of collagen fibers compared to CG. It was concluded that the alkaline treatment provided better biocompatibility for elastic cartilage when implanted subcutaneously in rats.Universidade Federal de Minas Gerais, Escola de Veterinária2022-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352022000100011Arquivo Brasileiro de Medicina Veterinária e Zootecnia v.74 n.1 2022reponame:Arquivo brasileiro de medicina veterinária e zootecnia (Online)instname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMG10.1590/1678-4162-12435info:eu-repo/semantics/openAccessAraújo,D.P.Araujo,G.H.M.Oliveira,L.P.Leite,L.B.M.Franzo,V.S.Santos,G.P.Souza,T.R.Vulcani,V.A.S.eng2022-04-19T00:00:00Zoai:scielo:S0102-09352022000100011Revistahttps://www.scielo.br/j/abmvz/PUBhttps://old.scielo.br/oai/scielo-oai.phpjournal@vet.ufmg.br||abmvz.artigo@abmvz.org.br1678-41620102-0935opendoar:2022-04-19T00:00Arquivo brasileiro de medicina veterinária e zootecnia (Online) - Universidade Federal de Minas Gerais (UFMG)false
dc.title.none.fl_str_mv Biocompatibility in vivo of elastic cartilage treated in alkaline solutions
title Biocompatibility in vivo of elastic cartilage treated in alkaline solutions
spellingShingle Biocompatibility in vivo of elastic cartilage treated in alkaline solutions
Araújo,D.P.
alkaline solution
biomaterial
cartilage
and collagen
title_short Biocompatibility in vivo of elastic cartilage treated in alkaline solutions
title_full Biocompatibility in vivo of elastic cartilage treated in alkaline solutions
title_fullStr Biocompatibility in vivo of elastic cartilage treated in alkaline solutions
title_full_unstemmed Biocompatibility in vivo of elastic cartilage treated in alkaline solutions
title_sort Biocompatibility in vivo of elastic cartilage treated in alkaline solutions
author Araújo,D.P.
author_facet Araújo,D.P.
Araujo,G.H.M.
Oliveira,L.P.
Leite,L.B.M.
Franzo,V.S.
Santos,G.P.
Souza,T.R.
Vulcani,V.A.S.
author_role author
author2 Araujo,G.H.M.
Oliveira,L.P.
Leite,L.B.M.
Franzo,V.S.
Santos,G.P.
Souza,T.R.
Vulcani,V.A.S.
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Araújo,D.P.
Araujo,G.H.M.
Oliveira,L.P.
Leite,L.B.M.
Franzo,V.S.
Santos,G.P.
Souza,T.R.
Vulcani,V.A.S.
dc.subject.por.fl_str_mv alkaline solution
biomaterial
cartilage
and collagen
topic alkaline solution
biomaterial
cartilage
and collagen
description ABSTRACT This study verified the in vivo biocompatibility of bovine elastic cartilage decellularized with alkaline solution in relation to the non-decellularized cartilage implanted in rats. Fifty Wistar rats were divided into two groups, with the experimental group (EG) receiving subcutaneous implants of cartilage treated in alkaline solution and the control group (CG) receiving subcutaneous implants of untreated cartilage. In both groups, the implants were removed on days 3, 7, 14, 21 and 42 with the preparation of histological slides stained with Hematoxylin and Eosin for the quantification of inflammatory cells, fibroblasts, angiogenesis, and cartilage degradation. The results showed that EG presented a less intense inflammatory infiltrate and better organization of collagen fibers compared to CG. It was concluded that the alkaline treatment provided better biocompatibility for elastic cartilage when implanted subcutaneously in rats.
publishDate 2022
dc.date.none.fl_str_mv 2022-02-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352022000100011
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352022000100011
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/1678-4162-12435
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Universidade Federal de Minas Gerais, Escola de Veterinária
publisher.none.fl_str_mv Universidade Federal de Minas Gerais, Escola de Veterinária
dc.source.none.fl_str_mv Arquivo Brasileiro de Medicina Veterinária e Zootecnia v.74 n.1 2022
reponame:Arquivo brasileiro de medicina veterinária e zootecnia (Online)
instname:Universidade Federal de Minas Gerais (UFMG)
instacron:UFMG
instname_str Universidade Federal de Minas Gerais (UFMG)
instacron_str UFMG
institution UFMG
reponame_str Arquivo brasileiro de medicina veterinária e zootecnia (Online)
collection Arquivo brasileiro de medicina veterinária e zootecnia (Online)
repository.name.fl_str_mv Arquivo brasileiro de medicina veterinária e zootecnia (Online) - Universidade Federal de Minas Gerais (UFMG)
repository.mail.fl_str_mv journal@vet.ufmg.br||abmvz.artigo@abmvz.org.br
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