Electroretinography and immunohistochemistry of retina in rabbits treated with sildenafil citrate
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Arquivo brasileiro de medicina veterinária e zootecnia (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352015000601589 |
Resumo: | Sildenafil citrate is a type-5 phosphodiesterase inhibitor (PDE-5), able to inhibit type-6 phosphodiesterase (PDE-6) as well, providing clinical benefits and paraeffects, some of them potentially related to the retina. The effects of the sildenafil on the retrobulbar and retinal circulation were studied in 27 adult male rabbits of the White New Zealand breed. The electric activity of the retina was evaluated before and at the end of the treatments, and immunohistochemistry studies were conducted. An amplitude increase of the b wave was found in the mixed response of cones and rods after 7 days of treatment with sildenafil citrate. However, in the other evaluations and periods, the values did not differ from the basal ones. Through immunohistochemistry, no significant decrease of the expression of PDE-5 and PDE-6 proteins was observed. Based on the results obtained, it is possible to admit that the sildenafil citrate did not change the expression of PDE-5 and PDE-6, neither the electroretinographic activity of the retina of male rabbits of the White New Zealand breed. |
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Electroretinography and immunohistochemistry of retina in rabbits treated with sildenafil citraterabbitsildenafil citrateelectroretinographyimmunohistochemistrySildenafil citrate is a type-5 phosphodiesterase inhibitor (PDE-5), able to inhibit type-6 phosphodiesterase (PDE-6) as well, providing clinical benefits and paraeffects, some of them potentially related to the retina. The effects of the sildenafil on the retrobulbar and retinal circulation were studied in 27 adult male rabbits of the White New Zealand breed. The electric activity of the retina was evaluated before and at the end of the treatments, and immunohistochemistry studies were conducted. An amplitude increase of the b wave was found in the mixed response of cones and rods after 7 days of treatment with sildenafil citrate. However, in the other evaluations and periods, the values did not differ from the basal ones. Through immunohistochemistry, no significant decrease of the expression of PDE-5 and PDE-6 proteins was observed. Based on the results obtained, it is possible to admit that the sildenafil citrate did not change the expression of PDE-5 and PDE-6, neither the electroretinographic activity of the retina of male rabbits of the White New Zealand breed.Universidade Federal de Minas Gerais, Escola de Veterinária2015-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352015000601589Arquivo Brasileiro de Medicina Veterinária e Zootecnia v.67 n.6 2015reponame:Arquivo brasileiro de medicina veterinária e zootecnia (Online)instname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMG10.1590/1678-4162-7464info:eu-repo/semantics/openAccessAmaral,A.V.C.Silva,G.A.Costa,A.P.A.Oliveira,K.S.Jordão,P.Ribeiro,A.P.Renzo,R.Laus,J.L.eng2015-12-09T00:00:00Zoai:scielo:S0102-09352015000601589Revistahttps://www.scielo.br/j/abmvz/PUBhttps://old.scielo.br/oai/scielo-oai.phpjournal@vet.ufmg.br||abmvz.artigo@abmvz.org.br1678-41620102-0935opendoar:2015-12-09T00:00Arquivo brasileiro de medicina veterinária e zootecnia (Online) - Universidade Federal de Minas Gerais (UFMG)false |
dc.title.none.fl_str_mv |
Electroretinography and immunohistochemistry of retina in rabbits treated with sildenafil citrate |
title |
Electroretinography and immunohistochemistry of retina in rabbits treated with sildenafil citrate |
spellingShingle |
Electroretinography and immunohistochemistry of retina in rabbits treated with sildenafil citrate Amaral,A.V.C. rabbit sildenafil citrate electroretinography immunohistochemistry |
title_short |
Electroretinography and immunohistochemistry of retina in rabbits treated with sildenafil citrate |
title_full |
Electroretinography and immunohistochemistry of retina in rabbits treated with sildenafil citrate |
title_fullStr |
Electroretinography and immunohistochemistry of retina in rabbits treated with sildenafil citrate |
title_full_unstemmed |
Electroretinography and immunohistochemistry of retina in rabbits treated with sildenafil citrate |
title_sort |
Electroretinography and immunohistochemistry of retina in rabbits treated with sildenafil citrate |
author |
Amaral,A.V.C. |
author_facet |
Amaral,A.V.C. Silva,G.A. Costa,A.P.A. Oliveira,K.S. Jordão,P. Ribeiro,A.P. Renzo,R. Laus,J.L. |
author_role |
author |
author2 |
Silva,G.A. Costa,A.P.A. Oliveira,K.S. Jordão,P. Ribeiro,A.P. Renzo,R. Laus,J.L. |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Amaral,A.V.C. Silva,G.A. Costa,A.P.A. Oliveira,K.S. Jordão,P. Ribeiro,A.P. Renzo,R. Laus,J.L. |
dc.subject.por.fl_str_mv |
rabbit sildenafil citrate electroretinography immunohistochemistry |
topic |
rabbit sildenafil citrate electroretinography immunohistochemistry |
description |
Sildenafil citrate is a type-5 phosphodiesterase inhibitor (PDE-5), able to inhibit type-6 phosphodiesterase (PDE-6) as well, providing clinical benefits and paraeffects, some of them potentially related to the retina. The effects of the sildenafil on the retrobulbar and retinal circulation were studied in 27 adult male rabbits of the White New Zealand breed. The electric activity of the retina was evaluated before and at the end of the treatments, and immunohistochemistry studies were conducted. An amplitude increase of the b wave was found in the mixed response of cones and rods after 7 days of treatment with sildenafil citrate. However, in the other evaluations and periods, the values did not differ from the basal ones. Through immunohistochemistry, no significant decrease of the expression of PDE-5 and PDE-6 proteins was observed. Based on the results obtained, it is possible to admit that the sildenafil citrate did not change the expression of PDE-5 and PDE-6, neither the electroretinographic activity of the retina of male rabbits of the White New Zealand breed. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-12-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352015000601589 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352015000601589 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/1678-4162-7464 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Universidade Federal de Minas Gerais, Escola de Veterinária |
publisher.none.fl_str_mv |
Universidade Federal de Minas Gerais, Escola de Veterinária |
dc.source.none.fl_str_mv |
Arquivo Brasileiro de Medicina Veterinária e Zootecnia v.67 n.6 2015 reponame:Arquivo brasileiro de medicina veterinária e zootecnia (Online) instname:Universidade Federal de Minas Gerais (UFMG) instacron:UFMG |
instname_str |
Universidade Federal de Minas Gerais (UFMG) |
instacron_str |
UFMG |
institution |
UFMG |
reponame_str |
Arquivo brasileiro de medicina veterinária e zootecnia (Online) |
collection |
Arquivo brasileiro de medicina veterinária e zootecnia (Online) |
repository.name.fl_str_mv |
Arquivo brasileiro de medicina veterinária e zootecnia (Online) - Universidade Federal de Minas Gerais (UFMG) |
repository.mail.fl_str_mv |
journal@vet.ufmg.br||abmvz.artigo@abmvz.org.br |
_version_ |
1750220889120571392 |