Analysis of EGFR and HER-2 expressions in ductal carcinomas in situ in canine mammary glands
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Arquivo brasileiro de medicina veterinária e zootecnia (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352014000300763 |
Resumo: | Biomolecular evidence has shown that ductal carcinoma in situ(DCIS) may develop into invasive carcinoma of the canine mammary gland, and mutations in proto-oncogenes HER2 and EGFR; two members of the family of epidermal growth factor receptors, may be involved in this process. The purpose of this study was the characterization of the immunohistochemical expression of the EGFR and HER2 proteins in the process of neoplastic transformation, supposedly present in ductal carcinomas in situin canine mammary glands. Fifteen cases of DCIS were evaluated, with a higher expression of HER2 and EGFR being observed in low-grade carcinomas when compared with high-grade neoplasms, and with a high positive statistical correlation in the latter. Results suggest that aggressive tumors tend to lose the expression of EGFR and HER2 simultaneously. The loss of the expression of these markers may be related to the process of neoplastic progression in canine mammary tumors. |
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Arquivo brasileiro de medicina veterinária e zootecnia (Online) |
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Analysis of EGFR and HER-2 expressions in ductal carcinomas in situ in canine mammary glandsdogneoplasmimmunohistochemistryEGFRCerbB2Biomolecular evidence has shown that ductal carcinoma in situ(DCIS) may develop into invasive carcinoma of the canine mammary gland, and mutations in proto-oncogenes HER2 and EGFR; two members of the family of epidermal growth factor receptors, may be involved in this process. The purpose of this study was the characterization of the immunohistochemical expression of the EGFR and HER2 proteins in the process of neoplastic transformation, supposedly present in ductal carcinomas in situin canine mammary glands. Fifteen cases of DCIS were evaluated, with a higher expression of HER2 and EGFR being observed in low-grade carcinomas when compared with high-grade neoplasms, and with a high positive statistical correlation in the latter. Results suggest that aggressive tumors tend to lose the expression of EGFR and HER2 simultaneously. The loss of the expression of these markers may be related to the process of neoplastic progression in canine mammary tumors.Universidade Federal de Minas Gerais, Escola de Veterinária2014-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352014000300763Arquivo Brasileiro de Medicina Veterinária e Zootecnia v.66 n.3 2014reponame:Arquivo brasileiro de medicina veterinária e zootecnia (Online)instname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMG10.1590/1678-41626128info:eu-repo/semantics/openAccessSilva,I.L.D.Dias,A.P.M.Bertagnolli,A.C.Cassali,G.D.Ferreira,E.eng2015-10-26T00:00:00Zoai:scielo:S0102-09352014000300763Revistahttps://www.scielo.br/j/abmvz/PUBhttps://old.scielo.br/oai/scielo-oai.phpjournal@vet.ufmg.br||abmvz.artigo@abmvz.org.br1678-41620102-0935opendoar:2015-10-26T00:00Arquivo brasileiro de medicina veterinária e zootecnia (Online) - Universidade Federal de Minas Gerais (UFMG)false |
dc.title.none.fl_str_mv |
Analysis of EGFR and HER-2 expressions in ductal carcinomas in situ in canine mammary glands |
title |
Analysis of EGFR and HER-2 expressions in ductal carcinomas in situ in canine mammary glands |
spellingShingle |
Analysis of EGFR and HER-2 expressions in ductal carcinomas in situ in canine mammary glands Silva,I.L.D. dog neoplasm immunohistochemistry EGFR CerbB2 |
title_short |
Analysis of EGFR and HER-2 expressions in ductal carcinomas in situ in canine mammary glands |
title_full |
Analysis of EGFR and HER-2 expressions in ductal carcinomas in situ in canine mammary glands |
title_fullStr |
Analysis of EGFR and HER-2 expressions in ductal carcinomas in situ in canine mammary glands |
title_full_unstemmed |
Analysis of EGFR and HER-2 expressions in ductal carcinomas in situ in canine mammary glands |
title_sort |
Analysis of EGFR and HER-2 expressions in ductal carcinomas in situ in canine mammary glands |
author |
Silva,I.L.D. |
author_facet |
Silva,I.L.D. Dias,A.P.M. Bertagnolli,A.C. Cassali,G.D. Ferreira,E. |
author_role |
author |
author2 |
Dias,A.P.M. Bertagnolli,A.C. Cassali,G.D. Ferreira,E. |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Silva,I.L.D. Dias,A.P.M. Bertagnolli,A.C. Cassali,G.D. Ferreira,E. |
dc.subject.por.fl_str_mv |
dog neoplasm immunohistochemistry EGFR CerbB2 |
topic |
dog neoplasm immunohistochemistry EGFR CerbB2 |
description |
Biomolecular evidence has shown that ductal carcinoma in situ(DCIS) may develop into invasive carcinoma of the canine mammary gland, and mutations in proto-oncogenes HER2 and EGFR; two members of the family of epidermal growth factor receptors, may be involved in this process. The purpose of this study was the characterization of the immunohistochemical expression of the EGFR and HER2 proteins in the process of neoplastic transformation, supposedly present in ductal carcinomas in situin canine mammary glands. Fifteen cases of DCIS were evaluated, with a higher expression of HER2 and EGFR being observed in low-grade carcinomas when compared with high-grade neoplasms, and with a high positive statistical correlation in the latter. Results suggest that aggressive tumors tend to lose the expression of EGFR and HER2 simultaneously. The loss of the expression of these markers may be related to the process of neoplastic progression in canine mammary tumors. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-06-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352014000300763 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352014000300763 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/1678-41626128 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Universidade Federal de Minas Gerais, Escola de Veterinária |
publisher.none.fl_str_mv |
Universidade Federal de Minas Gerais, Escola de Veterinária |
dc.source.none.fl_str_mv |
Arquivo Brasileiro de Medicina Veterinária e Zootecnia v.66 n.3 2014 reponame:Arquivo brasileiro de medicina veterinária e zootecnia (Online) instname:Universidade Federal de Minas Gerais (UFMG) instacron:UFMG |
instname_str |
Universidade Federal de Minas Gerais (UFMG) |
instacron_str |
UFMG |
institution |
UFMG |
reponame_str |
Arquivo brasileiro de medicina veterinária e zootecnia (Online) |
collection |
Arquivo brasileiro de medicina veterinária e zootecnia (Online) |
repository.name.fl_str_mv |
Arquivo brasileiro de medicina veterinária e zootecnia (Online) - Universidade Federal de Minas Gerais (UFMG) |
repository.mail.fl_str_mv |
journal@vet.ufmg.br||abmvz.artigo@abmvz.org.br |
_version_ |
1750220887672487936 |