Use of Triticum aestivum in open wound healing: a clinical, pathological, and tensiometric assessment in the rabbit model
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Arquivo brasileiro de medicina veterinária e zootecnia (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352014000601757 |
Resumo: | While Triticum sp. has been shown to act in wound healing, stimulating collagen synthesis by fibroblasts, the use of this plant extract has yet to be assessed in vivo, in commercially viable presentations. This study used rabbits and assessed, on days seven, 14, and 21, the presence or absence of granulation tissue and epithelialization, histopathological structures, and scar quality through the breaking and tension strength. Treatments, performed for 21 days, were aqueous extract of T. aestivum at a concentration of 2mg/mL (group I) and 10mg/mL (group II) and a nonionic cream (control group). We demonstrate that the formation of granulation tissue was not significantly different between treatments. In the analysis of epithelial tissue, wounds in group II differed from other treatments by day 7. On days 14 and 21 there was no significant clinical difference between groups. In the histopathological evaluation, scar quality and rupture strength did not differ between the groups in the studied period. In the tension strength evaluation, group I differed from the others, presenting a higher tension strength overall. The studied treatments did not differ regarding healing evolution of the skin wounds, but T. aestivum extract, at 2mg/mL, presents better results in the tension strength evaluation. |
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Use of Triticum aestivum in open wound healing: a clinical, pathological, and tensiometric assessment in the rabbit modelrabbithealingherbal medicinetensionwheatWhile Triticum sp. has been shown to act in wound healing, stimulating collagen synthesis by fibroblasts, the use of this plant extract has yet to be assessed in vivo, in commercially viable presentations. This study used rabbits and assessed, on days seven, 14, and 21, the presence or absence of granulation tissue and epithelialization, histopathological structures, and scar quality through the breaking and tension strength. Treatments, performed for 21 days, were aqueous extract of T. aestivum at a concentration of 2mg/mL (group I) and 10mg/mL (group II) and a nonionic cream (control group). We demonstrate that the formation of granulation tissue was not significantly different between treatments. In the analysis of epithelial tissue, wounds in group II differed from other treatments by day 7. On days 14 and 21 there was no significant clinical difference between groups. In the histopathological evaluation, scar quality and rupture strength did not differ between the groups in the studied period. In the tension strength evaluation, group I differed from the others, presenting a higher tension strength overall. The studied treatments did not differ regarding healing evolution of the skin wounds, but T. aestivum extract, at 2mg/mL, presents better results in the tension strength evaluation.Universidade Federal de Minas Gerais, Escola de Veterinária2014-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352014000601757Arquivo Brasileiro de Medicina Veterinária e Zootecnia v.66 n.6 2014reponame:Arquivo brasileiro de medicina veterinária e zootecnia (Online)instname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMG10.1590/1678-7132info:eu-repo/semantics/openAccessTillmann,M.T.Felix,A.O.C.Mueller,E.N.Felix,S.R.Alves,G.H.Ramos,T.S.Freitag,R.A.Fernandes,C.G.Nobre,M.O.eng2015-10-27T00:00:00Zoai:scielo:S0102-09352014000601757Revistahttps://www.scielo.br/j/abmvz/PUBhttps://old.scielo.br/oai/scielo-oai.phpjournal@vet.ufmg.br||abmvz.artigo@abmvz.org.br1678-41620102-0935opendoar:2015-10-27T00:00Arquivo brasileiro de medicina veterinária e zootecnia (Online) - Universidade Federal de Minas Gerais (UFMG)false |
dc.title.none.fl_str_mv |
Use of Triticum aestivum in open wound healing: a clinical, pathological, and tensiometric assessment in the rabbit model |
title |
Use of Triticum aestivum in open wound healing: a clinical, pathological, and tensiometric assessment in the rabbit model |
spellingShingle |
Use of Triticum aestivum in open wound healing: a clinical, pathological, and tensiometric assessment in the rabbit model Tillmann,M.T. rabbit healing herbal medicine tension wheat |
title_short |
Use of Triticum aestivum in open wound healing: a clinical, pathological, and tensiometric assessment in the rabbit model |
title_full |
Use of Triticum aestivum in open wound healing: a clinical, pathological, and tensiometric assessment in the rabbit model |
title_fullStr |
Use of Triticum aestivum in open wound healing: a clinical, pathological, and tensiometric assessment in the rabbit model |
title_full_unstemmed |
Use of Triticum aestivum in open wound healing: a clinical, pathological, and tensiometric assessment in the rabbit model |
title_sort |
Use of Triticum aestivum in open wound healing: a clinical, pathological, and tensiometric assessment in the rabbit model |
author |
Tillmann,M.T. |
author_facet |
Tillmann,M.T. Felix,A.O.C. Mueller,E.N. Felix,S.R. Alves,G.H. Ramos,T.S. Freitag,R.A. Fernandes,C.G. Nobre,M.O. |
author_role |
author |
author2 |
Felix,A.O.C. Mueller,E.N. Felix,S.R. Alves,G.H. Ramos,T.S. Freitag,R.A. Fernandes,C.G. Nobre,M.O. |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Tillmann,M.T. Felix,A.O.C. Mueller,E.N. Felix,S.R. Alves,G.H. Ramos,T.S. Freitag,R.A. Fernandes,C.G. Nobre,M.O. |
dc.subject.por.fl_str_mv |
rabbit healing herbal medicine tension wheat |
topic |
rabbit healing herbal medicine tension wheat |
description |
While Triticum sp. has been shown to act in wound healing, stimulating collagen synthesis by fibroblasts, the use of this plant extract has yet to be assessed in vivo, in commercially viable presentations. This study used rabbits and assessed, on days seven, 14, and 21, the presence or absence of granulation tissue and epithelialization, histopathological structures, and scar quality through the breaking and tension strength. Treatments, performed for 21 days, were aqueous extract of T. aestivum at a concentration of 2mg/mL (group I) and 10mg/mL (group II) and a nonionic cream (control group). We demonstrate that the formation of granulation tissue was not significantly different between treatments. In the analysis of epithelial tissue, wounds in group II differed from other treatments by day 7. On days 14 and 21 there was no significant clinical difference between groups. In the histopathological evaluation, scar quality and rupture strength did not differ between the groups in the studied period. In the tension strength evaluation, group I differed from the others, presenting a higher tension strength overall. The studied treatments did not differ regarding healing evolution of the skin wounds, but T. aestivum extract, at 2mg/mL, presents better results in the tension strength evaluation. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-12-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352014000601757 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352014000601757 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/1678-7132 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Universidade Federal de Minas Gerais, Escola de Veterinária |
publisher.none.fl_str_mv |
Universidade Federal de Minas Gerais, Escola de Veterinária |
dc.source.none.fl_str_mv |
Arquivo Brasileiro de Medicina Veterinária e Zootecnia v.66 n.6 2014 reponame:Arquivo brasileiro de medicina veterinária e zootecnia (Online) instname:Universidade Federal de Minas Gerais (UFMG) instacron:UFMG |
instname_str |
Universidade Federal de Minas Gerais (UFMG) |
instacron_str |
UFMG |
institution |
UFMG |
reponame_str |
Arquivo brasileiro de medicina veterinária e zootecnia (Online) |
collection |
Arquivo brasileiro de medicina veterinária e zootecnia (Online) |
repository.name.fl_str_mv |
Arquivo brasileiro de medicina veterinária e zootecnia (Online) - Universidade Federal de Minas Gerais (UFMG) |
repository.mail.fl_str_mv |
journal@vet.ufmg.br||abmvz.artigo@abmvz.org.br |
_version_ |
1750220888173707264 |