Dimethyl sulfoxide effects on the febrile response to lipopolysaccharide injection in rabbits
Autor(a) principal: | |
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Data de Publicação: | 2008 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Arquivo brasileiro de medicina veterinária e zootecnia (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352008000300016 |
Resumo: | The present study was designed to determine whether DMSO causes an inhibition on the development of fever in rabbits. The intravenous administration of LPS (1.5µg.kg-1 body weight) caused fever in both saline+LPS and DMSO+LPS group, but the onset and magnitude of the induced fever were significantly different. The saline+LPS group presented a prototypic biphasic fever whereas the DMSO+LPS group presented an attenuated febrile response, but it was not abolished. These results suggest that DMSO may provide a protective mechanism against pyrogen LPS, probably through the modulation of NF-kB mediated events, such as fever. |
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Dimethyl sulfoxide effects on the febrile response to lipopolysaccharide injection in rabbitsLPSfeverDMSOrabbitsThe present study was designed to determine whether DMSO causes an inhibition on the development of fever in rabbits. The intravenous administration of LPS (1.5µg.kg-1 body weight) caused fever in both saline+LPS and DMSO+LPS group, but the onset and magnitude of the induced fever were significantly different. The saline+LPS group presented a prototypic biphasic fever whereas the DMSO+LPS group presented an attenuated febrile response, but it was not abolished. These results suggest that DMSO may provide a protective mechanism against pyrogen LPS, probably through the modulation of NF-kB mediated events, such as fever.Universidade Federal de Minas Gerais, Escola de Veterinária2008-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352008000300016Arquivo Brasileiro de Medicina Veterinária e Zootecnia v.60 n.3 2008reponame:Arquivo brasileiro de medicina veterinária e zootecnia (Online)instname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMG10.1590/S0102-09352008000300016info:eu-repo/semantics/openAccessSouza,A.H.Valadão,C.A.A.Selegatto,M.A.Almeida,R.M.Macari,M.eng2008-07-17T00:00:00Zoai:scielo:S0102-09352008000300016Revistahttps://www.scielo.br/j/abmvz/PUBhttps://old.scielo.br/oai/scielo-oai.phpjournal@vet.ufmg.br||abmvz.artigo@abmvz.org.br1678-41620102-0935opendoar:2008-07-17T00:00Arquivo brasileiro de medicina veterinária e zootecnia (Online) - Universidade Federal de Minas Gerais (UFMG)false |
dc.title.none.fl_str_mv |
Dimethyl sulfoxide effects on the febrile response to lipopolysaccharide injection in rabbits |
title |
Dimethyl sulfoxide effects on the febrile response to lipopolysaccharide injection in rabbits |
spellingShingle |
Dimethyl sulfoxide effects on the febrile response to lipopolysaccharide injection in rabbits Souza,A.H. LPS fever DMSO rabbits |
title_short |
Dimethyl sulfoxide effects on the febrile response to lipopolysaccharide injection in rabbits |
title_full |
Dimethyl sulfoxide effects on the febrile response to lipopolysaccharide injection in rabbits |
title_fullStr |
Dimethyl sulfoxide effects on the febrile response to lipopolysaccharide injection in rabbits |
title_full_unstemmed |
Dimethyl sulfoxide effects on the febrile response to lipopolysaccharide injection in rabbits |
title_sort |
Dimethyl sulfoxide effects on the febrile response to lipopolysaccharide injection in rabbits |
author |
Souza,A.H. |
author_facet |
Souza,A.H. Valadão,C.A.A. Selegatto,M.A. Almeida,R.M. Macari,M. |
author_role |
author |
author2 |
Valadão,C.A.A. Selegatto,M.A. Almeida,R.M. Macari,M. |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Souza,A.H. Valadão,C.A.A. Selegatto,M.A. Almeida,R.M. Macari,M. |
dc.subject.por.fl_str_mv |
LPS fever DMSO rabbits |
topic |
LPS fever DMSO rabbits |
description |
The present study was designed to determine whether DMSO causes an inhibition on the development of fever in rabbits. The intravenous administration of LPS (1.5µg.kg-1 body weight) caused fever in both saline+LPS and DMSO+LPS group, but the onset and magnitude of the induced fever were significantly different. The saline+LPS group presented a prototypic biphasic fever whereas the DMSO+LPS group presented an attenuated febrile response, but it was not abolished. These results suggest that DMSO may provide a protective mechanism against pyrogen LPS, probably through the modulation of NF-kB mediated events, such as fever. |
publishDate |
2008 |
dc.date.none.fl_str_mv |
2008-06-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352008000300016 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352008000300016 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0102-09352008000300016 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Universidade Federal de Minas Gerais, Escola de Veterinária |
publisher.none.fl_str_mv |
Universidade Federal de Minas Gerais, Escola de Veterinária |
dc.source.none.fl_str_mv |
Arquivo Brasileiro de Medicina Veterinária e Zootecnia v.60 n.3 2008 reponame:Arquivo brasileiro de medicina veterinária e zootecnia (Online) instname:Universidade Federal de Minas Gerais (UFMG) instacron:UFMG |
instname_str |
Universidade Federal de Minas Gerais (UFMG) |
instacron_str |
UFMG |
institution |
UFMG |
reponame_str |
Arquivo brasileiro de medicina veterinária e zootecnia (Online) |
collection |
Arquivo brasileiro de medicina veterinária e zootecnia (Online) |
repository.name.fl_str_mv |
Arquivo brasileiro de medicina veterinária e zootecnia (Online) - Universidade Federal de Minas Gerais (UFMG) |
repository.mail.fl_str_mv |
journal@vet.ufmg.br||abmvz.artigo@abmvz.org.br |
_version_ |
1750220881454432256 |