Wistar audiogenic rats display abnormal behavioral traits associated with artificial selection for seizure susceptibility

• Autor(a) principal: Gabriel Perfeito Castro
• Data de Publicação: 2017
• Outros Autores: Daniel de Castro Medeiros, Leonardo de Oliveira Guarnieri, Flávio Afonso Gonçalves Mourão, Hyorrana Priscila Pereira Pinto, Grace Schenatto Pereira Moraes, Márcio Flávio Dutra Moraes
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Repositório Institucional da UFMG
• Texto Completo: https://doi.org/10.1016/j.yebeh.2015.08.039; http://hdl.handle.net/1843/56297; https://orcid.org/0000-0003-0243-1309; https://orcid.org/0000-0002-2566-2532; https://orcid.org/0000-0002-4519-3585; https://orcid.org/0000-0002-2513-1504
• topic: Epilepsy; Seizure predisposition; Wistaraudiogenic rat; Comorbidities; Psychiatric disorder; Epilepsia; Convulsões

Accumulating evidence from different animal models has contributed to the understanding of the bidirectional comorbidity associations between the epileptic condition and behavioral abnormalities. A strain of animals inbred to enhance seizure predisposition to high-intensity sound stimulation, the Wistar audiogenic rat (WAR), underwent several behavioral tests: forced swim test (FST), open-field test (OFT), sucrose preference test (SPT), elevated plus maze (EPM), social preference (SP), marble burying test (MBT), inhibitory avoidance (IAT), and two-way active avoidance (TWAA). The choice of tests aimed to investigate the correlation between underlying circuits believed to be participating in both WAR's innate susceptibility to sound-triggered seizures and the neurobiological substrates associated with test performance. Comparing WAR with its Wistar counterpart (i.e., resistant to audiogenic seizures) showed that WARs present behavioral despair traits (e.g., increased FST immobility) but no evidence of anhedonic behavior (e.g., increased sucrose consumption in SPT) or social impairment (e.g., no difference regarding juvenile exploration in SP). In addition, tests suggested that WARs are unable to properly evaluate degrees of aversiveness (e.g., performance on OFT, EPM, MBT, IAT, and TWAA). The particularities of the WAR model opens new venues to further untangle the neurobiology underlying the co-morbidity of behavioral disorders and epilepsy.