Meropenem pharmacokinetics in children: series of cases

Detalhes bibliográficos
Autor(a) principal: Geisa Cristina da Silva Alves
Data de Publicação: 2018
Outros Autores: Farah Maria Drumond Chequer, Cristina Sanches
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFMG
Texto Completo: https://doi.org/10.30968/rbfhss.2018.093.002
http://hdl.handle.net/1843/46325
Resumo: Daily doses of antibiotics recommended for children are based on studies in healthy adult volunteers, so this study aimed to describe the pharmacokinetic/pharmacodynamic characteristics of meropenem in children and to verify whether plasma concentrations were within the range therapy. This is a series of cases, which included 4 children, aged 02-12 years old using meropenem dose empirical, 8/8h in 75% of children. The study was conducted in a pediatric hospital from March 2016 to March 2017. Only one child had the result of the culture of biological material recorded in medical records at the time of collection. We observed high inter-patient variability of pharmacokinetic parameters, however plasma concentrations of meropenem were effective in 100% of the study population considering the parameter 40%f T>CIM to CIM of 0.25μg/mL.
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spelling 2022-10-18T15:45:04Z2022-10-18T15:45:04Z20189315https://doi.org/10.30968/rbfhss.2018.093.0022316-7750http://hdl.handle.net/1843/46325Daily doses of antibiotics recommended for children are based on studies in healthy adult volunteers, so this study aimed to describe the pharmacokinetic/pharmacodynamic characteristics of meropenem in children and to verify whether plasma concentrations were within the range therapy. This is a series of cases, which included 4 children, aged 02-12 years old using meropenem dose empirical, 8/8h in 75% of children. The study was conducted in a pediatric hospital from March 2016 to March 2017. Only one child had the result of the culture of biological material recorded in medical records at the time of collection. We observed high inter-patient variability of pharmacokinetic parameters, however plasma concentrations of meropenem were effective in 100% of the study population considering the parameter 40%f T>CIM to CIM of 0.25μg/mL.As doses diárias de antibióticos recomendadas para crianças baseiam-se em estudos realizados em voluntários adultos saudáveis, portanto, este estudo teve como objetivo descrever as características farmacocinéticas / farmacodinâmicas de meropenem em crianças e verificar se as concentrações plasmáticas se encontravam dentro da faixa terapêutica. Trata-se de uma série de casos, onde foram incluídas 4 crianças, com idades de 02-12 anos em utilização de meropenem dose empírica, de 8/8h em 75% das crianças. O estudo foi realizado em um hospital pediátrico, no período de março 2016 a março de 2017. Apenas uma criança tinha registrado em prontuário no momento da coleta o resultado da cultura de material biológico. Observamos alta variabilidade inter-paciente dos parâmetros farmacocinéticos, no entanto as concentrações plasmáticas de meropenem foram efetivas em 100% da população estudada considerando o parâmetro 40%f T>CIM para CIM de 0,25μg/mL.CAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível SuperiorengUniversidade Federal de Minas GeraisUFMGBrasilFAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICASRevista Brasileira de Farmácia Hospitalar e Serviços de SaúdeAntibacterianosMeropenémDosagemFarmacocinéticaCriançaAntibacterialsMeropenemChildrenPharmacokineticsMeropenem pharmacokinetics in children: series of casesFarmacocinética de meropenem em crianças: uma série de casosinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://rbfhss.org.br/sbrafh/article/view/380Geisa Cristina da Silva AlvesFarah Maria Drumond ChequerCristina Sanchesapplication/pdfinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMGLICENSELicense.txtLicense.txttext/plain; charset=utf-82042https://repositorio.ufmg.br/bitstream/1843/46325/1/License.txtfa505098d172de0bc8864fc1287ffe22MD51ORIGINALMeropenem pharmacokinetics in children series of cases.pdfMeropenem pharmacokinetics in children series of cases.pdfapplication/pdf119394https://repositorio.ufmg.br/bitstream/1843/46325/2/Meropenem%20pharmacokinetics%20in%20children%20series%20of%20cases.pdf46f2d14e1b12c577f2f679096fe8002cMD521843/463252022-10-18 12:45:04.597oai:repositorio.ufmg.br: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Repositório de PublicaçõesPUBhttps://repositorio.ufmg.br/oaiopendoar:2022-10-18T15:45:04Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)false
dc.title.pt_BR.fl_str_mv Meropenem pharmacokinetics in children: series of cases
dc.title.alternative.pt_BR.fl_str_mv Farmacocinética de meropenem em crianças: uma série de casos
title Meropenem pharmacokinetics in children: series of cases
spellingShingle Meropenem pharmacokinetics in children: series of cases
Geisa Cristina da Silva Alves
Antibacterials
Meropenem
Children
Pharmacokinetics
Antibacterianos
Meropeném
Dosagem
Farmacocinética
Criança
title_short Meropenem pharmacokinetics in children: series of cases
title_full Meropenem pharmacokinetics in children: series of cases
title_fullStr Meropenem pharmacokinetics in children: series of cases
title_full_unstemmed Meropenem pharmacokinetics in children: series of cases
title_sort Meropenem pharmacokinetics in children: series of cases
author Geisa Cristina da Silva Alves
author_facet Geisa Cristina da Silva Alves
Farah Maria Drumond Chequer
Cristina Sanches
author_role author
author2 Farah Maria Drumond Chequer
Cristina Sanches
author2_role author
author
dc.contributor.author.fl_str_mv Geisa Cristina da Silva Alves
Farah Maria Drumond Chequer
Cristina Sanches
dc.subject.por.fl_str_mv Antibacterials
Meropenem
Children
Pharmacokinetics
topic Antibacterials
Meropenem
Children
Pharmacokinetics
Antibacterianos
Meropeném
Dosagem
Farmacocinética
Criança
dc.subject.other.pt_BR.fl_str_mv Antibacterianos
Meropeném
Dosagem
Farmacocinética
Criança
description Daily doses of antibiotics recommended for children are based on studies in healthy adult volunteers, so this study aimed to describe the pharmacokinetic/pharmacodynamic characteristics of meropenem in children and to verify whether plasma concentrations were within the range therapy. This is a series of cases, which included 4 children, aged 02-12 years old using meropenem dose empirical, 8/8h in 75% of children. The study was conducted in a pediatric hospital from March 2016 to March 2017. Only one child had the result of the culture of biological material recorded in medical records at the time of collection. We observed high inter-patient variability of pharmacokinetic parameters, however plasma concentrations of meropenem were effective in 100% of the study population considering the parameter 40%f T>CIM to CIM of 0.25μg/mL.
publishDate 2018
dc.date.issued.fl_str_mv 2018
dc.date.accessioned.fl_str_mv 2022-10-18T15:45:04Z
dc.date.available.fl_str_mv 2022-10-18T15:45:04Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1843/46325
dc.identifier.doi.pt_BR.fl_str_mv https://doi.org/10.30968/rbfhss.2018.093.002
dc.identifier.issn.pt_BR.fl_str_mv 2316-7750
url https://doi.org/10.30968/rbfhss.2018.093.002
http://hdl.handle.net/1843/46325
identifier_str_mv 2316-7750
dc.language.iso.fl_str_mv eng
language eng
dc.relation.ispartof.pt_BR.fl_str_mv Revista Brasileira de Farmácia Hospitalar e Serviços de Saúde
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade Federal de Minas Gerais
dc.publisher.initials.fl_str_mv UFMG
dc.publisher.country.fl_str_mv Brasil
dc.publisher.department.fl_str_mv FAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICAS
publisher.none.fl_str_mv Universidade Federal de Minas Gerais
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFMG
instname:Universidade Federal de Minas Gerais (UFMG)
instacron:UFMG
instname_str Universidade Federal de Minas Gerais (UFMG)
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institution UFMG
reponame_str Repositório Institucional da UFMG
collection Repositório Institucional da UFMG
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https://repositorio.ufmg.br/bitstream/1843/46325/2/Meropenem%20pharmacokinetics%20in%20children%20series%20of%20cases.pdf
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