Compatibility by a nonisothermal kinetic study of azathioprine associated with usual excipients in the product quality review process
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2021 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFMG |
| Texto Completo: | https://dx.doi.org/10.21577/0103-5053.20200218 http://hdl.handle.net/1843/50603 https://orcid.org/0000-0001-8068-5211 https://orcid.org/0000-0002-0367-8170 https://orcid.org/0000-0002-5158-7783 https://orcid.org/0000-0002-9768-9830 https://orcid.org/0000-0002-6795-9457 https://orcid.org/0000-0002-0561-2343 |
Resumo: | CNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico |
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2023-03-02T14:52:21Z2023-03-02T14:52:21Z2021-03323638651https://dx.doi.org/10.21577/0103-5053.202002181678-4790http://hdl.handle.net/1843/50603https://orcid.org/0000-0001-8068-5211https://orcid.org/0000-0002-0367-8170https://orcid.org/0000-0002-5158-7783https://orcid.org/0000-0002-9768-9830https://orcid.org/0000-0002-6795-9457https://orcid.org/0000-0002-0561-2343CNPq - Conselho Nacional de Desenvolvimento Científico e TecnológicoFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas GeraisCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível SuperiorAzathioprine is an immunosuppressive drug for several inflammatory disorders. Due to its clinical relevance, to explore the solid-state properties for excipient compatibility in the product quality review process is essential. Fourier transform infrared spectroscopy, powder X-ray diffraction and thermal analysis (thermogravimetry/derivative thermogravimetry (TG/DTG), differential thermal analysis (DTA), and differential scanning calorimetry (DSC)) were applied. The compatibility studies evidenced that starch pregelatinized, colloidal silicon dioxide, and talc are fully compatible with azathioprine. However, stearic acid, magnesium stearate, and mannitol are incompatible after heat supply at temperatures easily reached by industrial processing. The nonlinear Vyazovkin isoconversional treatment performed the kinetic study of the thermal degradation. The activation energies were determined to clarify the influence of each excipient on the thermal drug stability, an essential procedure in the pharmaceutical development, and all over the commercial live span, in Good Manufacturing Practices.engUniversidade Federal de Minas GeraisUFMGBrasilICX - DEPARTAMENTO DE QUÍMICAQuímica farmacêuticaCinética químicaFourier, Espectroscopia de infravermelho por transformada deRaios X - DifraçãoAnálise térmicaTermogravimetriaCalorimetriaTecnologia farmacêutica - Controle de qualidadeMedicamentos - AnáliseExcipientesImmunosuppressive drugGood manufacturing practicesSolid-state propertiesActivation energyVyazovkin methodFukui functionCompatibility by a nonisothermal kinetic study of azathioprine associated with usual excipients in the product quality review processinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://jbcs.sbq.org.br/default.asp?ed=309Carolina Rossi Gouvêa SilvaSílvia Ligório FialhoJamile BarbosaBárbara Caroline Rodrigues de AraújoGuilherme CarneiroRita de Cássia de Oliveira SebastiãoWagner da Nova MusselMaria Irene YoshidaMaria Betânia de Freitas Marquesapplication/pdfinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMGORIGINALCompatibility by a nonisothermal kinetic study of azathioprine associated with usual excipients in the product quality review process.pdfCompatibility by a nonisothermal kinetic study of azathioprine associated with usual excipients in the product quality review process.pdfapplication/pdf7207159https://repositorio.ufmg.br/bitstream/1843/50603/2/Compatibility%20by%20a%20nonisothermal%20kinetic%20study%20of%20azathioprine%20associated%20with%20usual%20excipients%20in%20the%20product%20quality%20review%20process.pdfe9992a04a8987e49b6c62f450fe2ef49MD52LICENSELicense.txtLicense.txttext/plain; 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| dc.title.pt_BR.fl_str_mv |
Compatibility by a nonisothermal kinetic study of azathioprine associated with usual excipients in the product quality review process |
| title |
Compatibility by a nonisothermal kinetic study of azathioprine associated with usual excipients in the product quality review process |
| spellingShingle |
Compatibility by a nonisothermal kinetic study of azathioprine associated with usual excipients in the product quality review process Carolina Rossi Gouvêa Silva Immunosuppressive drug Good manufacturing practices Solid-state properties Activation energy Vyazovkin method Fukui function Química farmacêutica Cinética química Fourier, Espectroscopia de infravermelho por transformada de Raios X - Difração Análise térmica Termogravimetria Calorimetria Tecnologia farmacêutica - Controle de qualidade Medicamentos - Análise Excipientes |
| title_short |
Compatibility by a nonisothermal kinetic study of azathioprine associated with usual excipients in the product quality review process |
| title_full |
Compatibility by a nonisothermal kinetic study of azathioprine associated with usual excipients in the product quality review process |
| title_fullStr |
Compatibility by a nonisothermal kinetic study of azathioprine associated with usual excipients in the product quality review process |
| title_full_unstemmed |
Compatibility by a nonisothermal kinetic study of azathioprine associated with usual excipients in the product quality review process |
| title_sort |
Compatibility by a nonisothermal kinetic study of azathioprine associated with usual excipients in the product quality review process |
| author |
Carolina Rossi Gouvêa Silva |
| author_facet |
Carolina Rossi Gouvêa Silva Sílvia Ligório Fialho Jamile Barbosa Bárbara Caroline Rodrigues de Araújo Guilherme Carneiro Rita de Cássia de Oliveira Sebastião Wagner da Nova Mussel Maria Irene Yoshida Maria Betânia de Freitas Marques |
| author_role |
author |
| author2 |
Sílvia Ligório Fialho Jamile Barbosa Bárbara Caroline Rodrigues de Araújo Guilherme Carneiro Rita de Cássia de Oliveira Sebastião Wagner da Nova Mussel Maria Irene Yoshida Maria Betânia de Freitas Marques |
| author2_role |
author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Carolina Rossi Gouvêa Silva Sílvia Ligório Fialho Jamile Barbosa Bárbara Caroline Rodrigues de Araújo Guilherme Carneiro Rita de Cássia de Oliveira Sebastião Wagner da Nova Mussel Maria Irene Yoshida Maria Betânia de Freitas Marques |
| dc.subject.por.fl_str_mv |
Immunosuppressive drug Good manufacturing practices Solid-state properties Activation energy Vyazovkin method Fukui function |
| topic |
Immunosuppressive drug Good manufacturing practices Solid-state properties Activation energy Vyazovkin method Fukui function Química farmacêutica Cinética química Fourier, Espectroscopia de infravermelho por transformada de Raios X - Difração Análise térmica Termogravimetria Calorimetria Tecnologia farmacêutica - Controle de qualidade Medicamentos - Análise Excipientes |
| dc.subject.other.pt_BR.fl_str_mv |
Química farmacêutica Cinética química Fourier, Espectroscopia de infravermelho por transformada de Raios X - Difração Análise térmica Termogravimetria Calorimetria Tecnologia farmacêutica - Controle de qualidade Medicamentos - Análise Excipientes |
| description |
CNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico |
| publishDate |
2021 |
| dc.date.issued.fl_str_mv |
2021-03 |
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2023-03-02T14:52:21Z |
| dc.date.available.fl_str_mv |
2023-03-02T14:52:21Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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http://hdl.handle.net/1843/50603 |
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https://dx.doi.org/10.21577/0103-5053.20200218 |
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1678-4790 |
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https://orcid.org/0000-0001-8068-5211 https://orcid.org/0000-0002-0367-8170 https://orcid.org/0000-0002-5158-7783 https://orcid.org/0000-0002-9768-9830 https://orcid.org/0000-0002-6795-9457 https://orcid.org/0000-0002-0561-2343 |
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https://dx.doi.org/10.21577/0103-5053.20200218 http://hdl.handle.net/1843/50603 https://orcid.org/0000-0001-8068-5211 https://orcid.org/0000-0002-0367-8170 https://orcid.org/0000-0002-5158-7783 https://orcid.org/0000-0002-9768-9830 https://orcid.org/0000-0002-6795-9457 https://orcid.org/0000-0002-0561-2343 |
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1678-4790 |
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eng |
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eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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Universidade Federal de Minas Gerais |
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UFMG |
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Brasil |
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ICX - DEPARTAMENTO DE QUÍMICA |
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Universidade Federal de Minas Gerais |
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reponame:Repositório Institucional da UFMG instname:Universidade Federal de Minas Gerais (UFMG) instacron:UFMG |
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