Effects of chlorhexidine preprocedural rinse on bacteremia in periodontal patients: a randomized clinical trial
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFMG |
Texto Completo: | https://doi.org/10.1590/1678-7757-2017-0112 http://hdl.handle.net/1843/68069 |
Resumo: | Objective: Single dose of systemic antibiotics and short-term use of mouthwashes reduce bacteremia. However, the effects of a single dose of preprocedural rinse are still controversial. This study evaluated, in periodontally diseased patients, the effects of a pre-procedural mouth rinse on induced bacteremia. Material and methods: Systemically healthy individuals with gingivitis (n=27) or periodontitis (n = 27) were randomly allocated through a sealed envelope system to: 0.12% chlorhexidine pre-procedural rinse (13 gingivitis and 13 periodontitis patients) or no rinse before dental scaling (14 gingivitis and 15 periodontitis patients). Periodontal probing depth, clinical attachment level, plaque, and gingival indices were measured and subgingival samples were collected. Blood samples were collected before dental scaling, 2 and 6 minutes after scaling. Total bacterial load and levels of P. gingivalis were determined in oral and blood samples by real-time polymerase chain reaction, while aerobic and anaerobic counts were determined by culture in blood samples. The primary outcome was the antimicrobial effect of the pre-procedural rinse. Data was compared by Mann-Whitney and Signal tests (p<0.05). Results: In all sampling times, polymerase chain reaction revealed higher blood bacterial levels than culture (p<0.0001), while gingivitis patients presented lower bacterial levels in blood than periodontitis patients (p<0.0001). Individuals who experienced bacteremia showed worse mean clinical attachment level (3.4 mm vs. 1.1 mm) and more subgingival bacteria (p<0.005). The pre-procedural rinse did not reduce induced bacteremia. Conclusions: Bacteremia was influenced by periodontal parameters. In periodontally diseased patients, pre-procedural rinsing showed a discrete effect on bacteremia control. |
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2024-05-03T18:07:25Z2024-05-03T18:07:25Z2017256586595https://doi.org/10.1590/1678-7757-2017-01121678-7765http://hdl.handle.net/1843/68069sObjective: Single dose of systemic antibiotics and short-term use of mouthwashes reduce bacteremia. However, the effects of a single dose of preprocedural rinse are still controversial. This study evaluated, in periodontally diseased patients, the effects of a pre-procedural mouth rinse on induced bacteremia. Material and methods: Systemically healthy individuals with gingivitis (n=27) or periodontitis (n = 27) were randomly allocated through a sealed envelope system to: 0.12% chlorhexidine pre-procedural rinse (13 gingivitis and 13 periodontitis patients) or no rinse before dental scaling (14 gingivitis and 15 periodontitis patients). Periodontal probing depth, clinical attachment level, plaque, and gingival indices were measured and subgingival samples were collected. Blood samples were collected before dental scaling, 2 and 6 minutes after scaling. Total bacterial load and levels of P. gingivalis were determined in oral and blood samples by real-time polymerase chain reaction, while aerobic and anaerobic counts were determined by culture in blood samples. The primary outcome was the antimicrobial effect of the pre-procedural rinse. Data was compared by Mann-Whitney and Signal tests (p<0.05). Results: In all sampling times, polymerase chain reaction revealed higher blood bacterial levels than culture (p<0.0001), while gingivitis patients presented lower bacterial levels in blood than periodontitis patients (p<0.0001). Individuals who experienced bacteremia showed worse mean clinical attachment level (3.4 mm vs. 1.1 mm) and more subgingival bacteria (p<0.005). The pre-procedural rinse did not reduce induced bacteremia. Conclusions: Bacteremia was influenced by periodontal parameters. In periodontally diseased patients, pre-procedural rinsing showed a discrete effect on bacteremia control.engUniversidade Federal de Minas GeraisUFMGBrasilFAO - DEPARTAMENTO DE CLÍNICAJournal of Applied Oral ScienceBacteremiaPeriodontal diseasesPeriodontal debridementMouthwashesAnti-bacterial agentsGingivitisBacteriaDental plaque indexPeriodontal indexclorexidinemouthrinse Keywords: Bacteremia, Periodontal diseases, Periodontal debridement, Mouthwashesopen acess busca dia 13/03/2024assunto: Periodontal Diseases Effects of chlorhexidine preprocedural rinse on bacteremia in periodontal patients: a randomized clinical trial periódico: Journal of applied oral sciencePeriodontitisEffects of chlorhexidine preprocedural rinse on bacteremia in periodontal patients: a randomized clinical trialinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://www.scielo.br/j/jaos/a/D7CnDLzWFbJHZvVWNCHRzLK/?lang=en#Rodrigo Dalla Pria BalejoRenata Magalhães CyrinoFernando de Oliveira CostaJosé Roberto CortelliTaís Browne de MirandaDavi Romeiro AquinoSheila Cavalca CortelliKarina Cogo-MüllerSara Porto Mouraapplication/pdfinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMGLICENSELicense.txtLicense.txttext/plain; charset=utf-82042https://repositorio.ufmg.br/bitstream/1843/68069/1/License.txtfa505098d172de0bc8864fc1287ffe22MD51ORIGINALEffects of chlorhexidine preprocedural rinse on bacteremia in periodontal patients a randomized clinical trial.pdfEffects of chlorhexidine preprocedural rinse on bacteremia in periodontal patients a randomized clinical trial.pdfapplication/pdf241741https://repositorio.ufmg.br/bitstream/1843/68069/2/Effects%20of%20chlorhexidine%20preprocedural%20rinse%20on%20bacteremia%20in%20periodontal%20patients%20a%20randomized%20clinical%20trial.pdf57cd72a4030f13cd83eca91c634dbccbMD521843/680692024-05-03 15:07:27.815oai:repositorio.ufmg.br:1843/68069TElDRU7vv71BIERFIERJU1RSSUJVSe+/ve+/vU8gTu+/vU8tRVhDTFVTSVZBIERPIFJFUE9TSVTvv71SSU8gSU5TVElUVUNJT05BTCBEQSBVRk1HCiAKCkNvbSBhIGFwcmVzZW50Ye+/ve+/vW8gZGVzdGEgbGljZW7vv71hLCB2b2Pvv70gKG8gYXV0b3IgKGVzKSBvdSBvIHRpdHVsYXIgZG9zIGRpcmVpdG9zIGRlIGF1dG9yKSBjb25jZWRlIGFvIFJlcG9zaXTvv71yaW8gSW5zdGl0dWNpb25hbCBkYSBVRk1HIChSSS1VRk1HKSBvIGRpcmVpdG8gbu+/vW8gZXhjbHVzaXZvIGUgaXJyZXZvZ++/vXZlbCBkZSByZXByb2R1emlyIGUvb3UgZGlzdHJpYnVpciBhIHN1YSBwdWJsaWNh77+977+9byAoaW5jbHVpbmRvIG8gcmVzdW1vKSBwb3IgdG9kbyBvIG11bmRvIG5vIGZvcm1hdG8gaW1wcmVzc28gZSBlbGV0cu+/vW5pY28gZSBlbSBxdWFscXVlciBtZWlvLCBpbmNsdWluZG8gb3MgZm9ybWF0b3Mg77+9dWRpbyBvdSB277+9ZGVvLgoKVm9j77+9IGRlY2xhcmEgcXVlIGNvbmhlY2UgYSBwb2zvv710aWNhIGRlIGNvcHlyaWdodCBkYSBlZGl0b3JhIGRvIHNldSBkb2N1bWVudG8gZSBxdWUgY29uaGVjZSBlIGFjZWl0YSBhcyBEaXJldHJpemVzIGRvIFJJLVVGTUcuCgpWb2Pvv70gY29uY29yZGEgcXVlIG8gUmVwb3NpdO+/vXJpbyBJbnN0aXR1Y2lvbmFsIGRhIFVGTUcgcG9kZSwgc2VtIGFsdGVyYXIgbyBjb250Ze+/vWRvLCB0cmFuc3BvciBhIHN1YSBwdWJsaWNh77+977+9byBwYXJhIHF1YWxxdWVyIG1laW8gb3UgZm9ybWF0byBwYXJhIGZpbnMgZGUgcHJlc2VydmHvv73vv71vLgoKVm9j77+9IHRhbWLvv71tIGNvbmNvcmRhIHF1ZSBvIFJlcG9zaXTvv71yaW8gSW5zdGl0dWNpb25hbCBkYSBVRk1HIHBvZGUgbWFudGVyIG1haXMgZGUgdW1hIGPvv71waWEgZGUgc3VhIHB1YmxpY2Hvv73vv71vIHBhcmEgZmlucyBkZSBzZWd1cmFu77+9YSwgYmFjay11cCBlIHByZXNlcnZh77+977+9by4KClZvY++/vSBkZWNsYXJhIHF1ZSBhIHN1YSBwdWJsaWNh77+977+9byDvv70gb3JpZ2luYWwgZSBxdWUgdm9j77+9IHRlbSBvIHBvZGVyIGRlIGNvbmNlZGVyIG9zIGRpcmVpdG9zIGNvbnRpZG9zIG5lc3RhIGxpY2Vu77+9YS4gVm9j77+9IHRhbWLvv71tIGRlY2xhcmEgcXVlIG8gZGVw77+9c2l0byBkZSBzdWEgcHVibGljYe+/ve+/vW8gbu+/vW8sIHF1ZSBzZWphIGRlIHNldSBjb25oZWNpbWVudG8sIGluZnJpbmdlIGRpcmVpdG9zIGF1dG9yYWlzIGRlIG5pbmd177+9bS4KCkNhc28gYSBzdWEgcHVibGljYe+/ve+/vW8gY29udGVuaGEgbWF0ZXJpYWwgcXVlIHZvY++/vSBu77+9byBwb3NzdWkgYSB0aXR1bGFyaWRhZGUgZG9zIGRpcmVpdG9zIGF1dG9yYWlzLCB2b2Pvv70gZGVjbGFyYSBxdWUgb2J0ZXZlIGEgcGVybWlzc++/vW8gaXJyZXN0cml0YSBkbyBkZXRlbnRvciBkb3MgZGlyZWl0b3MgYXV0b3JhaXMgcGFyYSBjb25jZWRlciBhbyBSZXBvc2l077+9cmlvIEluc3RpdHVjaW9uYWwgZGEgVUZNRyBvcyBkaXJlaXRvcyBhcHJlc2VudGFkb3MgbmVzdGEgbGljZW7vv71hLCBlIHF1ZSBlc3NlIG1hdGVyaWFsIGRlIHByb3ByaWVkYWRlIGRlIHRlcmNlaXJvcyBlc3Tvv70gY2xhcmFtZW50ZSBpZGVudGlmaWNhZG8gZSByZWNvbmhlY2lkbyBubyB0ZXh0byBvdSBubyBjb250Ze+/vWRvIGRhIHB1YmxpY2Hvv73vv71vIG9yYSBkZXBvc2l0YWRhLgoKQ0FTTyBBIFBVQkxJQ0Hvv73vv71PIE9SQSBERVBPU0lUQURBIFRFTkhBIFNJRE8gUkVTVUxUQURPIERFIFVNIFBBVFJPQ++/vU5JTyBPVSBBUE9JTyBERSBVTUEgQUfvv71OQ0lBIERFIEZPTUVOVE8gT1UgT1VUUk8gT1JHQU5JU01PLCBWT0Pvv70gREVDTEFSQSBRVUUgUkVTUEVJVE9VIFRPRE9TIEUgUVVBSVNRVUVSIERJUkVJVE9TIERFIFJFVklT77+9TyBDT01PIFRBTULvv71NIEFTIERFTUFJUyBPQlJJR0Hvv73vv71FUyBFWElHSURBUyBQT1IgQ09OVFJBVE8gT1UgQUNPUkRPLgoKTyBSZXBvc2l077+9cmlvIEluc3RpdHVjaW9uYWwgZGEgVUZNRyBzZSBjb21wcm9tZXRlIGEgaWRlbnRpZmljYXIgY2xhcmFtZW50ZSBvIHNldSBub21lKHMpIG91IG8ocykgbm9tZXMocykgZG8ocykgZGV0ZW50b3IoZXMpIGRvcyBkaXJlaXRvcyBhdXRvcmFpcyBkYSBwdWJsaWNh77+977+9bywgZSBu77+9byBmYXLvv70gcXVhbHF1ZXIgYWx0ZXJh77+977+9bywgYWzvv71tIGRhcXVlbGFzIGNvbmNlZGlkYXMgcG9yIGVzdGEgbGljZW7vv71hLgo=Repositório de PublicaçõesPUBhttps://repositorio.ufmg.br/oaiopendoar:2024-05-03T18:07:27Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)false |
dc.title.pt_BR.fl_str_mv |
Effects of chlorhexidine preprocedural rinse on bacteremia in periodontal patients: a randomized clinical trial |
title |
Effects of chlorhexidine preprocedural rinse on bacteremia in periodontal patients: a randomized clinical trial |
spellingShingle |
Effects of chlorhexidine preprocedural rinse on bacteremia in periodontal patients: a randomized clinical trial Rodrigo Dalla Pria Balejo clorexidine mouthrinse Keywords: Bacteremia, Periodontal diseases, Periodontal debridement, Mouthwashes open acess busca dia 13/03/2024assunto: Periodontal Diseases Effects of chlorhexidine preprocedural rinse on bacteremia in periodontal patients: a randomized clinical trial periódico: Journal of applied oral science Periodontitis Bacteremia Periodontal diseases Periodontal debridement Mouthwashes Anti-bacterial agents Gingivitis Bacteria Dental plaque index Periodontal index |
title_short |
Effects of chlorhexidine preprocedural rinse on bacteremia in periodontal patients: a randomized clinical trial |
title_full |
Effects of chlorhexidine preprocedural rinse on bacteremia in periodontal patients: a randomized clinical trial |
title_fullStr |
Effects of chlorhexidine preprocedural rinse on bacteremia in periodontal patients: a randomized clinical trial |
title_full_unstemmed |
Effects of chlorhexidine preprocedural rinse on bacteremia in periodontal patients: a randomized clinical trial |
title_sort |
Effects of chlorhexidine preprocedural rinse on bacteremia in periodontal patients: a randomized clinical trial |
author |
Rodrigo Dalla Pria Balejo |
author_facet |
Rodrigo Dalla Pria Balejo Renata Magalhães Cyrino Fernando de Oliveira Costa José Roberto Cortelli Taís Browne de Miranda Davi Romeiro Aquino Sheila Cavalca Cortelli Karina Cogo-Müller Sara Porto Moura |
author_role |
author |
author2 |
Renata Magalhães Cyrino Fernando de Oliveira Costa José Roberto Cortelli Taís Browne de Miranda Davi Romeiro Aquino Sheila Cavalca Cortelli Karina Cogo-Müller Sara Porto Moura |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Rodrigo Dalla Pria Balejo Renata Magalhães Cyrino Fernando de Oliveira Costa José Roberto Cortelli Taís Browne de Miranda Davi Romeiro Aquino Sheila Cavalca Cortelli Karina Cogo-Müller Sara Porto Moura |
dc.subject.por.fl_str_mv |
clorexidine mouthrinse Keywords: Bacteremia, Periodontal diseases, Periodontal debridement, Mouthwashes open acess busca dia 13/03/2024assunto: Periodontal Diseases Effects of chlorhexidine preprocedural rinse on bacteremia in periodontal patients: a randomized clinical trial periódico: Journal of applied oral science Periodontitis |
topic |
clorexidine mouthrinse Keywords: Bacteremia, Periodontal diseases, Periodontal debridement, Mouthwashes open acess busca dia 13/03/2024assunto: Periodontal Diseases Effects of chlorhexidine preprocedural rinse on bacteremia in periodontal patients: a randomized clinical trial periódico: Journal of applied oral science Periodontitis Bacteremia Periodontal diseases Periodontal debridement Mouthwashes Anti-bacterial agents Gingivitis Bacteria Dental plaque index Periodontal index |
dc.subject.other.pt_BR.fl_str_mv |
Bacteremia Periodontal diseases Periodontal debridement Mouthwashes Anti-bacterial agents Gingivitis Bacteria Dental plaque index Periodontal index |
description |
Objective: Single dose of systemic antibiotics and short-term use of mouthwashes reduce bacteremia. However, the effects of a single dose of preprocedural rinse are still controversial. This study evaluated, in periodontally diseased patients, the effects of a pre-procedural mouth rinse on induced bacteremia. Material and methods: Systemically healthy individuals with gingivitis (n=27) or periodontitis (n = 27) were randomly allocated through a sealed envelope system to: 0.12% chlorhexidine pre-procedural rinse (13 gingivitis and 13 periodontitis patients) or no rinse before dental scaling (14 gingivitis and 15 periodontitis patients). Periodontal probing depth, clinical attachment level, plaque, and gingival indices were measured and subgingival samples were collected. Blood samples were collected before dental scaling, 2 and 6 minutes after scaling. Total bacterial load and levels of P. gingivalis were determined in oral and blood samples by real-time polymerase chain reaction, while aerobic and anaerobic counts were determined by culture in blood samples. The primary outcome was the antimicrobial effect of the pre-procedural rinse. Data was compared by Mann-Whitney and Signal tests (p<0.05). Results: In all sampling times, polymerase chain reaction revealed higher blood bacterial levels than culture (p<0.0001), while gingivitis patients presented lower bacterial levels in blood than periodontitis patients (p<0.0001). Individuals who experienced bacteremia showed worse mean clinical attachment level (3.4 mm vs. 1.1 mm) and more subgingival bacteria (p<0.005). The pre-procedural rinse did not reduce induced bacteremia. Conclusions: Bacteremia was influenced by periodontal parameters. In periodontally diseased patients, pre-procedural rinsing showed a discrete effect on bacteremia control. |
publishDate |
2017 |
dc.date.issued.fl_str_mv |
2017 |
dc.date.accessioned.fl_str_mv |
2024-05-03T18:07:25Z |
dc.date.available.fl_str_mv |
2024-05-03T18:07:25Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1843/68069 |
dc.identifier.doi.pt_BR.fl_str_mv |
https://doi.org/10.1590/1678-7757-2017-0112 |
dc.identifier.issn.pt_BR.fl_str_mv |
1678-7765 |
dc.identifier.orcid.pt_BR.fl_str_mv |
s |
url |
https://doi.org/10.1590/1678-7757-2017-0112 http://hdl.handle.net/1843/68069 |
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1678-7765 s |
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eng |
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eng |
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Journal of Applied Oral Science |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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Universidade Federal de Minas Gerais |
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UFMG |
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Brasil |
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FAO - DEPARTAMENTO DE CLÍNICA |
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Universidade Federal de Minas Gerais |
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