Chronic use of hydroxychloroquine did not protect against covid-19 in a large cohort of patients with rheumatic diseases in brazil
Autor(a) principal: | |
---|---|
Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFMG |
Texto Completo: | http://hdl.handle.net/1843/63085 |
Resumo: | Background: There is a lack of information on the role of chronic use of hydroxychloroquine during the SARS‑CoV‑2 outbreak. Our aim was to compare the occurrence of COVID‑19 between rheumatic disease patients on hydroxychlo‑roquine with individuals from the same household not taking the drug during the first 8 weeks of community viral transmission in Brazil.Methods: This baseline cross‑sectional analysis is part of a 24‑week observational multi‑center study involving 22 Brazilian academic outpatient centers. All information regarding COVID‑19 symptoms, epidemiological, clinical, and demographic data were recorded on a specific web‑based platform using telephone calls from physicians and medical students. COVID‑19 was defined according to the Brazilian Ministry of Health (BMH) criteria. Mann–Whitney, Chi‑square and Exact Fisher tests were used for statistical analysis and two binary Final Logistic Regression Model by Wald test were developed using a backward‑stepwise method for the presence of COVID‑19.Results: From March 29th to May 17st, 2020, a total of 10,443 participants were enrolled, including 5166 (53.9%) rheumatic disease patients, of whom 82.5% had systemic erythematosus lupus, 7.8% rheumatoid arthritis, 3.7% Sjögren’s syndrome and 0.8% systemic sclerosis. In total,1822 (19.1%) participants reported flu symptoms within the 30 days prior to enrollment, of which 3.1% fulfilled the BMH criteria, but with no significant difference between rheumatic disease patients (4.03%) and controls (3.25%). After adjustments for multiple confounders, the main risk fac‑tor significantly associated with a COVID‑19 diagnosis was lung disease (OR 1.63; 95% CI 1.03–2.58); and for rheumatic disease patients were diagnosis of systemic sclerosis (OR 2.8; 95% CI 1.19–6.63) and glucocorticoids above 10 mg/ day (OR 2.05; 95% CI 1.31–3.19). In addition, a recent influenza vaccination had a protective effect (OR 0.674; 95% CI 0.46–0.98). Conclusion: Patients with rheumatic disease on hydroxychloroquine presented a similar occurrence of COVID‑19 to household cohabitants, suggesting a lack of any protective role against SARS‑CoV‑2 infection. |
id |
UFMG_0e44301dd7185882185516b2b6ce723d |
---|---|
oai_identifier_str |
oai:repositorio.ufmg.br:1843/63085 |
network_acronym_str |
UFMG |
network_name_str |
Repositório Institucional da UFMG |
repository_id_str |
|
spelling |
2024-01-18T20:52:19Z2024-01-18T20:52:19Z2021616011110.1186/s42358-021-00217-025233106http://hdl.handle.net/1843/63085Background: There is a lack of information on the role of chronic use of hydroxychloroquine during the SARS‑CoV‑2 outbreak. Our aim was to compare the occurrence of COVID‑19 between rheumatic disease patients on hydroxychlo‑roquine with individuals from the same household not taking the drug during the first 8 weeks of community viral transmission in Brazil.Methods: This baseline cross‑sectional analysis is part of a 24‑week observational multi‑center study involving 22 Brazilian academic outpatient centers. All information regarding COVID‑19 symptoms, epidemiological, clinical, and demographic data were recorded on a specific web‑based platform using telephone calls from physicians and medical students. COVID‑19 was defined according to the Brazilian Ministry of Health (BMH) criteria. Mann–Whitney, Chi‑square and Exact Fisher tests were used for statistical analysis and two binary Final Logistic Regression Model by Wald test were developed using a backward‑stepwise method for the presence of COVID‑19.Results: From March 29th to May 17st, 2020, a total of 10,443 participants were enrolled, including 5166 (53.9%) rheumatic disease patients, of whom 82.5% had systemic erythematosus lupus, 7.8% rheumatoid arthritis, 3.7% Sjögren’s syndrome and 0.8% systemic sclerosis. In total,1822 (19.1%) participants reported flu symptoms within the 30 days prior to enrollment, of which 3.1% fulfilled the BMH criteria, but with no significant difference between rheumatic disease patients (4.03%) and controls (3.25%). After adjustments for multiple confounders, the main risk fac‑tor significantly associated with a COVID‑19 diagnosis was lung disease (OR 1.63; 95% CI 1.03–2.58); and for rheumatic disease patients were diagnosis of systemic sclerosis (OR 2.8; 95% CI 1.19–6.63) and glucocorticoids above 10 mg/ day (OR 2.05; 95% CI 1.31–3.19). In addition, a recent influenza vaccination had a protective effect (OR 0.674; 95% CI 0.46–0.98). Conclusion: Patients with rheumatic disease on hydroxychloroquine presented a similar occurrence of COVID‑19 to household cohabitants, suggesting a lack of any protective role against SARS‑CoV‑2 infection.engUniversidade Federal de Minas GeraisUFMGBrasilMED - DEPARTAMENTO DE APARELHO LOCOMOTORMED - DEPARTAMENTO DE CLÍNICA MÉDICAAdvances in RheumatologyCOVID‑19HydroxycloroquineRheumatic DiseasesCOVID‑19HydroxycloroquineRheumatic DiseasesChronic use of hydroxychloroquine did not protect against covid-19 in a large cohort of patients with rheumatic diseases in brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://doi.org/10.1186/s42358-021-00217-0Gecilmara SalviatopileggiBlanca BicaEloisa Duarte BonfaEduardo Ferreira BorbaDanielle Christinne Soares Egypto BritoÂngela Luzia Branco Pinto DuarteRafaela Cavalheiro Espírito SantoPaula Reale FernandesMariana Peixoto GuimarãesKirla Wagner Poti GomesAdriana Maria KakehasiGilda Aparecida FerreiraEvandro Mendes KlumbCristina Costa Duarte LannaClaudia Diniz Lopes MarquesOdirlei André MonticieloLicia Maria Henrique MotaGabriela Araújo MunhozEduardo Santos PaivaHelena Lucia Alves PereiraJosé Roberto ProvenzaSandra Lucia Euzébio RibeiroAna Paula Monteiro Gomides ReisLaurindo Ferreira Rocha JuniorCamila Santana Justo Cintra SampaioVanderson Souza SampaioEmília Inoue SatoThelma SkareViviane Angelina de SouzaValeria ValimMarcus Vinícius Guimarães LacerdaRicardo Machado XavierMarcelo Medeiros PinheiroEdgard Torres Reis-netoMirhelen Mendes AbreuCleandro Pires AlbuquerqueNafice Costa AraújoAna Beatriz BacchiegaDante Valdetaro Bianchiapplication/pdfinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMGLICENSELicense.txtLicense.txttext/plain; charset=utf-82042https://repositorio.ufmg.br/bitstream/1843/63085/1/License.txtfa505098d172de0bc8864fc1287ffe22MD51ORIGINALChronic use of hydroxychloroquine did pdfa.pdfChronic use of hydroxychloroquine did pdfa.pdfapplication/pdf438982https://repositorio.ufmg.br/bitstream/1843/63085/2/Chronic%20use%20of%20hydroxychloroquine%20did%20pdfa.pdf321571e4ecf692d7bbfedfeb003e1ec4MD521843/630852024-01-18 18:00:18.516oai:repositorio.ufmg.br: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Repositório de PublicaçõesPUBhttps://repositorio.ufmg.br/oaiopendoar:2024-01-18T21:00:18Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)false |
dc.title.pt_BR.fl_str_mv |
Chronic use of hydroxychloroquine did not protect against covid-19 in a large cohort of patients with rheumatic diseases in brazil |
title |
Chronic use of hydroxychloroquine did not protect against covid-19 in a large cohort of patients with rheumatic diseases in brazil |
spellingShingle |
Chronic use of hydroxychloroquine did not protect against covid-19 in a large cohort of patients with rheumatic diseases in brazil Gecilmara Salviatopileggi COVID‑19 Hydroxycloroquine Rheumatic Diseases COVID‑19 Hydroxycloroquine Rheumatic Diseases |
title_short |
Chronic use of hydroxychloroquine did not protect against covid-19 in a large cohort of patients with rheumatic diseases in brazil |
title_full |
Chronic use of hydroxychloroquine did not protect against covid-19 in a large cohort of patients with rheumatic diseases in brazil |
title_fullStr |
Chronic use of hydroxychloroquine did not protect against covid-19 in a large cohort of patients with rheumatic diseases in brazil |
title_full_unstemmed |
Chronic use of hydroxychloroquine did not protect against covid-19 in a large cohort of patients with rheumatic diseases in brazil |
title_sort |
Chronic use of hydroxychloroquine did not protect against covid-19 in a large cohort of patients with rheumatic diseases in brazil |
author |
Gecilmara Salviatopileggi |
author_facet |
Gecilmara Salviatopileggi Blanca Bica Eloisa Duarte Bonfa Eduardo Ferreira Borba Danielle Christinne Soares Egypto Brito Ângela Luzia Branco Pinto Duarte Rafaela Cavalheiro Espírito Santo Paula Reale Fernandes Mariana Peixoto Guimarães Kirla Wagner Poti Gomes Adriana Maria Kakehasi Gilda Aparecida Ferreira Evandro Mendes Klumb Cristina Costa Duarte Lanna Claudia Diniz Lopes Marques Odirlei André Monticielo Licia Maria Henrique Mota Gabriela Araújo Munhoz Eduardo Santos Paiva Helena Lucia Alves Pereira José Roberto Provenza Sandra Lucia Euzébio Ribeiro Ana Paula Monteiro Gomides Reis Laurindo Ferreira Rocha Junior Camila Santana Justo Cintra Sampaio Vanderson Souza Sampaio Emília Inoue Sato Thelma Skare Viviane Angelina de Souza Valeria Valim Marcus Vinícius Guimarães Lacerda Ricardo Machado Xavier Marcelo Medeiros Pinheiro Edgard Torres Reis-neto Mirhelen Mendes Abreu Cleandro Pires Albuquerque Nafice Costa Araújo Ana Beatriz Bacchiega Dante Valdetaro Bianchi |
author_role |
author |
author2 |
Blanca Bica Eloisa Duarte Bonfa Eduardo Ferreira Borba Danielle Christinne Soares Egypto Brito Ângela Luzia Branco Pinto Duarte Rafaela Cavalheiro Espírito Santo Paula Reale Fernandes Mariana Peixoto Guimarães Kirla Wagner Poti Gomes Adriana Maria Kakehasi Gilda Aparecida Ferreira Evandro Mendes Klumb Cristina Costa Duarte Lanna Claudia Diniz Lopes Marques Odirlei André Monticielo Licia Maria Henrique Mota Gabriela Araújo Munhoz Eduardo Santos Paiva Helena Lucia Alves Pereira José Roberto Provenza Sandra Lucia Euzébio Ribeiro Ana Paula Monteiro Gomides Reis Laurindo Ferreira Rocha Junior Camila Santana Justo Cintra Sampaio Vanderson Souza Sampaio Emília Inoue Sato Thelma Skare Viviane Angelina de Souza Valeria Valim Marcus Vinícius Guimarães Lacerda Ricardo Machado Xavier Marcelo Medeiros Pinheiro Edgard Torres Reis-neto Mirhelen Mendes Abreu Cleandro Pires Albuquerque Nafice Costa Araújo Ana Beatriz Bacchiega Dante Valdetaro Bianchi |
author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Gecilmara Salviatopileggi Blanca Bica Eloisa Duarte Bonfa Eduardo Ferreira Borba Danielle Christinne Soares Egypto Brito Ângela Luzia Branco Pinto Duarte Rafaela Cavalheiro Espírito Santo Paula Reale Fernandes Mariana Peixoto Guimarães Kirla Wagner Poti Gomes Adriana Maria Kakehasi Gilda Aparecida Ferreira Evandro Mendes Klumb Cristina Costa Duarte Lanna Claudia Diniz Lopes Marques Odirlei André Monticielo Licia Maria Henrique Mota Gabriela Araújo Munhoz Eduardo Santos Paiva Helena Lucia Alves Pereira José Roberto Provenza Sandra Lucia Euzébio Ribeiro Ana Paula Monteiro Gomides Reis Laurindo Ferreira Rocha Junior Camila Santana Justo Cintra Sampaio Vanderson Souza Sampaio Emília Inoue Sato Thelma Skare Viviane Angelina de Souza Valeria Valim Marcus Vinícius Guimarães Lacerda Ricardo Machado Xavier Marcelo Medeiros Pinheiro Edgard Torres Reis-neto Mirhelen Mendes Abreu Cleandro Pires Albuquerque Nafice Costa Araújo Ana Beatriz Bacchiega Dante Valdetaro Bianchi |
dc.subject.por.fl_str_mv |
COVID‑19 Hydroxycloroquine Rheumatic Diseases |
topic |
COVID‑19 Hydroxycloroquine Rheumatic Diseases COVID‑19 Hydroxycloroquine Rheumatic Diseases |
dc.subject.other.pt_BR.fl_str_mv |
COVID‑19 Hydroxycloroquine Rheumatic Diseases |
description |
Background: There is a lack of information on the role of chronic use of hydroxychloroquine during the SARS‑CoV‑2 outbreak. Our aim was to compare the occurrence of COVID‑19 between rheumatic disease patients on hydroxychlo‑roquine with individuals from the same household not taking the drug during the first 8 weeks of community viral transmission in Brazil.Methods: This baseline cross‑sectional analysis is part of a 24‑week observational multi‑center study involving 22 Brazilian academic outpatient centers. All information regarding COVID‑19 symptoms, epidemiological, clinical, and demographic data were recorded on a specific web‑based platform using telephone calls from physicians and medical students. COVID‑19 was defined according to the Brazilian Ministry of Health (BMH) criteria. Mann–Whitney, Chi‑square and Exact Fisher tests were used for statistical analysis and two binary Final Logistic Regression Model by Wald test were developed using a backward‑stepwise method for the presence of COVID‑19.Results: From March 29th to May 17st, 2020, a total of 10,443 participants were enrolled, including 5166 (53.9%) rheumatic disease patients, of whom 82.5% had systemic erythematosus lupus, 7.8% rheumatoid arthritis, 3.7% Sjögren’s syndrome and 0.8% systemic sclerosis. In total,1822 (19.1%) participants reported flu symptoms within the 30 days prior to enrollment, of which 3.1% fulfilled the BMH criteria, but with no significant difference between rheumatic disease patients (4.03%) and controls (3.25%). After adjustments for multiple confounders, the main risk fac‑tor significantly associated with a COVID‑19 diagnosis was lung disease (OR 1.63; 95% CI 1.03–2.58); and for rheumatic disease patients were diagnosis of systemic sclerosis (OR 2.8; 95% CI 1.19–6.63) and glucocorticoids above 10 mg/ day (OR 2.05; 95% CI 1.31–3.19). In addition, a recent influenza vaccination had a protective effect (OR 0.674; 95% CI 0.46–0.98). Conclusion: Patients with rheumatic disease on hydroxychloroquine presented a similar occurrence of COVID‑19 to household cohabitants, suggesting a lack of any protective role against SARS‑CoV‑2 infection. |
publishDate |
2021 |
dc.date.issued.fl_str_mv |
2021 |
dc.date.accessioned.fl_str_mv |
2024-01-18T20:52:19Z |
dc.date.available.fl_str_mv |
2024-01-18T20:52:19Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1843/63085 |
dc.identifier.doi.pt_BR.fl_str_mv |
10.1186/s42358-021-00217-0 |
dc.identifier.issn.pt_BR.fl_str_mv |
25233106 |
identifier_str_mv |
10.1186/s42358-021-00217-0 25233106 |
url |
http://hdl.handle.net/1843/63085 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.none.fl_str_mv |
Advances in Rheumatology |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade Federal de Minas Gerais |
dc.publisher.initials.fl_str_mv |
UFMG |
dc.publisher.country.fl_str_mv |
Brasil |
dc.publisher.department.fl_str_mv |
MED - DEPARTAMENTO DE APARELHO LOCOMOTOR MED - DEPARTAMENTO DE CLÍNICA MÉDICA |
publisher.none.fl_str_mv |
Universidade Federal de Minas Gerais |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UFMG instname:Universidade Federal de Minas Gerais (UFMG) instacron:UFMG |
instname_str |
Universidade Federal de Minas Gerais (UFMG) |
instacron_str |
UFMG |
institution |
UFMG |
reponame_str |
Repositório Institucional da UFMG |
collection |
Repositório Institucional da UFMG |
bitstream.url.fl_str_mv |
https://repositorio.ufmg.br/bitstream/1843/63085/1/License.txt https://repositorio.ufmg.br/bitstream/1843/63085/2/Chronic%20use%20of%20hydroxychloroquine%20did%20pdfa.pdf |
bitstream.checksum.fl_str_mv |
fa505098d172de0bc8864fc1287ffe22 321571e4ecf692d7bbfedfeb003e1ec4 |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 |
repository.name.fl_str_mv |
Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG) |
repository.mail.fl_str_mv |
|
_version_ |
1803589461864349696 |