Decisive role of histopathology of lens capsule in the diagnosis of chronic fungal postoperative endophthalmitis

Detalhes bibliográficos
Autor(a) principal: Mathias Paulo Loredo e Silva
Data de Publicação: 2022
Outros Autores: Rodrigo Magno da Silva Oliveira, Bruno Freitas Lage, Clóvis Arcoverde Freitas, Moisés Salgado Pedrosa, Márcio Bittar Nehemy, Daniel Vítor de Vasconcelos Santos
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFMG
Texto Completo: https://doi.org/10.1186/s40942-022-00370-8
http://hdl.handle.net/1843/61742
http://orcid.org/0000-0002-6747-2024
Resumo: We report three cases of refractory chronic endophthalmitis after cataract surgery presenting to a referral center, and with repeated negative cultures. Initial treatment consisted of intravitreal and systemic antibiotics, with partial improvement. After subsequent worsening, pars plana vitrectomy, intraocular lens explantation and en bloc capsulectomy were performed. Histopathological examination revealed multiple filamentous fungal structures, sequestered between anterior/posterior lens capsule in all cases. Chronic postoperative fungal endophthalmitis may manifest with negative cultures possibly associated with sequestration of the microorganism into the capsular bag. Careful histopathological examination of lens capsule in these cases may be essential for a definite diagnosis.
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spelling 2023-12-05T20:35:13Z2023-12-05T20:35:13Z202281814https://doi.org/10.1186/s40942-022-00370-82056-9920http://hdl.handle.net/1843/61742http://orcid.org/0000-0002-6747-2024We report three cases of refractory chronic endophthalmitis after cataract surgery presenting to a referral center, and with repeated negative cultures. Initial treatment consisted of intravitreal and systemic antibiotics, with partial improvement. After subsequent worsening, pars plana vitrectomy, intraocular lens explantation and en bloc capsulectomy were performed. Histopathological examination revealed multiple filamentous fungal structures, sequestered between anterior/posterior lens capsule in all cases. Chronic postoperative fungal endophthalmitis may manifest with negative cultures possibly associated with sequestration of the microorganism into the capsular bag. Careful histopathological examination of lens capsule in these cases may be essential for a definite diagnosis.engUniversidade Federal de Minas GeraisUFMGBrasilMED - DEPARTAMENTO DE OFTALMOLOGIA E OTORRINOLARINGOLOGIAMEDICINA - FACULDADE DE MEDICINAInternational Journal of Retina and VitreousUveíteInflamaçãoLentes IntraocularesCatarataFungosEndoftalmiteChronic endophthalmitisFungiCataract surgeryIntraocular lensIntraocular infammationUveitisDecisive role of histopathology of lens capsule in the diagnosis of chronic fungal postoperative endophthalmitisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://journalretinavitreous.biomedcentral.com/articles/10.1186/s40942-022-00370-8Mathias Paulo Loredo e SilvaRodrigo Magno da Silva OliveiraBruno Freitas LageClóvis Arcoverde FreitasMoisés Salgado PedrosaMárcio Bittar NehemyDaniel Vítor de Vasconcelos Santosapplication/pdfinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMGLICENSELicense.txtLicense.txttext/plain; charset=utf-82042https://repositorio.ufmg.br/bitstream/1843/61742/1/License.txtfa505098d172de0bc8864fc1287ffe22MD51ORIGINALDecisive role of histopathology of lens capsule in the diagnosis of chronic fungal postoperative endophthalmitis.pdfDecisive role of histopathology of lens capsule in the diagnosis of chronic fungal postoperative endophthalmitis.pdfapplication/pdf786262https://repositorio.ufmg.br/bitstream/1843/61742/2/Decisive%20role%20of%20histopathology%20of%20lens%20capsule%20in%20the%20diagnosis%20of%20chronic%20fungal%20postoperative%20endophthalmitis.pdf6c74e2333c07fa30b60251d6c4aaae4dMD521843/617422023-12-05 17:35:13.773oai:repositorio.ufmg.br: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Repositório de PublicaçõesPUBhttps://repositorio.ufmg.br/oaiopendoar:2023-12-05T20:35:13Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)false
dc.title.pt_BR.fl_str_mv Decisive role of histopathology of lens capsule in the diagnosis of chronic fungal postoperative endophthalmitis
title Decisive role of histopathology of lens capsule in the diagnosis of chronic fungal postoperative endophthalmitis
spellingShingle Decisive role of histopathology of lens capsule in the diagnosis of chronic fungal postoperative endophthalmitis
Mathias Paulo Loredo e Silva
Chronic endophthalmitis
Fungi
Cataract surgery
Intraocular lens
Intraocular infammation
Uveitis
Uveíte
Inflamação
Lentes Intraoculares
Catarata
Fungos
Endoftalmite
title_short Decisive role of histopathology of lens capsule in the diagnosis of chronic fungal postoperative endophthalmitis
title_full Decisive role of histopathology of lens capsule in the diagnosis of chronic fungal postoperative endophthalmitis
title_fullStr Decisive role of histopathology of lens capsule in the diagnosis of chronic fungal postoperative endophthalmitis
title_full_unstemmed Decisive role of histopathology of lens capsule in the diagnosis of chronic fungal postoperative endophthalmitis
title_sort Decisive role of histopathology of lens capsule in the diagnosis of chronic fungal postoperative endophthalmitis
author Mathias Paulo Loredo e Silva
author_facet Mathias Paulo Loredo e Silva
Rodrigo Magno da Silva Oliveira
Bruno Freitas Lage
Clóvis Arcoverde Freitas
Moisés Salgado Pedrosa
Márcio Bittar Nehemy
Daniel Vítor de Vasconcelos Santos
author_role author
author2 Rodrigo Magno da Silva Oliveira
Bruno Freitas Lage
Clóvis Arcoverde Freitas
Moisés Salgado Pedrosa
Márcio Bittar Nehemy
Daniel Vítor de Vasconcelos Santos
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Mathias Paulo Loredo e Silva
Rodrigo Magno da Silva Oliveira
Bruno Freitas Lage
Clóvis Arcoverde Freitas
Moisés Salgado Pedrosa
Márcio Bittar Nehemy
Daniel Vítor de Vasconcelos Santos
dc.subject.por.fl_str_mv Chronic endophthalmitis
Fungi
Cataract surgery
Intraocular lens
Intraocular infammation
Uveitis
topic Chronic endophthalmitis
Fungi
Cataract surgery
Intraocular lens
Intraocular infammation
Uveitis
Uveíte
Inflamação
Lentes Intraoculares
Catarata
Fungos
Endoftalmite
dc.subject.other.pt_BR.fl_str_mv Uveíte
Inflamação
Lentes Intraoculares
Catarata
Fungos
Endoftalmite
description We report three cases of refractory chronic endophthalmitis after cataract surgery presenting to a referral center, and with repeated negative cultures. Initial treatment consisted of intravitreal and systemic antibiotics, with partial improvement. After subsequent worsening, pars plana vitrectomy, intraocular lens explantation and en bloc capsulectomy were performed. Histopathological examination revealed multiple filamentous fungal structures, sequestered between anterior/posterior lens capsule in all cases. Chronic postoperative fungal endophthalmitis may manifest with negative cultures possibly associated with sequestration of the microorganism into the capsular bag. Careful histopathological examination of lens capsule in these cases may be essential for a definite diagnosis.
publishDate 2022
dc.date.issued.fl_str_mv 2022
dc.date.accessioned.fl_str_mv 2023-12-05T20:35:13Z
dc.date.available.fl_str_mv 2023-12-05T20:35:13Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1843/61742
dc.identifier.doi.pt_BR.fl_str_mv https://doi.org/10.1186/s40942-022-00370-8
dc.identifier.issn.pt_BR.fl_str_mv 2056-9920
dc.identifier.orcid.pt_BR.fl_str_mv http://orcid.org/0000-0002-6747-2024
url https://doi.org/10.1186/s40942-022-00370-8
http://hdl.handle.net/1843/61742
http://orcid.org/0000-0002-6747-2024
identifier_str_mv 2056-9920
dc.language.iso.fl_str_mv eng
language eng
dc.relation.ispartof.pt_BR.fl_str_mv International Journal of Retina and Vitreous
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
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dc.publisher.none.fl_str_mv Universidade Federal de Minas Gerais
dc.publisher.initials.fl_str_mv UFMG
dc.publisher.country.fl_str_mv Brasil
dc.publisher.department.fl_str_mv MED - DEPARTAMENTO DE OFTALMOLOGIA E OTORRINOLARINGOLOGIA
MEDICINA - FACULDADE DE MEDICINA
publisher.none.fl_str_mv Universidade Federal de Minas Gerais
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFMG
instname:Universidade Federal de Minas Gerais (UFMG)
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