Cell Division in genus Corynebacterium: protein-protein interaction and molecular docking of SepF and FtsZ in the understanding of cytokinesis in pathogenic species

Detalhes bibliográficos
Autor(a) principal: Alberto Fernandes de Oliveira Júnior
Data de Publicação: 2017
Outros Autores: Edson Luiz Folador, Anne Cybelle Pinto Gomide, Aristóteles Góes Neto, Rebecca Alice Wattam, Vasco Ariston de Carvalho Azevedo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFMG
Texto Completo: http://dx.doi.org/10.1590/0001-3765201820170385
http://hdl.handle.net/1843/55031
https://orcid.org/0000-0002-8222-4440
https://orcid.org/0000-0002-6752-9334
https://orcid.org/0000-0003-3948-5335
https://orcid.org/0000-0002-7692-6243
https://orcid.org/0000-0001-6018-6490
Resumo: The genus Corynebacterium includes species of great importance in medical, veterinary and biotechnological fields. The genus-specific families (PLfams) from PATRIC have been used to observe conserved proteins associated to all species. Our results showed a large number of conserved proteins that are associated with the cellular division process. Was not observe in our results other proteins like FtsA and ZapA that interact with FtsZ. Our findings point that SepF overlaps the function of this proteins explored by molecular docking, protein-protein interaction and sequence analysis. Transcriptomic analysis showed that these two (Sepf and FtsZ) proteins can be expressed in different conditions together. The work presents novelties on molecules participating in the cell division event, from the interaction of FtsZ and SepF, as new therapeutic targets.
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spelling Cell Division in genus Corynebacterium: protein-protein interaction and molecular docking of SepF and FtsZ in the understanding of cytokinesis in pathogenic speciesDivisão celular no gênero Corynebacterium: interação proteína-proteína e docking molecular de SepF e FtsZ no entendimento da citocinese em espécies patogênicasCell divisionCorynebacteriumFtsZSepFMolecular dockingDivisão celularCorynebacteriumSimulação de acoplamento molecularThe genus Corynebacterium includes species of great importance in medical, veterinary and biotechnological fields. The genus-specific families (PLfams) from PATRIC have been used to observe conserved proteins associated to all species. Our results showed a large number of conserved proteins that are associated with the cellular division process. Was not observe in our results other proteins like FtsA and ZapA that interact with FtsZ. Our findings point that SepF overlaps the function of this proteins explored by molecular docking, protein-protein interaction and sequence analysis. Transcriptomic analysis showed that these two (Sepf and FtsZ) proteins can be expressed in different conditions together. The work presents novelties on molecules participating in the cell division event, from the interaction of FtsZ and SepF, as new therapeutic targets.CNPq - Conselho Nacional de Desenvolvimento Científico e TecnológicoCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível SuperiorUniversidade Federal de Minas GeraisBrasilICB - DEPARTAMENTO DE MICROBIOLOGIAUFMG2023-06-16T20:59:47Z2023-06-16T20:59:47Z2017info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlepdfapplication/pdfhttp://dx.doi.org/10.1590/0001-37652018201703851678-2690http://hdl.handle.net/1843/55031https://orcid.org/0000-0002-8222-4440https://orcid.org/0000-0002-6752-9334https://orcid.org/0000-0003-3948-5335https://orcid.org/0000-0002-7692-6243https://orcid.org/0000-0001-6018-6490engAnais da Academia Brasileira de CiênciasAlberto Fernandes de Oliveira JúniorEdson Luiz FoladorAnne Cybelle Pinto GomideAristóteles Góes NetoRebecca Alice WattamVasco Ariston de Carvalho Azevedoinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMG2023-06-16T20:59:47Zoai:repositorio.ufmg.br:1843/55031Repositório InstitucionalPUBhttps://repositorio.ufmg.br/oairepositorio@ufmg.bropendoar:2023-06-16T20:59:47Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)false
dc.title.none.fl_str_mv Cell Division in genus Corynebacterium: protein-protein interaction and molecular docking of SepF and FtsZ in the understanding of cytokinesis in pathogenic species
Divisão celular no gênero Corynebacterium: interação proteína-proteína e docking molecular de SepF e FtsZ no entendimento da citocinese em espécies patogênicas
title Cell Division in genus Corynebacterium: protein-protein interaction and molecular docking of SepF and FtsZ in the understanding of cytokinesis in pathogenic species
spellingShingle Cell Division in genus Corynebacterium: protein-protein interaction and molecular docking of SepF and FtsZ in the understanding of cytokinesis in pathogenic species
Alberto Fernandes de Oliveira Júnior
Cell division
Corynebacterium
FtsZ
SepF
Molecular docking
Divisão celular
Corynebacterium
Simulação de acoplamento molecular
title_short Cell Division in genus Corynebacterium: protein-protein interaction and molecular docking of SepF and FtsZ in the understanding of cytokinesis in pathogenic species
title_full Cell Division in genus Corynebacterium: protein-protein interaction and molecular docking of SepF and FtsZ in the understanding of cytokinesis in pathogenic species
title_fullStr Cell Division in genus Corynebacterium: protein-protein interaction and molecular docking of SepF and FtsZ in the understanding of cytokinesis in pathogenic species
title_full_unstemmed Cell Division in genus Corynebacterium: protein-protein interaction and molecular docking of SepF and FtsZ in the understanding of cytokinesis in pathogenic species
title_sort Cell Division in genus Corynebacterium: protein-protein interaction and molecular docking of SepF and FtsZ in the understanding of cytokinesis in pathogenic species
author Alberto Fernandes de Oliveira Júnior
author_facet Alberto Fernandes de Oliveira Júnior
Edson Luiz Folador
Anne Cybelle Pinto Gomide
Aristóteles Góes Neto
Rebecca Alice Wattam
Vasco Ariston de Carvalho Azevedo
author_role author
author2 Edson Luiz Folador
Anne Cybelle Pinto Gomide
Aristóteles Góes Neto
Rebecca Alice Wattam
Vasco Ariston de Carvalho Azevedo
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Alberto Fernandes de Oliveira Júnior
Edson Luiz Folador
Anne Cybelle Pinto Gomide
Aristóteles Góes Neto
Rebecca Alice Wattam
Vasco Ariston de Carvalho Azevedo
dc.subject.por.fl_str_mv Cell division
Corynebacterium
FtsZ
SepF
Molecular docking
Divisão celular
Corynebacterium
Simulação de acoplamento molecular
topic Cell division
Corynebacterium
FtsZ
SepF
Molecular docking
Divisão celular
Corynebacterium
Simulação de acoplamento molecular
description The genus Corynebacterium includes species of great importance in medical, veterinary and biotechnological fields. The genus-specific families (PLfams) from PATRIC have been used to observe conserved proteins associated to all species. Our results showed a large number of conserved proteins that are associated with the cellular division process. Was not observe in our results other proteins like FtsA and ZapA that interact with FtsZ. Our findings point that SepF overlaps the function of this proteins explored by molecular docking, protein-protein interaction and sequence analysis. Transcriptomic analysis showed that these two (Sepf and FtsZ) proteins can be expressed in different conditions together. The work presents novelties on molecules participating in the cell division event, from the interaction of FtsZ and SepF, as new therapeutic targets.
publishDate 2017
dc.date.none.fl_str_mv 2017
2023-06-16T20:59:47Z
2023-06-16T20:59:47Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/0001-3765201820170385
1678-2690
http://hdl.handle.net/1843/55031
https://orcid.org/0000-0002-8222-4440
https://orcid.org/0000-0002-6752-9334
https://orcid.org/0000-0003-3948-5335
https://orcid.org/0000-0002-7692-6243
https://orcid.org/0000-0001-6018-6490
url http://dx.doi.org/10.1590/0001-3765201820170385
http://hdl.handle.net/1843/55031
https://orcid.org/0000-0002-8222-4440
https://orcid.org/0000-0002-6752-9334
https://orcid.org/0000-0003-3948-5335
https://orcid.org/0000-0002-7692-6243
https://orcid.org/0000-0001-6018-6490
identifier_str_mv 1678-2690
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Anais da Academia Brasileira de Ciências
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv pdf
application/pdf
dc.publisher.none.fl_str_mv Universidade Federal de Minas Gerais
Brasil
ICB - DEPARTAMENTO DE MICROBIOLOGIA
UFMG
publisher.none.fl_str_mv Universidade Federal de Minas Gerais
Brasil
ICB - DEPARTAMENTO DE MICROBIOLOGIA
UFMG
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFMG
instname:Universidade Federal de Minas Gerais (UFMG)
instacron:UFMG
instname_str Universidade Federal de Minas Gerais (UFMG)
instacron_str UFMG
institution UFMG
reponame_str Repositório Institucional da UFMG
collection Repositório Institucional da UFMG
repository.name.fl_str_mv Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)
repository.mail.fl_str_mv repositorio@ufmg.br
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