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Fabíola de Oliveira Paes Lemehttp://lattes.cnpq.br/6383021762144230Eduardo Bastianettohttp://lattes.cnpq.br/1425727640897648http://lattes.cnpq.br/6360758698321334Maria Clara Madureira de Lima Prado2023-01-02T18:42:47Z2023-01-02T18:42:47Z2022-06-30http://hdl.handle.net/1843/48564As endoparasitoses caninas representam um desafio para a Saúde Única devido ao caráter zoonótico que alguns parasitos podem representar, especialmente para as pessoas que trabalham diretamente com estes animais, como em ambiente de abrigos. Como já foram documentadas resistência em Ancylostoma caninum ao pirantel e aos benzimidazóis, o objetivo da presente pesquisa foi analisar o perfil hematológico, bioquímico sérico e parasitológico de cães provenientes de um condomínio (estudo 1) e de um abrigo comunitário (ONG GAPA/Lagoa Santa) do município de Lagoa Santa/MG, sendo as avaliações na ONG antes e após a vermifugação dos animais com pamoato de pirantel (estudo 2) e mebendazol (estudo 3). Os parasitos mais encontrados foram Ancylostoma sp. (39%), Toxocara canis (3%) e Trichuris vulpis (6%), sendo, os dois primeiros, parasitos considerados de maior importância, por causar as síndromes conhecidas como “Larva Migrans Cutânea” e “Larva Migrans Visceral e Ocular”, respectivamente. Dentre as alterações laboratoriais mais encontradas, destacou-se a anemia, observada em ~11%, a eosinofilia em ~44% e a trombocitopenia, observada em 50% dos animais avaliados. Nas condições em que este experimento foi realizado não houve evidência suficiente para afirmar casos de resistência parasitária em cães tratados com pirantel e mebendazol, porém os resultados despertam atenção sobre a importância da vigilância e do uso mais cauteloso de drogas anti-helmínticas em cães, além do cenário de que nem sempre a população exposta aos riscos de zoonoses tem alcance ao conhecimento sobre estas, fazendo-se necessário programas de educação sanitária, com a participação de profissionais relacionados à saúde e saneamento ambiental.Canine endoparasites represent a challenge for One Health due to the zoonotic character that some parasites can represent, especially for people who work directly with these animals, such as in a shelter environment. As resistance to pyrantel and benzimidazoles has already been documented in Ancylostoma caninum, the objective of the present research was to analyze the hematological, serum biochemical and parasitological profile of dogs from a condominium (study 1) and from a community shelter (NGO GAPA/Lagoa Santa ) from the municipality of Lagoa Santa/MG, with evaluations at the NGO before and after deworming the animals with pyrantel pamoate (study 2) and mebendazole (study 3). The most common parasites were Ancylostoma sp. (39%), Toxocara canis (3%) and Trichuris vulpis (6%). , respectively. Among the most common laboratory alterations, anemia stood out, observed in ~11%, eosinophilia in ~44% and thrombocytopenia, observed in 50% of the animals evaluated. In the conditions in which this experiment was carried out, there was not enough evidence to affirm cases of parasitic resistance in dogs treated with pyrantel and mebendazole, but the results draw attention to the importance of surveillance and a more cautious use of anthelmintic drugs in dogs, in addition to from the scenario that the population exposed to the risks of zoonoses does not always have access to knowledge about them, making health education programs necessary, with the participation of professionals related to health and environmental sanitation. Keywords: zoonoses, intestinal parasitosis, hematological and biochemical alterations, anthelmintic resistanceCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível SuperiorporUniversidade Federal de Minas GeraisPrograma de Pós-Graduação em Ciência AnimalUFMGBrasilCiência animalCãoHematologiaZoonosesAvaliação hematológica e bioquímica sérica de cães portadores de parasitos intestinais do município de Lagoa Santa, Minas Geraisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMGORIGINALDissertação Maria Clara Prado APROVADA 25.09.22.pdfDissertação Maria Clara Prado APROVADA 25.09.22.pdfapplication/pdf1379834https://repositorio.ufmg.br/bitstream/1843/48564/1/Disserta%c3%a7%c3%a3o%20Maria%20Clara%20Prado%20APROVADA%2025.09.22.pdf9455c9f5be33320ad41e00b6a7be953eMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-82118https://repositorio.ufmg.br/bitstream/1843/48564/2/license.txtcda590c95a0b51b4d15f60c9642ca272MD521843/485642023-01-02 15:42:47.807oai:repositorio.ufmg.br:1843/48564TElDRU7Dh0EgREUgRElTVFJJQlVJw4fDg08gTsODTy1FWENMVVNJVkEgRE8gUkVQT1NJVMOTUklPIElOU1RJVFVDSU9OQUwgREEgVUZNRwoKQ29tIGEgYXByZXNlbnRhw6fDo28gZGVzdGEgbGljZW7Dp2EsIHZvY8OqIChvIGF1dG9yIChlcykgb3UgbyB0aXR1bGFyIGRvcyBkaXJlaXRvcyBkZSBhdXRvcikgY29uY2VkZSBhbyBSZXBvc2l0w7NyaW8gSW5zdGl0dWNpb25hbCBkYSBVRk1HIChSSS1VRk1HKSBvIGRpcmVpdG8gbsOjbyBleGNsdXNpdm8gZSBpcnJldm9nw6F2ZWwgZGUgcmVwcm9kdXppciBlL291IGRpc3RyaWJ1aXIgYSBzdWEgcHVibGljYcOnw6NvIChpbmNsdWluZG8gbyByZXN1bW8pIHBvciB0b2RvIG8gbXVuZG8gbm8gZm9ybWF0byBpbXByZXNzbyBlIGVsZXRyw7RuaWNvIGUgZW0gcXVhbHF1ZXIgbWVpbywgaW5jbHVpbmRvIG9zIGZvcm1hdG9zIMOhdWRpbyBvdSB2w61kZW8uCgpWb2PDqiBkZWNsYXJhIHF1ZSBjb25oZWNlIGEgcG9sw610aWNhIGRlIGNvcHlyaWdodCBkYSBlZGl0b3JhIGRvIHNldSBkb2N1bWVudG8gZSBxdWUgY29uaGVjZSBlIGFjZWl0YSBhcyBEaXJldHJpemVzIGRvIFJJLVVGTUcuCgpWb2PDqiBjb25jb3JkYSBxdWUgbyBSZXBvc2l0w7NyaW8gSW5zdGl0dWNpb25hbCBkYSBVRk1HIHBvZGUsIHNlbSBhbHRlcmFyIG8gY29udGXDumRvLCB0cmFuc3BvciBhIHN1YSBwdWJsaWNhw6fDo28gcGFyYSBxdWFscXVlciBtZWlvIG91IGZvcm1hdG8gcGFyYSBmaW5zIGRlIHByZXNlcnZhw6fDo28uCgpWb2PDqiB0YW1iw6ltIGNvbmNvcmRhIHF1ZSBvIFJlcG9zaXTDs3JpbyBJbnN0aXR1Y2lvbmFsIGRhIFVGTUcgcG9kZSBtYW50ZXIgbWFpcyBkZSB1bWEgY8OzcGlhIGRlIHN1YSBwdWJsaWNhw6fDo28gcGFyYSBmaW5zIGRlIHNlZ3VyYW7Dp2EsIGJhY2stdXAgZSBwcmVzZXJ2YcOnw6NvLgoKVm9jw6ogZGVjbGFyYSBxdWUgYSBzdWEgcHVibGljYcOnw6NvIMOpIG9yaWdpbmFsIGUgcXVlIHZvY8OqIHRlbSBvIHBvZGVyIGRlIGNvbmNlZGVyIG9zIGRpcmVpdG9zIGNvbnRpZG9zIG5lc3RhIGxpY2Vuw6dhLiBWb2PDqiB0YW1iw6ltIGRlY2xhcmEgcXVlIG8gZGVww7NzaXRvIGRlIHN1YSBwdWJsaWNhw6fDo28gbsOjbywgcXVlIHNlamEgZGUgc2V1IGNvbmhlY2ltZW50bywgaW5mcmluZ2UgZGlyZWl0b3MgYXV0b3JhaXMgZGUgbmluZ3XDqW0uCgpDYXNvIGEgc3VhIHB1YmxpY2HDp8OjbyBjb250ZW5oYSBtYXRlcmlhbCBxdWUgdm9jw6ogbsOjbyBwb3NzdWkgYSB0aXR1bGFyaWRhZGUgZG9zIGRpcmVpdG9zIGF1dG9yYWlzLCB2b2PDqiBkZWNsYXJhIHF1ZSBvYnRldmUgYSBwZXJtaXNzw6NvIGlycmVzdHJpdGEgZG8gZGV0ZW50b3IgZG9zIGRpcmVpdG9zIGF1dG9yYWlzIHBhcmEgY29uY2VkZXIgYW8gUmVwb3NpdMOzcmlvIEluc3RpdHVjaW9uYWwgZGEgVUZNRyBvcyBkaXJlaXRvcyBhcHJlc2VudGFkb3MgbmVzdGEgbGljZW7Dp2EsIGUgcXVlIGVzc2UgbWF0ZXJpYWwgZGUgcHJvcHJpZWRhZGUgZGUgdGVyY2Vpcm9zIGVzdMOhIGNsYXJhbWVudGUgaWRlbnRpZmljYWRvIGUgcmVjb25oZWNpZG8gbm8gdGV4dG8gb3Ugbm8gY29udGXDumRvIGRhIHB1YmxpY2HDp8OjbyBvcmEgZGVwb3NpdGFkYS4KCkNBU08gQSBQVUJMSUNBw4fDg08gT1JBIERFUE9TSVRBREEgVEVOSEEgU0lETyBSRVNVTFRBRE8gREUgVU0gUEFUUk9Dw41OSU8gT1UgQVBPSU8gREUgVU1BIEFHw4pOQ0lBIERFIEZPTUVOVE8gT1UgT1VUUk8gT1JHQU5JU01PLCBWT0PDiiBERUNMQVJBIFFVRSBSRVNQRUlUT1UgVE9ET1MgRSBRVUFJU1FVRVIgRElSRUlUT1MgREUgUkVWSVPDg08gQ09NTyBUQU1Cw4lNIEFTIERFTUFJUyBPQlJJR0HDh8OVRVMgRVhJR0lEQVMgUE9SIENPTlRSQVRPIE9VIEFDT1JETy4KCk8gUmVwb3NpdMOzcmlvIEluc3RpdHVjaW9uYWwgZGEgVUZNRyBzZSBjb21wcm9tZXRlIGEgaWRlbnRpZmljYXIgY2xhcmFtZW50ZSBvIHNldSBub21lKHMpIG91IG8ocykgbm9tZXMocykgZG8ocykgZGV0ZW50b3IoZXMpIGRvcyBkaXJlaXRvcyBhdXRvcmFpcyBkYSBwdWJsaWNhw6fDo28sIGUgbsOjbyBmYXLDoSBxdWFscXVlciBhbHRlcmHDp8OjbywgYWzDqW0gZGFxdWVsYXMgY29uY2VkaWRhcyBwb3IgZXN0YSBsaWNlbsOnYS4KRepositório InstitucionalPUBhttps://repositorio.ufmg.br/oaiopendoar:2023-01-02T18:42:47Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)false
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