Blame the signaling: role of cAMP for the resolution of inflammation
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFMG |
Texto Completo: | https://doi.org/10.1016/j.phrs.2020.105030 http://hdl.handle.net/1843/47202 |
Resumo: | A complex intracellular signaling governs different cellular responses in inflammation. Extracellular stimuli are sensed, amplified, and transduced through a dynamic cellular network of messengers converting the first signal into a proper response: production of specific mediators, cell activation, survival, or death. Several overlapping pathways are coordinated to ensure specific and timely induction of inflammation to neutralize potential harms to the tissue. Ideally, the inflammatory response must be controlled and self-limited. Resolution of inflammation is an active process that culminates with termination of inflammation and restoration of tissue homeostasis. Comparably to the onset of inflammation, resolution responses are triggered by coordinated intracellular signaling pathways that transduce the message to the nucleus. However, the key messengers and pathways involved in signaling transduction for resolution are still poorly understood in comparison to the inflammatory network. cAMP has long been recognized as an inducer of anti-inflammatory responses and cAMP-dependent pathways have been extensively exploited pharmacologically to treat inflammatory diseases. Recently, cAMP has been pointed out as coordinator of key steps of resolution of inflammation. Here, we summarize the evidence for the role of cAMP at inducing important features of resolution of inflammation. |
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2022-11-11T20:15:21Z2022-11-11T20:15:21Z2020-09159105030112https://doi.org/10.1016/j.phrs.2020.1050301043-6618http://hdl.handle.net/1843/47202A complex intracellular signaling governs different cellular responses in inflammation. Extracellular stimuli are sensed, amplified, and transduced through a dynamic cellular network of messengers converting the first signal into a proper response: production of specific mediators, cell activation, survival, or death. Several overlapping pathways are coordinated to ensure specific and timely induction of inflammation to neutralize potential harms to the tissue. Ideally, the inflammatory response must be controlled and self-limited. Resolution of inflammation is an active process that culminates with termination of inflammation and restoration of tissue homeostasis. Comparably to the onset of inflammation, resolution responses are triggered by coordinated intracellular signaling pathways that transduce the message to the nucleus. However, the key messengers and pathways involved in signaling transduction for resolution are still poorly understood in comparison to the inflammatory network. cAMP has long been recognized as an inducer of anti-inflammatory responses and cAMP-dependent pathways have been extensively exploited pharmacologically to treat inflammatory diseases. Recently, cAMP has been pointed out as coordinator of key steps of resolution of inflammation. Here, we summarize the evidence for the role of cAMP at inducing important features of resolution of inflammation.Uma sinalização intracelular complexa governa diferentes respostas celulares na inflamação. Estímulos extracelulares são detectados, amplificados e transduzidos através de uma rede celular dinâmica de mensageiros convertendo o primeiro sinal em uma resposta adequada: produção de mediadores específicos, ativação celular, sobrevivência ou morte. Várias vias sobrepostas são coordenadas para garantir a indução específica e oportuna da inflamação para neutralizar possíveis danos ao tecido. Idealmente, a resposta inflamatória deve ser controlada e autolimitada. A resolução da inflamação é um processo ativo que culmina com o término da inflamação e restauração da homeostase tecidual. Comparativamente ao início da inflamação, as respostas de resolução são desencadeadas por vias de sinalização intracelular coordenadas que transduzem a mensagem para o núcleo. No entanto, os principais mensageiros e vias envolvidos na transdução de sinalização para resolução ainda são pouco compreendidos em comparação com a rede inflamatória. O cAMP tem sido reconhecido há muito tempo como um indutor de respostas anti-inflamatórias e as vias dependentes de cAMP têm sido extensivamente exploradas farmacologicamente para tratar doenças inflamatórias. Recentemente, o AMPc tem sido apontado como coordenador das principais etapas de resolução da inflamação. Aqui, resumimos as evidências do papel do AMPc na indução de características importantes da resolução da inflamação.CNPq - Conselho Nacional de Desenvolvimento Científico e TecnológicoFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas GeraisCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível SuperiorengUniversidade Federal de Minas GeraisUFMGBrasilFAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICASICB - DEPARTAMENTO DE BIOQUÍMICA E IMUNOLOGIAICB - DEPARTAMENTO DE FARMACOLOGIAICB - DEPARTAMENTO DE MORFOLOGIAPharmacological ResearchFarmacologiaAMP cíclicoInibidores da fosfodiesterase 4InflamaçãoResolution pharmacologycAMPPhosphodiesterase 4InflammationPro-resolving mediatorsBlame the signaling: role of cAMP for the resolution of inflammationinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://www.sciencedirect.com/science/article/pii/S1043661820313384?via%3DihubLuciana Pádua TavaresGraziele Letícia Negreiros LimaKátia Maciel LimaPatrícia Machado Rodrigues e Silva MartinsVanessa PinhoMauro Martins TeixeiraLirlândia Pires de Sousaapplication/pdfinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMGLICENSELicense.txtLicense.txttext/plain; charset=utf-82042https://repositorio.ufmg.br/bitstream/1843/47202/1/License.txtfa505098d172de0bc8864fc1287ffe22MD51ORIGINALBlame the signaling role of cAMP for the resolution of inflammation.pdfBlame the signaling role of cAMP for the resolution of inflammation.pdfapplication/pdf4687764https://repositorio.ufmg.br/bitstream/1843/47202/2/Blame%20the%20signaling%20role%20of%20cAMP%20for%20the%20resolution%20of%20inflammation.pdfc1f553dfc57429fa07050c518d0328bfMD521843/472022022-11-11 17:15:21.977oai:repositorio.ufmg.br:1843/47202TElDRU7vv71BIERFIERJU1RSSUJVSe+/ve+/vU8gTu+/vU8tRVhDTFVTSVZBIERPIFJFUE9TSVTvv71SSU8gSU5TVElUVUNJT05BTCBEQSBVRk1HCiAKCkNvbSBhIGFwcmVzZW50Ye+/ve+/vW8gZGVzdGEgbGljZW7vv71hLCB2b2Pvv70gKG8gYXV0b3IgKGVzKSBvdSBvIHRpdHVsYXIgZG9zIGRpcmVpdG9zIGRlIGF1dG9yKSBjb25jZWRlIGFvIFJlcG9zaXTvv71yaW8gSW5zdGl0dWNpb25hbCBkYSBVRk1HIChSSS1VRk1HKSBvIGRpcmVpdG8gbu+/vW8gZXhjbHVzaXZvIGUgaXJyZXZvZ++/vXZlbCBkZSByZXByb2R1emlyIGUvb3UgZGlzdHJpYnVpciBhIHN1YSBwdWJsaWNh77+977+9byAoaW5jbHVpbmRvIG8gcmVzdW1vKSBwb3IgdG9kbyBvIG11bmRvIG5vIGZvcm1hdG8gaW1wcmVzc28gZSBlbGV0cu+/vW5pY28gZSBlbSBxdWFscXVlciBtZWlvLCBpbmNsdWluZG8gb3MgZm9ybWF0b3Mg77+9dWRpbyBvdSB277+9ZGVvLgoKVm9j77+9IGRlY2xhcmEgcXVlIGNvbmhlY2UgYSBwb2zvv710aWNhIGRlIGNvcHlyaWdodCBkYSBlZGl0b3JhIGRvIHNldSBkb2N1bWVudG8gZSBxdWUgY29uaGVjZSBlIGFjZWl0YSBhcyBEaXJldHJpemVzIGRvIFJJLVVGTUcuCgpWb2Pvv70gY29uY29yZGEgcXVlIG8gUmVwb3NpdO+/vXJpbyBJbnN0aXR1Y2lvbmFsIGRhIFVGTUcgcG9kZSwgc2VtIGFsdGVyYXIgbyBjb250Ze+/vWRvLCB0cmFuc3BvciBhIHN1YSBwdWJsaWNh77+977+9byBwYXJhIHF1YWxxdWVyIG1laW8gb3UgZm9ybWF0byBwYXJhIGZpbnMgZGUgcHJlc2VydmHvv73vv71vLgoKVm9j77+9IHRhbWLvv71tIGNvbmNvcmRhIHF1ZSBvIFJlcG9zaXTvv71yaW8gSW5zdGl0dWNpb25hbCBkYSBVRk1HIHBvZGUgbWFudGVyIG1haXMgZGUgdW1hIGPvv71waWEgZGUgc3VhIHB1YmxpY2Hvv73vv71vIHBhcmEgZmlucyBkZSBzZWd1cmFu77+9YSwgYmFjay11cCBlIHByZXNlcnZh77+977+9by4KClZvY++/vSBkZWNsYXJhIHF1ZSBhIHN1YSBwdWJsaWNh77+977+9byDvv70gb3JpZ2luYWwgZSBxdWUgdm9j77+9IHRlbSBvIHBvZGVyIGRlIGNvbmNlZGVyIG9zIGRpcmVpdG9zIGNvbnRpZG9zIG5lc3RhIGxpY2Vu77+9YS4gVm9j77+9IHRhbWLvv71tIGRlY2xhcmEgcXVlIG8gZGVw77+9c2l0byBkZSBzdWEgcHVibGljYe+/ve+/vW8gbu+/vW8sIHF1ZSBzZWphIGRlIHNldSBjb25oZWNpbWVudG8sIGluZnJpbmdlIGRpcmVpdG9zIGF1dG9yYWlzIGRlIG5pbmd177+9bS4KCkNhc28gYSBzdWEgcHVibGljYe+/ve+/vW8gY29udGVuaGEgbWF0ZXJpYWwgcXVlIHZvY++/vSBu77+9byBwb3NzdWkgYSB0aXR1bGFyaWRhZGUgZG9zIGRpcmVpdG9zIGF1dG9yYWlzLCB2b2Pvv70gZGVjbGFyYSBxdWUgb2J0ZXZlIGEgcGVybWlzc++/vW8gaXJyZXN0cml0YSBkbyBkZXRlbnRvciBkb3MgZGlyZWl0b3MgYXV0b3JhaXMgcGFyYSBjb25jZWRlciBhbyBSZXBvc2l077+9cmlvIEluc3RpdHVjaW9uYWwgZGEgVUZNRyBvcyBkaXJlaXRvcyBhcHJlc2VudGFkb3MgbmVzdGEgbGljZW7vv71hLCBlIHF1ZSBlc3NlIG1hdGVyaWFsIGRlIHByb3ByaWVkYWRlIGRlIHRlcmNlaXJvcyBlc3Tvv70gY2xhcmFtZW50ZSBpZGVudGlmaWNhZG8gZSByZWNvbmhlY2lkbyBubyB0ZXh0byBvdSBubyBjb250Ze+/vWRvIGRhIHB1YmxpY2Hvv73vv71vIG9yYSBkZXBvc2l0YWRhLgoKQ0FTTyBBIFBVQkxJQ0Hvv73vv71PIE9SQSBERVBPU0lUQURBIFRFTkhBIFNJRE8gUkVTVUxUQURPIERFIFVNIFBBVFJPQ++/vU5JTyBPVSBBUE9JTyBERSBVTUEgQUfvv71OQ0lBIERFIEZPTUVOVE8gT1UgT1VUUk8gT1JHQU5JU01PLCBWT0Pvv70gREVDTEFSQSBRVUUgUkVTUEVJVE9VIFRPRE9TIEUgUVVBSVNRVUVSIERJUkVJVE9TIERFIFJFVklT77+9TyBDT01PIFRBTULvv71NIEFTIERFTUFJUyBPQlJJR0Hvv73vv71FUyBFWElHSURBUyBQT1IgQ09OVFJBVE8gT1UgQUNPUkRPLgoKTyBSZXBvc2l077+9cmlvIEluc3RpdHVjaW9uYWwgZGEgVUZNRyBzZSBjb21wcm9tZXRlIGEgaWRlbnRpZmljYXIgY2xhcmFtZW50ZSBvIHNldSBub21lKHMpIG91IG8ocykgbm9tZXMocykgZG8ocykgZGV0ZW50b3IoZXMpIGRvcyBkaXJlaXRvcyBhdXRvcmFpcyBkYSBwdWJsaWNh77+977+9bywgZSBu77+9byBmYXLvv70gcXVhbHF1ZXIgYWx0ZXJh77+977+9bywgYWzvv71tIGRhcXVlbGFzIGNvbmNlZGlkYXMgcG9yIGVzdGEgbGljZW7vv71hLgo=Repositório de PublicaçõesPUBhttps://repositorio.ufmg.br/oaiopendoar:2022-11-11T20:15:21Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)false |
dc.title.pt_BR.fl_str_mv |
Blame the signaling: role of cAMP for the resolution of inflammation |
title |
Blame the signaling: role of cAMP for the resolution of inflammation |
spellingShingle |
Blame the signaling: role of cAMP for the resolution of inflammation Luciana Pádua Tavares Resolution pharmacology cAMP Phosphodiesterase 4 Inflammation Pro-resolving mediators Farmacologia AMP cíclico Inibidores da fosfodiesterase 4 Inflamação |
title_short |
Blame the signaling: role of cAMP for the resolution of inflammation |
title_full |
Blame the signaling: role of cAMP for the resolution of inflammation |
title_fullStr |
Blame the signaling: role of cAMP for the resolution of inflammation |
title_full_unstemmed |
Blame the signaling: role of cAMP for the resolution of inflammation |
title_sort |
Blame the signaling: role of cAMP for the resolution of inflammation |
author |
Luciana Pádua Tavares |
author_facet |
Luciana Pádua Tavares Graziele Letícia Negreiros Lima Kátia Maciel Lima Patrícia Machado Rodrigues e Silva Martins Vanessa Pinho Mauro Martins Teixeira Lirlândia Pires de Sousa |
author_role |
author |
author2 |
Graziele Letícia Negreiros Lima Kátia Maciel Lima Patrícia Machado Rodrigues e Silva Martins Vanessa Pinho Mauro Martins Teixeira Lirlândia Pires de Sousa |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Luciana Pádua Tavares Graziele Letícia Negreiros Lima Kátia Maciel Lima Patrícia Machado Rodrigues e Silva Martins Vanessa Pinho Mauro Martins Teixeira Lirlândia Pires de Sousa |
dc.subject.por.fl_str_mv |
Resolution pharmacology cAMP Phosphodiesterase 4 Inflammation Pro-resolving mediators |
topic |
Resolution pharmacology cAMP Phosphodiesterase 4 Inflammation Pro-resolving mediators Farmacologia AMP cíclico Inibidores da fosfodiesterase 4 Inflamação |
dc.subject.other.pt_BR.fl_str_mv |
Farmacologia AMP cíclico Inibidores da fosfodiesterase 4 Inflamação |
description |
A complex intracellular signaling governs different cellular responses in inflammation. Extracellular stimuli are sensed, amplified, and transduced through a dynamic cellular network of messengers converting the first signal into a proper response: production of specific mediators, cell activation, survival, or death. Several overlapping pathways are coordinated to ensure specific and timely induction of inflammation to neutralize potential harms to the tissue. Ideally, the inflammatory response must be controlled and self-limited. Resolution of inflammation is an active process that culminates with termination of inflammation and restoration of tissue homeostasis. Comparably to the onset of inflammation, resolution responses are triggered by coordinated intracellular signaling pathways that transduce the message to the nucleus. However, the key messengers and pathways involved in signaling transduction for resolution are still poorly understood in comparison to the inflammatory network. cAMP has long been recognized as an inducer of anti-inflammatory responses and cAMP-dependent pathways have been extensively exploited pharmacologically to treat inflammatory diseases. Recently, cAMP has been pointed out as coordinator of key steps of resolution of inflammation. Here, we summarize the evidence for the role of cAMP at inducing important features of resolution of inflammation. |
publishDate |
2020 |
dc.date.issued.fl_str_mv |
2020-09 |
dc.date.accessioned.fl_str_mv |
2022-11-11T20:15:21Z |
dc.date.available.fl_str_mv |
2022-11-11T20:15:21Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1843/47202 |
dc.identifier.doi.pt_BR.fl_str_mv |
https://doi.org/10.1016/j.phrs.2020.105030 |
dc.identifier.issn.pt_BR.fl_str_mv |
1043-6618 |
url |
https://doi.org/10.1016/j.phrs.2020.105030 http://hdl.handle.net/1843/47202 |
identifier_str_mv |
1043-6618 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
Pharmacological Research |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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Universidade Federal de Minas Gerais |
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UFMG |
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Brasil |
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FAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICAS ICB - DEPARTAMENTO DE BIOQUÍMICA E IMUNOLOGIA ICB - DEPARTAMENTO DE FARMACOLOGIA ICB - DEPARTAMENTO DE MORFOLOGIA |
publisher.none.fl_str_mv |
Universidade Federal de Minas Gerais |
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reponame:Repositório Institucional da UFMG instname:Universidade Federal de Minas Gerais (UFMG) instacron:UFMG |
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