Evaluation of the Presence and Levels of Enrofloxacin, Ciprofloxacin, Sulfaquinoxaline and Oxytetracycline in Broiler Chickens after Drug Administration

• Autor(a) principal: Débora Cristina Sampaio de Assis
• Data de Publicação: 2016
• Outros Autores: Guilherme Resende da Silva, Isabela Pereira Lanza, Ana Cláudia Dos Santos Rossi Ribeiro, Ângela Maria Quintão Lana, Leonardo José Camargos Lara, Tadeu Chaves de Figueiredo, Silvana de Vasconcelos Cançado
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UFMG
• Texto Completo: https://doi.org/10.1371/journal.pone.0166402; http://hdl.handle.net/1843/56395; https://orcid.org/0000-0003-0066-6198
• topic: Zootecnia

The depletion times of enrofloxacin and its metabolite ciprofloxacin as well as sulfaquinoxaline and oxytetracycline were evaluated in broiler chickens that had been subjected to pharmacological treatment. The presence and residue levels of these drugs in muscle tissue were evaluated using an ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method that was validated in this work. The results showed the presence of all antimicrobial residues; however, the presence of residues at concentrations higher than the drugs’ maximum residue limit (MRL) of 100 μg kg-1 was found only during the treatment period for oxytetracycline and until two days after discontinuation of the medication for enrofloxacin, ciprofloxacin and sulfaquinoxaline. It was concluded that the residues of all antimicrobials were rapidly metabolized from the broiler muscles; after four days of withdrawal, the levels were lower than the limit of quantification (LOQ) of the method for the studied analytes.