High prevalence of obesity in rheumatoid arthritis patients: association with disease activity, hypertension, dyslipidemia and diabetes, a multi-center study

• Autor(a) principal: Maria Fernanda Brandão de Resende Guimarães
• Data de Publicação: 2019
• Outros Autores: Carlos Ewerton Maia Rodrigues, Kirla Wagner Poti Gomes, Carla Jorge Machado, Claiton Viegas Brenol, Susana Ferreira Krampe, Nicole Pamplona Bueno de Andrade, Adriana Maria Kakehasi
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UFMG
• Texto Completo: http://hdl.handle.net/1843/63273
• topic: Arthritis, Rheumatoid; Hypertension; Dyslipidemia; Diabetes; Arthritis, Rheumatoid; Hypertension; Dyslipidemia; Diabetes

Introduction: Rheumatoid arthritis (RA) is a well-documented independent risk factor for cardiovascular disease.Obesity may provide an additional link between inflammation and accelerated atherosclerosis in RA.Objective: To evaluate the association between obesity and disease parameters and cardiovascular risk factors in RApatients.Method: Cross-sectional study of a cohort of RA patients from three Brazilian teaching hospitals. Information on demographics, clinical parameters and the presence of cardiovascular risk factors was collected. Blood pressure, weight,height and waist circumference (WC) were measured during the first consultation. Laboratory data were retrieved from medical records. Obesity was defined according to the NCEP/ATPIII and IDF guidelines. The prevalence of obesity was determined cross-sectionally. Disease activity was evaluated using the DAS28 system (remission < 2.6; low 2.6–3.1; moderate 3.2–5.0; high > 5.1).Results: The sample consisted of 791 RA patients aged 54.7 ± 12.0 years, of whom 86.9% were women and 59.9% wereCaucasian. The mean disease duration was 12.8 ± 8.9 years. Three quarters were rheumatoid factor-positive, the mean body mass index (BMI) was 27.1 ± 4.9, and the mean WC was 93.5 ± 12.5 cm. The observed risk factors included dyslipidemia(34.3%), type-2 diabetes (15%), hypertension (49.2%) and family history of premature cardiovascular disease (16.5%). BMI defined obesity was highly prevalent (26.9%) and associated with age, hypertension and dyslipidemia. Increased WC was associated with diabetes, hypertension, dyslipidemia and disease activity. Conclusion: Obesity was highly prevalent in RA patients and associated with disease activity