Are the anatomical, clinical, and ultrasound characteristics of thyroid nodules with Bethesda III or IV cytology and ACR TI-RADS 3, 4, or 5 able to refine the indications for molecular diagnostic tests?
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFMG |
Texto Completo: | https://doi.org/10.20945/2359-3997000000402 http://hdl.handle.net/1843/52612 https://orcid.org/0000-0003-2125-7051 https://orcid.org/0000-0003-3227-1799 https://orcid.org/0000-0003-3312-4002 https://orcid.org/0000-0001-7971-5786 |
Resumo: | Objective: To analyze the association of clinical, anatomical, and ultrasound (US) characteristics of malignancies in Bethesda III or IV (III-B or IV-B) thyroid nodules. Subjects and methods: The association between malignancies and the following variables were analyzed: III-B or IV-B, age < 55 years and ≥ 55 years, sex, family history of thyroid cancer, history of irradiation, nodule size, and ACR TI-RADS classification in 62 participants who underwent thyroidectomy. Results: Of the 62 participants, 87.1% (54/62) were women, 74.2% were < 55 years old, 95.2% had no family history of thyroid cancer, 56.5% had nodules < 2 cm in size, 62.9% were IV-B, and 69.4% were ACR TI-RADS 4. Thirty-two patients had thyroid carcinoma, and 30 had benign histology. Among all factors associated with malignancy, only ACR TI-RADS 5 classification on US was found to be statistically significant (p = 0.014), while III-B with architectural atypia cytological classification was the only one significantly associated with benign status (p = 0.004). Conclusion: Only a high risk of malignancy as assessed using US was able to refine the indication for molecular tests in a group of patients with indeterminate nodules. We found 85% (53/62) of III-B or IV-B thyroid nodules would benefit from available molecular diagnostic tests. |
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2023-04-27T19:53:58Z2023-04-27T19:53:58Z2021-09-29655625631https://doi.org/10.20945/2359-39970000004022359-4292http://hdl.handle.net/1843/52612https://orcid.org/0000-0003-2125-7051https://orcid.org/0000-0003-3227-1799https://orcid.org/0000-0003-3312-4002https://orcid.org/0000-0001-7971-5786Objective: To analyze the association of clinical, anatomical, and ultrasound (US) characteristics of malignancies in Bethesda III or IV (III-B or IV-B) thyroid nodules. Subjects and methods: The association between malignancies and the following variables were analyzed: III-B or IV-B, age < 55 years and ≥ 55 years, sex, family history of thyroid cancer, history of irradiation, nodule size, and ACR TI-RADS classification in 62 participants who underwent thyroidectomy. Results: Of the 62 participants, 87.1% (54/62) were women, 74.2% were < 55 years old, 95.2% had no family history of thyroid cancer, 56.5% had nodules < 2 cm in size, 62.9% were IV-B, and 69.4% were ACR TI-RADS 4. Thirty-two patients had thyroid carcinoma, and 30 had benign histology. Among all factors associated with malignancy, only ACR TI-RADS 5 classification on US was found to be statistically significant (p = 0.014), while III-B with architectural atypia cytological classification was the only one significantly associated with benign status (p = 0.004). Conclusion: Only a high risk of malignancy as assessed using US was able to refine the indication for molecular tests in a group of patients with indeterminate nodules. We found 85% (53/62) of III-B or IV-B thyroid nodules would benefit from available molecular diagnostic tests.Objetivo: Analisar a associação das características clínicas, anatômicas e ultrassonográficas (US) das neoplasias em nódulos tireoidianos Bethesda III ou IV (III-B ou IV-B). Sujeitos e métodos: Foi analisada a associação entre malignidades e as seguintes variáveis: III-B ou IV-B, idade < 55 anos e ≥ 55 anos, sexo, história familiar de câncer de tireoide, história de irradiação, tamanho do nódulo e ACR TI -Classificação RADS em 62 participantes submetidos à tireoidectomia. Resultados: Dos 62 participantes, 87,1% (54/62) eram mulheres, 74,2% tinham < 55 anos, 95,2% não tinham histórico familiar de câncer de tireoide, 56,5% tinham nódulos < 2 cm de tamanho, 62,9% eram IV- B, e 69,4% eram ACR TI-RADS 4. Trinta e dois pacientes tinham carcinoma de tireoide e 30 tinham histologia benigna. Entre todos os fatores associados à malignidade, apenas a classificação ACR TI-RADS 5 na US foi estatisticamente significativa (p = 0,014), enquanto a classificação citológica III-B com atipia arquitetônica foi a única significativamente associada ao estado benigno (p = 0,004 ). Conclusão: Somente o alto risco de malignidade avaliado pela US foi capaz de refinar a indicação de testes moleculares em um grupo de pacientes com nódulos indeterminados. Descobrimos que 85% (53/62) dos nódulos tireoidianos III-B ou IV-B se beneficiariam com os testes de diagnóstico molecular disponíveis.engUniversidade Federal de Minas GeraisUFMGBrasilICX - DEPARTAMENTO DE ESTATÍSTICAMED - DEPARTAMENTO DE CIRURGIAMED - DEPARTAMENTO DE CLÍNICA MÉDICAMEDICINA - FACULDADE DE MEDICINAArchives of Endocrinology and MetabolismNódulo da glândula tireoideTécnicas de diagnóstico molecularNeoplasiasThyroid nodulesIndeterminate nodulesIndeterminate thyroid nodulesMolecular testsMolecular diagnostic testsAre the anatomical, clinical, and ultrasound characteristics of thyroid nodules with Bethesda III or IV cytology and ACR TI-RADS 3, 4, or 5 able to refine the indications for molecular diagnostic tests?São os aspectos anatômicos, clínicos e características ultrassonográficas de nódulos da tireoide com Bethesda III ou IV citologia e ACR TI-RADS 3, 4 ou 5 capaz de refinar as indicações para testes de diagnóstico molecular?info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://www.aem-sbem.com/article/are-the-anatomical-clinical-and-ultrasound-characteristics-of-thyroid-nodules-with-bethesda-iii-or-iv-cytology-and-acr-ti-rads-3-4-or-5-able-to-refine-the-indications-for-molecular-diagnostic-test/Gustavo Cancela e PennaCamila Teixeira CostaMagda Carvalho PiresTarcizo Afonso Nunesapplication/pdfinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMGLICENSELicense.txtLicense.txttext/plain; charset=utf-82042https://repositorio.ufmg.br/bitstream/1843/52612/1/License.txtfa505098d172de0bc8864fc1287ffe22MD51ORIGINALAre the anatomical, clinical, and ultrasound characteristics of thyroid nodules with Bethesda III or IV cytology and ACR TI-RADS 3, 4, or 5 able to refine the indications for molecular diagnostic tests.pdfAre the anatomical, clinical, and ultrasound characteristics of thyroid nodules with Bethesda III or IV cytology and ACR TI-RADS 3, 4, or 5 able to refine the indications for molecular diagnostic tests.pdfapplication/pdf114481https://repositorio.ufmg.br/bitstream/1843/52612/2/Are%20the%20anatomical%2c%20clinical%2c%20and%20ultrasound%20characteristics%20of%20thyroid%20nodules%20with%20Bethesda%20III%20or%20IV%20cytology%20and%20ACR%20TI-RADS%203%2c%204%2c%20or%205%20able%20to%20refine%20the%20indications%20for%20molecular%20diagnostic%20tests.pdf95b656bea485dbe4095984bdbdc7e962MD521843/526122023-04-27 16:53:58.26oai:repositorio.ufmg.br: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Repositório de PublicaçõesPUBhttps://repositorio.ufmg.br/oaiopendoar:2023-04-27T19:53:58Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)false |
dc.title.pt_BR.fl_str_mv |
Are the anatomical, clinical, and ultrasound characteristics of thyroid nodules with Bethesda III or IV cytology and ACR TI-RADS 3, 4, or 5 able to refine the indications for molecular diagnostic tests? |
dc.title.alternative.pt_BR.fl_str_mv |
São os aspectos anatômicos, clínicos e características ultrassonográficas de nódulos da tireoide com Bethesda III ou IV citologia e ACR TI-RADS 3, 4 ou 5 capaz de refinar as indicações para testes de diagnóstico molecular? |
title |
Are the anatomical, clinical, and ultrasound characteristics of thyroid nodules with Bethesda III or IV cytology and ACR TI-RADS 3, 4, or 5 able to refine the indications for molecular diagnostic tests? |
spellingShingle |
Are the anatomical, clinical, and ultrasound characteristics of thyroid nodules with Bethesda III or IV cytology and ACR TI-RADS 3, 4, or 5 able to refine the indications for molecular diagnostic tests? Gustavo Cancela e Penna Thyroid nodules Indeterminate nodules Indeterminate thyroid nodules Molecular tests Molecular diagnostic tests Nódulo da glândula tireoide Técnicas de diagnóstico molecular Neoplasias |
title_short |
Are the anatomical, clinical, and ultrasound characteristics of thyroid nodules with Bethesda III or IV cytology and ACR TI-RADS 3, 4, or 5 able to refine the indications for molecular diagnostic tests? |
title_full |
Are the anatomical, clinical, and ultrasound characteristics of thyroid nodules with Bethesda III or IV cytology and ACR TI-RADS 3, 4, or 5 able to refine the indications for molecular diagnostic tests? |
title_fullStr |
Are the anatomical, clinical, and ultrasound characteristics of thyroid nodules with Bethesda III or IV cytology and ACR TI-RADS 3, 4, or 5 able to refine the indications for molecular diagnostic tests? |
title_full_unstemmed |
Are the anatomical, clinical, and ultrasound characteristics of thyroid nodules with Bethesda III or IV cytology and ACR TI-RADS 3, 4, or 5 able to refine the indications for molecular diagnostic tests? |
title_sort |
Are the anatomical, clinical, and ultrasound characteristics of thyroid nodules with Bethesda III or IV cytology and ACR TI-RADS 3, 4, or 5 able to refine the indications for molecular diagnostic tests? |
author |
Gustavo Cancela e Penna |
author_facet |
Gustavo Cancela e Penna Camila Teixeira Costa Magda Carvalho Pires Tarcizo Afonso Nunes |
author_role |
author |
author2 |
Camila Teixeira Costa Magda Carvalho Pires Tarcizo Afonso Nunes |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Gustavo Cancela e Penna Camila Teixeira Costa Magda Carvalho Pires Tarcizo Afonso Nunes |
dc.subject.por.fl_str_mv |
Thyroid nodules Indeterminate nodules Indeterminate thyroid nodules Molecular tests Molecular diagnostic tests |
topic |
Thyroid nodules Indeterminate nodules Indeterminate thyroid nodules Molecular tests Molecular diagnostic tests Nódulo da glândula tireoide Técnicas de diagnóstico molecular Neoplasias |
dc.subject.other.pt_BR.fl_str_mv |
Nódulo da glândula tireoide Técnicas de diagnóstico molecular Neoplasias |
description |
Objective: To analyze the association of clinical, anatomical, and ultrasound (US) characteristics of malignancies in Bethesda III or IV (III-B or IV-B) thyroid nodules. Subjects and methods: The association between malignancies and the following variables were analyzed: III-B or IV-B, age < 55 years and ≥ 55 years, sex, family history of thyroid cancer, history of irradiation, nodule size, and ACR TI-RADS classification in 62 participants who underwent thyroidectomy. Results: Of the 62 participants, 87.1% (54/62) were women, 74.2% were < 55 years old, 95.2% had no family history of thyroid cancer, 56.5% had nodules < 2 cm in size, 62.9% were IV-B, and 69.4% were ACR TI-RADS 4. Thirty-two patients had thyroid carcinoma, and 30 had benign histology. Among all factors associated with malignancy, only ACR TI-RADS 5 classification on US was found to be statistically significant (p = 0.014), while III-B with architectural atypia cytological classification was the only one significantly associated with benign status (p = 0.004). Conclusion: Only a high risk of malignancy as assessed using US was able to refine the indication for molecular tests in a group of patients with indeterminate nodules. We found 85% (53/62) of III-B or IV-B thyroid nodules would benefit from available molecular diagnostic tests. |
publishDate |
2021 |
dc.date.issued.fl_str_mv |
2021-09-29 |
dc.date.accessioned.fl_str_mv |
2023-04-27T19:53:58Z |
dc.date.available.fl_str_mv |
2023-04-27T19:53:58Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1843/52612 |
dc.identifier.doi.pt_BR.fl_str_mv |
https://doi.org/10.20945/2359-3997000000402 |
dc.identifier.issn.pt_BR.fl_str_mv |
2359-4292 |
dc.identifier.orcid.pt_BR.fl_str_mv |
https://orcid.org/0000-0003-2125-7051 https://orcid.org/0000-0003-3227-1799 https://orcid.org/0000-0003-3312-4002 https://orcid.org/0000-0001-7971-5786 |
url |
https://doi.org/10.20945/2359-3997000000402 http://hdl.handle.net/1843/52612 https://orcid.org/0000-0003-2125-7051 https://orcid.org/0000-0003-3227-1799 https://orcid.org/0000-0003-3312-4002 https://orcid.org/0000-0001-7971-5786 |
identifier_str_mv |
2359-4292 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
Archives of Endocrinology and Metabolism |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
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application/pdf |
dc.publisher.none.fl_str_mv |
Universidade Federal de Minas Gerais |
dc.publisher.initials.fl_str_mv |
UFMG |
dc.publisher.country.fl_str_mv |
Brasil |
dc.publisher.department.fl_str_mv |
ICX - DEPARTAMENTO DE ESTATÍSTICA MED - DEPARTAMENTO DE CIRURGIA MED - DEPARTAMENTO DE CLÍNICA MÉDICA MEDICINA - FACULDADE DE MEDICINA |
publisher.none.fl_str_mv |
Universidade Federal de Minas Gerais |
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reponame:Repositório Institucional da UFMG instname:Universidade Federal de Minas Gerais (UFMG) instacron:UFMG |
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Universidade Federal de Minas Gerais (UFMG) |
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UFMG |
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UFMG |
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