Prevalence of latent mycobacterium tuberculosis infection in renal transplant recipients

• Autor(a) principal: Mônica Maria Moreira Delgadomaciel
• Data de Publicação: 2018
• Outros Autores: Maria Das Graças Braga Ceccato, Wânia da Silva Carvalho, Pedro Daibert de Navarro, Kátia de Paula Farah, Silvana Spindola de Miranda
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UFMG
• Texto Completo: http://hdl.handle.net/1843/61882
• topic: Tuberculosis; Tuberculin Test; Immunocompromised Host; Tuberculosis; Tuberculin Test; Immunocompromised Host

Objective: To estimate the prevalence of latent Mycobacterium tuberculosis infection (LTBI) in renal transplant recipients and to assess sociodemographic, behavioral, and clinical associations with positive tuberculin skin test (TST) results. Methods: This was a cross-sectional study of patients aged ≥ 18 years who underwent renal transplantation at the Renal Transplant Center of the Federal University of Minas Gerais Hospital das Clínicas, located in the city of Belo Horizonte, Brazil. We included renal transplant recipients who underwent the TST between January 2011 and July 2013. If the result of the fi rst TST was negative, a second TST was administered. Bivariate and multivariate analyses using logistic regression were used to determine factors associated with positive TST results. Results: The sample included 216 patients. The prevalence of LTBI was 18.5%. In the multivariate analysis, history of contact with a tuberculosis case and preserved graft function (estimated glomerular fi ltration rate ≥ 60 mL/min/1.73 m2) were associated with positive TST results. TST induration increased by 5.8% from the first to the second test, which was considered signifi cant (p = 0.012). Conclusions:The prevalence of LTBI was low in this sample of renal transplant recipients. The TST should be administered if renal graft function is preserved. A second TST should be administered if the fi rst TST is negative.