Zebrafish as a model to study inflammation: a tool for drug discovery
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFMG |
Texto Completo: | https://doi.org/10.1016/j.biopha.2021.112310 http://hdl.handle.net/1843/54822 |
Resumo: | Zebrafish is a small teleost (bony) fish used in many areas of pharmacology and toxicology. This animal model has advantages for the discovery of anti-inflammatory drugs, such as the potential for real-time assessment of cell migration mechanisms. Additionally, zebrafish display a repertoire of inflammatory cells, mediators, and receptors that are similar to those in mammals, including humans. Inflammatory disease modeling in either larvae or adult zebrafish represents a promising tool for the screening of new anti-inflammatory compounds, contributing to our understanding of the mechanisms involved in chronic inflammatory conditions. In this review, we provide an overview of the characterization of inflammatory responses in zebrafish, emphasizing its relevance for drug discovery in this research area. |
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2023-06-12T13:09:05Z2023-06-12T13:09:05Z2021-12144116https://doi.org/10.1016/j.biopha.2021.1123100753-3322http://hdl.handle.net/1843/54822Zebrafish is a small teleost (bony) fish used in many areas of pharmacology and toxicology. This animal model has advantages for the discovery of anti-inflammatory drugs, such as the potential for real-time assessment of cell migration mechanisms. Additionally, zebrafish display a repertoire of inflammatory cells, mediators, and receptors that are similar to those in mammals, including humans. Inflammatory disease modeling in either larvae or adult zebrafish represents a promising tool for the screening of new anti-inflammatory compounds, contributing to our understanding of the mechanisms involved in chronic inflammatory conditions. In this review, we provide an overview of the characterization of inflammatory responses in zebrafish, emphasizing its relevance for drug discovery in this research area.Zebrafish é um pequeno peixe teleósteo (ósseo) usado em muitas áreas da farmacologia e toxicologia. Este modelo animal tem vantagens para a descoberta de anti-inflamatórios, como o potencial para avaliação em tempo real de mecanismos de migração celular. Além disso, o peixe-zebra exibe um repertório de células inflamatórias, mediadores e receptores semelhantes aos dos mamíferos, incluindo humanos. Modelagem de doenças inflamatórias em larvas ou peixe-zebra adulto representa uma ferramenta promissora para a triagem de novos compostos anti-inflamatórios, contribuindo para a nossa compreensão os mecanismos envolvidos nas condições inflamatórias crônicas. Nessa revisão, fornecemos uma visão geral da caracterização de doenças inflamatórias respostas em peixe-zebra, enfatizando sua relevância para a descoberta de drogas neste área de pesquisa.CNPq - Conselho Nacional de Desenvolvimento Científico e TecnológicoFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas GeraisFAPESP - Fundação de Amparo à Pesquisa do Estado de São PauloengUniversidade Federal de Minas GeraisUFMGBrasilFAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICASICB - DEPARTAMENTO DE FARMACOLOGIAICB - DEPARTAMENTO DE MORFOLOGIAVET - DEPARTAMENTO DE ZOOTECNIABiomedicine & PharmacotherapyPeixe-zebraImunidade inataInflamaçãoAnti-inflamatóriosReação a corpo estranhoTransplante heterólogoInflamatory reactionTeleost fishInnate immunityAccute and chronic inflamationForeing body reactionXenotransplantationZebrafish as a model to study inflammation: a tool for drug discoveryinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://www.sciencedirect.com/science/article/pii/S0753332221010945Marco Antonio de Andrade BeloMelque Ferrari de OliveiraSusana Luporini de OliveiraMayumi Fernanda AracatiLetícia Franchin RodriguesCamila Carlino da CostaGabriel CondeJuliana Moreira Mendonça GomesMariana Nathuê Lôbo PrataAyslan BarraThalita Marcolan ValverdeDaniela Chemim de Melo HoyosSilas Fernandes EtoDayanne Carla FernandesMarina Gomes Miranda e Castor RomeroJosé Dias Corrêa JuniorJuliana de Oliveira SilvaAndré Luís Branco de BarrosAndrea de Castro PerezIves Charlie da Silvaapplication/pdfinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMGLICENSELicense.txtLicense.txttext/plain; charset=utf-82042https://repositorio.ufmg.br/bitstream/1843/54822/1/License.txtfa505098d172de0bc8864fc1287ffe22MD51ORIGINALZebrafish as a model to study inflammation a tool for drug discovery.pdfZebrafish as a model to study inflammation a tool for drug discovery.pdfapplication/pdf15391777https://repositorio.ufmg.br/bitstream/1843/54822/2/Zebrafish%20as%20a%20model%20to%20study%20inflammation%20a%20tool%20for%20drug%20discovery.pdfd9242aba1fa4fff614863fd40f076735MD521843/548222023-06-12 16:32:10.713oai:repositorio.ufmg.br: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Repositório de PublicaçõesPUBhttps://repositorio.ufmg.br/oaiopendoar:2023-06-12T19:32:10Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)false |
dc.title.pt_BR.fl_str_mv |
Zebrafish as a model to study inflammation: a tool for drug discovery |
title |
Zebrafish as a model to study inflammation: a tool for drug discovery |
spellingShingle |
Zebrafish as a model to study inflammation: a tool for drug discovery Marco Antonio de Andrade Belo Inflamatory reaction Teleost fish Innate immunity Accute and chronic inflamation Foreing body reaction Xenotransplantation Peixe-zebra Imunidade inata Inflamação Anti-inflamatórios Reação a corpo estranho Transplante heterólogo |
title_short |
Zebrafish as a model to study inflammation: a tool for drug discovery |
title_full |
Zebrafish as a model to study inflammation: a tool for drug discovery |
title_fullStr |
Zebrafish as a model to study inflammation: a tool for drug discovery |
title_full_unstemmed |
Zebrafish as a model to study inflammation: a tool for drug discovery |
title_sort |
Zebrafish as a model to study inflammation: a tool for drug discovery |
author |
Marco Antonio de Andrade Belo |
author_facet |
Marco Antonio de Andrade Belo Melque Ferrari de Oliveira Susana Luporini de Oliveira Mayumi Fernanda Aracati Letícia Franchin Rodrigues Camila Carlino da Costa Gabriel Conde Juliana Moreira Mendonça Gomes Mariana Nathuê Lôbo Prata Ayslan Barra Thalita Marcolan Valverde Daniela Chemim de Melo Hoyos Silas Fernandes Eto Dayanne Carla Fernandes Marina Gomes Miranda e Castor Romero José Dias Corrêa Junior Juliana de Oliveira Silva André Luís Branco de Barros Andrea de Castro Perez Ives Charlie da Silva |
author_role |
author |
author2 |
Melque Ferrari de Oliveira Susana Luporini de Oliveira Mayumi Fernanda Aracati Letícia Franchin Rodrigues Camila Carlino da Costa Gabriel Conde Juliana Moreira Mendonça Gomes Mariana Nathuê Lôbo Prata Ayslan Barra Thalita Marcolan Valverde Daniela Chemim de Melo Hoyos Silas Fernandes Eto Dayanne Carla Fernandes Marina Gomes Miranda e Castor Romero José Dias Corrêa Junior Juliana de Oliveira Silva André Luís Branco de Barros Andrea de Castro Perez Ives Charlie da Silva |
author2_role |
author author author author author author author author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Marco Antonio de Andrade Belo Melque Ferrari de Oliveira Susana Luporini de Oliveira Mayumi Fernanda Aracati Letícia Franchin Rodrigues Camila Carlino da Costa Gabriel Conde Juliana Moreira Mendonça Gomes Mariana Nathuê Lôbo Prata Ayslan Barra Thalita Marcolan Valverde Daniela Chemim de Melo Hoyos Silas Fernandes Eto Dayanne Carla Fernandes Marina Gomes Miranda e Castor Romero José Dias Corrêa Junior Juliana de Oliveira Silva André Luís Branco de Barros Andrea de Castro Perez Ives Charlie da Silva |
dc.subject.por.fl_str_mv |
Inflamatory reaction Teleost fish Innate immunity Accute and chronic inflamation Foreing body reaction Xenotransplantation |
topic |
Inflamatory reaction Teleost fish Innate immunity Accute and chronic inflamation Foreing body reaction Xenotransplantation Peixe-zebra Imunidade inata Inflamação Anti-inflamatórios Reação a corpo estranho Transplante heterólogo |
dc.subject.other.pt_BR.fl_str_mv |
Peixe-zebra Imunidade inata Inflamação Anti-inflamatórios Reação a corpo estranho Transplante heterólogo |
description |
Zebrafish is a small teleost (bony) fish used in many areas of pharmacology and toxicology. This animal model has advantages for the discovery of anti-inflammatory drugs, such as the potential for real-time assessment of cell migration mechanisms. Additionally, zebrafish display a repertoire of inflammatory cells, mediators, and receptors that are similar to those in mammals, including humans. Inflammatory disease modeling in either larvae or adult zebrafish represents a promising tool for the screening of new anti-inflammatory compounds, contributing to our understanding of the mechanisms involved in chronic inflammatory conditions. In this review, we provide an overview of the characterization of inflammatory responses in zebrafish, emphasizing its relevance for drug discovery in this research area. |
publishDate |
2021 |
dc.date.issued.fl_str_mv |
2021-12 |
dc.date.accessioned.fl_str_mv |
2023-06-12T13:09:05Z |
dc.date.available.fl_str_mv |
2023-06-12T13:09:05Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1843/54822 |
dc.identifier.doi.pt_BR.fl_str_mv |
https://doi.org/10.1016/j.biopha.2021.112310 |
dc.identifier.issn.pt_BR.fl_str_mv |
0753-3322 |
url |
https://doi.org/10.1016/j.biopha.2021.112310 http://hdl.handle.net/1843/54822 |
identifier_str_mv |
0753-3322 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.none.fl_str_mv |
Biomedicine & Pharmacotherapy |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
dc.publisher.none.fl_str_mv |
Universidade Federal de Minas Gerais |
dc.publisher.initials.fl_str_mv |
UFMG |
dc.publisher.country.fl_str_mv |
Brasil |
dc.publisher.department.fl_str_mv |
FAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICAS ICB - DEPARTAMENTO DE FARMACOLOGIA ICB - DEPARTAMENTO DE MORFOLOGIA VET - DEPARTAMENTO DE ZOOTECNIA |
publisher.none.fl_str_mv |
Universidade Federal de Minas Gerais |
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reponame:Repositório Institucional da UFMG instname:Universidade Federal de Minas Gerais (UFMG) instacron:UFMG |
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