Stem cell therapy for diabetic foot ulcers: a review of preclinical and clinical research
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFMG |
Texto Completo: | https://doi.org/10.1186/s13287-018-0938-6 http://hdl.handle.net/1843/56546 https://orcid.org/0000-0001-8134-5825 |
Resumo: | Background: Diabetic foot ulcer (DFU) is a severe complication of diabetes, preceding most diabetes-related amputations. DFUs require over US$9 billion for yearly treatment and are now a global public health issue. DFU occurs in the setting of ischemia, infection, neuropathy, and metabolic disorders that result in poor wound healing and poor treatment options. Recently, stem cell therapy has emerged as a new interventional strategy to treat DFU and appears to be safe and effective in both preclinical and clinical trials. However, variability in the stem cell type and origin, route and protocol for administration, and concomitant use of angioplasty confound easy interpretation and generalization of the results. Methods: The PubMed, Google Scholar, and EMBASE databases were searched and 89 preclinical and clinical studies were selected for analysis. Results: There was divergence between preclinical and clinical studies regarding stem cell type, origin, and delivery techniques. There was heterogeneous preclinical and clinical study design and few randomized clinical trials. Granulocyte-colony stimulating factor was employed in some studies but with differing protocols. Concomitant performance of angioplasty with stem cell therapy showed increased efficiency compared to either therapy alone. Conclusions: Stem cell therapy is an effective treatment for diabetic foot ulcers and is currently used as an alternative to amputation for some patients without other options for revascularization. Concordance between preclinical and clinical studies may help design future randomized clinical trials. |
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2023-07-17T21:48:34Z2023-07-17T21:48:34Z20189118816https://doi.org/10.1186/s13287-018-0938-61757-6512http://hdl.handle.net/1843/56546https://orcid.org/0000-0001-8134-5825Background: Diabetic foot ulcer (DFU) is a severe complication of diabetes, preceding most diabetes-related amputations. DFUs require over US$9 billion for yearly treatment and are now a global public health issue. DFU occurs in the setting of ischemia, infection, neuropathy, and metabolic disorders that result in poor wound healing and poor treatment options. Recently, stem cell therapy has emerged as a new interventional strategy to treat DFU and appears to be safe and effective in both preclinical and clinical trials. However, variability in the stem cell type and origin, route and protocol for administration, and concomitant use of angioplasty confound easy interpretation and generalization of the results. Methods: The PubMed, Google Scholar, and EMBASE databases were searched and 89 preclinical and clinical studies were selected for analysis. Results: There was divergence between preclinical and clinical studies regarding stem cell type, origin, and delivery techniques. There was heterogeneous preclinical and clinical study design and few randomized clinical trials. Granulocyte-colony stimulating factor was employed in some studies but with differing protocols. Concomitant performance of angioplasty with stem cell therapy showed increased efficiency compared to either therapy alone. Conclusions: Stem cell therapy is an effective treatment for diabetic foot ulcers and is currently used as an alternative to amputation for some patients without other options for revascularization. Concordance between preclinical and clinical studies may help design future randomized clinical trials.engUniversidade Federal de Minas GeraisUFMGBrasilMED - DEPARTAMENTO DE CIRURGIAStem Cell Research TherapyAmputaçãoCicatrizaçãoIsquemia Crônica Crítica de MembroDiabetes MellitusStem cell therapyCell therapyDiabetic foot ulcerDiabetic woundCritical limb ischemiaWound healingAmputationStem cell therapy for diabetic foot ulcers: a review of preclinical and clinical researchinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://stemcellres.biomedcentral.com/articles/10.1186/s13287-018-0938-6Lara LopesXiangjiang GuoBogdan YatsulaJianming GuoYongquan guTúlio Pinho NavarroAlan DardikOcean SetiaAfsha AurshinaShirley LiuHaidi huToshihiko IsajiHaiyang LiuTun WangShun Onoapplication/pdfinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMGLICENSELicense.txtLicense.txttext/plain; charset=utf-82042https://repositorio.ufmg.br/bitstream/1843/56546/1/License.txtfa505098d172de0bc8864fc1287ffe22MD51ORIGINALStem cell therapy for diabetic foot ulcers_ a review of preclinical and clinical research.pdfStem cell therapy for diabetic foot ulcers_ a review of preclinical and clinical research.pdfapplication/pdf854318https://repositorio.ufmg.br/bitstream/1843/56546/2/Stem%20cell%20therapy%20for%20diabetic%20foot%20ulcers_%20a%20review%20of%20preclinical%20and%20clinical%20research.pdf0fbc108188509f0796a779e233fa5fb5MD521843/565462023-07-17 18:49:01.623oai:repositorio.ufmg.br:1843/56546TElDRU7vv71BIERFIERJU1RSSUJVSe+/ve+/vU8gTu+/vU8tRVhDTFVTSVZBIERPIFJFUE9TSVTvv71SSU8gSU5TVElUVUNJT05BTCBEQSBVRk1HCiAKCkNvbSBhIGFwcmVzZW50Ye+/ve+/vW8gZGVzdGEgbGljZW7vv71hLCB2b2Pvv70gKG8gYXV0b3IgKGVzKSBvdSBvIHRpdHVsYXIgZG9zIGRpcmVpdG9zIGRlIGF1dG9yKSBjb25jZWRlIGFvIFJlcG9zaXTvv71yaW8gSW5zdGl0dWNpb25hbCBkYSBVRk1HIChSSS1VRk1HKSBvIGRpcmVpdG8gbu+/vW8gZXhjbHVzaXZvIGUgaXJyZXZvZ++/vXZlbCBkZSByZXByb2R1emlyIGUvb3UgZGlzdHJpYnVpciBhIHN1YSBwdWJsaWNh77+977+9byAoaW5jbHVpbmRvIG8gcmVzdW1vKSBwb3IgdG9kbyBvIG11bmRvIG5vIGZvcm1hdG8gaW1wcmVzc28gZSBlbGV0cu+/vW5pY28gZSBlbSBxdWFscXVlciBtZWlvLCBpbmNsdWluZG8gb3MgZm9ybWF0b3Mg77+9dWRpbyBvdSB277+9ZGVvLgoKVm9j77+9IGRlY2xhcmEgcXVlIGNvbmhlY2UgYSBwb2zvv710aWNhIGRlIGNvcHlyaWdodCBkYSBlZGl0b3JhIGRvIHNldSBkb2N1bWVudG8gZSBxdWUgY29uaGVjZSBlIGFjZWl0YSBhcyBEaXJldHJpemVzIGRvIFJJLVVGTUcuCgpWb2Pvv70gY29uY29yZGEgcXVlIG8gUmVwb3NpdO+/vXJpbyBJbnN0aXR1Y2lvbmFsIGRhIFVGTUcgcG9kZSwgc2VtIGFsdGVyYXIgbyBjb250Ze+/vWRvLCB0cmFuc3BvciBhIHN1YSBwdWJsaWNh77+977+9byBwYXJhIHF1YWxxdWVyIG1laW8gb3UgZm9ybWF0byBwYXJhIGZpbnMgZGUgcHJlc2VydmHvv73vv71vLgoKVm9j77+9IHRhbWLvv71tIGNvbmNvcmRhIHF1ZSBvIFJlcG9zaXTvv71yaW8gSW5zdGl0dWNpb25hbCBkYSBVRk1HIHBvZGUgbWFudGVyIG1haXMgZGUgdW1hIGPvv71waWEgZGUgc3VhIHB1YmxpY2Hvv73vv71vIHBhcmEgZmlucyBkZSBzZWd1cmFu77+9YSwgYmFjay11cCBlIHByZXNlcnZh77+977+9by4KClZvY++/vSBkZWNsYXJhIHF1ZSBhIHN1YSBwdWJsaWNh77+977+9byDvv70gb3JpZ2luYWwgZSBxdWUgdm9j77+9IHRlbSBvIHBvZGVyIGRlIGNvbmNlZGVyIG9zIGRpcmVpdG9zIGNvbnRpZG9zIG5lc3RhIGxpY2Vu77+9YS4gVm9j77+9IHRhbWLvv71tIGRlY2xhcmEgcXVlIG8gZGVw77+9c2l0byBkZSBzdWEgcHVibGljYe+/ve+/vW8gbu+/vW8sIHF1ZSBzZWphIGRlIHNldSBjb25oZWNpbWVudG8sIGluZnJpbmdlIGRpcmVpdG9zIGF1dG9yYWlzIGRlIG5pbmd177+9bS4KCkNhc28gYSBzdWEgcHVibGljYe+/ve+/vW8gY29udGVuaGEgbWF0ZXJpYWwgcXVlIHZvY++/vSBu77+9byBwb3NzdWkgYSB0aXR1bGFyaWRhZGUgZG9zIGRpcmVpdG9zIGF1dG9yYWlzLCB2b2Pvv70gZGVjbGFyYSBxdWUgb2J0ZXZlIGEgcGVybWlzc++/vW8gaXJyZXN0cml0YSBkbyBkZXRlbnRvciBkb3MgZGlyZWl0b3MgYXV0b3JhaXMgcGFyYSBjb25jZWRlciBhbyBSZXBvc2l077+9cmlvIEluc3RpdHVjaW9uYWwgZGEgVUZNRyBvcyBkaXJlaXRvcyBhcHJlc2VudGFkb3MgbmVzdGEgbGljZW7vv71hLCBlIHF1ZSBlc3NlIG1hdGVyaWFsIGRlIHByb3ByaWVkYWRlIGRlIHRlcmNlaXJvcyBlc3Tvv70gY2xhcmFtZW50ZSBpZGVudGlmaWNhZG8gZSByZWNvbmhlY2lkbyBubyB0ZXh0byBvdSBubyBjb250Ze+/vWRvIGRhIHB1YmxpY2Hvv73vv71vIG9yYSBkZXBvc2l0YWRhLgoKQ0FTTyBBIFBVQkxJQ0Hvv73vv71PIE9SQSBERVBPU0lUQURBIFRFTkhBIFNJRE8gUkVTVUxUQURPIERFIFVNIFBBVFJPQ++/vU5JTyBPVSBBUE9JTyBERSBVTUEgQUfvv71OQ0lBIERFIEZPTUVOVE8gT1UgT1VUUk8gT1JHQU5JU01PLCBWT0Pvv70gREVDTEFSQSBRVUUgUkVTUEVJVE9VIFRPRE9TIEUgUVVBSVNRVUVSIERJUkVJVE9TIERFIFJFVklT77+9TyBDT01PIFRBTULvv71NIEFTIERFTUFJUyBPQlJJR0Hvv73vv71FUyBFWElHSURBUyBQT1IgQ09OVFJBVE8gT1UgQUNPUkRPLgoKTyBSZXBvc2l077+9cmlvIEluc3RpdHVjaW9uYWwgZGEgVUZNRyBzZSBjb21wcm9tZXRlIGEgaWRlbnRpZmljYXIgY2xhcmFtZW50ZSBvIHNldSBub21lKHMpIG91IG8ocykgbm9tZXMocykgZG8ocykgZGV0ZW50b3IoZXMpIGRvcyBkaXJlaXRvcyBhdXRvcmFpcyBkYSBwdWJsaWNh77+977+9bywgZSBu77+9byBmYXLvv70gcXVhbHF1ZXIgYWx0ZXJh77+977+9bywgYWzvv71tIGRhcXVlbGFzIGNvbmNlZGlkYXMgcG9yIGVzdGEgbGljZW7vv71hLgo=Repositório de PublicaçõesPUBhttps://repositorio.ufmg.br/oaiopendoar:2023-07-17T21:49:01Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)false |
dc.title.pt_BR.fl_str_mv |
Stem cell therapy for diabetic foot ulcers: a review of preclinical and clinical research |
title |
Stem cell therapy for diabetic foot ulcers: a review of preclinical and clinical research |
spellingShingle |
Stem cell therapy for diabetic foot ulcers: a review of preclinical and clinical research Lara Lopes Stem cell therapy Cell therapy Diabetic foot ulcer Diabetic wound Critical limb ischemia Wound healing Amputation Amputação Cicatrização Isquemia Crônica Crítica de Membro Diabetes Mellitus |
title_short |
Stem cell therapy for diabetic foot ulcers: a review of preclinical and clinical research |
title_full |
Stem cell therapy for diabetic foot ulcers: a review of preclinical and clinical research |
title_fullStr |
Stem cell therapy for diabetic foot ulcers: a review of preclinical and clinical research |
title_full_unstemmed |
Stem cell therapy for diabetic foot ulcers: a review of preclinical and clinical research |
title_sort |
Stem cell therapy for diabetic foot ulcers: a review of preclinical and clinical research |
author |
Lara Lopes |
author_facet |
Lara Lopes Xiangjiang Guo Bogdan Yatsula Jianming Guo Yongquan gu Túlio Pinho Navarro Alan Dardik Ocean Setia Afsha Aurshina Shirley Liu Haidi hu Toshihiko Isaji Haiyang Liu Tun Wang Shun Ono |
author_role |
author |
author2 |
Xiangjiang Guo Bogdan Yatsula Jianming Guo Yongquan gu Túlio Pinho Navarro Alan Dardik Ocean Setia Afsha Aurshina Shirley Liu Haidi hu Toshihiko Isaji Haiyang Liu Tun Wang Shun Ono |
author2_role |
author author author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Lara Lopes Xiangjiang Guo Bogdan Yatsula Jianming Guo Yongquan gu Túlio Pinho Navarro Alan Dardik Ocean Setia Afsha Aurshina Shirley Liu Haidi hu Toshihiko Isaji Haiyang Liu Tun Wang Shun Ono |
dc.subject.por.fl_str_mv |
Stem cell therapy Cell therapy Diabetic foot ulcer Diabetic wound Critical limb ischemia Wound healing Amputation |
topic |
Stem cell therapy Cell therapy Diabetic foot ulcer Diabetic wound Critical limb ischemia Wound healing Amputation Amputação Cicatrização Isquemia Crônica Crítica de Membro Diabetes Mellitus |
dc.subject.other.pt_BR.fl_str_mv |
Amputação Cicatrização Isquemia Crônica Crítica de Membro Diabetes Mellitus |
description |
Background: Diabetic foot ulcer (DFU) is a severe complication of diabetes, preceding most diabetes-related amputations. DFUs require over US$9 billion for yearly treatment and are now a global public health issue. DFU occurs in the setting of ischemia, infection, neuropathy, and metabolic disorders that result in poor wound healing and poor treatment options. Recently, stem cell therapy has emerged as a new interventional strategy to treat DFU and appears to be safe and effective in both preclinical and clinical trials. However, variability in the stem cell type and origin, route and protocol for administration, and concomitant use of angioplasty confound easy interpretation and generalization of the results. Methods: The PubMed, Google Scholar, and EMBASE databases were searched and 89 preclinical and clinical studies were selected for analysis. Results: There was divergence between preclinical and clinical studies regarding stem cell type, origin, and delivery techniques. There was heterogeneous preclinical and clinical study design and few randomized clinical trials. Granulocyte-colony stimulating factor was employed in some studies but with differing protocols. Concomitant performance of angioplasty with stem cell therapy showed increased efficiency compared to either therapy alone. Conclusions: Stem cell therapy is an effective treatment for diabetic foot ulcers and is currently used as an alternative to amputation for some patients without other options for revascularization. Concordance between preclinical and clinical studies may help design future randomized clinical trials. |
publishDate |
2018 |
dc.date.issued.fl_str_mv |
2018 |
dc.date.accessioned.fl_str_mv |
2023-07-17T21:48:34Z |
dc.date.available.fl_str_mv |
2023-07-17T21:48:34Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1843/56546 |
dc.identifier.doi.pt_BR.fl_str_mv |
https://doi.org/10.1186/s13287-018-0938-6 |
dc.identifier.issn.pt_BR.fl_str_mv |
1757-6512 |
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https://orcid.org/0000-0001-8134-5825 |
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https://doi.org/10.1186/s13287-018-0938-6 http://hdl.handle.net/1843/56546 https://orcid.org/0000-0001-8134-5825 |
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1757-6512 |
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eng |
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eng |
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Stem Cell Research Therapy |
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openAccess |
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Universidade Federal de Minas Gerais |
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UFMG |
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Brasil |
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MED - DEPARTAMENTO DE CIRURGIA |
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Universidade Federal de Minas Gerais |
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