Polymorphisms of the renin-angiotensin system are not associated with overweight and obesity in a general adult population

Bibliographic Details
Main Author: Deborah de Farias Lelis
Publication Date: 2019
Other Authors: Alexandre Costa Pereira, José Eduardo Krieger, José Geraldo Mill, Sérgio Henrique Sousa Santos, Marcelo Perim Baldo
Format: Article
Language: eng
Source: Repositório Institucional da UFMG
Download full: https://doi.org/10.20945/2359-3997000000155
http://hdl.handle.net/1843/44493
Summary: CNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
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spelling 2022-08-23T16:45:26Z2022-08-23T16:45:26Z2019634402410https://doi.org/10.20945/2359-39970000001552359-4292http://hdl.handle.net/1843/44493CNPq - Conselho Nacional de Desenvolvimento Científico e TecnológicoCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível SuperiorObjective: the increased prevalence of obesity and associated comorbidities, such as cardiovascular and metabolic diseases, has gained attention worldwide, and the renin-angiotensin system (RAS) has been pointed out as a possible link. Thus, the present study aimed to verify the possible association between angiotensinogen (AGT) or angiotensin-converting enzyme (ACE) polymorphisms with overweight and obesity in adults. Subjects and methods: the present investigation was a population-based cross-sectional study including 1,567 individuals from an urban area in Brazil. Anthropometric, clinical and biochemical parameters were evaluated, and all individuals were genotyped for the ACE I/D and AGT M/T polymorphisms. Results: the prevalence of overweight was higher among men, whereas obesity was more prevalent among women. However, the frequency of ACE or AGT polymorphisms was similar among body mass index (BMI) categories. In addition, the mean age-adjusted BMI averages did not change significantly for ACE or AGT polymorphisms, regardless of sex or BMI category. The age-adjusted BMI average for the combination of ACE and AGT genotypes evidenced no significant differences regardless of sex or BMI categories. Results were similar when BMI was replaced by waist circumference (WC). Conclusions: we were not able to find any associations between BMI and WC (overweight/obesity) and ACE and AGT polymorphisms, indicating that the RAS system might not be involved in overweight and obesity, at least based on genetic backgrounds. However, further studies must measure RAS components to elucidate this question.engUniversidade Federal de Minas GeraisUFMGBrasilICA - INSTITUTO DE CIÊNCIAS AGRÁRIASArchives of Endocrinology and MetabolismSistema renina-angiotensinaPolimorfismo (Genética)ObesidadePolymorphisms of the renin-angiotensin system are not associated with overweight and obesity in a general adult populationinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://www.scielo.br/j/aem/a/DhTYqs78XCTD6nx4bNbYvvx/?lang=enDeborah de Farias LelisAlexandre Costa PereiraJosé Eduardo KriegerJosé Geraldo MillSérgio Henrique Sousa SantosMarcelo Perim Baldoinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMGLICENSELicense.txtLicense.txttext/plain; charset=utf-82042https://repositorio.ufmg.br/bitstream/1843/44493/1/License.txtfa505098d172de0bc8864fc1287ffe22MD51ORIGINALPolymorphisms of the renin-angiotensin system are not associated with overweight and obesity in a general adult population.pdfPolymorphisms of the renin-angiotensin system are not associated with overweight and obesity in a general adult population.pdfapplication/pdf222775https://repositorio.ufmg.br/bitstream/1843/44493/2/Polymorphisms%20of%20the%20renin-angiotensin%20system%20are%20not%20associated%20with%20overweight%20and%20obesity%20in%20a%20general%20adult%20population.pdfd2e7d403406e05337222e3946820adedMD521843/444932022-08-23 13:45:27.3oai:repositorio.ufmg.br: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Repositório de PublicaçõesPUBhttps://repositorio.ufmg.br/oaiopendoar:2022-08-23T16:45:27Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)false
dc.title.pt_BR.fl_str_mv Polymorphisms of the renin-angiotensin system are not associated with overweight and obesity in a general adult population
title Polymorphisms of the renin-angiotensin system are not associated with overweight and obesity in a general adult population
spellingShingle Polymorphisms of the renin-angiotensin system are not associated with overweight and obesity in a general adult population
Deborah de Farias Lelis
Sistema renina-angiotensina
Polimorfismo (Genética)
Obesidade
title_short Polymorphisms of the renin-angiotensin system are not associated with overweight and obesity in a general adult population
title_full Polymorphisms of the renin-angiotensin system are not associated with overweight and obesity in a general adult population
title_fullStr Polymorphisms of the renin-angiotensin system are not associated with overweight and obesity in a general adult population
title_full_unstemmed Polymorphisms of the renin-angiotensin system are not associated with overweight and obesity in a general adult population
title_sort Polymorphisms of the renin-angiotensin system are not associated with overweight and obesity in a general adult population
author Deborah de Farias Lelis
author_facet Deborah de Farias Lelis
Alexandre Costa Pereira
José Eduardo Krieger
José Geraldo Mill
Sérgio Henrique Sousa Santos
Marcelo Perim Baldo
author_role author
author2 Alexandre Costa Pereira
José Eduardo Krieger
José Geraldo Mill
Sérgio Henrique Sousa Santos
Marcelo Perim Baldo
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Deborah de Farias Lelis
Alexandre Costa Pereira
José Eduardo Krieger
José Geraldo Mill
Sérgio Henrique Sousa Santos
Marcelo Perim Baldo
dc.subject.other.pt_BR.fl_str_mv Sistema renina-angiotensina
Polimorfismo (Genética)
Obesidade
topic Sistema renina-angiotensina
Polimorfismo (Genética)
Obesidade
description CNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
publishDate 2019
dc.date.issued.fl_str_mv 2019
dc.date.accessioned.fl_str_mv 2022-08-23T16:45:26Z
dc.date.available.fl_str_mv 2022-08-23T16:45:26Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1843/44493
dc.identifier.doi.pt_BR.fl_str_mv https://doi.org/10.20945/2359-3997000000155
dc.identifier.issn.pt_BR.fl_str_mv 2359-4292
url https://doi.org/10.20945/2359-3997000000155
http://hdl.handle.net/1843/44493
identifier_str_mv 2359-4292
dc.language.iso.fl_str_mv eng
language eng
dc.relation.ispartof.pt_BR.fl_str_mv Archives of Endocrinology and Metabolism
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Universidade Federal de Minas Gerais
dc.publisher.initials.fl_str_mv UFMG
dc.publisher.country.fl_str_mv Brasil
dc.publisher.department.fl_str_mv ICA - INSTITUTO DE CIÊNCIAS AGRÁRIAS
publisher.none.fl_str_mv Universidade Federal de Minas Gerais
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFMG
instname:Universidade Federal de Minas Gerais (UFMG)
instacron:UFMG
instname_str Universidade Federal de Minas Gerais (UFMG)
instacron_str UFMG
institution UFMG
reponame_str Repositório Institucional da UFMG
collection Repositório Institucional da UFMG
bitstream.url.fl_str_mv https://repositorio.ufmg.br/bitstream/1843/44493/1/License.txt
https://repositorio.ufmg.br/bitstream/1843/44493/2/Polymorphisms%20of%20the%20renin-angiotensin%20system%20are%20not%20associated%20with%20overweight%20and%20obesity%20in%20a%20general%20adult%20population.pdf
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