Different metabolic responses induced by long-term interdisciplinary therapy in obese adolescents related to ACE I/D polymorphism
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2017 |
| Outros Autores: | , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFMG |
| Texto Completo: | https://doi.org/10.1177/1470320317703451 http://hdl.handle.net/1843/64075 https://orcid.org/0000-0002-4392-0953 https://orcid.org/0000-0002-8684-7290 https://orcid.org/0000-0002-6169-745X https://orcid.org/0000-0003-0187-6402 https://orcid.org/0000-0001-6433-0816 https://orcid.org/0000-0002-4507-632X https://orcid.org/0000-0001-7675-7470 https://orcid.org/0000-0003-3896-2208 https://orcid.org/0000-0003-0095-4608 |
Resumo: | CNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico |
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2024-02-16T16:54:10Z2024-02-16T16:54:10Z2017182https://doi.org/10.1177/14703203177034511752-8976http://hdl.handle.net/1843/64075https://orcid.org/0000-0002-4392-0953https://orcid.org/0000-0002-8684-7290https://orcid.org/0000-0002-6169-745Xhttps://orcid.org/0000-0003-0187-6402https://orcid.org/0000-0001-6433-0816https://orcid.org/0000-0002-4507-632Xhttps://orcid.org/0000-0001-7675-7470https://orcid.org/0000-0003-3896-2208https://orcid.org/0000-0003-0095-4608CNPq - Conselho Nacional de Desenvolvimento Científico e TecnológicoCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível SuperiorFAPESP - Fundação de Amparo à Pesquisa do Estado de São PauloIntroduction: The main purpose of the present study was to investigate whether I/D polymorphism of the ACE gene might affect metabolic changes related to the metabolic syndrome through a long-term interdisciplinary therapy in obese adolescents.Methods: In total, 125 obese adolescents who entered the interdisciplinary obesity programme were assigned to the following two subgroups: metabolic syndrome or non-metabolic syndrome. They were evaluated at baseline and after 1 year. Genomic DNA was extracted from circulating leukocytes.Results: Subjects with the II genotype in the non-metabolic syndrome group were only to increase their fat-free mass after therapy. Regarding lipid profile, subjects with ID and DD genotypes from both groups reduced their low-density lipoprotein cholesterol levels significantly. The metabolic parameters from the ID and DD genotypes of the non-metabolic syndrome group showed a significantly improved insulin response.Conclusion: In the present study, we showed that the ACE polymorphism was able to influence the fat-free mass in the I-carry allele in the non-metabolic syndrome group positively. In addition, the I-carry allele was able to improve the insulin resistance of the metabolic syndrome group significantly. These results suggest that the ACE I/D genotypes can influence, in different ways, the specific parameters of metabolism among obese adolescents submitted for long-term interdisciplinary therapy.engUniversidade Federal de Minas GeraisUFMGBrasilEEF - DEPARTAMENTO DE ESPORTESJournal of the Renin-Angiotensin-Aldosterone SystemSíndrome metabólicaObesidadeEnzima conversora da angiotensinaPolimorfismo genéticoInterdisciplinary therapyMetabolic syndromeObesityAngiotensin-converting enzymePolymorphismDifferent metabolic responses induced by long-term interdisciplinary therapy in obese adolescents related to ACE I/D polymorphisminfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://journals.sagepub.com/doi/10.1177/1470320317703451Sandro Soares AlmeidaFlávia Campos CorgosinhoCarlos EN AmorimMarcos Fernandes GregnaniRaquel Munhoz da Silveira CamposDeborah Cristina Landi MasquioPriscila de Lima SanchesAline de Piano GanenJoão Bosco PesqueroAna Raimunda DâmasoMarco Tulio de MelloSergio TufikRonaldo Carvalho Araújoinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMGLICENSELicense.txtLicense.txttext/plain; charset=utf-82042https://repositorio.ufmg.br/bitstream/1843/64075/1/License.txtfa505098d172de0bc8864fc1287ffe22MD51ORIGINALDifferent metabolic responses induced by long-term interdisciplinary therapy in obese adolescents related to ACE I_D polymorphism.pdfDifferent metabolic responses induced by long-term interdisciplinary therapy in obese adolescents related to ACE I_D polymorphism.pdfapplication/pdf2444647https://repositorio.ufmg.br/bitstream/1843/64075/2/Different%20metabolic%20responses%20induced%20by%20long-term%20interdisciplinary%20therapy%20in%20obese%20adolescents%20related%20to%20ACE%20I_D%20polymorphism.pdf90f50fa35c1ef808f958839ba5a2b569MD521843/640752024-02-16 13:54:11.125oai:repositorio.ufmg.br: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Repositório de PublicaçõesPUBhttps://repositorio.ufmg.br/oaiopendoar:2024-02-16T16:54:11Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)false |
| dc.title.pt_BR.fl_str_mv |
Different metabolic responses induced by long-term interdisciplinary therapy in obese adolescents related to ACE I/D polymorphism |
| title |
Different metabolic responses induced by long-term interdisciplinary therapy in obese adolescents related to ACE I/D polymorphism |
| spellingShingle |
Different metabolic responses induced by long-term interdisciplinary therapy in obese adolescents related to ACE I/D polymorphism Sandro Soares Almeida Interdisciplinary therapy Metabolic syndrome Obesity Angiotensin-converting enzyme Polymorphism Síndrome metabólica Obesidade Enzima conversora da angiotensina Polimorfismo genético |
| title_short |
Different metabolic responses induced by long-term interdisciplinary therapy in obese adolescents related to ACE I/D polymorphism |
| title_full |
Different metabolic responses induced by long-term interdisciplinary therapy in obese adolescents related to ACE I/D polymorphism |
| title_fullStr |
Different metabolic responses induced by long-term interdisciplinary therapy in obese adolescents related to ACE I/D polymorphism |
| title_full_unstemmed |
Different metabolic responses induced by long-term interdisciplinary therapy in obese adolescents related to ACE I/D polymorphism |
| title_sort |
Different metabolic responses induced by long-term interdisciplinary therapy in obese adolescents related to ACE I/D polymorphism |
| author |
Sandro Soares Almeida |
| author_facet |
Sandro Soares Almeida Flávia Campos Corgosinho Carlos EN Amorim Marcos Fernandes Gregnani Raquel Munhoz da Silveira Campos Deborah Cristina Landi Masquio Priscila de Lima Sanches Aline de Piano Ganen João Bosco Pesquero Ana Raimunda Dâmaso Marco Tulio de Mello Sergio Tufik Ronaldo Carvalho Araújo |
| author_role |
author |
| author2 |
Flávia Campos Corgosinho Carlos EN Amorim Marcos Fernandes Gregnani Raquel Munhoz da Silveira Campos Deborah Cristina Landi Masquio Priscila de Lima Sanches Aline de Piano Ganen João Bosco Pesquero Ana Raimunda Dâmaso Marco Tulio de Mello Sergio Tufik Ronaldo Carvalho Araújo |
| author2_role |
author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Sandro Soares Almeida Flávia Campos Corgosinho Carlos EN Amorim Marcos Fernandes Gregnani Raquel Munhoz da Silveira Campos Deborah Cristina Landi Masquio Priscila de Lima Sanches Aline de Piano Ganen João Bosco Pesquero Ana Raimunda Dâmaso Marco Tulio de Mello Sergio Tufik Ronaldo Carvalho Araújo |
| dc.subject.por.fl_str_mv |
Interdisciplinary therapy Metabolic syndrome Obesity Angiotensin-converting enzyme Polymorphism |
| topic |
Interdisciplinary therapy Metabolic syndrome Obesity Angiotensin-converting enzyme Polymorphism Síndrome metabólica Obesidade Enzima conversora da angiotensina Polimorfismo genético |
| dc.subject.other.pt_BR.fl_str_mv |
Síndrome metabólica Obesidade Enzima conversora da angiotensina Polimorfismo genético |
| description |
CNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico |
| publishDate |
2017 |
| dc.date.issued.fl_str_mv |
2017 |
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2024-02-16T16:54:10Z |
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2024-02-16T16:54:10Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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http://hdl.handle.net/1843/64075 |
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https://doi.org/10.1177/1470320317703451 |
| dc.identifier.issn.pt_BR.fl_str_mv |
1752-8976 |
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https://orcid.org/0000-0002-4392-0953 https://orcid.org/0000-0002-8684-7290 https://orcid.org/0000-0002-6169-745X https://orcid.org/0000-0003-0187-6402 https://orcid.org/0000-0001-6433-0816 https://orcid.org/0000-0002-4507-632X https://orcid.org/0000-0001-7675-7470 https://orcid.org/0000-0003-3896-2208 https://orcid.org/0000-0003-0095-4608 |
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https://doi.org/10.1177/1470320317703451 http://hdl.handle.net/1843/64075 https://orcid.org/0000-0002-4392-0953 https://orcid.org/0000-0002-8684-7290 https://orcid.org/0000-0002-6169-745X https://orcid.org/0000-0003-0187-6402 https://orcid.org/0000-0001-6433-0816 https://orcid.org/0000-0002-4507-632X https://orcid.org/0000-0001-7675-7470 https://orcid.org/0000-0003-3896-2208 https://orcid.org/0000-0003-0095-4608 |
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1752-8976 |
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eng |
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eng |
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Journal of the Renin-Angiotensin-Aldosterone System |
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info:eu-repo/semantics/openAccess |
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openAccess |
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Universidade Federal de Minas Gerais |
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UFMG |
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Brasil |
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EEF - DEPARTAMENTO DE ESPORTES |
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Universidade Federal de Minas Gerais |
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reponame:Repositório Institucional da UFMG instname:Universidade Federal de Minas Gerais (UFMG) instacron:UFMG |
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