High-Grade Transformation in Adenoid Cystic Carcinoma of the Bartholin Gland

• Autor(a) principal: Aline Evangelista Santiago
• Data de Publicação: 2021
• Outros Autores: Nicky Teunissen, Bernardo Ferreira de Paula Ricardo, Eduardo Batista Cândido, Rafaela de Souza Furtado, Agnaldo Lopes da Silva Filho
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UFMG
• Texto Completo: https://doi.org/10.1055/s-0041-1736301; http://hdl.handle.net/1843/56140
• topic: Adenoid cystic carcinoma; Bartholin gland; Gynecology; Oncology; Vulvar neoplasms; Carcinoma Adenoide Cístico; Glândulas Vestibulares Maiores; Ginecologia; Oncologia; Neoplasias Vulvares

Introduction In the present study, we report a case of primary adenoid cystic carcinoma (ACC) of the Bartholin gland with high-grade transformation (HGT). Adenoid cystic carcinoma of the Bartholin gland is a rare tumor and HGT has only been reported in head and neck tumors.Case Report A 77-year-old woman with a non-ulcerated vulvar lesion on the topogra phy of the right Bartholin gland. The patient was submitted to tumor resection followed by V–Y island flap and adjuvant radiotherapy. The histopathological examination revealed primary ACC of the Bartholin gland, with areas of HGT and extensive perineural invasion. The immunohistochemical study with p53 showed a diffuse and strong positive reaction in areas with HGT. After 24 months of follow-up, the patient presented distant metastases and died, despite having undergone to chemotherapy.Conclusion As far as we know, this case is the first description in the literature of HGT in ACC of the Bartholin gland, and HGT appears to be associated with tumor aggressiveness