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2022-09-01T20:02:12Z2022-09-01T20:02:12Z201910.1007/s00784-019-02886-01436-3771http://hdl.handle.net/1843/44821Objectives To assess the association between oral mucosa hyperpigmentation in patients with leukemia and imatinib mesylate use. Additionally, we compared our data to those obtained from a systematic review. Materials and methods A cross-sectional study was conducted with 74 patients undergoing treatment with imatinib mesylate. Sociodemographic characteristics, oral mucosa alterations, and medical history were evaluated. Oral hyperpigmentation was scored. The use of imatinib mesylate and hydroxyurea was evaluated. Association between oral hyperpigmentation and imatinib mesylate was assessed. A systematic review was also conducted to retrieve case reports or case series of patients with oral hyperpigmentation associated with imatinib mesylate. Results Among the 74 participants, 41 were male (55.4%) and 33 were female (44.6%). Participants’ mean age was 49.3 years. Sixty-six (89.2%) patients developed hyperpigmented lesions in the hard palate mucosa. In multivariate analysis, patients who had used imatinib mesylate for > 72 months had a hyperpigmentation score 1.62 times higher than those who had used this medication during a shorter period. Patients who had used hydroxyurea for > 30 days had a hyperpigmentation score 1.43 times higher than those who had used this medication during a shorter period. The systematic review retrieved 20 clinical cases of patients undergoing imatinib mesylate treatment and exhibiting oral hyperpigmentation. Conclusions The development of oral hyperpigmentation is associated with imatinib mesylate use. Hydroxyurea seems to increment such an association. Clinical relevance To assist providers in the differential diagnosis of hyperpigmented lesions associated with imatinib mesylate, as well as in the clinical management of such lesions.Objetivos Avaliar a associação entre hiperpigmentação da mucosa oral em pacientes com leucemia e mesilato de imatinibe usar. Além disso, comparamos nossos dados com os obtidos em uma revisão sistemática. Materiais e métodos Foi realizado um estudo transversal com 74 pacientes em tratamento com mesilato de imatinibe. Foram avaliadas características sociodemográficas, alterações da mucosa oral e histórico médico. A hiperpigmentação oral foi marcou. Foi avaliado o uso de mesilato de imatinibe e hidroxiureia. Associação entre hiperpigmentação oral e imatinibe mesilato foi avaliado. Uma revisão sistemática também foi realizada para recuperar relatos de casos ou séries de casos de pacientes com hiperpigmentação associada ao mesilato de imatinibe. Resultados Entre os 74 participantes, 41 eram do sexo masculino (55,4%) e 33 do sexo feminino (44,6%). A média de idade dos participantes foi de 49,3 anos. Sessenta e seis (89,2%) pacientes desenvolveram lesões hiperpigmentadas na mucosa do palato duro. Na análise multivariada, os pacientes que usaram mesilato de imatinibe por > 72 meses tiveram um escore de hiperpigmentação 1,62 vezes maior do que aqueles que usaram este medicação durante um período mais curto. Pacientes que usaram hidroxiureia por > 30 dias apresentaram escore de hiperpigmentação 1,43 vezes maior do que aqueles que usaram esse medicamento por um período menor. A revisão sistemática recuperou 20 casos clínicos de pacientes submetidos a tratamento com mesilato de imatinibe e exibindo hiperpigmentação oral. Conclusões O desenvolvimento de hiperpigmentação oral está associado ao uso de mesilato de imatinibe. A hidroxiureia parece incrementar tal associação. Relevância clínica Para auxiliar os profissionais no diagnóstico diferencial de lesões hiperpigmentadas associadas ao mesilato de imatinibe, bem como no manejo clínico dessas lesões.engUniversidade Federal de Minas GeraisUFMGBrasilFAO - DEPARTAMENTO DE ODONTOLOGIA SOCIAL E PREVENTIVAFAO - DEPARTAMENTO DE ODONTOPEDIATRIA E ORTODONTIAClinical oral investigationsFarmacologiaPatologia BucalAgentes AntineoplásicosMesilato de ImatinibeHidroxiureiaHiperpigmentação OralAssociation of oral mucosa hyperpigmentation with imatinib mesylate use: a cross-sectional study and a systematic literature reviewAssociação da hiperpigmentação da mucosa oral com o uso de mesilato de imatinibe: estudo transversal e revisão sistemática da literaturainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://www.odonto.ufmg.br/cenex/wp-content/uploads/sites/2/2021/09/Association-of-oral-mucosa-hyperpigmentation-with-imatinib-mesylate-use-a-cross-sectional-study-and-a-systematic-literature-review-1-1.pdfSicília Rezende OliveiraLuciana Gravito de Azevedo BrancoAmanda Leal RochaDenise Vieira TravassosGustavo Henrique Romani MagalhãesFelipe Paiva FonsecaRicardo Alves MesquitaLucas Guimarães AbreuTarcília Aparecida da Silvaapplication/pdfinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMGLICENSELicense.txtLicense.txttext/plain; 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