A national study on the use of opioid analgesics in dentistry
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFMG |
Texto Completo: | https://doi.org/10.1590/1807-3107bor-2019.vol33.0076 http://hdl.handle.net/1843/58114 http://orcid.org/0000-0001-5323-9662 http://orcid.org/0000-0002-7486-9652 http://orcid.org/0000-0001-9191-6978 http://orcid.org/0000-0002-5211-411X http://orcid.org/0000-0001-5803-7568 http://orcid.org/0000-0001-8794-5725 |
Resumo: | The aim of this study was to assess the frequency of opioid analgesics prescribed by Brazilian dentists, potential regional differences and their association with socioeconomic and health-related factors. Data for all opioid prescriptions by dentists was obtained from the 2012 database of the National Controlled Substances Management System, regulated by the Brazilian Health Surveillance Agency. The number of defined daily doses (DDD) and DDDs per 1,000 inhabitants per day for each Brazilian state were calculated as the primary outcomes. DDDs were compared by regions and Brazilian states. Spearman’s rho correlation coefficient was used to determine the influence of the states’ characteristics, such as the Human Development Index; poverty; education; number of dentists per 100,000 inhabitants; visit to the dentist; dental care plan; good or very good oral health; number of pharmaceutical establishments per 100,000/inhabitants; and ability to get all prescribed medications. Data analysis was performed using IBM SPSS Statistics 25.0. A total of 141,161 prescriptions for opioids analgesics by 36,929 dentists were recorded, corresponding to 658,855 doses of opioids dispensed in 2012. The most commonly dispensed opioids were codeine associated with paracetamol (83.2%; n = 117,493). The national DDDs per 1,000 inhabitants per day was 0.0093 (range: 0.0002-0.0216). DDD per 1,000 inhabitants per day was positively associated to visits to dentists (rs = 0.630; P < 0.001) and inversely associated to poverty (rs = -0.624; p = 0.001). There are significant differences in opioid prescriptions in dentistry among the Brazilian states. These differences may be associated with non-clinical factors. |
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2023-08-22T21:28:05Z2023-08-22T21:28:05Z201933https://doi.org/10.1590/1807-3107bor-2019.vol33.00761807-3107http://hdl.handle.net/1843/58114http://orcid.org/0000-0001-5323-9662http://orcid.org/0000-0002-7486-9652http://orcid.org/0000-0001-9191-6978http://orcid.org/0000-0002-5211-411Xhttp://orcid.org/0000-0001-5803-7568http://orcid.org/0000-0001-8794-5725The aim of this study was to assess the frequency of opioid analgesics prescribed by Brazilian dentists, potential regional differences and their association with socioeconomic and health-related factors. Data for all opioid prescriptions by dentists was obtained from the 2012 database of the National Controlled Substances Management System, regulated by the Brazilian Health Surveillance Agency. The number of defined daily doses (DDD) and DDDs per 1,000 inhabitants per day for each Brazilian state were calculated as the primary outcomes. DDDs were compared by regions and Brazilian states. Spearman’s rho correlation coefficient was used to determine the influence of the states’ characteristics, such as the Human Development Index; poverty; education; number of dentists per 100,000 inhabitants; visit to the dentist; dental care plan; good or very good oral health; number of pharmaceutical establishments per 100,000/inhabitants; and ability to get all prescribed medications. Data analysis was performed using IBM SPSS Statistics 25.0. A total of 141,161 prescriptions for opioids analgesics by 36,929 dentists were recorded, corresponding to 658,855 doses of opioids dispensed in 2012. The most commonly dispensed opioids were codeine associated with paracetamol (83.2%; n = 117,493). The national DDDs per 1,000 inhabitants per day was 0.0093 (range: 0.0002-0.0216). DDD per 1,000 inhabitants per day was positively associated to visits to dentists (rs = 0.630; P < 0.001) and inversely associated to poverty (rs = -0.624; p = 0.001). There are significant differences in opioid prescriptions in dentistry among the Brazilian states. These differences may be associated with non-clinical factors.O objetivo deste estudo foi avaliar a frequência de analgésicos opioides prescritos por dentistas brasileiros, potenciais diferenças regionais e sua associação com fatores socioeconômicos e relacionados à saúde. Os dados de todas as prescrições de opioides por dentistas foram obtidos do banco de dados de 2012 do Sistema Nacional de Gerenciamento de Substâncias Controladas, regulamentado pela Agência Nacional de Vigilância Sanitária. O número de doses diárias definidas (DDD) e DDDs por 1.000 habitantes por dia para cada estado brasileiro foram calculados como desfechos primários. Os DDDs foram comparados por regiões e estados brasileiros. O coeficiente de correlação rho de Spearman foi utilizado para determinar a influência das características dos estados, como o Índice de Desenvolvimento Humano; pobreza; Educação; número de dentistas por 100.000 habitantes; visita ao dentista; plano de assistência odontológica; saúde bucal boa ou muito boa; número de estabelecimentos farmacêuticos por 100.000/habitantes; e capacidade de obter todos os medicamentos prescritos. A análise dos dados foi realizada no IBM SPSS Statistics 25.0. Foram registradas 141.161 prescrições de analgésicos opioides por 36.929 dentistas, correspondendo a 658.855 doses de opioides dispensadas em 2012. Os opioides mais dispensados foram a codeína associada ao paracetamol (83,2%; n = 117.493). O DDD nacional por 1.000 habitantes por dia foi de 0,0093 (intervalo: 0,0002-0,0216). DDD por 1.000 habitantes por dia foi positivamente associado a visitas ao dentista (rs = 0,630; P < 0,001) e inversamente associado à pobreza (rs = -0,624; p = 0,001). Existem diferenças significativas nas prescrições de opioides na odontologia entre os estados brasileiros. Essas diferenças podem estar associadas a fatores não clínicos.CNPq - Conselho Nacional de Desenvolvimento Científico e TecnológicoCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível SuperiorengUniversidade Federal de Minas GeraisUFMGBrasilFAO - DEPARTAMENTO DE ODONTOLOGIA RESTAURADORAFAO - DEPARTAMENTO DE ODONTOLOGIA SOCIAL E PREVENTIVAFAR - DEPARTAMENTO DE PRODUTOS FARMACÊUTICOSBrazilian Oral ResearchAnalgésicos opioidesMedicamentos sob prescriçãoAssistência odontológicaDisparidades em assistência à saúdeAnalgesicsOpioidPrescription drugsDentistryHealthcare disparitiesDental careA national study on the use of opioid analgesics in dentistryUm estudo nacional sobre o uso de analgésicos opioides em odontologiainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://www.scielo.br/j/bor/a/8vkbT35GcLVMBwXgNBwNzhf/?lang=en#Patrícia Azevedo LinoWoosung SohnAstha SinghalMaria Auxiliadora Parreiras MartinsMaria Elisa Sousa e SilvaMauro Henrique Nogueira Guimarães de Abreuapplication/pdfinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMGLICENSELicense.txtLicense.txttext/plain; charset=utf-82042https://repositorio.ufmg.br/bitstream/1843/58114/1/License.txtfa505098d172de0bc8864fc1287ffe22MD51ORIGINALA national study on the use of opioid analgesics in dentistry.pdfA national study on the use of opioid analgesics in dentistry.pdfapplication/pdf328129https://repositorio.ufmg.br/bitstream/1843/58114/2/A%20national%20study%20on%20the%20use%20of%20opioid%20analgesics%20in%20dentistry.pdf0ca6d6c9e3a6ee80738daa323ea747b8MD521843/581142023-08-22 18:28:05.407oai:repositorio.ufmg.br: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Repositório de PublicaçõesPUBhttps://repositorio.ufmg.br/oaiopendoar:2023-08-22T21:28:05Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)false |
dc.title.pt_BR.fl_str_mv |
A national study on the use of opioid analgesics in dentistry |
dc.title.alternative.pt_BR.fl_str_mv |
Um estudo nacional sobre o uso de analgésicos opioides em odontologia |
title |
A national study on the use of opioid analgesics in dentistry |
spellingShingle |
A national study on the use of opioid analgesics in dentistry Patrícia Azevedo Lino Analgesics Opioid Prescription drugs Dentistry Healthcare disparities Dental care Analgésicos opioides Medicamentos sob prescrição Assistência odontológica Disparidades em assistência à saúde |
title_short |
A national study on the use of opioid analgesics in dentistry |
title_full |
A national study on the use of opioid analgesics in dentistry |
title_fullStr |
A national study on the use of opioid analgesics in dentistry |
title_full_unstemmed |
A national study on the use of opioid analgesics in dentistry |
title_sort |
A national study on the use of opioid analgesics in dentistry |
author |
Patrícia Azevedo Lino |
author_facet |
Patrícia Azevedo Lino Woosung Sohn Astha Singhal Maria Auxiliadora Parreiras Martins Maria Elisa Sousa e Silva Mauro Henrique Nogueira Guimarães de Abreu |
author_role |
author |
author2 |
Woosung Sohn Astha Singhal Maria Auxiliadora Parreiras Martins Maria Elisa Sousa e Silva Mauro Henrique Nogueira Guimarães de Abreu |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Patrícia Azevedo Lino Woosung Sohn Astha Singhal Maria Auxiliadora Parreiras Martins Maria Elisa Sousa e Silva Mauro Henrique Nogueira Guimarães de Abreu |
dc.subject.por.fl_str_mv |
Analgesics Opioid Prescription drugs Dentistry Healthcare disparities Dental care |
topic |
Analgesics Opioid Prescription drugs Dentistry Healthcare disparities Dental care Analgésicos opioides Medicamentos sob prescrição Assistência odontológica Disparidades em assistência à saúde |
dc.subject.other.pt_BR.fl_str_mv |
Analgésicos opioides Medicamentos sob prescrição Assistência odontológica Disparidades em assistência à saúde |
description |
The aim of this study was to assess the frequency of opioid analgesics prescribed by Brazilian dentists, potential regional differences and their association with socioeconomic and health-related factors. Data for all opioid prescriptions by dentists was obtained from the 2012 database of the National Controlled Substances Management System, regulated by the Brazilian Health Surveillance Agency. The number of defined daily doses (DDD) and DDDs per 1,000 inhabitants per day for each Brazilian state were calculated as the primary outcomes. DDDs were compared by regions and Brazilian states. Spearman’s rho correlation coefficient was used to determine the influence of the states’ characteristics, such as the Human Development Index; poverty; education; number of dentists per 100,000 inhabitants; visit to the dentist; dental care plan; good or very good oral health; number of pharmaceutical establishments per 100,000/inhabitants; and ability to get all prescribed medications. Data analysis was performed using IBM SPSS Statistics 25.0. A total of 141,161 prescriptions for opioids analgesics by 36,929 dentists were recorded, corresponding to 658,855 doses of opioids dispensed in 2012. The most commonly dispensed opioids were codeine associated with paracetamol (83.2%; n = 117,493). The national DDDs per 1,000 inhabitants per day was 0.0093 (range: 0.0002-0.0216). DDD per 1,000 inhabitants per day was positively associated to visits to dentists (rs = 0.630; P < 0.001) and inversely associated to poverty (rs = -0.624; p = 0.001). There are significant differences in opioid prescriptions in dentistry among the Brazilian states. These differences may be associated with non-clinical factors. |
publishDate |
2019 |
dc.date.issued.fl_str_mv |
2019 |
dc.date.accessioned.fl_str_mv |
2023-08-22T21:28:05Z |
dc.date.available.fl_str_mv |
2023-08-22T21:28:05Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1843/58114 |
dc.identifier.doi.pt_BR.fl_str_mv |
https://doi.org/10.1590/1807-3107bor-2019.vol33.0076 |
dc.identifier.issn.pt_BR.fl_str_mv |
1807-3107 |
dc.identifier.orcid.pt_BR.fl_str_mv |
http://orcid.org/0000-0001-5323-9662 http://orcid.org/0000-0002-7486-9652 http://orcid.org/0000-0001-9191-6978 http://orcid.org/0000-0002-5211-411X http://orcid.org/0000-0001-5803-7568 http://orcid.org/0000-0001-8794-5725 |
url |
https://doi.org/10.1590/1807-3107bor-2019.vol33.0076 http://hdl.handle.net/1843/58114 http://orcid.org/0000-0001-5323-9662 http://orcid.org/0000-0002-7486-9652 http://orcid.org/0000-0001-9191-6978 http://orcid.org/0000-0002-5211-411X http://orcid.org/0000-0001-5803-7568 http://orcid.org/0000-0001-8794-5725 |
identifier_str_mv |
1807-3107 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
Brazilian Oral Research |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
dc.publisher.none.fl_str_mv |
Universidade Federal de Minas Gerais |
dc.publisher.initials.fl_str_mv |
UFMG |
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Brasil |
dc.publisher.department.fl_str_mv |
FAO - DEPARTAMENTO DE ODONTOLOGIA RESTAURADORA FAO - DEPARTAMENTO DE ODONTOLOGIA SOCIAL E PREVENTIVA FAR - DEPARTAMENTO DE PRODUTOS FARMACÊUTICOS |
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Universidade Federal de Minas Gerais |
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reponame:Repositório Institucional da UFMG instname:Universidade Federal de Minas Gerais (UFMG) instacron:UFMG |
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UFMG |
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Repositório Institucional da UFMG |
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