Uniaxial and coaxial nanofibers PCL/alginate or PCL/gelatine transport and release tamoxifen and curcumin affecting the viability of MCF7 cell line

Detalhes bibliográficos
Autor(a) principal: Diego Fernando Suárez Peñaranda
Data de Publicação: 2022
Outros Autores: Ana Delia Pinzón García, Rubén Dario Sinisterra Millán, Anderson Dussan Cuenca, Fredy Mesa, Sandra Ramírez-Clavijo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFMG
Texto Completo: https://doi.org/10.3390/nano12193348
http://hdl.handle.net/1843/63434
https://orcid.org/0000-0002-3139-4239
https://orcid.org/0000-0002-8876-4907
https://orcid.org/0000-0001-7656-1849
https://orcid.org/0000-0001-5355-2640
https://orcid.org/0000-0003-0920-7748
https://orcid.org/0000-0003-0336-5614
Resumo: CNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
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spelling 2024-01-26T18:51:46Z2024-01-26T18:51:46Z20221219https://doi.org/10.3390/nano121933482079-4991http://hdl.handle.net/1843/63434https://orcid.org/0000-0002-3139-4239https://orcid.org/0000-0002-8876-4907https://orcid.org/0000-0001-7656-1849https://orcid.org/0000-0001-5355-2640https://orcid.org/0000-0003-0920-7748https://orcid.org/0000-0003-0336-5614CNPq - Conselho Nacional de Desenvolvimento Científico e TecnológicoFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas GeraisCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível SuperiorOutra AgênciaBreast cancer is the second cause of cancer death in women worldwide. The search for therapeutic and preventive alternatives has increased in recent years. One synthetic drug for patients with hormone receptor-positive tumours is tamoxifen citrate (TMX). Curcumin (Cur) is a natural compound that is being tested. Both were coupled with nanoscale-controlled and sustained release systems to increase the effectiveness of the treatment and reduce adverse effects. We produced a controlled release system based on uniaxial and coaxial polymeric nanofibers of polycaprolactone (PCL), alginate (Alg) and gelatine (Gel) for the transport and release of TMX and Cur, as a new alternative to breast cancer treatment. Nanofibers combining PCL–Alg and PCL–Gel were fabricated by the electrospinning technique and physicochemically characterised by thermal analysis, absorption spectroscopy in the infrared region and X-ray diffraction. Morphology and size were studied by scanning electron microscopy. Additionally, the release profile of TMX and Cur was obtained by UV-Vis spectroscopy. Additionally, the cytotoxic effect on breast cancer cell line MCF7 and peripheral-blood mononuclear cells (PBMCs) from a healthy donor were evaluated by a Resazurin reduction assay. These assays showed that PCL–TMX nanofiber was highly toxic to both cell types, while PCL–Cur was less toxic.engUniversidade Federal de Minas GeraisUFMGBrasilICX - DEPARTAMENTO DE QUÍMICANanomaterialsMamas - CâncerTecnologia de liberação controladaAgentes antineoplásicosNanofiberCurcuminTamoxifenBreast cancerElectrospinningMCF-7Uniaxial and coaxial nanofibers PCL/alginate or PCL/gelatine transport and release tamoxifen and curcumin affecting the viability of MCF7 cell lineinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://www.mdpi.com/2079-4991/12/19/3348Diego Fernando Suárez PeñarandaAna Delia Pinzón GarcíaRubén Dario Sinisterra MillánAnderson Dussan CuencaFredy MesaSandra Ramírez-Clavijoapplication/pdfinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMGLICENSELicense.txtLicense.txttext/plain; charset=utf-82042https://repositorio.ufmg.br/bitstream/1843/63434/1/License.txtfa505098d172de0bc8864fc1287ffe22MD51ORIGINALUniaxial and coaxial nanofibers pclalginate or pclgelatine transport and release tamoxifen and curcumin affecting the viability of mcf7 cell line.pdfUniaxial and coaxial nanofibers pclalginate or pclgelatine transport and release tamoxifen and curcumin affecting the viability of mcf7 cell line.pdfapplication/pdf2838090https://repositorio.ufmg.br/bitstream/1843/63434/2/Uniaxial%20and%20coaxial%20nanofibers%20pclalginate%20or%20pclgelatine%20transport%20and%20release%20tamoxifen%20and%20curcumin%20affecting%20the%20viability%20of%20mcf7%20cell%20line.pdf6baf312a4e0dc5b520c3ffb0cb1be888MD521843/634342024-01-26 15:51:46.802oai:repositorio.ufmg.br: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Repositório de PublicaçõesPUBhttps://repositorio.ufmg.br/oaiopendoar:2024-01-26T18:51:46Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)false
dc.title.pt_BR.fl_str_mv Uniaxial and coaxial nanofibers PCL/alginate or PCL/gelatine transport and release tamoxifen and curcumin affecting the viability of MCF7 cell line
title Uniaxial and coaxial nanofibers PCL/alginate or PCL/gelatine transport and release tamoxifen and curcumin affecting the viability of MCF7 cell line
spellingShingle Uniaxial and coaxial nanofibers PCL/alginate or PCL/gelatine transport and release tamoxifen and curcumin affecting the viability of MCF7 cell line
Diego Fernando Suárez Peñaranda
Nanofiber
Curcumin
Tamoxifen
Breast cancer
Electrospinning
MCF-7
Mamas - Câncer
Tecnologia de liberação controlada
Agentes antineoplásicos
title_short Uniaxial and coaxial nanofibers PCL/alginate or PCL/gelatine transport and release tamoxifen and curcumin affecting the viability of MCF7 cell line
title_full Uniaxial and coaxial nanofibers PCL/alginate or PCL/gelatine transport and release tamoxifen and curcumin affecting the viability of MCF7 cell line
title_fullStr Uniaxial and coaxial nanofibers PCL/alginate or PCL/gelatine transport and release tamoxifen and curcumin affecting the viability of MCF7 cell line
title_full_unstemmed Uniaxial and coaxial nanofibers PCL/alginate or PCL/gelatine transport and release tamoxifen and curcumin affecting the viability of MCF7 cell line
title_sort Uniaxial and coaxial nanofibers PCL/alginate or PCL/gelatine transport and release tamoxifen and curcumin affecting the viability of MCF7 cell line
author Diego Fernando Suárez Peñaranda
author_facet Diego Fernando Suárez Peñaranda
Ana Delia Pinzón García
Rubén Dario Sinisterra Millán
Anderson Dussan Cuenca
Fredy Mesa
Sandra Ramírez-Clavijo
author_role author
author2 Ana Delia Pinzón García
Rubén Dario Sinisterra Millán
Anderson Dussan Cuenca
Fredy Mesa
Sandra Ramírez-Clavijo
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Diego Fernando Suárez Peñaranda
Ana Delia Pinzón García
Rubén Dario Sinisterra Millán
Anderson Dussan Cuenca
Fredy Mesa
Sandra Ramírez-Clavijo
dc.subject.por.fl_str_mv Nanofiber
Curcumin
Tamoxifen
Breast cancer
Electrospinning
MCF-7
topic Nanofiber
Curcumin
Tamoxifen
Breast cancer
Electrospinning
MCF-7
Mamas - Câncer
Tecnologia de liberação controlada
Agentes antineoplásicos
dc.subject.other.pt_BR.fl_str_mv Mamas - Câncer
Tecnologia de liberação controlada
Agentes antineoplásicos
description CNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
publishDate 2022
dc.date.issued.fl_str_mv 2022
dc.date.accessioned.fl_str_mv 2024-01-26T18:51:46Z
dc.date.available.fl_str_mv 2024-01-26T18:51:46Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1843/63434
dc.identifier.doi.pt_BR.fl_str_mv https://doi.org/10.3390/nano12193348
dc.identifier.issn.pt_BR.fl_str_mv 2079-4991
dc.identifier.orcid.pt_BR.fl_str_mv https://orcid.org/0000-0002-3139-4239
https://orcid.org/0000-0002-8876-4907
https://orcid.org/0000-0001-7656-1849
https://orcid.org/0000-0001-5355-2640
https://orcid.org/0000-0003-0920-7748
https://orcid.org/0000-0003-0336-5614
url https://doi.org/10.3390/nano12193348
http://hdl.handle.net/1843/63434
https://orcid.org/0000-0002-3139-4239
https://orcid.org/0000-0002-8876-4907
https://orcid.org/0000-0001-7656-1849
https://orcid.org/0000-0001-5355-2640
https://orcid.org/0000-0003-0920-7748
https://orcid.org/0000-0003-0336-5614
identifier_str_mv 2079-4991
dc.language.iso.fl_str_mv eng
language eng
dc.relation.ispartof.pt_BR.fl_str_mv Nanomaterials
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade Federal de Minas Gerais
dc.publisher.initials.fl_str_mv UFMG
dc.publisher.country.fl_str_mv Brasil
dc.publisher.department.fl_str_mv ICX - DEPARTAMENTO DE QUÍMICA
publisher.none.fl_str_mv Universidade Federal de Minas Gerais
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFMG
instname:Universidade Federal de Minas Gerais (UFMG)
instacron:UFMG
instname_str Universidade Federal de Minas Gerais (UFMG)
instacron_str UFMG
institution UFMG
reponame_str Repositório Institucional da UFMG
collection Repositório Institucional da UFMG
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