A comparison of single versus multipletablet regimens in HIV-infected people initiating antiretroviral therapy
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo de conferência |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFMG |
Texto Completo: | https://doi.org/10.1002/pds.4275 http://hdl.handle.net/1843/46343 |
Resumo: | Background: The once-daily single-tablet regimen (STR) containing efavirenz, tenofovir and lamivudine is the first choice for HIV-infected people initiating antiretroviral therapy (ART) in Brazil and few studies have examined its influence on treatment and healthrelated characteristics compared to multiple-tablet regimen (MTR). Objectives: To evaluate the differences of antiretroviral therapy as a STR and MTR regarding treatment and health-related characteristics. Methods: Baseline evaluation of a cohort of 184 HIVinfected adults (79% male, mean age 35.9) with six or less months of ART under care in a reference hospital in Belo Horizonte, Brazil. Recruitment occurred between Sep/2015 and Aug/2016, and data were obtained through face-to-face interviews. Quality of life (QoL), symptoms of anxiety and depression, health state and adherence were assessed through self-report using validated instruments. A 40-item instrument to be validated during the cohort was used to assess perceived barriers with ART. The regimen used was collected from the Brazilian ART delivery database system (SICLOM). STR and MTR users were compared through non-parametric tests using Stata v.14. Results: A slightly lower proportion of STR versus MTR patients were non-adherent (54% vs 57%) and had adverse effects (85% vs. 88%), anxiety symptoms (36% vs. 41%) and depression symptoms (27% vs. 31%), though the statistical difference was not significant (p > 0.05). The STR group showed a higher QoL in the independence domain (p<0.01) (WHOQoLHIV-bref) and a better self-perception of health (p<0.05) (EQ5D VAS) than MTR group. The MTR group had twice the odds of having difficulties with the treatment (p<0.05). The perceived barriers associated with MTR were “incorporate ART into work routine” (p<0.05), “swallow the pills” (p= 0.05) and “social isolation (p<0.01)”. Conclusions: All the characteristics analyzed in this study tended to be better for patients using STR. Although adherence was not significantly higher in STR group, patients reporting difficulties with treatment had twice the odds of being non-adherent. The results indicate that single-tablet regimens may help patients in the management of ART, reflecting in aspects of daily life activities and self-perception of health. |
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2022-10-18T22:14:18Z2022-10-18T22:14:18Z2017-08-2233rd International Conference on Pharmacoepidemiology & Therapeutic Risk Management343343https://doi.org/10.1002/pds.42751099-1557http://hdl.handle.net/1843/46343Background: The once-daily single-tablet regimen (STR) containing efavirenz, tenofovir and lamivudine is the first choice for HIV-infected people initiating antiretroviral therapy (ART) in Brazil and few studies have examined its influence on treatment and healthrelated characteristics compared to multiple-tablet regimen (MTR). Objectives: To evaluate the differences of antiretroviral therapy as a STR and MTR regarding treatment and health-related characteristics. Methods: Baseline evaluation of a cohort of 184 HIVinfected adults (79% male, mean age 35.9) with six or less months of ART under care in a reference hospital in Belo Horizonte, Brazil. Recruitment occurred between Sep/2015 and Aug/2016, and data were obtained through face-to-face interviews. Quality of life (QoL), symptoms of anxiety and depression, health state and adherence were assessed through self-report using validated instruments. A 40-item instrument to be validated during the cohort was used to assess perceived barriers with ART. The regimen used was collected from the Brazilian ART delivery database system (SICLOM). STR and MTR users were compared through non-parametric tests using Stata v.14. Results: A slightly lower proportion of STR versus MTR patients were non-adherent (54% vs 57%) and had adverse effects (85% vs. 88%), anxiety symptoms (36% vs. 41%) and depression symptoms (27% vs. 31%), though the statistical difference was not significant (p > 0.05). The STR group showed a higher QoL in the independence domain (p<0.01) (WHOQoLHIV-bref) and a better self-perception of health (p<0.05) (EQ5D VAS) than MTR group. The MTR group had twice the odds of having difficulties with the treatment (p<0.05). The perceived barriers associated with MTR were “incorporate ART into work routine” (p<0.05), “swallow the pills” (p= 0.05) and “social isolation (p<0.01)”. Conclusions: All the characteristics analyzed in this study tended to be better for patients using STR. Although adherence was not significantly higher in STR group, patients reporting difficulties with treatment had twice the odds of being non-adherent. The results indicate that single-tablet regimens may help patients in the management of ART, reflecting in aspects of daily life activities and self-perception of health.engUniversidade Federal de Minas GeraisUFMGBrasilFAR - DEPARTAMENTO DE FARMÁCIA SOCIALInternational Conference on Pharmacoepidemiology & Therapeutic Risk ManagementHIVTerapia antirretroviralMedicamentosHIVTerapia antirretroviralMedicamentosA comparison of single versus multipletablet regimens in HIV-infected people initiating antiretroviral therapyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjecthttps://onlinelibrary.wiley.com/doi/full/10.1002/pds.4275Celline Cardoso Almeida BrasilJuliana Oliveira CostaElizabeth NascimentoRomara Elizeu Amaro PerdigãoMicheline Rosa SilveiraPalmira de Fátima BonoloFrancisco de Assis AcurcioMaria Das Graças Braga Ceccatoapplication/pdfinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMGLICENSELicense.txtLicense.txttext/plain; charset=utf-82042https://repositorio.ufmg.br/bitstream/1843/46343/1/License.txtfa505098d172de0bc8864fc1287ffe22MD51ORIGINALA Comparison of Single versus MultipleTablet Regimens in HIV-Infected People Initiating.pdfA Comparison of Single versus MultipleTablet Regimens in HIV-Infected People Initiating.pdfapplication/pdf62285https://repositorio.ufmg.br/bitstream/1843/46343/2/A%20Comparison%20of%20Single%20versus%20MultipleTablet%20Regimens%20in%20HIV-Infected%20People%20Initiating.pdf2f18ea7d866e0954c59884860f6ce29dMD521843/463432022-10-19 12:44:12.809oai:repositorio.ufmg.br:1843/46343TElDRU7vv71BIERFIERJU1RSSUJVSe+/ve+/vU8gTu+/vU8tRVhDTFVTSVZBIERPIFJFUE9TSVTvv71SSU8gSU5TVElUVUNJT05BTCBEQSBVRk1HCiAKCkNvbSBhIGFwcmVzZW50Ye+/ve+/vW8gZGVzdGEgbGljZW7vv71hLCB2b2Pvv70gKG8gYXV0b3IgKGVzKSBvdSBvIHRpdHVsYXIgZG9zIGRpcmVpdG9zIGRlIGF1dG9yKSBjb25jZWRlIGFvIFJlcG9zaXTvv71yaW8gSW5zdGl0dWNpb25hbCBkYSBVRk1HIChSSS1VRk1HKSBvIGRpcmVpdG8gbu+/vW8gZXhjbHVzaXZvIGUgaXJyZXZvZ++/vXZlbCBkZSByZXByb2R1emlyIGUvb3UgZGlzdHJpYnVpciBhIHN1YSBwdWJsaWNh77+977+9byAoaW5jbHVpbmRvIG8gcmVzdW1vKSBwb3IgdG9kbyBvIG11bmRvIG5vIGZvcm1hdG8gaW1wcmVzc28gZSBlbGV0cu+/vW5pY28gZSBlbSBxdWFscXVlciBtZWlvLCBpbmNsdWluZG8gb3MgZm9ybWF0b3Mg77+9dWRpbyBvdSB277+9ZGVvLgoKVm9j77+9IGRlY2xhcmEgcXVlIGNvbmhlY2UgYSBwb2zvv710aWNhIGRlIGNvcHlyaWdodCBkYSBlZGl0b3JhIGRvIHNldSBkb2N1bWVudG8gZSBxdWUgY29uaGVjZSBlIGFjZWl0YSBhcyBEaXJldHJpemVzIGRvIFJJLVVGTUcuCgpWb2Pvv70gY29uY29yZGEgcXVlIG8gUmVwb3NpdO+/vXJpbyBJbnN0aXR1Y2lvbmFsIGRhIFVGTUcgcG9kZSwgc2VtIGFsdGVyYXIgbyBjb250Ze+/vWRvLCB0cmFuc3BvciBhIHN1YSBwdWJsaWNh77+977+9byBwYXJhIHF1YWxxdWVyIG1laW8gb3UgZm9ybWF0byBwYXJhIGZpbnMgZGUgcHJlc2VydmHvv73vv71vLgoKVm9j77+9IHRhbWLvv71tIGNvbmNvcmRhIHF1ZSBvIFJlcG9zaXTvv71yaW8gSW5zdGl0dWNpb25hbCBkYSBVRk1HIHBvZGUgbWFudGVyIG1haXMgZGUgdW1hIGPvv71waWEgZGUgc3VhIHB1YmxpY2Hvv73vv71vIHBhcmEgZmlucyBkZSBzZWd1cmFu77+9YSwgYmFjay11cCBlIHByZXNlcnZh77+977+9by4KClZvY++/vSBkZWNsYXJhIHF1ZSBhIHN1YSBwdWJsaWNh77+977+9byDvv70gb3JpZ2luYWwgZSBxdWUgdm9j77+9IHRlbSBvIHBvZGVyIGRlIGNvbmNlZGVyIG9zIGRpcmVpdG9zIGNvbnRpZG9zIG5lc3RhIGxpY2Vu77+9YS4gVm9j77+9IHRhbWLvv71tIGRlY2xhcmEgcXVlIG8gZGVw77+9c2l0byBkZSBzdWEgcHVibGljYe+/ve+/vW8gbu+/vW8sIHF1ZSBzZWphIGRlIHNldSBjb25oZWNpbWVudG8sIGluZnJpbmdlIGRpcmVpdG9zIGF1dG9yYWlzIGRlIG5pbmd177+9bS4KCkNhc28gYSBzdWEgcHVibGljYe+/ve+/vW8gY29udGVuaGEgbWF0ZXJpYWwgcXVlIHZvY++/vSBu77+9byBwb3NzdWkgYSB0aXR1bGFyaWRhZGUgZG9zIGRpcmVpdG9zIGF1dG9yYWlzLCB2b2Pvv70gZGVjbGFyYSBxdWUgb2J0ZXZlIGEgcGVybWlzc++/vW8gaXJyZXN0cml0YSBkbyBkZXRlbnRvciBkb3MgZGlyZWl0b3MgYXV0b3JhaXMgcGFyYSBjb25jZWRlciBhbyBSZXBvc2l077+9cmlvIEluc3RpdHVjaW9uYWwgZGEgVUZNRyBvcyBkaXJlaXRvcyBhcHJlc2VudGFkb3MgbmVzdGEgbGljZW7vv71hLCBlIHF1ZSBlc3NlIG1hdGVyaWFsIGRlIHByb3ByaWVkYWRlIGRlIHRlcmNlaXJvcyBlc3Tvv70gY2xhcmFtZW50ZSBpZGVudGlmaWNhZG8gZSByZWNvbmhlY2lkbyBubyB0ZXh0byBvdSBubyBjb250Ze+/vWRvIGRhIHB1YmxpY2Hvv73vv71vIG9yYSBkZXBvc2l0YWRhLgoKQ0FTTyBBIFBVQkxJQ0Hvv73vv71PIE9SQSBERVBPU0lUQURBIFRFTkhBIFNJRE8gUkVTVUxUQURPIERFIFVNIFBBVFJPQ++/vU5JTyBPVSBBUE9JTyBERSBVTUEgQUfvv71OQ0lBIERFIEZPTUVOVE8gT1UgT1VUUk8gT1JHQU5JU01PLCBWT0Pvv70gREVDTEFSQSBRVUUgUkVTUEVJVE9VIFRPRE9TIEUgUVVBSVNRVUVSIERJUkVJVE9TIERFIFJFVklT77+9TyBDT01PIFRBTULvv71NIEFTIERFTUFJUyBPQlJJR0Hvv73vv71FUyBFWElHSURBUyBQT1IgQ09OVFJBVE8gT1UgQUNPUkRPLgoKTyBSZXBvc2l077+9cmlvIEluc3RpdHVjaW9uYWwgZGEgVUZNRyBzZSBjb21wcm9tZXRlIGEgaWRlbnRpZmljYXIgY2xhcmFtZW50ZSBvIHNldSBub21lKHMpIG91IG8ocykgbm9tZXMocykgZG8ocykgZGV0ZW50b3IoZXMpIGRvcyBkaXJlaXRvcyBhdXRvcmFpcyBkYSBwdWJsaWNh77+977+9bywgZSBu77+9byBmYXLvv70gcXVhbHF1ZXIgYWx0ZXJh77+977+9bywgYWzvv71tIGRhcXVlbGFzIGNvbmNlZGlkYXMgcG9yIGVzdGEgbGljZW7vv71hLgo=Repositório de PublicaçõesPUBhttps://repositorio.ufmg.br/oaiopendoar:2022-10-19T15:44:12Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)false |
dc.title.pt_BR.fl_str_mv |
A comparison of single versus multipletablet regimens in HIV-infected people initiating antiretroviral therapy |
title |
A comparison of single versus multipletablet regimens in HIV-infected people initiating antiretroviral therapy |
spellingShingle |
A comparison of single versus multipletablet regimens in HIV-infected people initiating antiretroviral therapy Celline Cardoso Almeida Brasil HIV Terapia antirretroviral Medicamentos HIV Terapia antirretroviral Medicamentos |
title_short |
A comparison of single versus multipletablet regimens in HIV-infected people initiating antiretroviral therapy |
title_full |
A comparison of single versus multipletablet regimens in HIV-infected people initiating antiretroviral therapy |
title_fullStr |
A comparison of single versus multipletablet regimens in HIV-infected people initiating antiretroviral therapy |
title_full_unstemmed |
A comparison of single versus multipletablet regimens in HIV-infected people initiating antiretroviral therapy |
title_sort |
A comparison of single versus multipletablet regimens in HIV-infected people initiating antiretroviral therapy |
author |
Celline Cardoso Almeida Brasil |
author_facet |
Celline Cardoso Almeida Brasil Juliana Oliveira Costa Elizabeth Nascimento Romara Elizeu Amaro Perdigão Micheline Rosa Silveira Palmira de Fátima Bonolo Francisco de Assis Acurcio Maria Das Graças Braga Ceccato |
author_role |
author |
author2 |
Juliana Oliveira Costa Elizabeth Nascimento Romara Elizeu Amaro Perdigão Micheline Rosa Silveira Palmira de Fátima Bonolo Francisco de Assis Acurcio Maria Das Graças Braga Ceccato |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Celline Cardoso Almeida Brasil Juliana Oliveira Costa Elizabeth Nascimento Romara Elizeu Amaro Perdigão Micheline Rosa Silveira Palmira de Fátima Bonolo Francisco de Assis Acurcio Maria Das Graças Braga Ceccato |
dc.subject.por.fl_str_mv |
HIV Terapia antirretroviral Medicamentos |
topic |
HIV Terapia antirretroviral Medicamentos HIV Terapia antirretroviral Medicamentos |
dc.subject.other.pt_BR.fl_str_mv |
HIV Terapia antirretroviral Medicamentos |
description |
Background: The once-daily single-tablet regimen (STR) containing efavirenz, tenofovir and lamivudine is the first choice for HIV-infected people initiating antiretroviral therapy (ART) in Brazil and few studies have examined its influence on treatment and healthrelated characteristics compared to multiple-tablet regimen (MTR). Objectives: To evaluate the differences of antiretroviral therapy as a STR and MTR regarding treatment and health-related characteristics. Methods: Baseline evaluation of a cohort of 184 HIVinfected adults (79% male, mean age 35.9) with six or less months of ART under care in a reference hospital in Belo Horizonte, Brazil. Recruitment occurred between Sep/2015 and Aug/2016, and data were obtained through face-to-face interviews. Quality of life (QoL), symptoms of anxiety and depression, health state and adherence were assessed through self-report using validated instruments. A 40-item instrument to be validated during the cohort was used to assess perceived barriers with ART. The regimen used was collected from the Brazilian ART delivery database system (SICLOM). STR and MTR users were compared through non-parametric tests using Stata v.14. Results: A slightly lower proportion of STR versus MTR patients were non-adherent (54% vs 57%) and had adverse effects (85% vs. 88%), anxiety symptoms (36% vs. 41%) and depression symptoms (27% vs. 31%), though the statistical difference was not significant (p > 0.05). The STR group showed a higher QoL in the independence domain (p<0.01) (WHOQoLHIV-bref) and a better self-perception of health (p<0.05) (EQ5D VAS) than MTR group. The MTR group had twice the odds of having difficulties with the treatment (p<0.05). The perceived barriers associated with MTR were “incorporate ART into work routine” (p<0.05), “swallow the pills” (p= 0.05) and “social isolation (p<0.01)”. Conclusions: All the characteristics analyzed in this study tended to be better for patients using STR. Although adherence was not significantly higher in STR group, patients reporting difficulties with treatment had twice the odds of being non-adherent. The results indicate that single-tablet regimens may help patients in the management of ART, reflecting in aspects of daily life activities and self-perception of health. |
publishDate |
2017 |
dc.date.issued.fl_str_mv |
2017-08-22 |
dc.date.accessioned.fl_str_mv |
2022-10-18T22:14:18Z |
dc.date.available.fl_str_mv |
2022-10-18T22:14:18Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/conferenceObject |
format |
conferenceObject |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1843/46343 |
dc.identifier.doi.pt_BR.fl_str_mv |
https://doi.org/10.1002/pds.4275 |
dc.identifier.issn.pt_BR.fl_str_mv |
1099-1557 |
url |
https://doi.org/10.1002/pds.4275 http://hdl.handle.net/1843/46343 |
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1099-1557 |
dc.language.iso.fl_str_mv |
eng |
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eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
International Conference on Pharmacoepidemiology & Therapeutic Risk Management |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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Universidade Federal de Minas Gerais |
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UFMG |
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Brasil |
dc.publisher.department.fl_str_mv |
FAR - DEPARTAMENTO DE FARMÁCIA SOCIAL |
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Universidade Federal de Minas Gerais |
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UFMG |
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