Tomografia por emissão de pósitrosn assoaciada à tomografia computadorizada (PET/CT) e composição corporal

Detalhes bibliográficos
Autor(a) principal: Josiane Monteiro Almeida
Data de Publicação: 2022
Tipo de documento: Dissertação
Idioma: por
Título da fonte: Repositório Institucional da UFMG
Texto Completo: http://hdl.handle.net/1843/50694
Resumo: Introduction: Positron emission tomography in combination with computed tomography (PET/CT) is an important tool for the diagnosis and staging in oncology, and can provide important information about the body composition and the nutritional status of individuals with cancer. Objectives: To evaluate the relationship between the values of hepatic and tumor uptake of 18FDG obtained by PET/CT with body composition quantified by CT in cancer patients. Methods: Cross-sectional study, in which the values of hepatic (SUV mean hepatic) and tumoral (SUV maximum tumoral) of 18FDG obtained by PET/CT were related to body composition analysis provided by CT images. Other markers of body composition, nutritional status and functionality were also evaluated. Individuals aged over 18 years, of both sexes, with suspected or diagnosed cancer who underwent PET/CT at the request of the attending physician were included. Results: One hundred and fifty-four patients, with a median age of 60.5 years, 84 elderly and 70 adults were assessed. Most of them (78.6%) had a diagnosis of solid neoplasm, and 34% of the patients were classified instage IV. The median weight, skeletal muscle mass, muscular, visceral and subcutaneous adipose tissue, muscle radiodensity (SMD) and skeletal muscle index (SMI) were respectively 70.8kg (61.1 - 80.0kg), 121.1cm² (102 .8 – 144.3cm², 6.3 cm² (3.7 – 8.9cm²), 99.9 cm² (61.9 – 179.1cm²), 165.8 cm² (106.1 – 228.9 cm²), 36.6 HU (30.6 – 41.7 HU) and 44.1 cm²/m² (39.1 – 51.2 cm²/m²). Women had lower SMI values [40.8 cm/m² (37, 2 cm/m² – 46.2 cm/m² )] The median hepatic SUV was 2.3 (2.1 – 2.6) and the median maximum tumor SUV was 4.7 (2.8 – 8, 8) Anthropometric measurements, standardized phase angle, dynamometry and body mass index (BMI) were associated with SMI (p< 0.05). However, only the arm circumference (AC) and calf were associated with the maximum tumor SUV (p< 0.05), and the relationship with the AC was inverse. Individuals classified as having low weight by BMI had a significant correlation between maximum tumor SUV, SMI (rho: -0.624) and SMD (rho: -0.502). Higher values of SMI and SMD were indicative of lower values of maximum tumor SUV in this group (p=0.001 and p=0.015 respectively). The “severely malnourished” group had a lower mean hepatic SUV [2,1 (1,9 – 2,3)] and higher tumor maximum SUV values [7.7 (5.7 - 11.8)]. There was no correlation between SMI and SMD with mean hepatic SUV (p>0.05). The maximum tumor SUV was correlated with the SMI -0.163 (p=0.043), the higher the SMI, the lower the maximum tumor SUV. We did not observe any difference between SMI and maximum tumor SUV when segmented by sex and age (p>0.05). Regarding stage, there was a correlation between SMI and maximum tumor SUV between individuals in stage III and IV -0.277 (p<0.05), higher maximum tumor SUV, lower SMI. Conclusion: Tumor uptake of 18FDG in cancer patients is related to SMI by CT.
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spelling Tomografia por emissão de pósitrosn assoaciada à tomografia computadorizada (PET/CT) e composição corporalTomografia por emissão de pósitrons combinada à tomografia computadorizadaFluordesoxiglucose F18Composição corporalÍndice de Músculo EsqueléticoCâncerTomografia por Emissão de Pósitrons combinada à Tomografia ComputadorizadaFluordesoxiglucose F18Composição CorporalMúsculo EsqueléticoNeoplasiasIntroduction: Positron emission tomography in combination with computed tomography (PET/CT) is an important tool for the diagnosis and staging in oncology, and can provide important information about the body composition and the nutritional status of individuals with cancer. Objectives: To evaluate the relationship between the values of hepatic and tumor uptake of 18FDG obtained by PET/CT with body composition quantified by CT in cancer patients. Methods: Cross-sectional study, in which the values of hepatic (SUV mean hepatic) and tumoral (SUV maximum tumoral) of 18FDG obtained by PET/CT were related to body composition analysis provided by CT images. Other markers of body composition, nutritional status and functionality were also evaluated. Individuals aged over 18 years, of both sexes, with suspected or diagnosed cancer who underwent PET/CT at the request of the attending physician were included. Results: One hundred and fifty-four patients, with a median age of 60.5 years, 84 elderly and 70 adults were assessed. Most of them (78.6%) had a diagnosis of solid neoplasm, and 34% of the patients were classified instage IV. The median weight, skeletal muscle mass, muscular, visceral and subcutaneous adipose tissue, muscle radiodensity (SMD) and skeletal muscle index (SMI) were respectively 70.8kg (61.1 - 80.0kg), 121.1cm² (102 .8 – 144.3cm², 6.3 cm² (3.7 – 8.9cm²), 99.9 cm² (61.9 – 179.1cm²), 165.8 cm² (106.1 – 228.9 cm²), 36.6 HU (30.6 – 41.7 HU) and 44.1 cm²/m² (39.1 – 51.2 cm²/m²). Women had lower SMI values [40.8 cm/m² (37, 2 cm/m² – 46.2 cm/m² )] The median hepatic SUV was 2.3 (2.1 – 2.6) and the median maximum tumor SUV was 4.7 (2.8 – 8, 8) Anthropometric measurements, standardized phase angle, dynamometry and body mass index (BMI) were associated with SMI (p< 0.05). However, only the arm circumference (AC) and calf were associated with the maximum tumor SUV (p< 0.05), and the relationship with the AC was inverse. Individuals classified as having low weight by BMI had a significant correlation between maximum tumor SUV, SMI (rho: -0.624) and SMD (rho: -0.502). Higher values of SMI and SMD were indicative of lower values of maximum tumor SUV in this group (p=0.001 and p=0.015 respectively). The “severely malnourished” group had a lower mean hepatic SUV [2,1 (1,9 – 2,3)] and higher tumor maximum SUV values [7.7 (5.7 - 11.8)]. There was no correlation between SMI and SMD with mean hepatic SUV (p>0.05). The maximum tumor SUV was correlated with the SMI -0.163 (p=0.043), the higher the SMI, the lower the maximum tumor SUV. We did not observe any difference between SMI and maximum tumor SUV when segmented by sex and age (p>0.05). Regarding stage, there was a correlation between SMI and maximum tumor SUV between individuals in stage III and IV -0.277 (p<0.05), higher maximum tumor SUV, lower SMI. Conclusion: Tumor uptake of 18FDG in cancer patients is related to SMI by CT.Introdução: A tomografia por emissão de pósitrons em combinação com tomografia computadorizada (PET/CT) é um exame de relevância para diagnóstico e estadiamento em oncologia e pode fornecer informações importantes sobre a composição corporal e o estado nutricional dos indivíduos com câncer. Objetivos: Avaliar a relação entre os valores de captação hepática e tumoral de 18FDG obtidos a partir da PET/CT com a composição corporal quantificada pela CT, em pacientes oncológicos. Métodos: Estudo transversal, em que os valores de captação hepática (SUV médio hepático) e tumoral (SUV máximo tumoral) de 18FDG obtidos da PET/CT foram relacionados à composição corporal a partir da análise das imagens da CT. Outros marcadores da composição corporal, do estado nutricional e da funcionalidade, também foram avaliados. Foram incluídos indivíduos com idade superior a 18 anos, de ambos os sexos, com suspeita ou diagnóstico de câncer que realizaram a PET/CT a pedido do médico assistente. Resultados: Cento e cinquenta e quatro pacientes, com idade mediana de 60,5 anos, 84 idosos e 70 adultos foram avaliados. A maioria (78,6%) tinha diagnóstico de neoplasia sólida, 34% dos doentes foram classificados com importa IV. A mediana do peso, massa muscular esquelética, tecido adiposo intermuscular, visceral e subcutâneo, radiodensidade do músculo (SMD) e índice do músculo esquelético (SMI) foram respectivamente 70,8kg (61,1 – 80,0Kg), 121,1cm² (102,8 – 144,3cm², 6,3 cm² (3,7 – 8,9cm²), 99,9 cm² (61,9 – 179,1cm²), 165,8 cm² (106,1 – 228,9 cm²), 36,6 HU (30,6 – 41,7 HU) e 44,1 cm²/m² (39,1 – 51,2cm²/m²). As mulheres apresentaram menores valores de SMI [40,8 cm/m² (37,2 cm/m² – 46,2 cm/m²)]. O SUV médio hepático teve mediana de 2,3 (2,1 – 2,6) e o SUV máximo tumoral mediana de 4,7 (2,8 – 8,8). Medidas antropométricas, ângulo de fase padronizado, dinamometria e índice de massa corporal (IMC) relacionaram-se com o SMI (p< 0,05). Mas, apenas a circunferência do braço (CB) e da panturrilha associaram-se ao SUV máximo tumoral (p< 0,05), sendo a relação com a CB inversa. Indivíduos classificados com baixo peso pelo IMC apresentaram correlação significativa entre SUV máximo tumoral, SMI (rho: -0,624) e SMD (rho: -0,502). Maiores valores de SMI e SMD, foram indicativos de menores valores de SUV máximo tumoral nesse grupo (p=0,001 e p=0,015 respectivamente). O grupo “desnutrido grave” apresentou menores valores de SUV médio hepático [2,1 (1,9 – 2,3)] e maiores valores de SUV máximo tumoral [7,7 (5,7 – 11,8)]. Não houve correlação entre SMI e SMD com o SUV médio hepático (p>0,05). O SUV máximo tumoral teve correlação com o SMI -0,163 (p=0,043), quanto maior o SMI, menor o SUV máximo tumoral. Não observamos diferença entre SMI e SUV máximo tumoral ao segmentar por sexo e idade (p>0,05). Em relação ao importa, houve correlação do SMI e SUV máximo tumoral entre os indivíduos em importa III e IV -0,277 (p<0,05), maior SUV máximo tumoral, menor SMI. Conclusão: A captação tumoral de 18FDG em pacientes oncológicos tem relação como SMI obtido a partir da composição corporal analisada pela CT.Universidade Federal de Minas GeraisBrasilENF - DEPARTAMENTO DE NUTRIÇÃOPrograma de Pós-Graduação em Nutrição e SaúdeUFMGMaria Isabel Toulson Davisson Correiahttp://lattes.cnpq.br/9525506968461169Camila Kümmel DuarteSílvia Fernandes MaurícioJosiane Monteiro Almeida2023-03-07T11:48:18Z2023-03-07T11:48:18Z2022-12-21info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisapplication/pdfhttp://hdl.handle.net/1843/50694porhttp://creativecommons.org/licenses/by-nc-nd/3.0/pt/info:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMG2023-03-07T11:48:18Zoai:repositorio.ufmg.br:1843/50694Repositório InstitucionalPUBhttps://repositorio.ufmg.br/oairepositorio@ufmg.bropendoar:2023-03-07T11:48:18Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)false
dc.title.none.fl_str_mv Tomografia por emissão de pósitrosn assoaciada à tomografia computadorizada (PET/CT) e composição corporal
title Tomografia por emissão de pósitrosn assoaciada à tomografia computadorizada (PET/CT) e composição corporal
spellingShingle Tomografia por emissão de pósitrosn assoaciada à tomografia computadorizada (PET/CT) e composição corporal
Josiane Monteiro Almeida
Tomografia por emissão de pósitrons combinada à tomografia computadorizada
Fluordesoxiglucose F18
Composição corporal
Índice de Músculo Esquelético
Câncer
Tomografia por Emissão de Pósitrons combinada à Tomografia Computadorizada
Fluordesoxiglucose F18
Composição Corporal
Músculo Esquelético
Neoplasias
title_short Tomografia por emissão de pósitrosn assoaciada à tomografia computadorizada (PET/CT) e composição corporal
title_full Tomografia por emissão de pósitrosn assoaciada à tomografia computadorizada (PET/CT) e composição corporal
title_fullStr Tomografia por emissão de pósitrosn assoaciada à tomografia computadorizada (PET/CT) e composição corporal
title_full_unstemmed Tomografia por emissão de pósitrosn assoaciada à tomografia computadorizada (PET/CT) e composição corporal
title_sort Tomografia por emissão de pósitrosn assoaciada à tomografia computadorizada (PET/CT) e composição corporal
author Josiane Monteiro Almeida
author_facet Josiane Monteiro Almeida
author_role author
dc.contributor.none.fl_str_mv Maria Isabel Toulson Davisson Correia
http://lattes.cnpq.br/9525506968461169
Camila Kümmel Duarte
Sílvia Fernandes Maurício
dc.contributor.author.fl_str_mv Josiane Monteiro Almeida
dc.subject.por.fl_str_mv Tomografia por emissão de pósitrons combinada à tomografia computadorizada
Fluordesoxiglucose F18
Composição corporal
Índice de Músculo Esquelético
Câncer
Tomografia por Emissão de Pósitrons combinada à Tomografia Computadorizada
Fluordesoxiglucose F18
Composição Corporal
Músculo Esquelético
Neoplasias
topic Tomografia por emissão de pósitrons combinada à tomografia computadorizada
Fluordesoxiglucose F18
Composição corporal
Índice de Músculo Esquelético
Câncer
Tomografia por Emissão de Pósitrons combinada à Tomografia Computadorizada
Fluordesoxiglucose F18
Composição Corporal
Músculo Esquelético
Neoplasias
description Introduction: Positron emission tomography in combination with computed tomography (PET/CT) is an important tool for the diagnosis and staging in oncology, and can provide important information about the body composition and the nutritional status of individuals with cancer. Objectives: To evaluate the relationship between the values of hepatic and tumor uptake of 18FDG obtained by PET/CT with body composition quantified by CT in cancer patients. Methods: Cross-sectional study, in which the values of hepatic (SUV mean hepatic) and tumoral (SUV maximum tumoral) of 18FDG obtained by PET/CT were related to body composition analysis provided by CT images. Other markers of body composition, nutritional status and functionality were also evaluated. Individuals aged over 18 years, of both sexes, with suspected or diagnosed cancer who underwent PET/CT at the request of the attending physician were included. Results: One hundred and fifty-four patients, with a median age of 60.5 years, 84 elderly and 70 adults were assessed. Most of them (78.6%) had a diagnosis of solid neoplasm, and 34% of the patients were classified instage IV. The median weight, skeletal muscle mass, muscular, visceral and subcutaneous adipose tissue, muscle radiodensity (SMD) and skeletal muscle index (SMI) were respectively 70.8kg (61.1 - 80.0kg), 121.1cm² (102 .8 – 144.3cm², 6.3 cm² (3.7 – 8.9cm²), 99.9 cm² (61.9 – 179.1cm²), 165.8 cm² (106.1 – 228.9 cm²), 36.6 HU (30.6 – 41.7 HU) and 44.1 cm²/m² (39.1 – 51.2 cm²/m²). Women had lower SMI values [40.8 cm/m² (37, 2 cm/m² – 46.2 cm/m² )] The median hepatic SUV was 2.3 (2.1 – 2.6) and the median maximum tumor SUV was 4.7 (2.8 – 8, 8) Anthropometric measurements, standardized phase angle, dynamometry and body mass index (BMI) were associated with SMI (p< 0.05). However, only the arm circumference (AC) and calf were associated with the maximum tumor SUV (p< 0.05), and the relationship with the AC was inverse. Individuals classified as having low weight by BMI had a significant correlation between maximum tumor SUV, SMI (rho: -0.624) and SMD (rho: -0.502). Higher values of SMI and SMD were indicative of lower values of maximum tumor SUV in this group (p=0.001 and p=0.015 respectively). The “severely malnourished” group had a lower mean hepatic SUV [2,1 (1,9 – 2,3)] and higher tumor maximum SUV values [7.7 (5.7 - 11.8)]. There was no correlation between SMI and SMD with mean hepatic SUV (p>0.05). The maximum tumor SUV was correlated with the SMI -0.163 (p=0.043), the higher the SMI, the lower the maximum tumor SUV. We did not observe any difference between SMI and maximum tumor SUV when segmented by sex and age (p>0.05). Regarding stage, there was a correlation between SMI and maximum tumor SUV between individuals in stage III and IV -0.277 (p<0.05), higher maximum tumor SUV, lower SMI. Conclusion: Tumor uptake of 18FDG in cancer patients is related to SMI by CT.
publishDate 2022
dc.date.none.fl_str_mv 2022-12-21
2023-03-07T11:48:18Z
2023-03-07T11:48:18Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/masterThesis
format masterThesis
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dc.identifier.uri.fl_str_mv http://hdl.handle.net/1843/50694
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rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-nd/3.0/pt/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade Federal de Minas Gerais
Brasil
ENF - DEPARTAMENTO DE NUTRIÇÃO
Programa de Pós-Graduação em Nutrição e Saúde
UFMG
publisher.none.fl_str_mv Universidade Federal de Minas Gerais
Brasil
ENF - DEPARTAMENTO DE NUTRIÇÃO
Programa de Pós-Graduação em Nutrição e Saúde
UFMG
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFMG
instname:Universidade Federal de Minas Gerais (UFMG)
instacron:UFMG
instname_str Universidade Federal de Minas Gerais (UFMG)
instacron_str UFMG
institution UFMG
reponame_str Repositório Institucional da UFMG
collection Repositório Institucional da UFMG
repository.name.fl_str_mv Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)
repository.mail.fl_str_mv repositorio@ufmg.br
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