Evaluation of inflammatory biomarkers, carotid intima-media thickness and cardiovascular risk in HIV-1 treatment-naive patients
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFMG |
Texto Completo: | https://doi.org/10.1590/0037-8682-0472-2017 http://hdl.handle.net/1843/47659 |
Resumo: | Introduction: Mortality among HIV patients is 3-15 times higher than that among the general population. Currently, most deaths are due to non-infectious diseases. Chronic inflammation and adverse events due to antiretroviral therapy play crucial roles in increasing cardiovascular risk (CVR). Methods: This cross-sectional study aimed to evaluate carotid intima-media thickness (CIMT) and inflammatory biomarkers (D-dimer, ADAMTS13, GDF-15, sICAM-1, MPO, myoglobin, NGAL, SAA, sVCAM-1, and p selectin) among naïve patients. Results: Sixty-seven participants were included: median age, 32 years; males, 82.1%; non-white, 61.1%; higher education level, 62.7%; and exposed to HIV through sexual relationship (men who have sex with men), 68.7%. The median viral load and LTCD4+ value were 42,033 copies/mL and 426 cells/mm³. The prevalence of arterial hypertension was 16.4%; those of diabetes mellitus and dyslipidemia were 3% and 70.1%, respectively. The CIMT was 494.08 (± 96.84mm). The mean vascular age was 33.2 ± 18.9 years, one year longer than the chronological age, without statistical significance. Conclusions: The majority of participants had a low CVR (94%). After reclassification, considering the CIMT percentiles, 13 (19.4%) patients had medium/ high CVR, while 54 (80.6%) patients had low CVR. The difference between the proportions of CVR when considering the CIMT and its corresponding percentile was statistically relevant. Body mass index was the only predictor of higher CVR (p = 0.03). No biomarker was found to predict CVR. People living with HIV have a high prevalence of dyslipidemia before ARV therapy. |
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2022-12-01T21:37:04Z2022-12-01T21:37:04Z2018513277283https://doi.org/10.1590/0037-8682-0472-201716789849http://hdl.handle.net/1843/476590000-0001-6833-3870Introduction: Mortality among HIV patients is 3-15 times higher than that among the general population. Currently, most deaths are due to non-infectious diseases. Chronic inflammation and adverse events due to antiretroviral therapy play crucial roles in increasing cardiovascular risk (CVR). Methods: This cross-sectional study aimed to evaluate carotid intima-media thickness (CIMT) and inflammatory biomarkers (D-dimer, ADAMTS13, GDF-15, sICAM-1, MPO, myoglobin, NGAL, SAA, sVCAM-1, and p selectin) among naïve patients. Results: Sixty-seven participants were included: median age, 32 years; males, 82.1%; non-white, 61.1%; higher education level, 62.7%; and exposed to HIV through sexual relationship (men who have sex with men), 68.7%. The median viral load and LTCD4+ value were 42,033 copies/mL and 426 cells/mm³. The prevalence of arterial hypertension was 16.4%; those of diabetes mellitus and dyslipidemia were 3% and 70.1%, respectively. The CIMT was 494.08 (± 96.84mm). The mean vascular age was 33.2 ± 18.9 years, one year longer than the chronological age, without statistical significance. Conclusions: The majority of participants had a low CVR (94%). After reclassification, considering the CIMT percentiles, 13 (19.4%) patients had medium/ high CVR, while 54 (80.6%) patients had low CVR. The difference between the proportions of CVR when considering the CIMT and its corresponding percentile was statistically relevant. Body mass index was the only predictor of higher CVR (p = 0.03). No biomarker was found to predict CVR. People living with HIV have a high prevalence of dyslipidemia before ARV therapy.Introdução: A mortalidade entre pacientes com HIV é de 3 a 15 vezes maior do que na população em geral. Atualmente, a maioria das mortes é devida a doenças não infecciosas. A inflamação crônica e os eventos adversos decorrentes da terapia antirretroviral desempenham papéis cruciais no aumento do risco cardiovascular (CVR). Métodos: Este estudo transversal teve como objetivo avaliar a espessura médio-intimal da carótida (CIMT) e biomarcadores inflamatórios (dímero D, ADAMTS13, GDF-15, sICAM-1, MPO, mioglobina, NGAL, SAA, sVCAM-1 e p selectina) entre pacientes virgens. Resultados: Foram incluídos 67 participantes: mediana de idade, 32 anos; homens, 82,1%; não brancos, 61,1%; nível superior, 62,7%; e expostos ao HIV por meio de relação sexual (homens que fazem sexo com homens), 68,7%. A carga viral mediana e o valor de LTCD4+ foram 42.033 cópias/mL e 426 células/mm³. A prevalência de hipertensão arterial foi de 16,4%; os de diabetes melito e dislipidemia foram de 3% e 70,1%, respectivamente. A CIMT foi de 494,08 (± 96,84mm). A idade vascular média foi de 33,2 ± 18,9 anos, um ano a mais que a idade cronológica, sem significância estatística. Conclusões: A maioria dos participantes apresentou baixa RCV (94%). Após a reclassificação, considerando os percentis da EIMC, 13 (19,4%) pacientes apresentaram RCV média/alta, enquanto 54 (80,6%) pacientes apresentaram RCV baixa. A diferença entre as proporções de RCV quando se considera a EIMC e seu percentil correspondente foi estatisticamente relevante. O índice de massa corporal foi o único preditor de maior RCV (p = 0,03). Nenhum biomarcador foi encontrado para prever a RCV. Pessoas vivendo com HIV têm alta prevalência de dislipidemia antes da terapia ARV.engUniversidade Federal de Minas GeraisUFMGBrasilMED - DEPARTAMENTO DE CLÍNICA MÉDICARevista da Sociedade Brasileira de Medicina TropicalHIVFatores de Risco de Doenças CardíacasBiomarcadoresInflamaçãoEspessura Intima-Media CarotídeaHIVCardiovascular riskBiomarkersInflammationIntima-media thicknessEvaluation of inflammatory biomarkers, carotid intima-media thickness and cardiovascular risk in HIV-1 treatment-naive patientsAvaliação de biomarcadores inflamatórios, espessura íntima-média da carótida e risco cardiovascular em pacientes virgens de tratamento para HIV-1info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://www.scielo.br/j/rsbmt/a/PqkRcrvSDxvSj7Z8SDZLJYP/abstract/?lang=enPriscila Valéria do Carmo CarvalhoJúlia Fonseca de Morais CaporaliÉrica Leandro Marciano VieiraNathalia Sernizon GuimarãesMarise Oliveira FonsecaUnai Tupinambásapplication/pdfinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMGLICENSELicense.txtLicense.txttext/plain; charset=utf-82042https://repositorio.ufmg.br/bitstream/1843/47659/1/License.txtfa505098d172de0bc8864fc1287ffe22MD51ORIGINALEvaluation of inflammatory biomarkers, carotid intima-media thickness and cardiovascular risk in hiv-1 treatment-naive patients.pdfEvaluation of inflammatory biomarkers, carotid intima-media thickness and cardiovascular risk in hiv-1 treatment-naive patients.pdfapplication/pdf499558https://repositorio.ufmg.br/bitstream/1843/47659/2/Evaluation%20of%20inflammatory%20biomarkers%2c%20carotid%20intima-media%20thickness%20and%20cardiovascular%20risk%20in%20hiv-1%20treatment-naive%20patients.pdf527d50cf560e6233f9292b6ba0656cf3MD521843/476592022-12-01 18:37:05.203oai:repositorio.ufmg.br:1843/47659TElDRU7vv71BIERFIERJU1RSSUJVSe+/ve+/vU8gTu+/vU8tRVhDTFVTSVZBIERPIFJFUE9TSVTvv71SSU8gSU5TVElUVUNJT05BTCBEQSBVRk1HCiAKCkNvbSBhIGFwcmVzZW50Ye+/ve+/vW8gZGVzdGEgbGljZW7vv71hLCB2b2Pvv70gKG8gYXV0b3IgKGVzKSBvdSBvIHRpdHVsYXIgZG9zIGRpcmVpdG9zIGRlIGF1dG9yKSBjb25jZWRlIGFvIFJlcG9zaXTvv71yaW8gSW5zdGl0dWNpb25hbCBkYSBVRk1HIChSSS1VRk1HKSBvIGRpcmVpdG8gbu+/vW8gZXhjbHVzaXZvIGUgaXJyZXZvZ++/vXZlbCBkZSByZXByb2R1emlyIGUvb3UgZGlzdHJpYnVpciBhIHN1YSBwdWJsaWNh77+977+9byAoaW5jbHVpbmRvIG8gcmVzdW1vKSBwb3IgdG9kbyBvIG11bmRvIG5vIGZvcm1hdG8gaW1wcmVzc28gZSBlbGV0cu+/vW5pY28gZSBlbSBxdWFscXVlciBtZWlvLCBpbmNsdWluZG8gb3MgZm9ybWF0b3Mg77+9dWRpbyBvdSB277+9ZGVvLgoKVm9j77+9IGRlY2xhcmEgcXVlIGNvbmhlY2UgYSBwb2zvv710aWNhIGRlIGNvcHlyaWdodCBkYSBlZGl0b3JhIGRvIHNldSBkb2N1bWVudG8gZSBxdWUgY29uaGVjZSBlIGFjZWl0YSBhcyBEaXJldHJpemVzIGRvIFJJLVVGTUcuCgpWb2Pvv70gY29uY29yZGEgcXVlIG8gUmVwb3NpdO+/vXJpbyBJbnN0aXR1Y2lvbmFsIGRhIFVGTUcgcG9kZSwgc2VtIGFsdGVyYXIgbyBjb250Ze+/vWRvLCB0cmFuc3BvciBhIHN1YSBwdWJsaWNh77+977+9byBwYXJhIHF1YWxxdWVyIG1laW8gb3UgZm9ybWF0byBwYXJhIGZpbnMgZGUgcHJlc2VydmHvv73vv71vLgoKVm9j77+9IHRhbWLvv71tIGNvbmNvcmRhIHF1ZSBvIFJlcG9zaXTvv71yaW8gSW5zdGl0dWNpb25hbCBkYSBVRk1HIHBvZGUgbWFudGVyIG1haXMgZGUgdW1hIGPvv71waWEgZGUgc3VhIHB1YmxpY2Hvv73vv71vIHBhcmEgZmlucyBkZSBzZWd1cmFu77+9YSwgYmFjay11cCBlIHByZXNlcnZh77+977+9by4KClZvY++/vSBkZWNsYXJhIHF1ZSBhIHN1YSBwdWJsaWNh77+977+9byDvv70gb3JpZ2luYWwgZSBxdWUgdm9j77+9IHRlbSBvIHBvZGVyIGRlIGNvbmNlZGVyIG9zIGRpcmVpdG9zIGNvbnRpZG9zIG5lc3RhIGxpY2Vu77+9YS4gVm9j77+9IHRhbWLvv71tIGRlY2xhcmEgcXVlIG8gZGVw77+9c2l0byBkZSBzdWEgcHVibGljYe+/ve+/vW8gbu+/vW8sIHF1ZSBzZWphIGRlIHNldSBjb25oZWNpbWVudG8sIGluZnJpbmdlIGRpcmVpdG9zIGF1dG9yYWlzIGRlIG5pbmd177+9bS4KCkNhc28gYSBzdWEgcHVibGljYe+/ve+/vW8gY29udGVuaGEgbWF0ZXJpYWwgcXVlIHZvY++/vSBu77+9byBwb3NzdWkgYSB0aXR1bGFyaWRhZGUgZG9zIGRpcmVpdG9zIGF1dG9yYWlzLCB2b2Pvv70gZGVjbGFyYSBxdWUgb2J0ZXZlIGEgcGVybWlzc++/vW8gaXJyZXN0cml0YSBkbyBkZXRlbnRvciBkb3MgZGlyZWl0b3MgYXV0b3JhaXMgcGFyYSBjb25jZWRlciBhbyBSZXBvc2l077+9cmlvIEluc3RpdHVjaW9uYWwgZGEgVUZNRyBvcyBkaXJlaXRvcyBhcHJlc2VudGFkb3MgbmVzdGEgbGljZW7vv71hLCBlIHF1ZSBlc3NlIG1hdGVyaWFsIGRlIHByb3ByaWVkYWRlIGRlIHRlcmNlaXJvcyBlc3Tvv70gY2xhcmFtZW50ZSBpZGVudGlmaWNhZG8gZSByZWNvbmhlY2lkbyBubyB0ZXh0byBvdSBubyBjb250Ze+/vWRvIGRhIHB1YmxpY2Hvv73vv71vIG9yYSBkZXBvc2l0YWRhLgoKQ0FTTyBBIFBVQkxJQ0Hvv73vv71PIE9SQSBERVBPU0lUQURBIFRFTkhBIFNJRE8gUkVTVUxUQURPIERFIFVNIFBBVFJPQ++/vU5JTyBPVSBBUE9JTyBERSBVTUEgQUfvv71OQ0lBIERFIEZPTUVOVE8gT1UgT1VUUk8gT1JHQU5JU01PLCBWT0Pvv70gREVDTEFSQSBRVUUgUkVTUEVJVE9VIFRPRE9TIEUgUVVBSVNRVUVSIERJUkVJVE9TIERFIFJFVklT77+9TyBDT01PIFRBTULvv71NIEFTIERFTUFJUyBPQlJJR0Hvv73vv71FUyBFWElHSURBUyBQT1IgQ09OVFJBVE8gT1UgQUNPUkRPLgoKTyBSZXBvc2l077+9cmlvIEluc3RpdHVjaW9uYWwgZGEgVUZNRyBzZSBjb21wcm9tZXRlIGEgaWRlbnRpZmljYXIgY2xhcmFtZW50ZSBvIHNldSBub21lKHMpIG91IG8ocykgbm9tZXMocykgZG8ocykgZGV0ZW50b3IoZXMpIGRvcyBkaXJlaXRvcyBhdXRvcmFpcyBkYSBwdWJsaWNh77+977+9bywgZSBu77+9byBmYXLvv70gcXVhbHF1ZXIgYWx0ZXJh77+977+9bywgYWzvv71tIGRhcXVlbGFzIGNvbmNlZGlkYXMgcG9yIGVzdGEgbGljZW7vv71hLgo=Repositório de PublicaçõesPUBhttps://repositorio.ufmg.br/oaiopendoar:2022-12-01T21:37:05Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)false |
dc.title.pt_BR.fl_str_mv |
Evaluation of inflammatory biomarkers, carotid intima-media thickness and cardiovascular risk in HIV-1 treatment-naive patients |
dc.title.alternative.pt_BR.fl_str_mv |
Avaliação de biomarcadores inflamatórios, espessura íntima-média da carótida e risco cardiovascular em pacientes virgens de tratamento para HIV-1 |
title |
Evaluation of inflammatory biomarkers, carotid intima-media thickness and cardiovascular risk in HIV-1 treatment-naive patients |
spellingShingle |
Evaluation of inflammatory biomarkers, carotid intima-media thickness and cardiovascular risk in HIV-1 treatment-naive patients Priscila Valéria do Carmo Carvalho HIV Cardiovascular risk Biomarkers Inflammation Intima-media thickness HIV Fatores de Risco de Doenças Cardíacas Biomarcadores Inflamação Espessura Intima-Media Carotídea |
title_short |
Evaluation of inflammatory biomarkers, carotid intima-media thickness and cardiovascular risk in HIV-1 treatment-naive patients |
title_full |
Evaluation of inflammatory biomarkers, carotid intima-media thickness and cardiovascular risk in HIV-1 treatment-naive patients |
title_fullStr |
Evaluation of inflammatory biomarkers, carotid intima-media thickness and cardiovascular risk in HIV-1 treatment-naive patients |
title_full_unstemmed |
Evaluation of inflammatory biomarkers, carotid intima-media thickness and cardiovascular risk in HIV-1 treatment-naive patients |
title_sort |
Evaluation of inflammatory biomarkers, carotid intima-media thickness and cardiovascular risk in HIV-1 treatment-naive patients |
author |
Priscila Valéria do Carmo Carvalho |
author_facet |
Priscila Valéria do Carmo Carvalho Júlia Fonseca de Morais Caporali Érica Leandro Marciano Vieira Nathalia Sernizon Guimarães Marise Oliveira Fonseca Unai Tupinambás |
author_role |
author |
author2 |
Júlia Fonseca de Morais Caporali Érica Leandro Marciano Vieira Nathalia Sernizon Guimarães Marise Oliveira Fonseca Unai Tupinambás |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Priscila Valéria do Carmo Carvalho Júlia Fonseca de Morais Caporali Érica Leandro Marciano Vieira Nathalia Sernizon Guimarães Marise Oliveira Fonseca Unai Tupinambás |
dc.subject.por.fl_str_mv |
HIV Cardiovascular risk Biomarkers Inflammation Intima-media thickness |
topic |
HIV Cardiovascular risk Biomarkers Inflammation Intima-media thickness HIV Fatores de Risco de Doenças Cardíacas Biomarcadores Inflamação Espessura Intima-Media Carotídea |
dc.subject.other.pt_BR.fl_str_mv |
HIV Fatores de Risco de Doenças Cardíacas Biomarcadores Inflamação Espessura Intima-Media Carotídea |
description |
Introduction: Mortality among HIV patients is 3-15 times higher than that among the general population. Currently, most deaths are due to non-infectious diseases. Chronic inflammation and adverse events due to antiretroviral therapy play crucial roles in increasing cardiovascular risk (CVR). Methods: This cross-sectional study aimed to evaluate carotid intima-media thickness (CIMT) and inflammatory biomarkers (D-dimer, ADAMTS13, GDF-15, sICAM-1, MPO, myoglobin, NGAL, SAA, sVCAM-1, and p selectin) among naïve patients. Results: Sixty-seven participants were included: median age, 32 years; males, 82.1%; non-white, 61.1%; higher education level, 62.7%; and exposed to HIV through sexual relationship (men who have sex with men), 68.7%. The median viral load and LTCD4+ value were 42,033 copies/mL and 426 cells/mm³. The prevalence of arterial hypertension was 16.4%; those of diabetes mellitus and dyslipidemia were 3% and 70.1%, respectively. The CIMT was 494.08 (± 96.84mm). The mean vascular age was 33.2 ± 18.9 years, one year longer than the chronological age, without statistical significance. Conclusions: The majority of participants had a low CVR (94%). After reclassification, considering the CIMT percentiles, 13 (19.4%) patients had medium/ high CVR, while 54 (80.6%) patients had low CVR. The difference between the proportions of CVR when considering the CIMT and its corresponding percentile was statistically relevant. Body mass index was the only predictor of higher CVR (p = 0.03). No biomarker was found to predict CVR. People living with HIV have a high prevalence of dyslipidemia before ARV therapy. |
publishDate |
2018 |
dc.date.issued.fl_str_mv |
2018 |
dc.date.accessioned.fl_str_mv |
2022-12-01T21:37:04Z |
dc.date.available.fl_str_mv |
2022-12-01T21:37:04Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1843/47659 |
dc.identifier.doi.pt_BR.fl_str_mv |
https://doi.org/10.1590/0037-8682-0472-2017 |
dc.identifier.issn.pt_BR.fl_str_mv |
16789849 |
dc.identifier.orcid.pt_BR.fl_str_mv |
0000-0001-6833-3870 |
url |
https://doi.org/10.1590/0037-8682-0472-2017 http://hdl.handle.net/1843/47659 |
identifier_str_mv |
16789849 0000-0001-6833-3870 |
dc.language.iso.fl_str_mv |
eng |
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eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
Revista da Sociedade Brasileira de Medicina Tropical |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
dc.publisher.none.fl_str_mv |
Universidade Federal de Minas Gerais |
dc.publisher.initials.fl_str_mv |
UFMG |
dc.publisher.country.fl_str_mv |
Brasil |
dc.publisher.department.fl_str_mv |
MED - DEPARTAMENTO DE CLÍNICA MÉDICA |
publisher.none.fl_str_mv |
Universidade Federal de Minas Gerais |
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reponame:Repositório Institucional da UFMG instname:Universidade Federal de Minas Gerais (UFMG) instacron:UFMG |
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UFMG |
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