Barriers in precision medicine implementation among advanced nonsquamous cell lung cancer-patients: a real-world evidence scenario
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFMG |
Texto Completo: | https://doi.org/10.1080/20016689.2022.2077905 http://hdl.handle.net/1843/61656 http://orcid.org/0000-0002-4647-9788 http://orcid.org/0000-0002-7228-7018 http://orcid.org/0000-0001-5997-318X http://orcid.org/0000-0001-8839-3491 http://orcid.org/0000-0003-2016-5593 |
Resumo: | Background: Precision oncology has a prominent role in nonsquamous non-small cell lung cancer (nsNSCLC) treatment progress; however, its access in a real-world scenario might be limited. Objective: To investigate the time spent in nsNSCLC molecular profile evaluation and its influence on clinical decisions. Methods: nsNSCLC patients who underwent molecular testing in a private referral Brazilian center between November 2015 and February 2020 were identified. The interval from nsNSCLC diagnosis to the characterization of the molecular profile was determined. Other outcomes, focusing on the biomarker tissue journey, were also assessed. Results: In this cohort (n = 78), the median time between the advanced nsNSCLC diagnosis and biomarker characterization was 40.5 days (range, 29.5–68.5). The median interval between the diagnosis and the test request was longer than the interval between the request and the results (respectively 29.0 versus 12.0 days; p < 0.001). At the treatment initiation, 51% (36/71) of the patients who received any systemic therapy did not have their driver mutations panel results available. But on these, 42% (15/36) had a targetable alteration identified later on. Among patients harboring a targetable alteration, only 46% (n = 13/28) received a tyrosine kinase inhibitor (TKI) as first-line therapy. The median time to the TKI initiation was even longer than the median time to all treatment initiation (92.0 versus 40.0 days). Conclusions: Our data show a long median time from advanced nsNSCLC diagnosis and the availability of the biomarker testing in medical practice, which impacted the choice of a non-personalized therapy as the first-line. |
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2023-12-01T21:11:54Z2023-12-01T21:11:54Z2022101https://doi.org/10.1080/20016689.2022.20779052001-6689http://hdl.handle.net/1843/61656http://orcid.org/0000-0002-4647-9788http://orcid.org/0000-0002-7228-7018http://orcid.org/0000-0001-5997-318Xhttp://orcid.org/0000-0001-8839-3491http://orcid.org/0000-0003-2016-5593Background: Precision oncology has a prominent role in nonsquamous non-small cell lung cancer (nsNSCLC) treatment progress; however, its access in a real-world scenario might be limited. Objective: To investigate the time spent in nsNSCLC molecular profile evaluation and its influence on clinical decisions. Methods: nsNSCLC patients who underwent molecular testing in a private referral Brazilian center between November 2015 and February 2020 were identified. The interval from nsNSCLC diagnosis to the characterization of the molecular profile was determined. Other outcomes, focusing on the biomarker tissue journey, were also assessed. Results: In this cohort (n = 78), the median time between the advanced nsNSCLC diagnosis and biomarker characterization was 40.5 days (range, 29.5–68.5). The median interval between the diagnosis and the test request was longer than the interval between the request and the results (respectively 29.0 versus 12.0 days; p < 0.001). At the treatment initiation, 51% (36/71) of the patients who received any systemic therapy did not have their driver mutations panel results available. But on these, 42% (15/36) had a targetable alteration identified later on. Among patients harboring a targetable alteration, only 46% (n = 13/28) received a tyrosine kinase inhibitor (TKI) as first-line therapy. The median time to the TKI initiation was even longer than the median time to all treatment initiation (92.0 versus 40.0 days). Conclusions: Our data show a long median time from advanced nsNSCLC diagnosis and the availability of the biomarker testing in medical practice, which impacted the choice of a non-personalized therapy as the first-line.engUniversidade Federal de Minas GeraisUFMGBrasilMED - DEPARTAMENTO DE CLÍNICA MÉDICAJournal of Market Access & Health PolicyMedicina de precisãoAcesso aos serviços de saúdeCarcinoma pulmonar de células não pequenasPrecision medicineDrug accessNon-small cell lung cancerBarriers in precision medicine implementation among advanced nonsquamous cell lung cancer-patients: a real-world evidence scenarioinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://www.tandfonline.com/doi/full/10.1080/20016689.2022.2077905Flavia Amaral DuarteCarlos Gil FerreiraRodrigo DienstmannBruno L. FerrariMatheus Costa e SilvaPedro Nazareth A . JuniorPaulo Guilherme de Oliveira SallesPaulo Henrique Costa Dinizapplication/pdfinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMGLICENSELicense.txtLicense.txttext/plain; charset=utf-82042https://repositorio.ufmg.br/bitstream/1843/61656/1/License.txtfa505098d172de0bc8864fc1287ffe22MD51ORIGINALBarriers in precision medicine implementation among advanced nonsquamous cell lung cancer-patients_ a real-world evidence scenario .pdfBarriers in precision medicine implementation among advanced nonsquamous cell lung cancer-patients_ a real-world evidence scenario .pdfapplication/pdf7256233https://repositorio.ufmg.br/bitstream/1843/61656/2/Barriers%20in%20precision%20medicine%20implementation%20among%20advanced%20nonsquamous%20cell%20lung%20cancer-patients_%20a%20real-world%20evidence%20scenario%20.pdfb8732f1613cc57b8b995656c73d9c23dMD521843/616562023-12-01 18:11:54.552oai:repositorio.ufmg.br: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Repositório de PublicaçõesPUBhttps://repositorio.ufmg.br/oaiopendoar:2023-12-01T21:11:54Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)false |
dc.title.pt_BR.fl_str_mv |
Barriers in precision medicine implementation among advanced nonsquamous cell lung cancer-patients: a real-world evidence scenario |
title |
Barriers in precision medicine implementation among advanced nonsquamous cell lung cancer-patients: a real-world evidence scenario |
spellingShingle |
Barriers in precision medicine implementation among advanced nonsquamous cell lung cancer-patients: a real-world evidence scenario Flavia Amaral Duarte Precision medicine Drug access Non-small cell lung cancer Medicina de precisão Acesso aos serviços de saúde Carcinoma pulmonar de células não pequenas |
title_short |
Barriers in precision medicine implementation among advanced nonsquamous cell lung cancer-patients: a real-world evidence scenario |
title_full |
Barriers in precision medicine implementation among advanced nonsquamous cell lung cancer-patients: a real-world evidence scenario |
title_fullStr |
Barriers in precision medicine implementation among advanced nonsquamous cell lung cancer-patients: a real-world evidence scenario |
title_full_unstemmed |
Barriers in precision medicine implementation among advanced nonsquamous cell lung cancer-patients: a real-world evidence scenario |
title_sort |
Barriers in precision medicine implementation among advanced nonsquamous cell lung cancer-patients: a real-world evidence scenario |
author |
Flavia Amaral Duarte |
author_facet |
Flavia Amaral Duarte Carlos Gil Ferreira Rodrigo Dienstmann Bruno L. Ferrari Matheus Costa e Silva Pedro Nazareth A . Junior Paulo Guilherme de Oliveira Salles Paulo Henrique Costa Diniz |
author_role |
author |
author2 |
Carlos Gil Ferreira Rodrigo Dienstmann Bruno L. Ferrari Matheus Costa e Silva Pedro Nazareth A . Junior Paulo Guilherme de Oliveira Salles Paulo Henrique Costa Diniz |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Flavia Amaral Duarte Carlos Gil Ferreira Rodrigo Dienstmann Bruno L. Ferrari Matheus Costa e Silva Pedro Nazareth A . Junior Paulo Guilherme de Oliveira Salles Paulo Henrique Costa Diniz |
dc.subject.por.fl_str_mv |
Precision medicine Drug access Non-small cell lung cancer |
topic |
Precision medicine Drug access Non-small cell lung cancer Medicina de precisão Acesso aos serviços de saúde Carcinoma pulmonar de células não pequenas |
dc.subject.other.pt_BR.fl_str_mv |
Medicina de precisão Acesso aos serviços de saúde Carcinoma pulmonar de células não pequenas |
description |
Background: Precision oncology has a prominent role in nonsquamous non-small cell lung cancer (nsNSCLC) treatment progress; however, its access in a real-world scenario might be limited. Objective: To investigate the time spent in nsNSCLC molecular profile evaluation and its influence on clinical decisions. Methods: nsNSCLC patients who underwent molecular testing in a private referral Brazilian center between November 2015 and February 2020 were identified. The interval from nsNSCLC diagnosis to the characterization of the molecular profile was determined. Other outcomes, focusing on the biomarker tissue journey, were also assessed. Results: In this cohort (n = 78), the median time between the advanced nsNSCLC diagnosis and biomarker characterization was 40.5 days (range, 29.5–68.5). The median interval between the diagnosis and the test request was longer than the interval between the request and the results (respectively 29.0 versus 12.0 days; p < 0.001). At the treatment initiation, 51% (36/71) of the patients who received any systemic therapy did not have their driver mutations panel results available. But on these, 42% (15/36) had a targetable alteration identified later on. Among patients harboring a targetable alteration, only 46% (n = 13/28) received a tyrosine kinase inhibitor (TKI) as first-line therapy. The median time to the TKI initiation was even longer than the median time to all treatment initiation (92.0 versus 40.0 days). Conclusions: Our data show a long median time from advanced nsNSCLC diagnosis and the availability of the biomarker testing in medical practice, which impacted the choice of a non-personalized therapy as the first-line. |
publishDate |
2022 |
dc.date.issued.fl_str_mv |
2022 |
dc.date.accessioned.fl_str_mv |
2023-12-01T21:11:54Z |
dc.date.available.fl_str_mv |
2023-12-01T21:11:54Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1843/61656 |
dc.identifier.doi.pt_BR.fl_str_mv |
https://doi.org/10.1080/20016689.2022.2077905 |
dc.identifier.issn.pt_BR.fl_str_mv |
2001-6689 |
dc.identifier.orcid.pt_BR.fl_str_mv |
http://orcid.org/0000-0002-4647-9788 http://orcid.org/0000-0002-7228-7018 http://orcid.org/0000-0001-5997-318X http://orcid.org/0000-0001-8839-3491 http://orcid.org/0000-0003-2016-5593 |
url |
https://doi.org/10.1080/20016689.2022.2077905 http://hdl.handle.net/1843/61656 http://orcid.org/0000-0002-4647-9788 http://orcid.org/0000-0002-7228-7018 http://orcid.org/0000-0001-5997-318X http://orcid.org/0000-0001-8839-3491 http://orcid.org/0000-0003-2016-5593 |
identifier_str_mv |
2001-6689 |
dc.language.iso.fl_str_mv |
eng |
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eng |
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Journal of Market Access & Health Policy |
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info:eu-repo/semantics/openAccess |
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openAccess |
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Universidade Federal de Minas Gerais |
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Brasil |
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MED - DEPARTAMENTO DE CLÍNICA MÉDICA |
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Universidade Federal de Minas Gerais |
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