CXCL-16, IL-17, and bone morphogenetic protein 2 (BMP-2) are associated with overweight and obesity conditions in middle-aged and elderly women
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFMG |
Texto Completo: | http://hdl.handle.net/1843/44239 |
Resumo: | Background The current concept of overweight/obesity is most likely related to a combination of increased caloric intake and decreased energy expenditure. Widespread inflammation, associated with both conditions, appears to contribute to the development of some obesity-related comorbidities. Interventions that directly or indirectly target individuals at high risk of developing obesity have been largely proposed because of the increasing number of overweight/obese cases worldwide. The aim of the present study was to assess CXCL16, IL-17, and BMP-2 plasma factors in middle-aged and elderly women and relate them to an overweight or obese status. In total, 117 women were selected and grouped as eutrophic, overweight, and obese, according to anthropometric parameters. Analyses of anthropometric and circulating biochemical parameters were followed by plasma immunoassays for CXCL-16, IL-17, and BMP-2. Results Plasma mediators increased in all overweight and obese individuals, with the exception of BMP-2 in the elderly group, whereas CXCL16 levels were shown to differentiate overweight and obese individuals. Overweight and/or obese middle-aged and elderly individuals presented with high LDL, triglycerides, and glycemia levels. Anthropometric parameters indicating increased-cardiovascular risk were positively correlated with CXCL-16, BMP-2, and IL-17 levels in overweight and obese middle-aged and elderly individuals. Conclusion This study provides evidence that CXCL-16, IL-17, and BMP-2 are potential plasma indicators of inflammatory status in middle-aged and elderly women; therefore, further investigation of obesity-related comorbidities is recommended. CXCL16, in particular, could be a potential marker for middle-aged and elderly individuals transitioning from eutrophic to overweight body types, which represents an asymptomatic and dangerous condition. |
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2022-08-12T17:23:58Z2022-08-12T17:23:58Z20171411610.1186/s12979-017-0089-01742-4933http://hdl.handle.net/1843/44239Background The current concept of overweight/obesity is most likely related to a combination of increased caloric intake and decreased energy expenditure. Widespread inflammation, associated with both conditions, appears to contribute to the development of some obesity-related comorbidities. Interventions that directly or indirectly target individuals at high risk of developing obesity have been largely proposed because of the increasing number of overweight/obese cases worldwide. The aim of the present study was to assess CXCL16, IL-17, and BMP-2 plasma factors in middle-aged and elderly women and relate them to an overweight or obese status. In total, 117 women were selected and grouped as eutrophic, overweight, and obese, according to anthropometric parameters. Analyses of anthropometric and circulating biochemical parameters were followed by plasma immunoassays for CXCL-16, IL-17, and BMP-2. Results Plasma mediators increased in all overweight and obese individuals, with the exception of BMP-2 in the elderly group, whereas CXCL16 levels were shown to differentiate overweight and obese individuals. Overweight and/or obese middle-aged and elderly individuals presented with high LDL, triglycerides, and glycemia levels. Anthropometric parameters indicating increased-cardiovascular risk were positively correlated with CXCL-16, BMP-2, and IL-17 levels in overweight and obese middle-aged and elderly individuals. Conclusion This study provides evidence that CXCL-16, IL-17, and BMP-2 are potential plasma indicators of inflammatory status in middle-aged and elderly women; therefore, further investigation of obesity-related comorbidities is recommended. CXCL16, in particular, could be a potential marker for middle-aged and elderly individuals transitioning from eutrophic to overweight body types, which represents an asymptomatic and dangerous condition.Fundo O conceito atual de sobrepeso/obesidade provavelmente está relacionado a uma combinação de aumento da ingestão calórica e diminuição do gasto energético. A inflamação generalizada, associada a ambas as condições, parece contribuir para o desenvolvimento de algumas comorbidades relacionadas à obesidade. Intervenções que visam direta ou indiretamente indivíduos com alto risco de desenvolver obesidade têm sido amplamente propostas devido ao crescente número de casos de sobrepeso/obesidade em todo o mundo. O objetivo do presente estudo foi avaliar os fatores plasmáticos de CXCL16, IL-17 e BMP-2 em mulheres de meia-idade e idosas e relacioná-los ao estado de sobrepeso ou obesidade. No total, 117 mulheres foram selecionadas e agrupadas em eutróficas, com sobrepeso e obesas, de acordo com parâmetros antropométricos. As análises dos parâmetros antropométricos e bioquímicos circulantes foram seguidas por imunoensaios plasmáticos para CXCL-16, IL-17 e BMP-2. Resultados Os mediadores plasmáticos aumentaram em todos os indivíduos com sobrepeso e obesos, com exceção de BMP-2 no grupo de idosos, enquanto os níveis de CXCL16 mostraram diferenciar indivíduos com sobrepeso e obesos. Indivíduos de meia-idade e idosos com sobrepeso e/ou obesidade apresentaram níveis elevados de LDL, triglicerídeos e glicemia. Parâmetros antropométricos indicando risco cardiovascular aumentado foram positivamente correlacionados com os níveis de CXCL-16, BMP-2 e IL-17 em indivíduos de meia-idade e idosos com sobrepeso e obesidade. Conclusão Este estudo fornece evidências de que CXCL-16, IL-17 e BMP-2 são potenciais indicadores plasmáticos de estado inflamatório em mulheres de meia-idade e idosas; portanto, recomenda-se uma investigação mais aprofundada das comorbidades relacionadas à obesidade. CXCL16, em particular, poderia ser um marcador potencial para indivíduos de meia-idade e idosos em transição de tipos corporais eutróficos para com sobrepeso, o que representa uma condição assintomática e perigosa.engUniversidade Federal de Minas GeraisUFMGBrasilICB - DEPARTAMENTO DE MORFOLOGIAImmunity & AgeingBiomarcadores PlasmáticosCXCL-16IdososSobrepesoObesidadeIL-17CXCL-16, IL-17, and bone morphogenetic protein 2 (BMP-2) are associated with overweight and obesity conditions in middle-aged and elderly womenCXCL-16, IL-17 e proteína morfogenética óssea 2 (BMP-2) estão associados a condições de sobrepeso e obesidade em mulheres de meia-idade e idosasinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://immunityageing.biomedcentral.com/articles/10.1186/s12979-017-0089-0Silvana Mara Turbino Luz RibeiroAndre TalvaniLaís Roquete LopesGuilherme de Paula CostaVivian Paulino FigueiredoDeena ShresthaAline Priscila BatistaRoney Luiz de Carvalho NicolatoFernando Luiz Pereira de OliveiraJuliana Assis Silva Gomesapplication/pdfinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMGORIGINAL2017_Cxcl-16, il-17, and bone morphogenetic protein 2 (bmp-2) are associated with overweight and obesity conditions in middle-aged and elderly women.pdf2017_Cxcl-16, il-17, and bone morphogenetic protein 2 (bmp-2) are associated with overweight and obesity conditions in middle-aged and elderly women.pdfapplication/pdf531801https://repositorio.ufmg.br/bitstream/1843/44239/2/2017_Cxcl-16%2c%20il-17%2c%20and%20bone%20morphogenetic%20protein%202%20%28bmp-2%29%20are%20associated%20with%20overweight%20and%20obesity%20conditions%20in%20middle-aged%20and%20elderly%20women.pdf4450512921bc5b5189318568cb299743MD52LICENSELicense.txtLicense.txttext/plain; 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dc.title.pt_BR.fl_str_mv |
CXCL-16, IL-17, and bone morphogenetic protein 2 (BMP-2) are associated with overweight and obesity conditions in middle-aged and elderly women |
dc.title.alternative.pt_BR.fl_str_mv |
CXCL-16, IL-17 e proteína morfogenética óssea 2 (BMP-2) estão associados a condições de sobrepeso e obesidade em mulheres de meia-idade e idosas |
title |
CXCL-16, IL-17, and bone morphogenetic protein 2 (BMP-2) are associated with overweight and obesity conditions in middle-aged and elderly women |
spellingShingle |
CXCL-16, IL-17, and bone morphogenetic protein 2 (BMP-2) are associated with overweight and obesity conditions in middle-aged and elderly women Silvana Mara Turbino Luz Ribeiro Biomarcadores Plasmáticos CXCL-16 Idosos Sobrepeso Obesidade IL-17 |
title_short |
CXCL-16, IL-17, and bone morphogenetic protein 2 (BMP-2) are associated with overweight and obesity conditions in middle-aged and elderly women |
title_full |
CXCL-16, IL-17, and bone morphogenetic protein 2 (BMP-2) are associated with overweight and obesity conditions in middle-aged and elderly women |
title_fullStr |
CXCL-16, IL-17, and bone morphogenetic protein 2 (BMP-2) are associated with overweight and obesity conditions in middle-aged and elderly women |
title_full_unstemmed |
CXCL-16, IL-17, and bone morphogenetic protein 2 (BMP-2) are associated with overweight and obesity conditions in middle-aged and elderly women |
title_sort |
CXCL-16, IL-17, and bone morphogenetic protein 2 (BMP-2) are associated with overweight and obesity conditions in middle-aged and elderly women |
author |
Silvana Mara Turbino Luz Ribeiro |
author_facet |
Silvana Mara Turbino Luz Ribeiro Andre Talvani Laís Roquete Lopes Guilherme de Paula Costa Vivian Paulino Figueiredo Deena Shrestha Aline Priscila Batista Roney Luiz de Carvalho Nicolato Fernando Luiz Pereira de Oliveira Juliana Assis Silva Gomes |
author_role |
author |
author2 |
Andre Talvani Laís Roquete Lopes Guilherme de Paula Costa Vivian Paulino Figueiredo Deena Shrestha Aline Priscila Batista Roney Luiz de Carvalho Nicolato Fernando Luiz Pereira de Oliveira Juliana Assis Silva Gomes |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Silvana Mara Turbino Luz Ribeiro Andre Talvani Laís Roquete Lopes Guilherme de Paula Costa Vivian Paulino Figueiredo Deena Shrestha Aline Priscila Batista Roney Luiz de Carvalho Nicolato Fernando Luiz Pereira de Oliveira Juliana Assis Silva Gomes |
dc.subject.other.pt_BR.fl_str_mv |
Biomarcadores Plasmáticos CXCL-16 Idosos Sobrepeso Obesidade IL-17 |
topic |
Biomarcadores Plasmáticos CXCL-16 Idosos Sobrepeso Obesidade IL-17 |
description |
Background The current concept of overweight/obesity is most likely related to a combination of increased caloric intake and decreased energy expenditure. Widespread inflammation, associated with both conditions, appears to contribute to the development of some obesity-related comorbidities. Interventions that directly or indirectly target individuals at high risk of developing obesity have been largely proposed because of the increasing number of overweight/obese cases worldwide. The aim of the present study was to assess CXCL16, IL-17, and BMP-2 plasma factors in middle-aged and elderly women and relate them to an overweight or obese status. In total, 117 women were selected and grouped as eutrophic, overweight, and obese, according to anthropometric parameters. Analyses of anthropometric and circulating biochemical parameters were followed by plasma immunoassays for CXCL-16, IL-17, and BMP-2. Results Plasma mediators increased in all overweight and obese individuals, with the exception of BMP-2 in the elderly group, whereas CXCL16 levels were shown to differentiate overweight and obese individuals. Overweight and/or obese middle-aged and elderly individuals presented with high LDL, triglycerides, and glycemia levels. Anthropometric parameters indicating increased-cardiovascular risk were positively correlated with CXCL-16, BMP-2, and IL-17 levels in overweight and obese middle-aged and elderly individuals. Conclusion This study provides evidence that CXCL-16, IL-17, and BMP-2 are potential plasma indicators of inflammatory status in middle-aged and elderly women; therefore, further investigation of obesity-related comorbidities is recommended. CXCL16, in particular, could be a potential marker for middle-aged and elderly individuals transitioning from eutrophic to overweight body types, which represents an asymptomatic and dangerous condition. |
publishDate |
2017 |
dc.date.issued.fl_str_mv |
2017 |
dc.date.accessioned.fl_str_mv |
2022-08-12T17:23:58Z |
dc.date.available.fl_str_mv |
2022-08-12T17:23:58Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
format |
article |
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publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1843/44239 |
dc.identifier.doi.pt_BR.fl_str_mv |
10.1186/s12979-017-0089-0 |
dc.identifier.issn.pt_BR.fl_str_mv |
1742-4933 |
identifier_str_mv |
10.1186/s12979-017-0089-0 1742-4933 |
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http://hdl.handle.net/1843/44239 |
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eng |
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eng |
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Immunity & Ageing |
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openAccess |
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Universidade Federal de Minas Gerais |
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UFMG |
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Brasil |
dc.publisher.department.fl_str_mv |
ICB - DEPARTAMENTO DE MORFOLOGIA |
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Universidade Federal de Minas Gerais |
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