Is HIF1-a deregulated in malignant salivary neoplasms?

• Autor(a) principal: Cláudio Marcelo Cardoso
• Data de Publicação: 2019
• Outros Autores: Sabrina Ferreira de Jesus, Marcela Gonçalves de Souza, Eloa Mangabeira Santos, Cristiane Karine Cordeiro Santos, Christine Mendes Silveira, Sergio Henrique Sousa Santos, Alfredo Maurício Batista de Paula, Lucyana Conceição Farias, André Luiz Sena Guimarães
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UFMG
• Texto Completo: https://doi.org/10.1016/j.gene.2019.03.017; http://hdl.handle.net/1843/44646
• topic: Tumores odontogênicos; Câncer - Quimioterapia

Background: there is significant controversy in the literature regarding the relationship between hypoxia and salivary gland neoplasms (SGNs). Objective: the current study aims to investigate levels of hypoxia markers in both benign and malignant salivary neoplasms. Patients and methods: the current study sample is comprised of a total of 62 samples. HIF-1α expression was evaluated by immunohistochemistry. Additionally, HIF-1α mRNA and miR-210 levels were assessed using qRT-PCR. Results: no differences in HIF-1α expression were observed among the control group, benign and malignant SGNs. Similarly, HIF-1α mRNA levels were similar between benign and malignant SGNs. Also, there was no difference in miR-210 expression between case and control groups. Conclusion: the angiogenic markers, miR-210 and HIF-1α, do not appear to distinguish malignancy in salivary glands.