Is HIF1-a deregulated in malignant salivary neoplasms?
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2019 |
| Outros Autores: | , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFMG |
| Texto Completo: | https://doi.org/10.1016/j.gene.2019.03.017 http://hdl.handle.net/1843/44646 |
Resumo: | CNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico |
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2022-08-29T13:43:28Z2022-08-29T13:43:28Z2019-05-157014145https://doi.org/10.1016/j.gene.2019.03.0170378-1119http://hdl.handle.net/1843/44646CNPq - Conselho Nacional de Desenvolvimento Científico e TecnológicoFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas GeraisCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível SuperiorBackground: there is significant controversy in the literature regarding the relationship between hypoxia and salivary gland neoplasms (SGNs). Objective: the current study aims to investigate levels of hypoxia markers in both benign and malignant salivary neoplasms. Patients and methods: the current study sample is comprised of a total of 62 samples. HIF-1α expression was evaluated by immunohistochemistry. Additionally, HIF-1α mRNA and miR-210 levels were assessed using qRT-PCR. Results: no differences in HIF-1α expression were observed among the control group, benign and malignant SGNs. Similarly, HIF-1α mRNA levels were similar between benign and malignant SGNs. Also, there was no difference in miR-210 expression between case and control groups. Conclusion: the angiogenic markers, miR-210 and HIF-1α, do not appear to distinguish malignancy in salivary glands.engUniversidade Federal de Minas GeraisUFMGBrasilICA - INSTITUTO DE CIÊNCIAS AGRÁRIASGeneTumores odontogênicosCâncer - QuimioterapiaIs HIF1-a deregulated in malignant salivary neoplasms?info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://www.sciencedirect.com/science/article/pii/S0378111919302434?via%3DihubCláudio Marcelo CardosoSabrina Ferreira de JesusMarcela Gonçalves de SouzaEloa Mangabeira SantosCristiane Karine Cordeiro SantosChristine Mendes SilveiraSergio Henrique Sousa SantosAlfredo Maurício Batista de PaulaLucyana Conceição FariasAndré Luiz Sena Guimarãesinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMGORIGINALIs HIF1-a deregulated in malignant salivary neoplasms.pdfIs HIF1-a deregulated in malignant salivary neoplasms.pdfapplication/pdf1090269https://repositorio.ufmg.br/bitstream/1843/44646/2/Is%20HIF1-a%20deregulated%20in%20malignant%20salivary%20neoplasms.pdf0d6286131b4dd3234012af5cdb0f94aaMD52LICENSELicense.txtLicense.txttext/plain; charset=utf-82042https://repositorio.ufmg.br/bitstream/1843/44646/1/License.txtfa505098d172de0bc8864fc1287ffe22MD511843/446462022-08-29 10:43:29.113oai:repositorio.ufmg.br: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Repositório de PublicaçõesPUBhttps://repositorio.ufmg.br/oaiopendoar:2022-08-29T13:43:29Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)false |
| dc.title.pt_BR.fl_str_mv |
Is HIF1-a deregulated in malignant salivary neoplasms? |
| title |
Is HIF1-a deregulated in malignant salivary neoplasms? |
| spellingShingle |
Is HIF1-a deregulated in malignant salivary neoplasms? Cláudio Marcelo Cardoso Tumores odontogênicos Câncer - Quimioterapia |
| title_short |
Is HIF1-a deregulated in malignant salivary neoplasms? |
| title_full |
Is HIF1-a deregulated in malignant salivary neoplasms? |
| title_fullStr |
Is HIF1-a deregulated in malignant salivary neoplasms? |
| title_full_unstemmed |
Is HIF1-a deregulated in malignant salivary neoplasms? |
| title_sort |
Is HIF1-a deregulated in malignant salivary neoplasms? |
| author |
Cláudio Marcelo Cardoso |
| author_facet |
Cláudio Marcelo Cardoso Sabrina Ferreira de Jesus Marcela Gonçalves de Souza Eloa Mangabeira Santos Cristiane Karine Cordeiro Santos Christine Mendes Silveira Sergio Henrique Sousa Santos Alfredo Maurício Batista de Paula Lucyana Conceição Farias André Luiz Sena Guimarães |
| author_role |
author |
| author2 |
Sabrina Ferreira de Jesus Marcela Gonçalves de Souza Eloa Mangabeira Santos Cristiane Karine Cordeiro Santos Christine Mendes Silveira Sergio Henrique Sousa Santos Alfredo Maurício Batista de Paula Lucyana Conceição Farias André Luiz Sena Guimarães |
| author2_role |
author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Cláudio Marcelo Cardoso Sabrina Ferreira de Jesus Marcela Gonçalves de Souza Eloa Mangabeira Santos Cristiane Karine Cordeiro Santos Christine Mendes Silveira Sergio Henrique Sousa Santos Alfredo Maurício Batista de Paula Lucyana Conceição Farias André Luiz Sena Guimarães |
| dc.subject.other.pt_BR.fl_str_mv |
Tumores odontogênicos Câncer - Quimioterapia |
| topic |
Tumores odontogênicos Câncer - Quimioterapia |
| description |
CNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico |
| publishDate |
2019 |
| dc.date.issued.fl_str_mv |
2019-05-15 |
| dc.date.accessioned.fl_str_mv |
2022-08-29T13:43:28Z |
| dc.date.available.fl_str_mv |
2022-08-29T13:43:28Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1843/44646 |
| dc.identifier.doi.pt_BR.fl_str_mv |
https://doi.org/10.1016/j.gene.2019.03.017 |
| dc.identifier.issn.pt_BR.fl_str_mv |
0378-1119 |
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https://doi.org/10.1016/j.gene.2019.03.017 http://hdl.handle.net/1843/44646 |
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0378-1119 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.ispartof.pt_BR.fl_str_mv |
Gene |
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info:eu-repo/semantics/openAccess |
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openAccess |
| dc.publisher.none.fl_str_mv |
Universidade Federal de Minas Gerais |
| dc.publisher.initials.fl_str_mv |
UFMG |
| dc.publisher.country.fl_str_mv |
Brasil |
| dc.publisher.department.fl_str_mv |
ICA - INSTITUTO DE CIÊNCIAS AGRÁRIAS |
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Universidade Federal de Minas Gerais |
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reponame:Repositório Institucional da UFMG instname:Universidade Federal de Minas Gerais (UFMG) instacron:UFMG |
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