Histomorphometric characterization of subgemmal neurogenous plaques
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Repositório Institucional da UFMG |
Texto Completo: | https://doi.org/10.1016/j.oooo.2016.12.014 http://hdl.handle.net/1843/57555 https://orcid.org/0000-0002-1624-0178 https://orcid.org/0000-0003-2040-6617 https://orcid.org/0000-0002-6657-4547 https://orcid.org/0000-0003-4979-4318 https://orcid.org/0000-0003-2002-8003 https://orcid.org/0000-0003-1840-4911 https://orcid.org/0000-0001-6677-0065 https://orcid.org/0000-0002-7609-8804 https://orcid.org/0000-0001-8662-5965 |
Resumo: | Objectives The aim of this study was to characterize the histomorphometric features of subgemmal neurogenous plaques (SNPs) to better understand their relationship to surrounding microanatomy included in the tissue biopsy samples of the tongue. Study Design A 12-year retrospective study on the files of 3 oral pathology centers yielded 28 SNPs. Hematoxylin and eosin–stained sections were used for histologic analysis, and immunohistochemical staining for S100 protein was performed to better characterize the neural structures. Slides were scanned and histomorphometric analysis carried out using ImageScope software. Results Twenty-one women (75%) and 6 men (21.4%) comprised the sample (mean age 46.4 and 49 years, respectively). Twenty cases (71.4%) were juxtaposed to the tongue epithelium and 16 cases (57.1%) were associated with lymphoid tissue. The mean area of the SNPs was 0.160 mm2, and the mean distance to the overlying epithelium was 0.312 mm. Conclusions SNPs are normal neural structures located on the posterior border of the tongue that represent a non-neoplastic regional anatomic variation. In some cases, signs or symptoms may be present, and further investigation should be performed. Pathologists should be aware of this entity to avoid confusion with neural lesions. |
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2023-08-07T18:18:53Z2023-08-07T18:18:53Z20171234477481https://doi.org/10.1016/j.oooo.2016.12.0142212-4403http://hdl.handle.net/1843/57555https://orcid.org/0000-0002-1624-0178https://orcid.org/0000-0003-2040-6617https://orcid.org/0000-0002-6657-4547https://orcid.org/0000-0003-4979-4318https://orcid.org/0000-0003-2002-8003https://orcid.org/0000-0003-1840-4911https://orcid.org/0000-0001-6677-0065https://orcid.org/0000-0002-7609-8804https://orcid.org/0000-0001-8662-5965Objectives The aim of this study was to characterize the histomorphometric features of subgemmal neurogenous plaques (SNPs) to better understand their relationship to surrounding microanatomy included in the tissue biopsy samples of the tongue. Study Design A 12-year retrospective study on the files of 3 oral pathology centers yielded 28 SNPs. Hematoxylin and eosin–stained sections were used for histologic analysis, and immunohistochemical staining for S100 protein was performed to better characterize the neural structures. Slides were scanned and histomorphometric analysis carried out using ImageScope software. Results Twenty-one women (75%) and 6 men (21.4%) comprised the sample (mean age 46.4 and 49 years, respectively). Twenty cases (71.4%) were juxtaposed to the tongue epithelium and 16 cases (57.1%) were associated with lymphoid tissue. The mean area of the SNPs was 0.160 mm2, and the mean distance to the overlying epithelium was 0.312 mm. Conclusions SNPs are normal neural structures located on the posterior border of the tongue that represent a non-neoplastic regional anatomic variation. In some cases, signs or symptoms may be present, and further investigation should be performed. Pathologists should be aware of this entity to avoid confusion with neural lesions.porUniversidade Federal de Minas GeraisUFMGBrasilFAO - DEPARTAMENTO DE ODONTOLOGIA SOCIAL E PREVENTIVAOral Surgery, Oral Medicine, Oral Pathology and Oral RadiologyBiópsiaLínguaPatologia bucalTissue biopsyTongueOral pathologyPathologistsHistomorphometric characterization of subgemmal neurogenous plaquesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://www.sciencedirect.com/science/article/pii/S2212440317300019Ana Carolina PellicioliVinicius Coelho CarrardAlan Roger dos Santos SilvaFelipe Paiva FonsecaRodrigo Neves SilvaLuiz Alcino Monteiro GueirosOslei Paes de AlmeidaPablo Agustin VargasMárcio Ajudarte LopesHélder Antônio Rebelo PontesManoela Domingues Martinsinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMGLICENSELicense.txtLicense.txttext/plain; charset=utf-82042https://repositorio.ufmg.br/bitstream/1843/57555/1/License.txtfa505098d172de0bc8864fc1287ffe22MD51ORIGINALHistomorphometric characterization of subgemmal neurogenous plaques.pdfHistomorphometric characterization of subgemmal neurogenous plaques.pdfapplication/pdf1246699https://repositorio.ufmg.br/bitstream/1843/57555/2/Histomorphometric%20characterization%20of%20subgemmal%20neurogenous%20plaques.pdf8008d884f64d72bcb27d2e4d55b94786MD521843/575552023-08-07 15:18:53.385oai:repositorio.ufmg.br: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Repositório de PublicaçõesPUBhttps://repositorio.ufmg.br/oaiopendoar:2023-08-07T18:18:53Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)false |
dc.title.pt_BR.fl_str_mv |
Histomorphometric characterization of subgemmal neurogenous plaques |
title |
Histomorphometric characterization of subgemmal neurogenous plaques |
spellingShingle |
Histomorphometric characterization of subgemmal neurogenous plaques Ana Carolina Pellicioli Tissue biopsy Tongue Oral pathology Pathologists Biópsia Língua Patologia bucal |
title_short |
Histomorphometric characterization of subgemmal neurogenous plaques |
title_full |
Histomorphometric characterization of subgemmal neurogenous plaques |
title_fullStr |
Histomorphometric characterization of subgemmal neurogenous plaques |
title_full_unstemmed |
Histomorphometric characterization of subgemmal neurogenous plaques |
title_sort |
Histomorphometric characterization of subgemmal neurogenous plaques |
author |
Ana Carolina Pellicioli |
author_facet |
Ana Carolina Pellicioli Vinicius Coelho Carrard Alan Roger dos Santos Silva Felipe Paiva Fonseca Rodrigo Neves Silva Luiz Alcino Monteiro Gueiros Oslei Paes de Almeida Pablo Agustin Vargas Márcio Ajudarte Lopes Hélder Antônio Rebelo Pontes Manoela Domingues Martins |
author_role |
author |
author2 |
Vinicius Coelho Carrard Alan Roger dos Santos Silva Felipe Paiva Fonseca Rodrigo Neves Silva Luiz Alcino Monteiro Gueiros Oslei Paes de Almeida Pablo Agustin Vargas Márcio Ajudarte Lopes Hélder Antônio Rebelo Pontes Manoela Domingues Martins |
author2_role |
author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Ana Carolina Pellicioli Vinicius Coelho Carrard Alan Roger dos Santos Silva Felipe Paiva Fonseca Rodrigo Neves Silva Luiz Alcino Monteiro Gueiros Oslei Paes de Almeida Pablo Agustin Vargas Márcio Ajudarte Lopes Hélder Antônio Rebelo Pontes Manoela Domingues Martins |
dc.subject.por.fl_str_mv |
Tissue biopsy Tongue Oral pathology Pathologists |
topic |
Tissue biopsy Tongue Oral pathology Pathologists Biópsia Língua Patologia bucal |
dc.subject.other.pt_BR.fl_str_mv |
Biópsia Língua Patologia bucal |
description |
Objectives The aim of this study was to characterize the histomorphometric features of subgemmal neurogenous plaques (SNPs) to better understand their relationship to surrounding microanatomy included in the tissue biopsy samples of the tongue. Study Design A 12-year retrospective study on the files of 3 oral pathology centers yielded 28 SNPs. Hematoxylin and eosin–stained sections were used for histologic analysis, and immunohistochemical staining for S100 protein was performed to better characterize the neural structures. Slides were scanned and histomorphometric analysis carried out using ImageScope software. Results Twenty-one women (75%) and 6 men (21.4%) comprised the sample (mean age 46.4 and 49 years, respectively). Twenty cases (71.4%) were juxtaposed to the tongue epithelium and 16 cases (57.1%) were associated with lymphoid tissue. The mean area of the SNPs was 0.160 mm2, and the mean distance to the overlying epithelium was 0.312 mm. Conclusions SNPs are normal neural structures located on the posterior border of the tongue that represent a non-neoplastic regional anatomic variation. In some cases, signs or symptoms may be present, and further investigation should be performed. Pathologists should be aware of this entity to avoid confusion with neural lesions. |
publishDate |
2017 |
dc.date.issued.fl_str_mv |
2017 |
dc.date.accessioned.fl_str_mv |
2023-08-07T18:18:53Z |
dc.date.available.fl_str_mv |
2023-08-07T18:18:53Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1843/57555 |
dc.identifier.doi.pt_BR.fl_str_mv |
https://doi.org/10.1016/j.oooo.2016.12.014 |
dc.identifier.issn.pt_BR.fl_str_mv |
2212-4403 |
dc.identifier.orcid.pt_BR.fl_str_mv |
https://orcid.org/0000-0002-1624-0178 https://orcid.org/0000-0003-2040-6617 https://orcid.org/0000-0002-6657-4547 https://orcid.org/0000-0003-4979-4318 https://orcid.org/0000-0003-2002-8003 https://orcid.org/0000-0003-1840-4911 https://orcid.org/0000-0001-6677-0065 https://orcid.org/0000-0002-7609-8804 https://orcid.org/0000-0001-8662-5965 |
url |
https://doi.org/10.1016/j.oooo.2016.12.014 http://hdl.handle.net/1843/57555 https://orcid.org/0000-0002-1624-0178 https://orcid.org/0000-0003-2040-6617 https://orcid.org/0000-0002-6657-4547 https://orcid.org/0000-0003-4979-4318 https://orcid.org/0000-0003-2002-8003 https://orcid.org/0000-0003-1840-4911 https://orcid.org/0000-0001-6677-0065 https://orcid.org/0000-0002-7609-8804 https://orcid.org/0000-0001-8662-5965 |
identifier_str_mv |
2212-4403 |
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por |
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por |
dc.relation.ispartof.pt_BR.fl_str_mv |
Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology |
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info:eu-repo/semantics/openAccess |
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openAccess |
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Universidade Federal de Minas Gerais |
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UFMG |
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Brasil |
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FAO - DEPARTAMENTO DE ODONTOLOGIA SOCIAL E PREVENTIVA |
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Universidade Federal de Minas Gerais |
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