Oral tolerance as antigen-specific immunotherapy
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2021 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFMG |
| Texto Completo: | https://doi.org/10.1093/immadv/ltab017 http://hdl.handle.net/1843/66225 https://orcid.org/0000-0002-2048-0318 https://orcid.org/0000-0002-0604-8510 https://orcid.org/0000-0002-7538-3208 |
Resumo: | CNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico |
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2024-03-20T20:14:11Z2024-03-20T20:14:11Z2021-08-2511121https://doi.org/10.1093/immadv/ltab0172732-4303http://hdl.handle.net/1843/66225https://orcid.org/0000-0002-2048-0318https://orcid.org/0000-0002-0604-8510https://orcid.org/0000-0002-7538-3208CNPq - Conselho Nacional de Desenvolvimento Científico e TecnológicoFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas GeraisCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível SuperiorOral tolerance is a physiological phenomenon described more than a century ago as a suppressive immune response to antigens that gain access to the body by the oral route. It is a robust and long-lasting event with local and systemic effects in which the generation of mucosally induced regulatory T cells (iTreg) plays an essential role. The idea of using oral tolerance to inhibit autoimmune and allergic diseases by oral administration of target antigens was an important development that was successfully tested in 1980s. Since then, several studies have shown that feeding specific antigens can be used to prevent and control chronic inflammatory diseases in both animal models and clinically. Therefore, oral tolerance can be classified as an antigen-specific form of oral immunotherapy (OIT). In the light of novel findings on mechanisms, sites of induction and factors affecting oral tolerance, this review will focus on specific characteristics of oral tolerance induction and how they impact in its therapeutic application.engUniversidade Federal de Minas GeraisUFMGBrasilENF - DEPARTAMENTO DE NUTRIÇÃOENFERMAGEM - ESCOLA DE ENFERMAGEMICB - DEPARTAMENTO DE BIOQUÍMICA E IMUNOLOGIAImmunotherapy AdvancesImunologiaImunoterapiaMucosa bucalLinfócitos T ReguladoresOral toleranceGut mucosaOral immunotherapyRegulatory T CellsOral tolerance as antigen-specific immunotherapyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://academic.oup.com/immunotherapyadv/article/1/1/ltab017/6357638Natália Pinheiro RosaLícia TorresMariana de Almeida OliveiraMarcos Felipe Andrade-oliveiraMauro Andrade de Freitas GuimarãesMonique Macedo CoelhoJuliana de Lima AlvesTatiani Uceli MaioliAna M. Caetano Fariaapplication/pdfinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMGLICENSELicense.txtLicense.txttext/plain; charset=utf-82042https://repositorio.ufmg.br/bitstream/1843/66225/1/License.txtfa505098d172de0bc8864fc1287ffe22MD51ORIGINALOral tolerance as antigen-specific immunotherapy.pdfOral tolerance as antigen-specific immunotherapy.pdfapplication/pdf377494https://repositorio.ufmg.br/bitstream/1843/66225/2/Oral%20tolerance%20as%20antigen-specific%20immunotherapy.pdfc443f34b2955c73415ef752611467e13MD521843/662252024-03-20 17:14:11.933oai:repositorio.ufmg.br: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Repositório de PublicaçõesPUBhttps://repositorio.ufmg.br/oaiopendoar:2024-03-20T20:14:11Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)false |
| dc.title.pt_BR.fl_str_mv |
Oral tolerance as antigen-specific immunotherapy |
| title |
Oral tolerance as antigen-specific immunotherapy |
| spellingShingle |
Oral tolerance as antigen-specific immunotherapy Natália Pinheiro Rosa Oral tolerance Gut mucosa Oral immunotherapy Regulatory T Cells Imunologia Imunoterapia Mucosa bucal Linfócitos T Reguladores |
| title_short |
Oral tolerance as antigen-specific immunotherapy |
| title_full |
Oral tolerance as antigen-specific immunotherapy |
| title_fullStr |
Oral tolerance as antigen-specific immunotherapy |
| title_full_unstemmed |
Oral tolerance as antigen-specific immunotherapy |
| title_sort |
Oral tolerance as antigen-specific immunotherapy |
| author |
Natália Pinheiro Rosa |
| author_facet |
Natália Pinheiro Rosa Lícia Torres Mariana de Almeida Oliveira Marcos Felipe Andrade-oliveira Mauro Andrade de Freitas Guimarães Monique Macedo Coelho Juliana de Lima Alves Tatiani Uceli Maioli Ana M. Caetano Faria |
| author_role |
author |
| author2 |
Lícia Torres Mariana de Almeida Oliveira Marcos Felipe Andrade-oliveira Mauro Andrade de Freitas Guimarães Monique Macedo Coelho Juliana de Lima Alves Tatiani Uceli Maioli Ana M. Caetano Faria |
| author2_role |
author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Natália Pinheiro Rosa Lícia Torres Mariana de Almeida Oliveira Marcos Felipe Andrade-oliveira Mauro Andrade de Freitas Guimarães Monique Macedo Coelho Juliana de Lima Alves Tatiani Uceli Maioli Ana M. Caetano Faria |
| dc.subject.por.fl_str_mv |
Oral tolerance Gut mucosa Oral immunotherapy Regulatory T Cells |
| topic |
Oral tolerance Gut mucosa Oral immunotherapy Regulatory T Cells Imunologia Imunoterapia Mucosa bucal Linfócitos T Reguladores |
| dc.subject.other.pt_BR.fl_str_mv |
Imunologia Imunoterapia Mucosa bucal Linfócitos T Reguladores |
| description |
CNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico |
| publishDate |
2021 |
| dc.date.issued.fl_str_mv |
2021-08-25 |
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2024-03-20T20:14:11Z |
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2024-03-20T20:14:11Z |
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http://hdl.handle.net/1843/66225 |
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https://doi.org/10.1093/immadv/ltab017 |
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2732-4303 |
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Immunotherapy Advances |
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