Thermosensitive nanosystems associated with hyperthermia for cancer treatment

• Autor(a) principal: Isabela Pereira Gomes
• Data de Publicação: 2019
• Outros Autores: Jaqueline Aparecida Duarte, Ana Luiza Chaves Maia, Domenico Rubello, Danyelle M. Townsend, André Luís Branco de Barros, Elaine Amaral Leite
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Repositório Institucional da UFMG
• Texto Completo: https://doi.org/10.3390/ph12040171; http://hdl.handle.net/1843/56502; https://orcid.org/0000-0001-7750-036X; https://orcid.org/0000-0001-6841-3061; https://orcid.org/0000-0003-1592-7936; https://orcid.org/0000-0003-3885-9374; https://orcid.org/0000-0003-4679-1891; https://orcid.org/0000-0002-7641-6585; https://orcid.org/0000-0001-8812-3811
• topic: Hyperthermia; Thermosensitive systems; Cancer treatment; Cancer - Tratamento

Conventional chemotherapy regimens have limitations due to serious adverse effects. Targeted drug delivery systems to reduce systemic toxicity are a powerful drug development platform. Encapsulation of antitumor drug(s) in thermosensitive nanocarriers is an emerging approach with a promise to improve uptake and increase therapeutic efficacy, as they can be activated by hyperthermia selectively at the tumor site. In this review, we focus on thermosensitive nanosystems associated with hyperthermia for the treatment of cancer, in preclinical and clinical use.