Cytotoxic action and proliferation in vitro and analgesic activity in vivo of resin from Hymenaea stigonocarpa
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2019 |
| Outros Autores: | , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFMG |
| Texto Completo: | http://hdl.handle.net/1843/44178 |
Resumo: | FAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais |
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2022-08-11T11:01:17Z2022-08-11T11:01:17Z201911319320010.4103/pr.pr_30_190974-8490http://hdl.handle.net/1843/44178FAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas GeraisCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível SuperiorBackground: Hymenaea stigonocarpa Mart. (Fabaceae ) is one of the plant species commonly found in Brazilian cerrado. It is popularly known as jatobá-do-cerrado. Phytochemical studies of different parts of the plant demonstrated the presence of sesquiterpenes, diterpenes, and oligosaccharides. The species produces an opaque, translucent, pale yellow, or almost white resin rich in labdanóides compounds, widely used in folk medicine, but without proving its pharmacological actions. Objective: To analyze the H. stigonocarpa resin to confirm its pharmacological actions through specific tests for cicatrization, nociception, and cytotoxicity and to evaluate the chemical composition through the gas chromatography coupled to mass spectrometry (GC-MS). Materials and Methods: The cell proliferation/migration capacity was evaluated using the scratch assay method and the cell viability determined by the 3-[4,5-dimethylthiazol-2-yl]–tetrazolium 2,5-diphenyl-bromide cytotoxicity assay. In the pharmacological tests were performed Abdominal Contortions induced by acetic acid and Nociceptive Response evaluated by the Formalin Test. GC-MS was used to trace the profile of the bioactive compounds of the resin. Results: It was possible to verify the presence of terpene compounds with the labdanos skeleton. Structures that revealed important pharmacological actions regarding healing, evidenced by the scratch assay test and nociceptive activity demonstrated by the animal tests. No cytotoxic activity was detected at the dosages tested. Conclusion: The results obtained confirm the pharmacological action of the species and can be used to elaborate on new therapies, which will increase the therapeutic arsenal available to the population.engUniversidade Federal de Minas GeraisUFMGBrasilICA - INSTITUTO DE CIÊNCIAS AGRÁRIASPharmacognosy ResearchPlantas dos cerradosFarmacologiaAnálise cromatográficaEspectroscopia de massaQuímica vegetalDiterpenosTerpenosSesquiterpenosOligossacarídeosCytotoxic action and proliferation in vitro and analgesic activity in vivo of resin from Hymenaea stigonocarpainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://www.phcogres.com/article/2019/11/3/104103prpr3019Keyla Laisa Araújo e SaldanhaVanessa de Andrade RoyoFrancine Souza Alves da FonsecaElytania Veiga MenezesDario Alves de OliveiraAfrânio Farias de Melo JúniorKamylla Santos TeixeiraMurilo Malveira BrandãoMarcel Nani LeiteGuilherme Ferreira CaetanoMarco Andrey Cipriani Fradeinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMGLICENSELicense.txtLicense.txttext/plain; charset=utf-82042https://repositorio.ufmg.br/bitstream/1843/44178/1/License.txtfa505098d172de0bc8864fc1287ffe22MD51ORIGINALCytotoxic action and proliferation in vitro and analgesic activity in vivo of resin from Hymenaea stigonocarpa.pdfCytotoxic action and proliferation in vitro and analgesic activity in vivo of resin from Hymenaea stigonocarpa.pdfapplication/pdf1748749https://repositorio.ufmg.br/bitstream/1843/44178/2/Cytotoxic%20action%20and%20proliferation%20in%20vitro%20and%20analgesic%20activity%20in%20vivo%20of%20resin%20from%20Hymenaea%20stigonocarpa.pdf9ab02aed80e63ffa795a1472ded5f7b3MD521843/441782022-08-11 08:01:17.979oai:repositorio.ufmg.br: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Repositório de PublicaçõesPUBhttps://repositorio.ufmg.br/oaiopendoar:2022-08-11T11:01:17Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)false |
| dc.title.pt_BR.fl_str_mv |
Cytotoxic action and proliferation in vitro and analgesic activity in vivo of resin from Hymenaea stigonocarpa |
| title |
Cytotoxic action and proliferation in vitro and analgesic activity in vivo of resin from Hymenaea stigonocarpa |
| spellingShingle |
Cytotoxic action and proliferation in vitro and analgesic activity in vivo of resin from Hymenaea stigonocarpa Keyla Laisa Araújo e Saldanha Plantas dos cerrados Farmacologia Análise cromatográfica Espectroscopia de massa Química vegetal Diterpenos Terpenos Sesquiterpenos Oligossacarídeos |
| title_short |
Cytotoxic action and proliferation in vitro and analgesic activity in vivo of resin from Hymenaea stigonocarpa |
| title_full |
Cytotoxic action and proliferation in vitro and analgesic activity in vivo of resin from Hymenaea stigonocarpa |
| title_fullStr |
Cytotoxic action and proliferation in vitro and analgesic activity in vivo of resin from Hymenaea stigonocarpa |
| title_full_unstemmed |
Cytotoxic action and proliferation in vitro and analgesic activity in vivo of resin from Hymenaea stigonocarpa |
| title_sort |
Cytotoxic action and proliferation in vitro and analgesic activity in vivo of resin from Hymenaea stigonocarpa |
| author |
Keyla Laisa Araújo e Saldanha |
| author_facet |
Keyla Laisa Araújo e Saldanha Vanessa de Andrade Royo Francine Souza Alves da Fonseca Elytania Veiga Menezes Dario Alves de Oliveira Afrânio Farias de Melo Júnior Kamylla Santos Teixeira Murilo Malveira Brandão Marcel Nani Leite Guilherme Ferreira Caetano Marco Andrey Cipriani Frade |
| author_role |
author |
| author2 |
Vanessa de Andrade Royo Francine Souza Alves da Fonseca Elytania Veiga Menezes Dario Alves de Oliveira Afrânio Farias de Melo Júnior Kamylla Santos Teixeira Murilo Malveira Brandão Marcel Nani Leite Guilherme Ferreira Caetano Marco Andrey Cipriani Frade |
| author2_role |
author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Keyla Laisa Araújo e Saldanha Vanessa de Andrade Royo Francine Souza Alves da Fonseca Elytania Veiga Menezes Dario Alves de Oliveira Afrânio Farias de Melo Júnior Kamylla Santos Teixeira Murilo Malveira Brandão Marcel Nani Leite Guilherme Ferreira Caetano Marco Andrey Cipriani Frade |
| dc.subject.other.pt_BR.fl_str_mv |
Plantas dos cerrados Farmacologia Análise cromatográfica Espectroscopia de massa Química vegetal Diterpenos Terpenos Sesquiterpenos Oligossacarídeos |
| topic |
Plantas dos cerrados Farmacologia Análise cromatográfica Espectroscopia de massa Química vegetal Diterpenos Terpenos Sesquiterpenos Oligossacarídeos |
| description |
FAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais |
| publishDate |
2019 |
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2019 |
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2022-08-11T11:01:17Z |
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2022-08-11T11:01:17Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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http://hdl.handle.net/1843/44178 |
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10.4103/pr.pr_30_19 |
| dc.identifier.issn.pt_BR.fl_str_mv |
0974-8490 |
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10.4103/pr.pr_30_19 0974-8490 |
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http://hdl.handle.net/1843/44178 |
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eng |
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eng |
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Pharmacognosy Research |
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info:eu-repo/semantics/openAccess |
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openAccess |
| dc.publisher.none.fl_str_mv |
Universidade Federal de Minas Gerais |
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UFMG |
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Brasil |
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ICA - INSTITUTO DE CIÊNCIAS AGRÁRIAS |
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Universidade Federal de Minas Gerais |
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reponame:Repositório Institucional da UFMG instname:Universidade Federal de Minas Gerais (UFMG) instacron:UFMG |
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