The COVID-19 pandemic in Brazilian pregnant and postpartum women: results from the REBRACO prospective cohort study

Detalhes bibliográficos
Autor(a) principal: Renato T. Souza
Data de Publicação: 2022
Outros Autores: Silvana F. Bento, Bruna E. Parreira, José P. Guida, Mário Dias Corrêa Júnior, Caio Leal, Rayra Amana, Marcos A. B. Dias, Marcos Nakamura-Pereira, Bruna O. Guerra, Gabriela Gorga, Leandro de Oliveira, Carla Silveira, Kevin F. A. Oliveira, Mariana Emi Varicoda Makyama, Elias F. Melo Junior, Débora F. Leite, Isabella Monteiro, Marília G. Q. Luz, Isabela R. Pereira, Clélia Andrade Salustrino, Valéria B. Pontes, Roberto Allen Silva Franco, Fernanda G. Surita, João Paolo Bilibio, Gislânia P. F. Brito, Hana Paula C. Pinto, Danielle Leal Oliveira, Andrezza A. Guerra, Andrea O. Moura, Natasha Pantoja, Fernanda David, Alina Silva, Maria J. Miele, Ricardo P. Tedesco, Karayna G. Fernandes, Sérgio H. A. Martins-Costa, Frederico J. A. Peret, Francisco E. Feitosa, Rosiane Mattar, Jose G. Cecatti, Evelyn Traina, Edson V. Cunha Filho, Janete Vettorazzi, Samira M. Haddad, Carla B. Andreucci, Rodolfo C. Pacagnella, Maria Laura Costa, Carolina C. Ribeiro-do-Valle, Adriana G. Luz, Giuliane J. Lajos, Guilherme M. Nobrega, Thayna B. Griggrio, Charles M. Charles, Sherly Metelus, Lester Castro, Stephanie Pabon, Amanda D. Silva, Paulo S. R. Junior, Thais G. Sardinha, Rodolfo R. Japenga, Erica R. F. Urquiza, Maíra R. Machado, Marcela Maria Simões, Larissa M. Solda, Juliana Vasconcellos Freitas-Jesus, Rachel Esteves Soeiro, Patrícia B. Peres, Cristiane L. Arbeli, Rafael M. Quevedo, Carolina F. Yamashita, Julia D. Corradin, Isabella Bergamini, José Geraldo L. Ramos, Maria Lúcia R. Oppermann, Laisa S. Quadro, Lina Marins, Érika V. Paniz, Thaís Vicentini Xavier, Marina H. L. Almeida, Bruna F. V. Moura, Lidiane R. França, Hanna Vieira, Rafael B. Aquino, Thayna B. Griggio, Aline C. Costa, Daisy Pinheiro, Denise Cordeiro, Priscila L. Miná, Carol Dornellas, Sue Yazaki-sun, Priscilla Mota, Arimaza C. Soares, Ellen Machado, Anne Bergmann, Gustavo Raupp Santos, Aline Tosetto, Sabrina Savazoni
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFMG
Texto Completo: https://doi.org/10.1038/s41598-022-15647-z
http://hdl.handle.net/1843/61844
https://orcid.org/0000-0003-4198-0546
Resumo: Brazil presented a very high number of maternal deaths and evident delays in healthcare. We aimed at evaluating the characteristics of SARS-CoV-2 infection and associated outcomes in the obstetric population. We conducted a prospective cohort study in 15 Brazilian centers including symptomatic pregnant or postpartum women with suspected COVID-19 from Feb/2020 to Feb/2021. Women were followed from suspected infection until the end of pregnancy. We analyzed maternal characteristics and pregnancy outcomes associated with confirmed COVID-19 infection and SARS, determining unadjusted risk ratios. In total, 729 symptomatic women with suspected COVID-19 were initially included. Among those investigated for COVID-19, 51.3% (n = 289) were confirmed COVID-19 and 48% (n = 270) were negative. Initially (before May 15th), only 52.9% of the suspected cases were tested and it was the period with the highest proportion of ICU admission and maternal deaths. Non-white ethnicity (RR 1.78 [1.04–3.04]), primary schooling or less (RR 2.16 [1.21–3.87]), being overweight (RR 4.34 [1.04–19.01]) or obese (RR 6.55 [1.57–27.37]), having public prenatal care (RR 2.16 [1.01–4.68]), planned pregnancies (RR 2.09 [1.15–3.78]), onset of infection in postpartum period (RR 6.00 [1.37–26.26]), chronic hypertension (RR 2.15 [1.37–4.10]), pre-existing diabetes (RR 3.20 [1.37–7.46]), asthma (RR 2.22 [1.14–4.34]), and anaemia (RR 3.15 [1.14–8.71]) were associated with higher risk for SARS. The availability of tests and maternal outcomes varied throughout the pandemic period of the study; the beginning was the most challenging period, with worse outcomes. Socially vulnerable, postpartum and previously ill women were more likely to present SARS related to COVID-19.
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spelling The COVID-19 pandemic in Brazilian pregnant and postpartum women: results from the REBRACO prospective cohort studyCOVID-19GravidezBrasilPeríodo Pós-PartoCOVID-19GravidezBrasilPeríodo Pós-PartoBrazil presented a very high number of maternal deaths and evident delays in healthcare. We aimed at evaluating the characteristics of SARS-CoV-2 infection and associated outcomes in the obstetric population. We conducted a prospective cohort study in 15 Brazilian centers including symptomatic pregnant or postpartum women with suspected COVID-19 from Feb/2020 to Feb/2021. Women were followed from suspected infection until the end of pregnancy. We analyzed maternal characteristics and pregnancy outcomes associated with confirmed COVID-19 infection and SARS, determining unadjusted risk ratios. In total, 729 symptomatic women with suspected COVID-19 were initially included. Among those investigated for COVID-19, 51.3% (n = 289) were confirmed COVID-19 and 48% (n = 270) were negative. Initially (before May 15th), only 52.9% of the suspected cases were tested and it was the period with the highest proportion of ICU admission and maternal deaths. Non-white ethnicity (RR 1.78 [1.04–3.04]), primary schooling or less (RR 2.16 [1.21–3.87]), being overweight (RR 4.34 [1.04–19.01]) or obese (RR 6.55 [1.57–27.37]), having public prenatal care (RR 2.16 [1.01–4.68]), planned pregnancies (RR 2.09 [1.15–3.78]), onset of infection in postpartum period (RR 6.00 [1.37–26.26]), chronic hypertension (RR 2.15 [1.37–4.10]), pre-existing diabetes (RR 3.20 [1.37–7.46]), asthma (RR 2.22 [1.14–4.34]), and anaemia (RR 3.15 [1.14–8.71]) were associated with higher risk for SARS. The availability of tests and maternal outcomes varied throughout the pandemic period of the study; the beginning was the most challenging period, with worse outcomes. Socially vulnerable, postpartum and previously ill women were more likely to present SARS related to COVID-19.Outra AgênciaUniversidade Federal de Minas GeraisBrasilMED - DEPARTAMENTO DE GINECOLOGIA OBSTETRÍCIAMEDICINA - FACULDADE DE MEDICINAUFMG2023-12-07T21:26:54Z2023-12-07T21:26:54Z2022-07-11info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlepdfapplication/pdfhttps://doi.org/10.1038/s41598-022-15647-z2045-2322http://hdl.handle.net/1843/61844https://orcid.org/0000-0003-4198-0546engScientific ReportsRenato T. SouzaSilvana F. BentoBruna E. ParreiraJosé P. GuidaMário Dias Corrêa JúniorCaio LealRayra AmanaMarcos A. B. DiasMarcos Nakamura-PereiraBruna O. GuerraGabriela GorgaLeandro de OliveiraCarla SilveiraKevin F. A. OliveiraMariana Emi Varicoda MakyamaElias F. Melo JuniorDébora F. LeiteIsabella MonteiroMarília G. Q. LuzIsabela R. PereiraClélia Andrade SalustrinoValéria B. PontesRoberto Allen Silva FrancoFernanda G. SuritaJoão Paolo BilibioGislânia P. F. BritoHana Paula C. PintoDanielle Leal OliveiraAndrezza A. GuerraAndrea O. MouraNatasha PantojaFernanda DavidAlina SilvaMaria J. MieleRicardo P. TedescoKarayna G. FernandesSérgio H. A. Martins-CostaFrederico J. A. PeretFrancisco E. FeitosaRosiane MattarJose G. CecattiEvelyn TrainaEdson V. Cunha FilhoJanete VettorazziSamira M. HaddadCarla B. AndreucciRodolfo C. PacagnellaMaria Laura CostaCarolina C. Ribeiro-do-ValleAdriana G. LuzGiuliane J. LajosGuilherme M. NobregaThayna B. GriggrioCharles M. CharlesSherly MetelusLester CastroStephanie PabonAmanda D. SilvaPaulo S. R. JuniorThais G. SardinhaRodolfo R. JapengaErica R. F. UrquizaMaíra R. MachadoMarcela Maria SimõesLarissa M. SoldaJuliana Vasconcellos Freitas-JesusRachel Esteves SoeiroPatrícia B. PeresCristiane L. ArbeliRafael M. QuevedoCarolina F. YamashitaJulia D. CorradinIsabella BergaminiJosé Geraldo L. RamosMaria Lúcia R. OppermannLaisa S. QuadroLina MarinsÉrika V. PanizThaís Vicentini XavierMarina H. L. AlmeidaBruna F. V. MouraLidiane R. FrançaHanna VieiraRafael B. AquinoThayna B. GriggioAline C. CostaDaisy PinheiroDenise CordeiroPriscila L. MináCarol DornellasSue Yazaki-sunPriscilla MotaArimaza C. SoaresEdson V. Cunha FilhoEllen MachadoAnne BergmannGustavo Raupp SantosAline TosettoSabrina Savazoniinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMG2023-12-07T21:26:54Zoai:repositorio.ufmg.br:1843/61844Repositório InstitucionalPUBhttps://repositorio.ufmg.br/oairepositorio@ufmg.bropendoar:2023-12-07T21:26:54Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)false
dc.title.none.fl_str_mv The COVID-19 pandemic in Brazilian pregnant and postpartum women: results from the REBRACO prospective cohort study
title The COVID-19 pandemic in Brazilian pregnant and postpartum women: results from the REBRACO prospective cohort study
spellingShingle The COVID-19 pandemic in Brazilian pregnant and postpartum women: results from the REBRACO prospective cohort study
Renato T. Souza
COVID-19
Gravidez
Brasil
Período Pós-Parto
COVID-19
Gravidez
Brasil
Período Pós-Parto
title_short The COVID-19 pandemic in Brazilian pregnant and postpartum women: results from the REBRACO prospective cohort study
title_full The COVID-19 pandemic in Brazilian pregnant and postpartum women: results from the REBRACO prospective cohort study
title_fullStr The COVID-19 pandemic in Brazilian pregnant and postpartum women: results from the REBRACO prospective cohort study
title_full_unstemmed The COVID-19 pandemic in Brazilian pregnant and postpartum women: results from the REBRACO prospective cohort study
title_sort The COVID-19 pandemic in Brazilian pregnant and postpartum women: results from the REBRACO prospective cohort study
author Renato T. Souza
author_facet Renato T. Souza
Silvana F. Bento
Bruna E. Parreira
José P. Guida
Mário Dias Corrêa Júnior
Caio Leal
Rayra Amana
Marcos A. B. Dias
Marcos Nakamura-Pereira
Bruna O. Guerra
Gabriela Gorga
Leandro de Oliveira
Carla Silveira
Kevin F. A. Oliveira
Mariana Emi Varicoda Makyama
Elias F. Melo Junior
Débora F. Leite
Isabella Monteiro
Marília G. Q. Luz
Isabela R. Pereira
Clélia Andrade Salustrino
Valéria B. Pontes
Roberto Allen Silva Franco
Fernanda G. Surita
João Paolo Bilibio
Gislânia P. F. Brito
Hana Paula C. Pinto
Danielle Leal Oliveira
Andrezza A. Guerra
Andrea O. Moura
Natasha Pantoja
Fernanda David
Alina Silva
Maria J. Miele
Ricardo P. Tedesco
Karayna G. Fernandes
Sérgio H. A. Martins-Costa
Frederico J. A. Peret
Francisco E. Feitosa
Rosiane Mattar
Jose G. Cecatti
Evelyn Traina
Edson V. Cunha Filho
Janete Vettorazzi
Samira M. Haddad
Carla B. Andreucci
Rodolfo C. Pacagnella
Maria Laura Costa
Carolina C. Ribeiro-do-Valle
Adriana G. Luz
Giuliane J. Lajos
Guilherme M. Nobrega
Thayna B. Griggrio
Charles M. Charles
Sherly Metelus
Lester Castro
Stephanie Pabon
Amanda D. Silva
Paulo S. R. Junior
Thais G. Sardinha
Rodolfo R. Japenga
Erica R. F. Urquiza
Maíra R. Machado
Marcela Maria Simões
Larissa M. Solda
Juliana Vasconcellos Freitas-Jesus
Rachel Esteves Soeiro
Patrícia B. Peres
Cristiane L. Arbeli
Rafael M. Quevedo
Carolina F. Yamashita
Julia D. Corradin
Isabella Bergamini
José Geraldo L. Ramos
Maria Lúcia R. Oppermann
Laisa S. Quadro
Lina Marins
Érika V. Paniz
Thaís Vicentini Xavier
Marina H. L. Almeida
Bruna F. V. Moura
Lidiane R. França
Hanna Vieira
Rafael B. Aquino
Thayna B. Griggio
Aline C. Costa
Daisy Pinheiro
Denise Cordeiro
Priscila L. Miná
Carol Dornellas
Sue Yazaki-sun
Priscilla Mota
Arimaza C. Soares
Ellen Machado
Anne Bergmann
Gustavo Raupp Santos
Aline Tosetto
Sabrina Savazoni
author_role author
author2 Silvana F. Bento
Bruna E. Parreira
José P. Guida
Mário Dias Corrêa Júnior
Caio Leal
Rayra Amana
Marcos A. B. Dias
Marcos Nakamura-Pereira
Bruna O. Guerra
Gabriela Gorga
Leandro de Oliveira
Carla Silveira
Kevin F. A. Oliveira
Mariana Emi Varicoda Makyama
Elias F. Melo Junior
Débora F. Leite
Isabella Monteiro
Marília G. Q. Luz
Isabela R. Pereira
Clélia Andrade Salustrino
Valéria B. Pontes
Roberto Allen Silva Franco
Fernanda G. Surita
João Paolo Bilibio
Gislânia P. F. Brito
Hana Paula C. Pinto
Danielle Leal Oliveira
Andrezza A. Guerra
Andrea O. Moura
Natasha Pantoja
Fernanda David
Alina Silva
Maria J. Miele
Ricardo P. Tedesco
Karayna G. Fernandes
Sérgio H. A. Martins-Costa
Frederico J. A. Peret
Francisco E. Feitosa
Rosiane Mattar
Jose G. Cecatti
Evelyn Traina
Edson V. Cunha Filho
Janete Vettorazzi
Samira M. Haddad
Carla B. Andreucci
Rodolfo C. Pacagnella
Maria Laura Costa
Carolina C. Ribeiro-do-Valle
Adriana G. Luz
Giuliane J. Lajos
Guilherme M. Nobrega
Thayna B. Griggrio
Charles M. Charles
Sherly Metelus
Lester Castro
Stephanie Pabon
Amanda D. Silva
Paulo S. R. Junior
Thais G. Sardinha
Rodolfo R. Japenga
Erica R. F. Urquiza
Maíra R. Machado
Marcela Maria Simões
Larissa M. Solda
Juliana Vasconcellos Freitas-Jesus
Rachel Esteves Soeiro
Patrícia B. Peres
Cristiane L. Arbeli
Rafael M. Quevedo
Carolina F. Yamashita
Julia D. Corradin
Isabella Bergamini
José Geraldo L. Ramos
Maria Lúcia R. Oppermann
Laisa S. Quadro
Lina Marins
Érika V. Paniz
Thaís Vicentini Xavier
Marina H. L. Almeida
Bruna F. V. Moura
Lidiane R. França
Hanna Vieira
Rafael B. Aquino
Thayna B. Griggio
Aline C. Costa
Daisy Pinheiro
Denise Cordeiro
Priscila L. Miná
Carol Dornellas
Sue Yazaki-sun
Priscilla Mota
Arimaza C. Soares
Ellen Machado
Anne Bergmann
Gustavo Raupp Santos
Aline Tosetto
Sabrina Savazoni
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dc.contributor.author.fl_str_mv Renato T. Souza
Silvana F. Bento
Bruna E. Parreira
José P. Guida
Mário Dias Corrêa Júnior
Caio Leal
Rayra Amana
Marcos A. B. Dias
Marcos Nakamura-Pereira
Bruna O. Guerra
Gabriela Gorga
Leandro de Oliveira
Carla Silveira
Kevin F. A. Oliveira
Mariana Emi Varicoda Makyama
Elias F. Melo Junior
Débora F. Leite
Isabella Monteiro
Marília G. Q. Luz
Isabela R. Pereira
Clélia Andrade Salustrino
Valéria B. Pontes
Roberto Allen Silva Franco
Fernanda G. Surita
João Paolo Bilibio
Gislânia P. F. Brito
Hana Paula C. Pinto
Danielle Leal Oliveira
Andrezza A. Guerra
Andrea O. Moura
Natasha Pantoja
Fernanda David
Alina Silva
Maria J. Miele
Ricardo P. Tedesco
Karayna G. Fernandes
Sérgio H. A. Martins-Costa
Frederico J. A. Peret
Francisco E. Feitosa
Rosiane Mattar
Jose G. Cecatti
Evelyn Traina
Edson V. Cunha Filho
Janete Vettorazzi
Samira M. Haddad
Carla B. Andreucci
Rodolfo C. Pacagnella
Maria Laura Costa
Carolina C. Ribeiro-do-Valle
Adriana G. Luz
Giuliane J. Lajos
Guilherme M. Nobrega
Thayna B. Griggrio
Charles M. Charles
Sherly Metelus
Lester Castro
Stephanie Pabon
Amanda D. Silva
Paulo S. R. Junior
Thais G. Sardinha
Rodolfo R. Japenga
Erica R. F. Urquiza
Maíra R. Machado
Marcela Maria Simões
Larissa M. Solda
Juliana Vasconcellos Freitas-Jesus
Rachel Esteves Soeiro
Patrícia B. Peres
Cristiane L. Arbeli
Rafael M. Quevedo
Carolina F. Yamashita
Julia D. Corradin
Isabella Bergamini
José Geraldo L. Ramos
Maria Lúcia R. Oppermann
Laisa S. Quadro
Lina Marins
Érika V. Paniz
Thaís Vicentini Xavier
Marina H. L. Almeida
Bruna F. V. Moura
Lidiane R. França
Hanna Vieira
Rafael B. Aquino
Thayna B. Griggio
Aline C. Costa
Daisy Pinheiro
Denise Cordeiro
Priscila L. Miná
Carol Dornellas
Sue Yazaki-sun
Priscilla Mota
Arimaza C. Soares
Edson V. Cunha Filho
Ellen Machado
Anne Bergmann
Gustavo Raupp Santos
Aline Tosetto
Sabrina Savazoni
dc.subject.por.fl_str_mv COVID-19
Gravidez
Brasil
Período Pós-Parto
COVID-19
Gravidez
Brasil
Período Pós-Parto
topic COVID-19
Gravidez
Brasil
Período Pós-Parto
COVID-19
Gravidez
Brasil
Período Pós-Parto
description Brazil presented a very high number of maternal deaths and evident delays in healthcare. We aimed at evaluating the characteristics of SARS-CoV-2 infection and associated outcomes in the obstetric population. We conducted a prospective cohort study in 15 Brazilian centers including symptomatic pregnant or postpartum women with suspected COVID-19 from Feb/2020 to Feb/2021. Women were followed from suspected infection until the end of pregnancy. We analyzed maternal characteristics and pregnancy outcomes associated with confirmed COVID-19 infection and SARS, determining unadjusted risk ratios. In total, 729 symptomatic women with suspected COVID-19 were initially included. Among those investigated for COVID-19, 51.3% (n = 289) were confirmed COVID-19 and 48% (n = 270) were negative. Initially (before May 15th), only 52.9% of the suspected cases were tested and it was the period with the highest proportion of ICU admission and maternal deaths. Non-white ethnicity (RR 1.78 [1.04–3.04]), primary schooling or less (RR 2.16 [1.21–3.87]), being overweight (RR 4.34 [1.04–19.01]) or obese (RR 6.55 [1.57–27.37]), having public prenatal care (RR 2.16 [1.01–4.68]), planned pregnancies (RR 2.09 [1.15–3.78]), onset of infection in postpartum period (RR 6.00 [1.37–26.26]), chronic hypertension (RR 2.15 [1.37–4.10]), pre-existing diabetes (RR 3.20 [1.37–7.46]), asthma (RR 2.22 [1.14–4.34]), and anaemia (RR 3.15 [1.14–8.71]) were associated with higher risk for SARS. The availability of tests and maternal outcomes varied throughout the pandemic period of the study; the beginning was the most challenging period, with worse outcomes. Socially vulnerable, postpartum and previously ill women were more likely to present SARS related to COVID-19.
publishDate 2022
dc.date.none.fl_str_mv 2022-07-11
2023-12-07T21:26:54Z
2023-12-07T21:26:54Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://doi.org/10.1038/s41598-022-15647-z
2045-2322
http://hdl.handle.net/1843/61844
https://orcid.org/0000-0003-4198-0546
url https://doi.org/10.1038/s41598-022-15647-z
http://hdl.handle.net/1843/61844
https://orcid.org/0000-0003-4198-0546
identifier_str_mv 2045-2322
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Scientific Reports
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv pdf
application/pdf
dc.publisher.none.fl_str_mv Universidade Federal de Minas Gerais
Brasil
MED - DEPARTAMENTO DE GINECOLOGIA OBSTETRÍCIA
MEDICINA - FACULDADE DE MEDICINA
UFMG
publisher.none.fl_str_mv Universidade Federal de Minas Gerais
Brasil
MED - DEPARTAMENTO DE GINECOLOGIA OBSTETRÍCIA
MEDICINA - FACULDADE DE MEDICINA
UFMG
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFMG
instname:Universidade Federal de Minas Gerais (UFMG)
instacron:UFMG
instname_str Universidade Federal de Minas Gerais (UFMG)
instacron_str UFMG
institution UFMG
reponame_str Repositório Institucional da UFMG
collection Repositório Institucional da UFMG
repository.name.fl_str_mv Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)
repository.mail.fl_str_mv repositorio@ufmg.br
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