Health-related quality of life in psoriatic arthritis: findings and implications
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Repositório Institucional da UFMG |
Texto Completo: | https://doi.org/10.1016/j.vhri.2021.06.003 http://hdl.handle.net/1843/56641 https://orcid.org/0000-0002-5880-5261 https://orcid.org/0000-0003-0138-9401 https://orcid.org/0000-0001-9411-7493 https://orcid.org/0000-0002-0210-0721 |
Resumo: | Objectives: To assess the quality of life (QOL) and its associated factors in patients with psoriatic arthritis (PsA) who would start treatment with biologic drugs at the Brazilian Unified Health System. Methods: A cross-sectional study was performed at a single center pharmacy in Belo Horizonte, State of Minas Gerais, Brazil. EQ-5D was used to assess the patients’ QOL. The functional status was assessed using the Health Assessment Questionnaire Disability Index, whereas disease activity was evaluated through the Bath Ankylosing Spondylitis Disease Activity Index and the Clinical Disease Activity Index. Simple and multiple linear regression analyses were performed to assess the factors associated with QOL. Results: A total of 212 patients with PsA were included, of which 185 (87.3%) reported having some pain/discomfort, and 148 (69.8%) presented some level of anxiety/depression. Patients with PsA had a mean QOL score of 0.651 (SD 0.12) with a sig nificant reduction in female patients, concomitant use of nonsteroidal anti-inflammatory drugs, comorbidity, and worse clinical and functional status. Poor QOL was associated with worse functional status by the Health Assessment Questionnaire-Disability Index, disease activity by the Bath Ankylosing Spondylitis Disease Activity Index, and with diagnoses of osteoporosis, hypothyroidism, and depression. Conclusion: PsA and its associated comorbidities negatively affect the QOL, evidencing the need for a comprehensive and effective clinical approach. |
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2023-07-18T20:31:08Z2023-07-18T20:31:08Z202126135141https://doi.org/10.1016/j.vhri.2021.06.0032212-1102http://hdl.handle.net/1843/56641https://orcid.org/0000-0002-5880-5261https://orcid.org/0000-0003-0138-9401https://orcid.org/0000-0001-9411-7493https://orcid.org/0000-0002-0210-0721Objectives: To assess the quality of life (QOL) and its associated factors in patients with psoriatic arthritis (PsA) who would start treatment with biologic drugs at the Brazilian Unified Health System. Methods: A cross-sectional study was performed at a single center pharmacy in Belo Horizonte, State of Minas Gerais, Brazil. EQ-5D was used to assess the patients’ QOL. The functional status was assessed using the Health Assessment Questionnaire Disability Index, whereas disease activity was evaluated through the Bath Ankylosing Spondylitis Disease Activity Index and the Clinical Disease Activity Index. Simple and multiple linear regression analyses were performed to assess the factors associated with QOL. Results: A total of 212 patients with PsA were included, of which 185 (87.3%) reported having some pain/discomfort, and 148 (69.8%) presented some level of anxiety/depression. Patients with PsA had a mean QOL score of 0.651 (SD 0.12) with a sig nificant reduction in female patients, concomitant use of nonsteroidal anti-inflammatory drugs, comorbidity, and worse clinical and functional status. Poor QOL was associated with worse functional status by the Health Assessment Questionnaire-Disability Index, disease activity by the Bath Ankylosing Spondylitis Disease Activity Index, and with diagnoses of osteoporosis, hypothyroidism, and depression. Conclusion: PsA and its associated comorbidities negatively affect the QOL, evidencing the need for a comprehensive and effective clinical approach.porUniversidade Federal de Minas GeraisUFMGBrasilFAR - DEPARTAMENTO DE FARMÁCIA SOCIALMED - DEPARTAMENTO DE APARELHO LOCOMOTORMED - DEPARTAMENTO DE CLÍNICA MÉDICAValue in Health Regional IssuesArtriteQualidade de vidaCross-sectional studyHealth systemPsoriatic arthritisQuality of lifeHealth-related quality of life in psoriatic arthritis: findings and implicationsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://www.sciencedirect.com/science/article/pii/S2212109921000935#:~:text=When%20compared%20with%20the%20general,and%20significantly%20increased%20mortality%20rate.Felipe A. MoraesMichael R. R. da SilvaJéssica B. R. dos SantosFrancisco de Assis AcurcioAlessandra Maciel AlmeidaAdriana Maria KakehasiJuliana Alvares Teodoroinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMGLICENSELicense.txtLicense.txttext/plain; charset=utf-82042https://repositorio.ufmg.br/bitstream/1843/56641/1/License.txtfa505098d172de0bc8864fc1287ffe22MD51ORIGINALHealth-Related Quality of Life in Psoriatic Arthritis Findings and Implications.pdfHealth-Related Quality of Life in Psoriatic Arthritis Findings and Implications.pdfapplication/pdf578885https://repositorio.ufmg.br/bitstream/1843/56641/2/Health-Related%20Quality%20of%20Life%20in%20Psoriatic%20Arthritis%20Findings%20and%20Implications.pdf98bf2a7d674a6c9f916921bb7e2b1e6bMD521843/566412023-07-18 17:31:09.014oai:repositorio.ufmg.br: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Repositório de PublicaçõesPUBhttps://repositorio.ufmg.br/oaiopendoar:2023-07-18T20:31:09Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)false |
dc.title.pt_BR.fl_str_mv |
Health-related quality of life in psoriatic arthritis: findings and implications |
title |
Health-related quality of life in psoriatic arthritis: findings and implications |
spellingShingle |
Health-related quality of life in psoriatic arthritis: findings and implications Felipe A. Moraes Cross-sectional study Health system Psoriatic arthritis Quality of life Artrite Qualidade de vida |
title_short |
Health-related quality of life in psoriatic arthritis: findings and implications |
title_full |
Health-related quality of life in psoriatic arthritis: findings and implications |
title_fullStr |
Health-related quality of life in psoriatic arthritis: findings and implications |
title_full_unstemmed |
Health-related quality of life in psoriatic arthritis: findings and implications |
title_sort |
Health-related quality of life in psoriatic arthritis: findings and implications |
author |
Felipe A. Moraes |
author_facet |
Felipe A. Moraes Michael R. R. da Silva Jéssica B. R. dos Santos Francisco de Assis Acurcio Alessandra Maciel Almeida Adriana Maria Kakehasi Juliana Alvares Teodoro |
author_role |
author |
author2 |
Michael R. R. da Silva Jéssica B. R. dos Santos Francisco de Assis Acurcio Alessandra Maciel Almeida Adriana Maria Kakehasi Juliana Alvares Teodoro |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Felipe A. Moraes Michael R. R. da Silva Jéssica B. R. dos Santos Francisco de Assis Acurcio Alessandra Maciel Almeida Adriana Maria Kakehasi Juliana Alvares Teodoro |
dc.subject.por.fl_str_mv |
Cross-sectional study Health system Psoriatic arthritis Quality of life |
topic |
Cross-sectional study Health system Psoriatic arthritis Quality of life Artrite Qualidade de vida |
dc.subject.other.pt_BR.fl_str_mv |
Artrite Qualidade de vida |
description |
Objectives: To assess the quality of life (QOL) and its associated factors in patients with psoriatic arthritis (PsA) who would start treatment with biologic drugs at the Brazilian Unified Health System. Methods: A cross-sectional study was performed at a single center pharmacy in Belo Horizonte, State of Minas Gerais, Brazil. EQ-5D was used to assess the patients’ QOL. The functional status was assessed using the Health Assessment Questionnaire Disability Index, whereas disease activity was evaluated through the Bath Ankylosing Spondylitis Disease Activity Index and the Clinical Disease Activity Index. Simple and multiple linear regression analyses were performed to assess the factors associated with QOL. Results: A total of 212 patients with PsA were included, of which 185 (87.3%) reported having some pain/discomfort, and 148 (69.8%) presented some level of anxiety/depression. Patients with PsA had a mean QOL score of 0.651 (SD 0.12) with a sig nificant reduction in female patients, concomitant use of nonsteroidal anti-inflammatory drugs, comorbidity, and worse clinical and functional status. Poor QOL was associated with worse functional status by the Health Assessment Questionnaire-Disability Index, disease activity by the Bath Ankylosing Spondylitis Disease Activity Index, and with diagnoses of osteoporosis, hypothyroidism, and depression. Conclusion: PsA and its associated comorbidities negatively affect the QOL, evidencing the need for a comprehensive and effective clinical approach. |
publishDate |
2021 |
dc.date.issued.fl_str_mv |
2021 |
dc.date.accessioned.fl_str_mv |
2023-07-18T20:31:08Z |
dc.date.available.fl_str_mv |
2023-07-18T20:31:08Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1843/56641 |
dc.identifier.doi.pt_BR.fl_str_mv |
https://doi.org/10.1016/j.vhri.2021.06.003 |
dc.identifier.issn.pt_BR.fl_str_mv |
2212-1102 |
dc.identifier.orcid.pt_BR.fl_str_mv |
https://orcid.org/0000-0002-5880-5261 https://orcid.org/0000-0003-0138-9401 https://orcid.org/0000-0001-9411-7493 https://orcid.org/0000-0002-0210-0721 |
url |
https://doi.org/10.1016/j.vhri.2021.06.003 http://hdl.handle.net/1843/56641 https://orcid.org/0000-0002-5880-5261 https://orcid.org/0000-0003-0138-9401 https://orcid.org/0000-0001-9411-7493 https://orcid.org/0000-0002-0210-0721 |
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2212-1102 |
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por |
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por |
dc.relation.ispartof.pt_BR.fl_str_mv |
Value in Health Regional Issues |
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info:eu-repo/semantics/openAccess |
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openAccess |
dc.publisher.none.fl_str_mv |
Universidade Federal de Minas Gerais |
dc.publisher.initials.fl_str_mv |
UFMG |
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Brasil |
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FAR - DEPARTAMENTO DE FARMÁCIA SOCIAL MED - DEPARTAMENTO DE APARELHO LOCOMOTOR MED - DEPARTAMENTO DE CLÍNICA MÉDICA |
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Universidade Federal de Minas Gerais |
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