Prevalence of low bone mass and changes in vitamin D levels in human immunodeficiency virus-infected adults unexposed to antiretrovirals
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFMG |
Texto Completo: | https://doi.org/10.1590/0037-8682-0475-2017 http://hdl.handle.net/1843/47675 |
Resumo: | Introduction: The prevalence of low bone mass is 3 times higher in people living with human immunodeficiency virus (PLWH) and using antiretrovirals than in the HIV-unaffected population. Changes in vitamin D levels is one of the factors associated with decreased bone mass. The objective of this study is to evaluate the low bone mass and altered vitamin D levels in PLWH who have not been exposed to antiretrovirals. Methods: A cross-sectional study was carried out with HIV-infected individuals between the ages of 18 and 55 years immediately prior to the start of antiretroviral therapy in a specialized reference center focusing on infectious and parasitic diseases. Results of clinical examination (patient’s weight, height, blood pressure, and clinical history), laboratory tests, and X-ray absorptiometry, were collected. Results: Sixty patients were included, with a mean age of 34 years. Nine (16.7%) patients presented with low bone mass and 4 (7.1%) patients showed low total femur BMD. Analysis revealed that 23.3% and 36.7% of the patients had deficient and insufficient levels of 25-hydroxyvitamin D3, respectively. Conclusions: Our study population presented with compromised bone health and with low bone mineral density and 25-(OH)-vitamin D levels. |
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2022-12-01T23:15:56Z2022-12-01T23:15:56Z2018515596602https://doi.org/10.1590/0037-8682-0475-201716789849http://hdl.handle.net/1843/476750000-0001-6833-3870Introduction: The prevalence of low bone mass is 3 times higher in people living with human immunodeficiency virus (PLWH) and using antiretrovirals than in the HIV-unaffected population. Changes in vitamin D levels is one of the factors associated with decreased bone mass. The objective of this study is to evaluate the low bone mass and altered vitamin D levels in PLWH who have not been exposed to antiretrovirals. Methods: A cross-sectional study was carried out with HIV-infected individuals between the ages of 18 and 55 years immediately prior to the start of antiretroviral therapy in a specialized reference center focusing on infectious and parasitic diseases. Results of clinical examination (patient’s weight, height, blood pressure, and clinical history), laboratory tests, and X-ray absorptiometry, were collected. Results: Sixty patients were included, with a mean age of 34 years. Nine (16.7%) patients presented with low bone mass and 4 (7.1%) patients showed low total femur BMD. Analysis revealed that 23.3% and 36.7% of the patients had deficient and insufficient levels of 25-hydroxyvitamin D3, respectively. Conclusions: Our study population presented with compromised bone health and with low bone mineral density and 25-(OH)-vitamin D levels.Introdução: A prevalência de baixa massa óssea é 3 vezes maior em pessoas vivendo com o vírus da imunodeficiência humana (PVH) e em uso de antirretrovirais do que na população não infectada pelo HIV. A alteração nos níveis de vitamina D é um dos fatores associados à diminuição da massa óssea. O objetivo deste estudo é avaliar a baixa massa óssea e os níveis alterados de vitamina D em PVHA não expostas a antirretrovirais. Métodos: Foi realizado um estudo transversal com indivíduos infectados pelo HIV entre 18 e 55 anos imediatamente antes do início da terapia antirretroviral em um centro de referência especializado em doenças infecciosas e parasitárias. Os resultados do exame clínico (peso, altura, pressão arterial e história clínica do paciente), exames laboratoriais e absorciometria de raios-X foram coletados. Resultados: Foram incluídos 60 pacientes, com idade média de 34 anos. Nove (16,7%) pacientes apresentaram baixa massa óssea e 4 (7,1%) pacientes apresentaram baixa DMO total do fêmur. A análise revelou que 23,3% e 36,7% dos pacientes apresentavam níveis deficientes e insuficientes de 25-hidroxivitamina D3, respectivamente. Conclusões: Nossa população de estudo apresentou saúde óssea comprometida e com baixa densidade mineral óssea e níveis de 25-(OH)-vitamina D.engUniversidade Federal de Minas GeraisUFMGBrasilMED - DEPARTAMENTO DE APARELHO LOCOMOTORMED - DEPARTAMENTO DE CLÍNICA MÉDICARevista da Sociedade Brasileira de Medicina TropicalVitamina DHIVBiomarcadoresBone massVitamin DHIVPeople living with HIVBiomarkerPrevalence of low bone mass and changes in vitamin D levels in human immunodeficiency virus-infected adults unexposed to antiretroviralsPrevalência de baixa massa óssea e alterações nos níveis de vitamina D em adultos infectados pelo vírus da imunodeficiência humana não expostos a antirretroviraisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://www.scielo.br/j/rsbmt/a/ZSBpz4tSVzRXxXtGBYsf34y/?format=html&lang=enNathalia Sernizon GuimarãesMilena Maria Moreira GuimarãesAdriana Maria KakehasiMariana Guimarães Penido de PaulaJúlia Fonseca de Morais CaporaliÉrica Leandro Marciano VieiraPedro Rezende TanajuraUnaí Tupinambásapplication/pdfinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMGORIGINALPrevalence of low bone mass and changes in vitamin d levels in human immunodeficiency virus-infected adults unexposed to antiretrovirals.pdfPrevalence of low bone mass and changes in vitamin d levels in human immunodeficiency virus-infected adults unexposed to antiretrovirals.pdfapplication/pdf830792https://repositorio.ufmg.br/bitstream/1843/47675/2/Prevalence%20of%20low%20bone%20mass%20and%20changes%20in%20vitamin%20d%20levels%20in%20human%20immunodeficiency%20virus-infected%20adults%20unexposed%20to%20antiretrovirals.pdf826d4630d5563f90482797798ca4572cMD52LICENSELicense.txtLicense.txttext/plain; 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dc.title.pt_BR.fl_str_mv |
Prevalence of low bone mass and changes in vitamin D levels in human immunodeficiency virus-infected adults unexposed to antiretrovirals |
dc.title.alternative.pt_BR.fl_str_mv |
Prevalência de baixa massa óssea e alterações nos níveis de vitamina D em adultos infectados pelo vírus da imunodeficiência humana não expostos a antirretrovirais |
title |
Prevalence of low bone mass and changes in vitamin D levels in human immunodeficiency virus-infected adults unexposed to antiretrovirals |
spellingShingle |
Prevalence of low bone mass and changes in vitamin D levels in human immunodeficiency virus-infected adults unexposed to antiretrovirals Nathalia Sernizon Guimarães Bone mass Vitamin D HIV People living with HIV Biomarker Vitamina D HIV Biomarcadores |
title_short |
Prevalence of low bone mass and changes in vitamin D levels in human immunodeficiency virus-infected adults unexposed to antiretrovirals |
title_full |
Prevalence of low bone mass and changes in vitamin D levels in human immunodeficiency virus-infected adults unexposed to antiretrovirals |
title_fullStr |
Prevalence of low bone mass and changes in vitamin D levels in human immunodeficiency virus-infected adults unexposed to antiretrovirals |
title_full_unstemmed |
Prevalence of low bone mass and changes in vitamin D levels in human immunodeficiency virus-infected adults unexposed to antiretrovirals |
title_sort |
Prevalence of low bone mass and changes in vitamin D levels in human immunodeficiency virus-infected adults unexposed to antiretrovirals |
author |
Nathalia Sernizon Guimarães |
author_facet |
Nathalia Sernizon Guimarães Milena Maria Moreira Guimarães Adriana Maria Kakehasi Mariana Guimarães Penido de Paula Júlia Fonseca de Morais Caporali Érica Leandro Marciano Vieira Pedro Rezende Tanajura Unaí Tupinambás |
author_role |
author |
author2 |
Milena Maria Moreira Guimarães Adriana Maria Kakehasi Mariana Guimarães Penido de Paula Júlia Fonseca de Morais Caporali Érica Leandro Marciano Vieira Pedro Rezende Tanajura Unaí Tupinambás |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Nathalia Sernizon Guimarães Milena Maria Moreira Guimarães Adriana Maria Kakehasi Mariana Guimarães Penido de Paula Júlia Fonseca de Morais Caporali Érica Leandro Marciano Vieira Pedro Rezende Tanajura Unaí Tupinambás |
dc.subject.por.fl_str_mv |
Bone mass Vitamin D HIV People living with HIV Biomarker |
topic |
Bone mass Vitamin D HIV People living with HIV Biomarker Vitamina D HIV Biomarcadores |
dc.subject.other.pt_BR.fl_str_mv |
Vitamina D HIV Biomarcadores |
description |
Introduction: The prevalence of low bone mass is 3 times higher in people living with human immunodeficiency virus (PLWH) and using antiretrovirals than in the HIV-unaffected population. Changes in vitamin D levels is one of the factors associated with decreased bone mass. The objective of this study is to evaluate the low bone mass and altered vitamin D levels in PLWH who have not been exposed to antiretrovirals. Methods: A cross-sectional study was carried out with HIV-infected individuals between the ages of 18 and 55 years immediately prior to the start of antiretroviral therapy in a specialized reference center focusing on infectious and parasitic diseases. Results of clinical examination (patient’s weight, height, blood pressure, and clinical history), laboratory tests, and X-ray absorptiometry, were collected. Results: Sixty patients were included, with a mean age of 34 years. Nine (16.7%) patients presented with low bone mass and 4 (7.1%) patients showed low total femur BMD. Analysis revealed that 23.3% and 36.7% of the patients had deficient and insufficient levels of 25-hydroxyvitamin D3, respectively. Conclusions: Our study population presented with compromised bone health and with low bone mineral density and 25-(OH)-vitamin D levels. |
publishDate |
2018 |
dc.date.issued.fl_str_mv |
2018 |
dc.date.accessioned.fl_str_mv |
2022-12-01T23:15:56Z |
dc.date.available.fl_str_mv |
2022-12-01T23:15:56Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1843/47675 |
dc.identifier.doi.pt_BR.fl_str_mv |
https://doi.org/10.1590/0037-8682-0475-2017 |
dc.identifier.issn.pt_BR.fl_str_mv |
16789849 |
dc.identifier.orcid.pt_BR.fl_str_mv |
0000-0001-6833-3870 |
url |
https://doi.org/10.1590/0037-8682-0475-2017 http://hdl.handle.net/1843/47675 |
identifier_str_mv |
16789849 0000-0001-6833-3870 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
Revista da Sociedade Brasileira de Medicina Tropical |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
dc.publisher.none.fl_str_mv |
Universidade Federal de Minas Gerais |
dc.publisher.initials.fl_str_mv |
UFMG |
dc.publisher.country.fl_str_mv |
Brasil |
dc.publisher.department.fl_str_mv |
MED - DEPARTAMENTO DE APARELHO LOCOMOTOR MED - DEPARTAMENTO DE CLÍNICA MÉDICA |
publisher.none.fl_str_mv |
Universidade Federal de Minas Gerais |
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reponame:Repositório Institucional da UFMG instname:Universidade Federal de Minas Gerais (UFMG) instacron:UFMG |
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Universidade Federal de Minas Gerais (UFMG) |
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UFMG |
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UFMG |
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