Triggering different brain states using asynchronous serial communication to the rat amygdala
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Repositório Institucional da UFMG |
Texto Completo: | https://doi.org/10.1093/cercor/bhu313 http://hdl.handle.net/1843/56295 https://orcid.org/0000-0002-4519-3585 https://orcid.org/0000-0002-1456-4689 https://orcid.org/0000-0003-0243-1309 https://orcid.org/0000-0002-2170-6649 https://orcid.org/0000-0002-1508-3801 |
Resumo: | Inputting information to the brain through direct electrical microstimulation must consider how underlying neural networks encode information. One unexplored possibility is that a single electrode delivering temporally coded stimuli, mimicking an asynchronous serial communication port to the brain, can trigger the emergence of different brain states. This work used a discriminative fear-conditioning paradigm in rodents in which 2 temporally coded microstimulation patterns were targeted at the amygdaloid complex. Each stimulus was a binary-coded “word” made up of 10 ms bins, with 1's representing a single pulse stimulus: A-1001111001 and B-1110000111. During 3 consecutive retention tests (i.e., day-word: 1-B; 2-A, and 3-B), only binary-coded words previously paired with a foot-electroshock elicited proper aversive behavior. To determine the neural substrates recruited by the different stimulation patterns, c-Fos expression was evaluated 90 min after the last retention test. Animals conditioned to word-B, after stimulation with word-B, demonstrated increased hypothalamic c-Fos staining. Animals conditioned to word-A, however, showed increased prefrontal c-Fos labeling. In addition, prefrontal-cortex and hypothalamic c-Fos staining for, respectively, word-B- and word-A-conditioned animals, was not different than that of an unpaired control group. Our results suggest that, depending on the valence acquired from previous learning, temporally coded microstimulation activates distinct neural networks and associated behavior. |
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2023-07-14T20:31:27Z2023-07-14T20:31:27Z201626518661877https://doi.org/10.1093/cercor/bhu3131047-3211http://hdl.handle.net/1843/56295https://orcid.org/0000-0002-4519-3585https://orcid.org/0000-0002-1456-4689https://orcid.org/0000-0003-0243-1309https://orcid.org/0000-0002-2170-6649https://orcid.org/0000-0002-1508-3801Inputting information to the brain through direct electrical microstimulation must consider how underlying neural networks encode information. One unexplored possibility is that a single electrode delivering temporally coded stimuli, mimicking an asynchronous serial communication port to the brain, can trigger the emergence of different brain states. This work used a discriminative fear-conditioning paradigm in rodents in which 2 temporally coded microstimulation patterns were targeted at the amygdaloid complex. Each stimulus was a binary-coded “word” made up of 10 ms bins, with 1's representing a single pulse stimulus: A-1001111001 and B-1110000111. During 3 consecutive retention tests (i.e., day-word: 1-B; 2-A, and 3-B), only binary-coded words previously paired with a foot-electroshock elicited proper aversive behavior. To determine the neural substrates recruited by the different stimulation patterns, c-Fos expression was evaluated 90 min after the last retention test. Animals conditioned to word-B, after stimulation with word-B, demonstrated increased hypothalamic c-Fos staining. Animals conditioned to word-A, however, showed increased prefrontal c-Fos labeling. In addition, prefrontal-cortex and hypothalamic c-Fos staining for, respectively, word-B- and word-A-conditioned animals, was not different than that of an unpaired control group. Our results suggest that, depending on the valence acquired from previous learning, temporally coded microstimulation activates distinct neural networks and associated behavior.porUniversidade Federal de Minas GeraisUFMGBrasilICB - DEPARTAMENTO DE FISIOLOGIA E BIOFÍSICACerebral CortexAmigdalasMedoAmygdaloid complexElectrical microstimulationFear-conditioningPrefrontal cortexTemporal codingTriggering different brain states using asynchronous serial communication to the rat amygdalainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://academic.oup.com/cercor/article/26/5/1866/1753715?login=trueFlávio Afonso Gonçalves MourãoAndré Luiz Vieira LockmannGabriel Perfeito CastroDaniel de Castro MedeirosMarina Pádua ReisGrace Schenatto Pereira MoraesAndré Ricardo MassensiniMarcio Flávio Dutra Moraesinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMGLICENSELicense.txtLicense.txttext/plain; charset=utf-82042https://repositorio.ufmg.br/bitstream/1843/56295/1/License.txtfa505098d172de0bc8864fc1287ffe22MD51ORIGINALTriggering Different Brain States Using Asynchronous Serial Communication to the Rat Amygdala.pdfTriggering Different Brain States Using Asynchronous Serial Communication to the Rat Amygdala.pdfapplication/pdf1516080https://repositorio.ufmg.br/bitstream/1843/56295/2/Triggering%20Different%20Brain%20States%20Using%20Asynchronous%20Serial%20Communication%20to%20the%20Rat%20Amygdala.pdf1ea0c2c6a1a558da8f58c5c5b9878b7fMD521843/562952023-07-14 17:31:27.656oai:repositorio.ufmg.br:1843/56295TElDRU7vv71BIERFIERJU1RSSUJVSe+/ve+/vU8gTu+/vU8tRVhDTFVTSVZBIERPIFJFUE9TSVTvv71SSU8gSU5TVElUVUNJT05BTCBEQSBVRk1HCiAKCkNvbSBhIGFwcmVzZW50Ye+/ve+/vW8gZGVzdGEgbGljZW7vv71hLCB2b2Pvv70gKG8gYXV0b3IgKGVzKSBvdSBvIHRpdHVsYXIgZG9zIGRpcmVpdG9zIGRlIGF1dG9yKSBjb25jZWRlIGFvIFJlcG9zaXTvv71yaW8gSW5zdGl0dWNpb25hbCBkYSBVRk1HIChSSS1VRk1HKSBvIGRpcmVpdG8gbu+/vW8gZXhjbHVzaXZvIGUgaXJyZXZvZ++/vXZlbCBkZSByZXByb2R1emlyIGUvb3UgZGlzdHJpYnVpciBhIHN1YSBwdWJsaWNh77+977+9byAoaW5jbHVpbmRvIG8gcmVzdW1vKSBwb3IgdG9kbyBvIG11bmRvIG5vIGZvcm1hdG8gaW1wcmVzc28gZSBlbGV0cu+/vW5pY28gZSBlbSBxdWFscXVlciBtZWlvLCBpbmNsdWluZG8gb3MgZm9ybWF0b3Mg77+9dWRpbyBvdSB277+9ZGVvLgoKVm9j77+9IGRlY2xhcmEgcXVlIGNvbmhlY2UgYSBwb2zvv710aWNhIGRlIGNvcHlyaWdodCBkYSBlZGl0b3JhIGRvIHNldSBkb2N1bWVudG8gZSBxdWUgY29uaGVjZSBlIGFjZWl0YSBhcyBEaXJldHJpemVzIGRvIFJJLVVGTUcuCgpWb2Pvv70gY29uY29yZGEgcXVlIG8gUmVwb3NpdO+/vXJpbyBJbnN0aXR1Y2lvbmFsIGRhIFVGTUcgcG9kZSwgc2VtIGFsdGVyYXIgbyBjb250Ze+/vWRvLCB0cmFuc3BvciBhIHN1YSBwdWJsaWNh77+977+9byBwYXJhIHF1YWxxdWVyIG1laW8gb3UgZm9ybWF0byBwYXJhIGZpbnMgZGUgcHJlc2VydmHvv73vv71vLgoKVm9j77+9IHRhbWLvv71tIGNvbmNvcmRhIHF1ZSBvIFJlcG9zaXTvv71yaW8gSW5zdGl0dWNpb25hbCBkYSBVRk1HIHBvZGUgbWFudGVyIG1haXMgZGUgdW1hIGPvv71waWEgZGUgc3VhIHB1YmxpY2Hvv73vv71vIHBhcmEgZmlucyBkZSBzZWd1cmFu77+9YSwgYmFjay11cCBlIHByZXNlcnZh77+977+9by4KClZvY++/vSBkZWNsYXJhIHF1ZSBhIHN1YSBwdWJsaWNh77+977+9byDvv70gb3JpZ2luYWwgZSBxdWUgdm9j77+9IHRlbSBvIHBvZGVyIGRlIGNvbmNlZGVyIG9zIGRpcmVpdG9zIGNvbnRpZG9zIG5lc3RhIGxpY2Vu77+9YS4gVm9j77+9IHRhbWLvv71tIGRlY2xhcmEgcXVlIG8gZGVw77+9c2l0byBkZSBzdWEgcHVibGljYe+/ve+/vW8gbu+/vW8sIHF1ZSBzZWphIGRlIHNldSBjb25oZWNpbWVudG8sIGluZnJpbmdlIGRpcmVpdG9zIGF1dG9yYWlzIGRlIG5pbmd177+9bS4KCkNhc28gYSBzdWEgcHVibGljYe+/ve+/vW8gY29udGVuaGEgbWF0ZXJpYWwgcXVlIHZvY++/vSBu77+9byBwb3NzdWkgYSB0aXR1bGFyaWRhZGUgZG9zIGRpcmVpdG9zIGF1dG9yYWlzLCB2b2Pvv70gZGVjbGFyYSBxdWUgb2J0ZXZlIGEgcGVybWlzc++/vW8gaXJyZXN0cml0YSBkbyBkZXRlbnRvciBkb3MgZGlyZWl0b3MgYXV0b3JhaXMgcGFyYSBjb25jZWRlciBhbyBSZXBvc2l077+9cmlvIEluc3RpdHVjaW9uYWwgZGEgVUZNRyBvcyBkaXJlaXRvcyBhcHJlc2VudGFkb3MgbmVzdGEgbGljZW7vv71hLCBlIHF1ZSBlc3NlIG1hdGVyaWFsIGRlIHByb3ByaWVkYWRlIGRlIHRlcmNlaXJvcyBlc3Tvv70gY2xhcmFtZW50ZSBpZGVudGlmaWNhZG8gZSByZWNvbmhlY2lkbyBubyB0ZXh0byBvdSBubyBjb250Ze+/vWRvIGRhIHB1YmxpY2Hvv73vv71vIG9yYSBkZXBvc2l0YWRhLgoKQ0FTTyBBIFBVQkxJQ0Hvv73vv71PIE9SQSBERVBPU0lUQURBIFRFTkhBIFNJRE8gUkVTVUxUQURPIERFIFVNIFBBVFJPQ++/vU5JTyBPVSBBUE9JTyBERSBVTUEgQUfvv71OQ0lBIERFIEZPTUVOVE8gT1UgT1VUUk8gT1JHQU5JU01PLCBWT0Pvv70gREVDTEFSQSBRVUUgUkVTUEVJVE9VIFRPRE9TIEUgUVVBSVNRVUVSIERJUkVJVE9TIERFIFJFVklT77+9TyBDT01PIFRBTULvv71NIEFTIERFTUFJUyBPQlJJR0Hvv73vv71FUyBFWElHSURBUyBQT1IgQ09OVFJBVE8gT1UgQUNPUkRPLgoKTyBSZXBvc2l077+9cmlvIEluc3RpdHVjaW9uYWwgZGEgVUZNRyBzZSBjb21wcm9tZXRlIGEgaWRlbnRpZmljYXIgY2xhcmFtZW50ZSBvIHNldSBub21lKHMpIG91IG8ocykgbm9tZXMocykgZG8ocykgZGV0ZW50b3IoZXMpIGRvcyBkaXJlaXRvcyBhdXRvcmFpcyBkYSBwdWJsaWNh77+977+9bywgZSBu77+9byBmYXLvv70gcXVhbHF1ZXIgYWx0ZXJh77+977+9bywgYWzvv71tIGRhcXVlbGFzIGNvbmNlZGlkYXMgcG9yIGVzdGEgbGljZW7vv71hLgo=Repositório de PublicaçõesPUBhttps://repositorio.ufmg.br/oaiopendoar:2023-07-14T20:31:27Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)false |
dc.title.pt_BR.fl_str_mv |
Triggering different brain states using asynchronous serial communication to the rat amygdala |
title |
Triggering different brain states using asynchronous serial communication to the rat amygdala |
spellingShingle |
Triggering different brain states using asynchronous serial communication to the rat amygdala Flávio Afonso Gonçalves Mourão Amygdaloid complex Electrical microstimulation Fear-conditioning Prefrontal cortex Temporal coding Amigdalas Medo |
title_short |
Triggering different brain states using asynchronous serial communication to the rat amygdala |
title_full |
Triggering different brain states using asynchronous serial communication to the rat amygdala |
title_fullStr |
Triggering different brain states using asynchronous serial communication to the rat amygdala |
title_full_unstemmed |
Triggering different brain states using asynchronous serial communication to the rat amygdala |
title_sort |
Triggering different brain states using asynchronous serial communication to the rat amygdala |
author |
Flávio Afonso Gonçalves Mourão |
author_facet |
Flávio Afonso Gonçalves Mourão André Luiz Vieira Lockmann Gabriel Perfeito Castro Daniel de Castro Medeiros Marina Pádua Reis Grace Schenatto Pereira Moraes André Ricardo Massensini Marcio Flávio Dutra Moraes |
author_role |
author |
author2 |
André Luiz Vieira Lockmann Gabriel Perfeito Castro Daniel de Castro Medeiros Marina Pádua Reis Grace Schenatto Pereira Moraes André Ricardo Massensini Marcio Flávio Dutra Moraes |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Flávio Afonso Gonçalves Mourão André Luiz Vieira Lockmann Gabriel Perfeito Castro Daniel de Castro Medeiros Marina Pádua Reis Grace Schenatto Pereira Moraes André Ricardo Massensini Marcio Flávio Dutra Moraes |
dc.subject.por.fl_str_mv |
Amygdaloid complex Electrical microstimulation Fear-conditioning Prefrontal cortex Temporal coding |
topic |
Amygdaloid complex Electrical microstimulation Fear-conditioning Prefrontal cortex Temporal coding Amigdalas Medo |
dc.subject.other.pt_BR.fl_str_mv |
Amigdalas Medo |
description |
Inputting information to the brain through direct electrical microstimulation must consider how underlying neural networks encode information. One unexplored possibility is that a single electrode delivering temporally coded stimuli, mimicking an asynchronous serial communication port to the brain, can trigger the emergence of different brain states. This work used a discriminative fear-conditioning paradigm in rodents in which 2 temporally coded microstimulation patterns were targeted at the amygdaloid complex. Each stimulus was a binary-coded “word” made up of 10 ms bins, with 1's representing a single pulse stimulus: A-1001111001 and B-1110000111. During 3 consecutive retention tests (i.e., day-word: 1-B; 2-A, and 3-B), only binary-coded words previously paired with a foot-electroshock elicited proper aversive behavior. To determine the neural substrates recruited by the different stimulation patterns, c-Fos expression was evaluated 90 min after the last retention test. Animals conditioned to word-B, after stimulation with word-B, demonstrated increased hypothalamic c-Fos staining. Animals conditioned to word-A, however, showed increased prefrontal c-Fos labeling. In addition, prefrontal-cortex and hypothalamic c-Fos staining for, respectively, word-B- and word-A-conditioned animals, was not different than that of an unpaired control group. Our results suggest that, depending on the valence acquired from previous learning, temporally coded microstimulation activates distinct neural networks and associated behavior. |
publishDate |
2016 |
dc.date.issued.fl_str_mv |
2016 |
dc.date.accessioned.fl_str_mv |
2023-07-14T20:31:27Z |
dc.date.available.fl_str_mv |
2023-07-14T20:31:27Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1843/56295 |
dc.identifier.doi.pt_BR.fl_str_mv |
https://doi.org/10.1093/cercor/bhu313 |
dc.identifier.issn.pt_BR.fl_str_mv |
1047-3211 |
dc.identifier.orcid.pt_BR.fl_str_mv |
https://orcid.org/0000-0002-4519-3585 https://orcid.org/0000-0002-1456-4689 https://orcid.org/0000-0003-0243-1309 https://orcid.org/0000-0002-2170-6649 https://orcid.org/0000-0002-1508-3801 |
url |
https://doi.org/10.1093/cercor/bhu313 http://hdl.handle.net/1843/56295 https://orcid.org/0000-0002-4519-3585 https://orcid.org/0000-0002-1456-4689 https://orcid.org/0000-0003-0243-1309 https://orcid.org/0000-0002-2170-6649 https://orcid.org/0000-0002-1508-3801 |
identifier_str_mv |
1047-3211 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.ispartof.pt_BR.fl_str_mv |
Cerebral Cortex |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
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openAccess |
dc.publisher.none.fl_str_mv |
Universidade Federal de Minas Gerais |
dc.publisher.initials.fl_str_mv |
UFMG |
dc.publisher.country.fl_str_mv |
Brasil |
dc.publisher.department.fl_str_mv |
ICB - DEPARTAMENTO DE FISIOLOGIA E BIOFÍSICA |
publisher.none.fl_str_mv |
Universidade Federal de Minas Gerais |
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reponame:Repositório Institucional da UFMG instname:Universidade Federal de Minas Gerais (UFMG) instacron:UFMG |
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Repositório Institucional da UFMG |
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