Sleep pattern and locomotor activity are impaired by doxorubicin in non-tumor-bearing rats
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFMG |
Texto Completo: | https://doi.org/10.1016/j.slsci.2016.10.006 http://hdl.handle.net/1843/64039 https://orcid.org/0000-0002-9645-1003 https://orcid.org/0000-0003-2435-5335 https://orcid.org/0000-0002-6917-0230 https://orcid.org/0000-0003-4241-2743 https://orcid.org/0000-0003-3114-6611 https://orcid.org/0000-0003-3896-2208 |
Resumo: | Purpose: We sought explore the effects of doxorubicin on sleep patterns and locomotor activity. To investigate these effects, two groups were formed: a control group and a Doxorubicin (DOXO) group. Methods: Sixteen rats were randomly assigned to either the control or DOXO groups. The sleep patterns were examined by polysomnographic recording and locomotor activity was evaluated in an open-field test. Results: In the light period, the total sleep time and slow wave sleep were decreased, while the wake after sleep onset and arousal were increased in the DOXO group compared with the control group (p < 0.05). In the dark period, the total sleep time, arousal, and slow wave sleep were increased, while the wake after sleep onset was decreased in the DOXO group compared with the control group (p < 0.05). Moreover, DOXO induced a decrease of crossing and rearing numbers when compared control group (p < 0.05). Conclusions: Therefore, our results suggest that doxorubicin induces sleep pattern impairments and reduction of locomotor activity. |
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2024-02-16T16:34:44Z2024-02-16T16:34:44Z201693232235https://doi.org/10.1016/j.slsci.2016.10.0061984-0063http://hdl.handle.net/1843/64039https://orcid.org/0000-0002-9645-1003https://orcid.org/0000-0003-2435-5335https://orcid.org/0000-0002-6917-0230https://orcid.org/0000-0003-4241-2743https://orcid.org/0000-0003-3114-6611https://orcid.org/0000-0003-3896-2208Purpose: We sought explore the effects of doxorubicin on sleep patterns and locomotor activity. To investigate these effects, two groups were formed: a control group and a Doxorubicin (DOXO) group. Methods: Sixteen rats were randomly assigned to either the control or DOXO groups. The sleep patterns were examined by polysomnographic recording and locomotor activity was evaluated in an open-field test. Results: In the light period, the total sleep time and slow wave sleep were decreased, while the wake after sleep onset and arousal were increased in the DOXO group compared with the control group (p < 0.05). In the dark period, the total sleep time, arousal, and slow wave sleep were increased, while the wake after sleep onset was decreased in the DOXO group compared with the control group (p < 0.05). Moreover, DOXO induced a decrease of crossing and rearing numbers when compared control group (p < 0.05). Conclusions: Therefore, our results suggest that doxorubicin induces sleep pattern impairments and reduction of locomotor activity.Objetivo: Procuramos explorar os efeitos da doxorrubicina nos padrões de sono e na atividade locomotora. Para investigar esses efeitos, foram formados dois grupos: um grupo controle e um grupo Doxorrubicina (DOXO). Métodos: Dezesseis ratos foram designados aleatoriamente para o grupo controle ou DOXO. Os padrões de sono foram examinados por registro polissonográfico e a atividade locomotora foi avaliada em teste de campo aberto. Resultados: No período claro, o tempo total de sono e o sono de ondas lentas diminuíram, enquanto a vigília após o início do sono e o despertar aumentaram no grupo DOXO em comparação com o grupo controle (p < 0,05). No período escuro, o tempo total de sono, o despertar e o sono de ondas lentas aumentaram, enquanto a vigília após o início do sono diminuiu no grupo DOXO em comparação com o grupo controle (p < 0,05). Além disso, DOXO induziu uma diminuição no número de cruzamentos e criações quando comparado ao grupo controle (p < 0,05). Conclusões: Portanto, nossos resultados sugerem que a doxorrubicina induz prejuízos no padrão de sono e redução da atividade locomotora.CNPq - Conselho Nacional de Desenvolvimento Científico e TecnológicoFAPESP - Fundação de Amparo à Pesquisa do Estado de São PauloengUniversidade Federal de Minas GeraisUFMGBrasilEEF - DEPARTAMENTO DE ESPORTESSleep ScienceSonoLocomoção - atividade motoraDoxorrubicinaRatosSleepLocomotor activityDoxorubicinRatsSleep pattern and locomotor activity are impaired by doxorubicin in non-tumor-bearing ratsO padrão de sono e a atividade locomotora são prejudicados pela doxorrubicina em ratos não portadores de tumorinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://www.sciencedirect.com/science/article/pii/S1984006316300827?via%3DihubFabio Santos LiraAndrea Maculano EstevesGustavo Duarte PimentelJosé Cesar RosaMiriam Kannebley FrankMelise Oliveira MarianoJosiane BudniJoão QuevedoRonaldo Vagner dos SantosMarco Tulio de Melloinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMGLICENSELicense.txtLicense.txttext/plain; charset=utf-82042https://repositorio.ufmg.br/bitstream/1843/64039/1/License.txtfa505098d172de0bc8864fc1287ffe22MD51ORIGINALSleep pattern and locomotor activity are impaired by doxorubicin in non-tumor-bearing rats.pdfSleep pattern and locomotor activity are impaired by doxorubicin in non-tumor-bearing rats.pdfapplication/pdf520850https://repositorio.ufmg.br/bitstream/1843/64039/2/Sleep%20pattern%20and%20locomotor%20activity%20are%20impaired%20by%20doxorubicin%20in%20non-tumor-bearing%20rats.pdf5de0d118e0a7785c9909534e07d7a185MD521843/640392024-02-16 13:34:44.576oai:repositorio.ufmg.br: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Repositório de PublicaçõesPUBhttps://repositorio.ufmg.br/oaiopendoar:2024-02-16T16:34:44Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)false |
dc.title.pt_BR.fl_str_mv |
Sleep pattern and locomotor activity are impaired by doxorubicin in non-tumor-bearing rats |
dc.title.alternative.pt_BR.fl_str_mv |
O padrão de sono e a atividade locomotora são prejudicados pela doxorrubicina em ratos não portadores de tumor |
title |
Sleep pattern and locomotor activity are impaired by doxorubicin in non-tumor-bearing rats |
spellingShingle |
Sleep pattern and locomotor activity are impaired by doxorubicin in non-tumor-bearing rats Fabio Santos Lira Sleep Locomotor activity Doxorubicin Rats Sono Locomoção - atividade motora Doxorrubicina Ratos |
title_short |
Sleep pattern and locomotor activity are impaired by doxorubicin in non-tumor-bearing rats |
title_full |
Sleep pattern and locomotor activity are impaired by doxorubicin in non-tumor-bearing rats |
title_fullStr |
Sleep pattern and locomotor activity are impaired by doxorubicin in non-tumor-bearing rats |
title_full_unstemmed |
Sleep pattern and locomotor activity are impaired by doxorubicin in non-tumor-bearing rats |
title_sort |
Sleep pattern and locomotor activity are impaired by doxorubicin in non-tumor-bearing rats |
author |
Fabio Santos Lira |
author_facet |
Fabio Santos Lira Andrea Maculano Esteves Gustavo Duarte Pimentel José Cesar Rosa Miriam Kannebley Frank Melise Oliveira Mariano Josiane Budni João Quevedo Ronaldo Vagner dos Santos Marco Tulio de Mello |
author_role |
author |
author2 |
Andrea Maculano Esteves Gustavo Duarte Pimentel José Cesar Rosa Miriam Kannebley Frank Melise Oliveira Mariano Josiane Budni João Quevedo Ronaldo Vagner dos Santos Marco Tulio de Mello |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Fabio Santos Lira Andrea Maculano Esteves Gustavo Duarte Pimentel José Cesar Rosa Miriam Kannebley Frank Melise Oliveira Mariano Josiane Budni João Quevedo Ronaldo Vagner dos Santos Marco Tulio de Mello |
dc.subject.por.fl_str_mv |
Sleep Locomotor activity Doxorubicin Rats |
topic |
Sleep Locomotor activity Doxorubicin Rats Sono Locomoção - atividade motora Doxorrubicina Ratos |
dc.subject.other.pt_BR.fl_str_mv |
Sono Locomoção - atividade motora Doxorrubicina Ratos |
description |
Purpose: We sought explore the effects of doxorubicin on sleep patterns and locomotor activity. To investigate these effects, two groups were formed: a control group and a Doxorubicin (DOXO) group. Methods: Sixteen rats were randomly assigned to either the control or DOXO groups. The sleep patterns were examined by polysomnographic recording and locomotor activity was evaluated in an open-field test. Results: In the light period, the total sleep time and slow wave sleep were decreased, while the wake after sleep onset and arousal were increased in the DOXO group compared with the control group (p < 0.05). In the dark period, the total sleep time, arousal, and slow wave sleep were increased, while the wake after sleep onset was decreased in the DOXO group compared with the control group (p < 0.05). Moreover, DOXO induced a decrease of crossing and rearing numbers when compared control group (p < 0.05). Conclusions: Therefore, our results suggest that doxorubicin induces sleep pattern impairments and reduction of locomotor activity. |
publishDate |
2016 |
dc.date.issued.fl_str_mv |
2016 |
dc.date.accessioned.fl_str_mv |
2024-02-16T16:34:44Z |
dc.date.available.fl_str_mv |
2024-02-16T16:34:44Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1843/64039 |
dc.identifier.doi.pt_BR.fl_str_mv |
https://doi.org/10.1016/j.slsci.2016.10.006 |
dc.identifier.issn.pt_BR.fl_str_mv |
1984-0063 |
dc.identifier.orcid.pt_BR.fl_str_mv |
https://orcid.org/0000-0002-9645-1003 https://orcid.org/0000-0003-2435-5335 https://orcid.org/0000-0002-6917-0230 https://orcid.org/0000-0003-4241-2743 https://orcid.org/0000-0003-3114-6611 https://orcid.org/0000-0003-3896-2208 |
url |
https://doi.org/10.1016/j.slsci.2016.10.006 http://hdl.handle.net/1843/64039 https://orcid.org/0000-0002-9645-1003 https://orcid.org/0000-0003-2435-5335 https://orcid.org/0000-0002-6917-0230 https://orcid.org/0000-0003-4241-2743 https://orcid.org/0000-0003-3114-6611 https://orcid.org/0000-0003-3896-2208 |
identifier_str_mv |
1984-0063 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
Sleep Science |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Universidade Federal de Minas Gerais |
dc.publisher.initials.fl_str_mv |
UFMG |
dc.publisher.country.fl_str_mv |
Brasil |
dc.publisher.department.fl_str_mv |
EEF - DEPARTAMENTO DE ESPORTES |
publisher.none.fl_str_mv |
Universidade Federal de Minas Gerais |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UFMG instname:Universidade Federal de Minas Gerais (UFMG) instacron:UFMG |
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Universidade Federal de Minas Gerais (UFMG) |
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UFMG |
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UFMG |
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Repositório Institucional da UFMG |
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Repositório Institucional da UFMG |
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